Review:

Insulin-like Growth Factor-binding Protein 2 in Tumorigenesis: Protector or Promoter?

Andreas Hoeflich, Raquel Reisinger, Harald Lahm, Wieland Kiess, Werner F. Blum, Helmut J. Kolb, Matthias M. Weber, and Eckhard Wolf
Cancer Res 2001 61: 8601-8610. [Full Text] [PDF]  

Advances in Brief:

Reversal of GSTP1 CpG Island Hypermethylation and Reactivation of -Class Glutathione S-Transferase (GSTP1) Expression in Human Prostate Cancer Cells by Treatment with Procainamide

Xiaohui Lin, Kekule Asgari, Mathew J. Putzi, Wesley R. Gage, Xiang Yu, Brian S. Cornblatt, Arunima Kumar, Steven Piantadosi, Theodore L. DeWeese, Angelo M. De Marzo, and William G. Nelson
Cancer Res 2001 61: 8611-8616. [Abstract] [Full Text] [PDF]  

Cyclooxygenase-2 Is Up-Regulated in Proliferative Inflammatory Atrophy of the Prostate, but not in Prostate Carcinoma

Shan Zha, Wesley R. Gage, Jurga Sauvageot, Elizabeth A. Saria, Mathew J. Putzi, Charles M. Ewing, Dennis A. Faith, William G. Nelson, Angelo M. De Marzo, and William B. Isaacs
Cancer Res 2001 61: 8617-8623. [Abstract] [Full Text] [PDF]  

Gastrointestinal Stromal Tumors with KIT Mutations Exhibit a Remarkably Homogeneous Gene Expression Profile

Susanne V. Allander, Nina N. Nupponen, Markus Ringnér, Galen Hostetter, Greg W. Maher, Natalie Goldberger, Yidong Chen, John Carpten, Abdel G. Elkahloun, and Paul S. Meltzer
Cancer Res 2001 61: 8624-8628. [Abstract] [Full Text] [PDF]  

A Receptor for Vascular Endothelial Growth Factor That Stimulates Endothelial Apoptosis

Timothy P. Quinn, Scott J. Soifer, Kevin Ramer, Lewis T. Williams, and Mary C. Nakamura
Cancer Res 2001 61: 8629-8637. [Abstract] [Full Text] [PDF]  

Boron Neutron Capture Therapy for the Treatment of Oral Cancer in the Hamster Cheek Pouch Model

Erica L. Kreimann, Maria E. Itoiz, Juan Longhino, Herman Blaumann, Osvaldo Calzetta, and Amanda E. Schwint
Cancer Res 2001 61: 8638-8642. [Abstract] [Full Text] [PDF]  

Depletion of CD25⁺ CD4⁺ T Cells and Treatment with Tyrosinase-related Protein 2-transduced Dendritic Cells Enhance the Interferon -induced, CD8⁺ T-Cell-dependent Immune Defense of B16 Melanoma

Julia Steitz, Jürgen Brück, Julia Lenz, Jürgen Knop, and Thomas Tüting
Cancer Res 2001 61: 8643-8646. [Abstract] [Full Text] [PDF]  

Immune Escape of Melanoma: First Evidence of Structural Alterations in Two Distinct Components of the MHC Class I Antigen Processing Pathway

Barbara Seliger, Ulrike Ritz, Rupert Abele, Michaela Bock, Robert Tampé, Gert Sutter, Ingo Drexler, Christoph Huber, and Soldano Ferrone
Cancer Res 2001 61: 8647-8650. [Abstract] [Full Text] [PDF]  

Loss of Heterozygosity of the Putative Prostate Cancer Susceptibility Gene HPC2/ELAC2 Is Uncommon in Sporadic and Familial Prostate Cancer

Yu-Qun Wu, Hong Chen, Mark A. Rubin, Kirk J. Wojno, and Kathleen A. Cooney
Cancer Res 2001 61: 8651-8653. [Abstract] [Full Text] [PDF]  

A Xeroderma Pigmentosum Group D Gene Polymorphism Predicts Clinical Outcome to Platinum-based Chemotherapy in Patients with Advanced Colorectal Cancer

David J. Park, Jan Stoehlmacher, Wu Zhang, Denice D. Tsao-Wei, Susan Groshen, and Heinz-Josef Lenz
Cancer Res 2001 61: 8654-8658. [Abstract] [Full Text] [PDF]  

Aberrant Promoter Methylation Profile of Bladder Cancer and Its Relationship to Clinicopathological Features

Riichiroh Maruyama, Shinichi Toyooka, Kiyomi O. Toyooka, Kenichi Harada, Arvind K. Virmani, Sabine Zöchbauer-Müller, Alfredo J. Farinas, Funda Vakar-Lopez, John D. Minna, Arthur Sagalowsky, Bogdan Czerniak, and Adi F. Gazdar
Cancer Res 2001 61: 8659-8663. [Abstract] [Full Text] [PDF]  

Evidence That APC Regulates Survivin Expression: A Possible Mechanism Contributing to the Stem Cell Origin of Colon Cancer

Tao Zhang, Tomas Otevrel, Zhenqiang Gao, Zhiping Gao, Saundra M. Ehrlich, Jeremy Z. Fields, and Bruce M. Boman
Cancer Res 2001 61: 8664-8667. [Abstract] [Full Text] [PDF]  

Biochemistry and Biophysics:

Kinase Suppressor of Ras Determines Survival of Intestinal Epithelial Cells Exposed to Tumor Necrosis Factor

Fang Yan, Sutha K. John, and D. Brent Polk
Cancer Res 2001 61: 8668-8675. [Abstract] [Full Text] [PDF]  

Pleiotrophic Inhibition of Pericellular Urokinase-type Plasminogen Activator System by Endogenous Tumor Suppressive Maspin

Hector Biliran, Jr. and Shijie Sheng
Cancer Res 2001 61: 8676-8682. [Abstract] [Full Text] [PDF]  

Carcinogenesis:

LAS, a Novel Selective Estrogen Receptor Modulator with Chemopreventive and Therapeutic Activity in the N-Nitroso-N-methylurea-induced Rat Mammary Tumor Model

Leonard A. Cohen, Brian Pittman, Chung-Xiou Wang, César Aliaga, Li Yu, and James D. Moyer
Cancer Res 2001 61: 8683-8688. [Abstract] [Full Text] [PDF]  

Intestinal Tumorigenesis in Multiple Intestinal Neoplasia Mice Induced by the Food Mutagen 2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine: Perinatal Susceptibility, Regional Variation, and Correlation with DNA Adducts

Inger-Lise Steffensen, Herman A. J. Schut, Jan Erik Paulsen, Åshild Andreassen, and Jan Alexander
Cancer Res 2001 61: 8689-8696. [Abstract] [Full Text] [PDF]  

Clinical Investigations:

Normalization of Elevated Hepatic 8-Hydroxy-2'-Deoxyguanosine Levels in Chronic Hepatitis C Patients by Phlebotomy and Low Iron Diet

Junji Kato, Masayoshi Kobune, Tokiko Nakamura, Ganji Kuroiwa, Kohichi Takada, Rishu Takimoto, Yasuhiro Sato, Koshi Fujikawa, Minoru Takahashi, Tetsuji Takayama, Tatsuru Ikeda, and Yoshiro Niitsu
Cancer Res 2001 61: 8697-8702. [Abstract] [Full Text] [PDF]  

Endocrinology:

Synergistic Cytotoxicity Exhibited by Combination Treatment of Selective Retinoid Ligands with Taxol (Paclitaxel)

Valerie Vivat-Hannah, Dan You, Cheryl Rizzo, Jean-Paul Daris, Philippe Lapointe, F. Christopher Zusi, Anne Marinier, Matthew V. Lorenzi, and Marco M. Gottardis
Cancer Res 2001 61: 8703-8711. [Abstract] [Full Text] [PDF]  

Glucocorticoids Manifest Androgenic Activity in a Cell Line Derived from a Metastatic Prostate Cancer

Ching-Yi Chang, Philip J. Walther, and Donald P. McDonnell
Cancer Res 2001 61: 8712-8717. [Abstract] [Full Text] [PDF]  

Epidemiology and Prevention:

Differential Association of the Codon 72 p53 and GSTM1 Polymorphisms on Histological Subtype of Non-Small Cell Lung Carcinoma

Geoffrey Liu, David P. Miller, Wei Zhou, Sally W. Thurston, Rong Fan, Li-Lian Xu, Thomas J. Lynch, John C. Wain, Li Su, and David C. Christiani
Cancer Res 2001 61: 8718-8722. [Abstract] [Full Text] [PDF]  

Experimental Therapeutics:

Interaction of p53 and DNA-PK in Response to Nucleoside Analogues: Potential Role As a Sensor Complex for DNA Damage

Geetha Achanta, Helene Pelicano, Li Feng, William Plunkett, and Peng Huang
Cancer Res 2001 61: 8723-8729. [Abstract] [Full Text] [PDF]  

Simultaneous Inhibition of Glioma Angiogenesis, Cell Proliferation, and Invasion by a Naturally Occurring Fragment of Human Metalloproteinase-2

Lorenzo Bello, Valeria Lucini, Giorgio Carrabba, Carlo Giussani, Marcelle Machluf, Mauro Pluderi, Demetrios Nikas, Jianping Zhang, Giustino Tomei, Roberto M. Villani, Rona S. Carroll, Andreas Bikfalvi, and Peter M. Black
Cancer Res 2001 61: 8730-8736. [Abstract] [Full Text] [PDF]  

Human Angiogenin Fused to Human CD30 Ligand (Ang-CD30L) Exhibits Specific Cytotoxicity against CD30-positive Lymphoma

Michael Huhn, Stephanie Sasse, Mehmet K. Tur, Bärbel Matthey, Timo Schinköthe, Susanna M. Rybak, Stefan Barth, and Andreas Engert
Cancer Res 2001 61: 8737-8742. [Abstract] [Full Text] [PDF]  

Treatment of Malignant Gliomas with a Replicating Adenoviral Vector Expressing Herpes Simplex Virus-Thymidine Kinase

Dharmin Nanda, Ronald Vogels, Menzo Havenga, Cees J. Avezaat, Abraham Bout, and Peter Sillevis Smitt
Cancer Res 2001 61: 8743-8750. [Abstract] [Full Text] [PDF]  

Systemic Cancer Therapy with a Tumor-selective Vaccinia Virus Mutant Lacking Thymidine Kinase and Vaccinia Growth Factor Genes

J. Andrea McCart, Jerrold M. Ward, John Lee, Yun Hu, H. Richard Alexander, Steven K. Libutti, Bernard Moss, and David L. Bartlett
Cancer Res 2001 61: 8751-8757. [Abstract] [Full Text] [PDF]  

Evaluation of Farnesyl:Protein Transferase and Geranylgeranyl:Protein Transferase Inhibitor Combinations in Preclinical Models

Robert B. Lobell, Charles A. Omer, Marc T. Abrams, Hema G. Bhimnathwala, Mary Jo Brucker, Carolyn A. Buser, Joseph P. Davide, S. Jane deSolms, Christopher J. Dinsmore, Michelle S. Ellis-Hutchings, Astrid M. Kral, Dongming Liu, William C. Lumma, Samuel V. Machotka, Elaine Rands, Theresa M. Williams, Samuel L. Graham, George D. Hartman, Allen I. Oliff, David C. Heimbrook, and Nancy E. Kohl
Cancer Res 2001 61: 8758-8768. [Abstract] [Full Text] [PDF]  

Induction of Immunity in Peripheral Tissues Combined with Intracerebral Transplantation of Interleukin-2-producing Cells Eliminates Established Brain Tumors

Yasuo Iwadate, Akira Yamaura, Yasuo Sato, Shigeru Sakiyama, and Masatoshi Tagawa
Cancer Res 2001 61: 8769-8774. [Abstract] [Full Text] [PDF]  

The Hamster Cheek Pouch as a Model of Oral Cancer for Boron Neutron Capture Therapy Studies: Selective Delivery of Boron by Boronophenylalanine

Erica L. Kreimann, Maria E. Itoiz, Alejandra Dagrosa, Ricardo Garavaglia, Silvia Farías, Daniel Batistoni, and Amanda E. Schwint
Cancer Res 2001 61: 8775-8781. [Abstract] [Full Text] [PDF]  

-Fetoprotein-specific Tumor Immunity Induced by Plasmid Prime-Adenovirus Boost Genetic Vaccination

Wilson S. Meng, Lisa H. Butterfield, Antoni Ribas, Vivian B. Dissette, Justin B. Heller, Gustavo A. Miranda, John A. Glaspy, William H. McBride, and James S. Economou
Cancer Res 2001 61: 8782-8786. [Abstract] [Full Text] [PDF]  

Immunology:

CD40 Cross-Linking Bypasses the Absolute Requirement for CD4 T Cells during Immunization with Melanoma Antigen Gene-modified Dendritic Cells

Antoni Ribas, Lisa H. Butterfield, Saral N. Amarnani, Vivian B. Dissette, Donald Kim, Wilson S. Meng, Gustavo A. Miranda, He-Jing Wang, William H. McBride, John A. Glaspy, and James S. Economou
Cancer Res 2001 61: 8787-8793. [Abstract] [Full Text] [PDF]  

The Dynamics of the T-Cell Antitumor Response: Chemokine-secreting Dendritic Cells Can Prime Tumor-reactive T Cells Extranodally

Christopher J. Kirk, Dennis Hartigan-O’Connor, and James J. Mulé
Cancer Res 2001 61: 8794-8802. [Abstract] [Full Text] [PDF]  

Molecular and Genetics:

Expression of Id Helix-Loop-Helix Proteins in Colorectal Adenocarcinoma Correlates with p53 Expression and Mitotic Index

James W. Wilson, Richard W. Deed, Toshiaki Inoue, Manuela Balzi, Aldo Becciolini, Paola Faraoni, Christopher S. Potten, and John D. Norton
Cancer Res 2001 61: 8803-8810. [Abstract] [Full Text] [PDF]  

Regulation of Cyclin D1 and p16^INK4A Is Critical for Growth Arrest during Mammary Involution

Michele Gadd, Carmen Pisc, John Branda, Viviana Ionescu-Tiba, Zeljko Nikolic, Chuanwei Yang, Timothy Wang, Gregory M. Shackleford, Robert D. Cardiff, and Emmett V. Schmidt
Cancer Res 2001 61: 8811-8819. [Abstract] [Full Text] [PDF]  

The FOXP1 Winged Helix Transcription Factor Is a Novel Candidate Tumor Suppressor Gene on Chromosome 3p

Alison H. Banham, Nigel Beasley, Elias Campo, Pedro L. Fernandez, Carrie Fidler, Kevin Gatter, Margaret Jones, David Y. Mason, John E. Prime, Philippe Trougouboff, Katrina Wood, and Jacqueline L. Cordell
Cancer Res 2001 61: 8820-8829. [Abstract] [Full Text] [PDF]  

Overexpression of p21^WAF1/CIP1 is an Early Event in the Development of Pancreatic Intraepithelial Neoplasia

Andrew V. Biankin, James G. Kench, Adrienne L. Morey, C.-Soon Lee, Sandra A. Biankin, Darren R. Head, Thomas B. Hugh, Susan M. Henshall, and Robert L. Sutherland
Cancer Res 2001 61: 8830-8837. [Abstract] [Full Text] [PDF]  

Derivation of Human Tumor Cells in Vitro without Widespread Genomic Instability

Drazen Zimonjic, Mary W. Brooks, Nicholas Popescu, Robert A. Weinberg, and William C. Hahn
Cancer Res 2001 61: 8838-8844. [Abstract] [Full Text] [PDF]  

Detection of Occult Metastatic Breast Cancer Cells in Blood by a Multimolecular Marker Assay: Correlation with Clinical Stage of Disease

Bret Taback, Arden D. Chan, Christine T. Kuo, Peter J. Bostick, He-Jing Wang, Armando E. Giuliano, and Dave S. B. Hoon
Cancer Res 2001 61: 8845-8850. [Abstract] [Full Text] [PDF]  

Autocrine Production of Interleukin 6 Causes Multidrug Resistance in Breast Cancer Cells

Dietrich Conze, Linda Weiss, Patricia Susan Regen, Alok Bhushan, Donald Weaver, Peter Johnson, and Mercedes Rincón
Cancer Res 2001 61: 8851-8858. [Abstract] [Full Text] [PDF]  

The Role of Tumor Necrosis Factor Signaling Pathways in the Response of Murine Brain to Irradiation

Jennifer L. Daigle, Ji-Hong Hong, Chi-Shiun Chiang, and William H. McBride
Cancer Res 2001 61: 8859-8865. [Abstract] [Full Text] [PDF]  

Predisposition to Efficient Mammary Tumor Metastatic Progression Is Linked to the Breast Cancer Metastasis Suppressor Gene Brms1

Kent W. Hunter, Karl W. Broman, Thomas Le Voyer, Luanne Lukes, Diana Cozma, Michael T. Debies, Jessica Rouse, and Danny R. Welch
Cancer Res 2001 61: 8866-8872. [Abstract] [Full Text] [PDF]  

Tumor Biology:

Novel Transmembrane GTPase of Non-Small Cell Lung Cancer Identified by mRNA Differential Display

Jing-Gung Chung, Kun-Tu Yeh, Shih-Lu Wu, Nan-Yung Hsu, Guang-Wei Chen, Yea-Wen Yeh, and Heng-Chien Ho
Cancer Res 2001 61: 8873-8879. [Abstract] [Full Text] [PDF]  

Deleted in Malignant Brain Tumors 1 Is a Versatile Mucin-like Molecule Likely to Play a Differential Role in Digestive Tract Cancer

Jan Mollenhauer, Stephan Herbertz, Burkhard Helmke, Gaby Kollender, Inge Krebs, Jens Madsen, Uffe Holmskov, Karin Sorger, Liane Schmitt, Stefan Wiemann, Herwart F. Otto, Hermann-Josef Gröne, and Annemarie Poustka
Cancer Res 2001 61: 8880-8886. [Abstract] [Full Text] [PDF]  

Epidermal Growth Factor Receptor (HER1) Tyrosine Kinase Inhibitor ZD1839 (Iressa) Inhibits HER2/neu (erbB2)-overexpressing Breast Cancer Cells in Vitro and in Vivo

Stacy L. Moulder, F. Michael Yakes, Senthil K. Muthuswamy, Roberto Bianco, Jean F. Simpson, and Carlos L. Arteaga
Cancer Res 2001 61: 8887-8895. [Abstract] [Full Text] [PDF]  

Suppression of Membrane-type 1 Matrix Metalloproteinase (MMP)-mediated MMP-2 Activation and Tumor Invasion by Testican 3 and Its Splicing Variant Gene Product, N-Tes

Mitsutoshi Nakada, Akio Yamada, Takahisa Takino, Hisashi Miyamori, Tomoya Takahashi, Junkoh Yamashita, and Hiroshi Sato
Cancer Res 2001 61: 8896-8902. [Abstract] [Full Text] [PDF]  

Acute (Cyclic) Hypoxia Enhances Spontaneous Metastasis of KHT Murine Tumors

Rob A. Cairns, Tuula Kalliomaki, and Richard P. Hill
Cancer Res 2001 61: 8903-8908. [Abstract] [Full Text] [PDF]  

The Chimeric Protein Tyrosine Kinase ETV6-NTRK3 Requires both Ras-Erk1/2 and PI3-Kinase-Akt Signaling for Fibroblast Transformation

Cristina Tognon, Mathew Garnett, Elizabeth Kenward, R. Kay, Kevin Morrison, and Poul H. B. Sorensen
Cancer Res 2001 61: 8909-8916. [Abstract] [Full Text] [PDF]  

Elevated Levels of Connective Tissue Growth Factor, WISP-1, and CYR61 in Primary Breast Cancers Associated with More Advanced Features

Dong Xie, Kei Nakachi, Heming Wang, Robert Elashoff, and H. Phillip Koeffler
Cancer Res 2001 61: 8917-8923. [Abstract] [Full Text] [PDF]  

Carbonic Anhydrase 9 as an Endogenous Marker for Hypoxic Cells in Cervical Cancer

Peggy L. Olive, Christina Aquino-Parsons, Susan H. MacPhail, Shu-Yuan Liao, James A. Raleigh, Michael I. Lerman, and Eric J. Stanbridge
Cancer Res 2001 61: 8924-8929. [Abstract] [Full Text] [PDF]  

In Memoriam:

In Memoriam

Cancer Res 2001 61: 8930-8931. [Full Text] [PDF]  

To see an article, click its [Full Text] or [PDF] link. To review many abstracts, check the boxes to the left of the titles you want, and click the 'Get All Checked Abstract(s)' button. To see one abstract at a time, click its [Abstract] link.