Family pedigree with proband (1265, arrow) diagnosed with both breast cancer and sarcoma. A heterozygous germline mutation in CHK2 is accompanied by loss of the wild-type CHK2 allele in breast tumor of the proband. The mutant R145W allele encodes an unstable protein. For details, see the article by S.B. Lee et al. on p. 8062 of this issue.

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