Perspectives in Cancer Research:

A Gene Hypermethylation Profile of Human Cancer

Manel Esteller, Paul G. Corn, Stephen B. Baylin, and James G. Herman
Cancer Res 2001 61: 3225-3229. [Abstract] [Full Text] [PDF]  

A Mutator Phenotype in Cancer

Lawrence A. Loeb
Cancer Res 2001 61: 3230-3239. [Abstract] [Full Text] [PDF]  

Advances in Brief:

Tumor Cells Regulate the Lytic Activity of Tumor-specific Cytotoxic T Lymphocytes by Modulating the Inhibitory Natural Killer Receptor Function

Asma Gati, Nadia Guerra, Julien Giron-Michel, Bruno Azzarone, Eric Angevin, Alessandro Moretta, Salem Chouaib, and Anne Caignard
Cancer Res 2001 61: 3240-3244. [Abstract] [Full Text] [PDF]  

Hepatomegaly in Transgenic Mice Expressing an Oncogenic Form of ß-Catenin

Axelle Cadoret, Christine Ovejero, Sihem Saadi-Kheddouci, Evelyne Souil, Monique Fabre, Béatrice Romagnolo, Axel Kahn, and Christine Perret
Cancer Res 2001 61: 3245-3249. [Abstract] [Full Text] [PDF]  

Molecular Regulation of Tumor Cell Vasculogenic Mimicry by Tyrosine Phosphorylation: Role of Epithelial Cell Kinase (Eck/EphA2)

Angela R. Hess, Elisabeth A. Seftor, Lynn M. G. Gardner, Kelly Carles-Kinch, Galen B. Schneider, Richard E. B. Seftor, Michael S. Kinch, and Mary J. C. Hendrix
Cancer Res 2001 61: 3250-3255. [Abstract] [Full Text] [PDF]  

Alternative Pathways to Prostate Carcinoma Activate Prostate Stem Cell Antigen Expression

Purnima Dubey, Hong Wu, Robert E. Reiter, and Owen N. Witte
Cancer Res 2001 61: 3256-3261. [Abstract] [Full Text] [PDF]  

Cytosine-Phosphoguanine Methylation of Estrogen Receptors in Endometrial Cancer

Masahiro Sasaki, Loulia Kotcherguina, Abhipsa Dharia, Seiichiro Fujimoto, and Rajvir Dahiya
Cancer Res 2001 61: 3262-3266. [Abstract] [Full Text] [PDF]  

Promotion of Seminomatous Tumors by Targeted Overexpression of Glial Cell Line-derived Neurotrophic Factor in Mouse Testis

Xiaojuan Meng, Dirk G. de Rooij, Kennet Westerdahl, Mart Saarma, and Hannu Sariola
Cancer Res 2001 61: 3267-3271. [Abstract] [Full Text] [PDF]  

Methylenetetrahydrofolate Reductase Polymorphisms Increase Risk of Esophageal Squamous Cell Carcinoma in a Chinese Population

Chunying Song, Deyin Xing, Wen Tan, Qingyi Wei, and Dongxin Lin
Cancer Res 2001 61: 3272-3275. [Abstract] [Full Text] [PDF]  

Overexpression of a Dominant-Negative Signal Transducer and Activator of Transcription 3 Variant in Tumor Cells Leads to Production of SolubleFactors That Induce Apoptosis and Cell Cycle Arrest

Guilian Niu, Kenneth H. Shain, Mei Huang, Rajani Ravi, Atul Bedi, William S. Dalton, Richard Jove, and Hua Yu
Cancer Res 2001 61: 3276-3280. [Abstract] [Full Text] [PDF]  

Effective Tumor Therapy with Plasmid-encoded Cytokines Combined with in Vivo Electroporation

Frank Lohr, David Y. Lo, David A. Zaharoff, Kang Hu, Xiuwu Zhang, Yongping Li, Yulin Zhao, Mark W. Dewhirst, Fan Yuan, and Chuan-Yuan Li
Cancer Res 2001 61: 3281-3284. [Abstract] [Full Text] [PDF]  

Nitric Oxide-releasing Nonsteroidal Anti-inflammatory Drugs (NSAIDs) Alter the Kinetics of Human Colon Cancer Cell Lines More Effectively than Traditional NSAIDs: Implications for Colon Cancer Chemoprevention

Jennie L. Williams, Simona Borgo, Izhar Hasan, Eddy Castillo, Frank Traganos, and Basil Rigas
Cancer Res 2001 61: 3285-3289. [Abstract] [Full Text] [PDF]  

Angiogenic Activity of Pyruvic Acid in in Vivo and in Vitro Angiogenesis Models

Mi-Sook Lee, Eun-Joung Moon, Sae-Won Lee, Myoung Sook Kim, Kyu-Won Kim, and Yung-Jin Kim
Cancer Res 2001 61: 3290-3293. [Abstract] [Full Text] [PDF]  

Neutral Endopeptidase Inhibits Neuropeptide-mediated Transactivation of the Insulin-like Growth Factor Receptor-Akt Cell Survival Pathway

Makoto Sumitomo, Matthew I. Milowsky, Ruoqian Shen, Daniel Navarro, Jie Dai, Tomohiko Asano, Masamichi Hayakawa, and David M. Nanus
Cancer Res 2001 61: 3294-3298. [Abstract] [Full Text] [PDF]  

Carcinogenesis:

The Cap ‘n’ Collar Basic Leucine Zipper Transcription Factor Nrf2 (NF-E2 p45-related Factor 2) Controls Both Constitutive and Inducible Expression of Intestinal Detoxification and Glutathione Biosynthetic Enzymes

Michael McMahon, Ken Itoh, Masayuki Yamamoto, Simon A. Chanas, Colin J. Henderson, Lesley I. McLellan, C. Roland Wolf, Christophe Cavin, and John D. Hayes
Cancer Res 2001 61: 3299-3307. [Abstract] [Full Text] [PDF]  

Synthetic Peptides Inhibit Adhesion of Human Tumor Cells to Extracellular Matrix Proteins

Ian B. DeRoock, Michael E. Pennington, Thomas C. Sroka, Kit S. Lam, G. Tim Bowden, Elisabeth L. Bair, and Anne E. Cress
Cancer Res 2001 61: 3308-3313. [Abstract] [Full Text] [PDF]  

Prevention of Apoptosis by 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) in the MCF-10A Cell Line: Correlation with Increased Transforming GrowthFactor Production

John W. Davis, II, Fredine T. Lauer, Andrew D. Burdick, Laurie G. Hudson, and Scott W. Burchiel
Cancer Res 2001 61: 3314-3320. [Abstract] [Full Text] [PDF]  

Epidemiology and Prevention:

An Intronic Poly (AT) Polymorphism of the DNA Repair Gene XPC and Risk of Squamous Cell Carcinoma of the Head and Neck: A Case-Control Study

Hongbing Shen, Erich M. Sturgis, Sikandar G. Khan, Yawei Qiao, Tala Shahlavi, Susan A. Eicher, Yiaochu Xu, Xinru Wang, Sara S. Strom, Margaret R. Spitz, Kenneth H. Kraemer, and Qingyi Wei
Cancer Res 2001 61: 3321-3325. [Abstract] [Full Text] [PDF]  

Do Urinary Estrogen Metabolites Reflect the Differences in Breast Cancer Risk between Singapore Chinese and United States African-American and White Women?

Giske Ursin, Melissa Wilson, Brian E. Henderson, Laurence N. Kolonel, Kristine Monroe, Hin-Peng Lee, Adeline Seow, Mimi C. Yu, Frank Z. Stanczyk, and Elisabet Gentzschein
Cancer Res 2001 61: 3326-3329. [Abstract] [Full Text] [PDF]  

Experimental Therapeutics:

Antitumor Activity and Bystander Effects of the Tumor Necrosis Factor-related Apoptosis-inducing Ligand (TRAIL) Gene

Shunsuke Kagawa, Chao He, Jian Gu, Patricia Koch, Suk-Joo Rha, Jack A. Roth, Steven A. Curley, L. Clifton Stephens, and Bingliang Fang
Cancer Res 2001 61: 3330-3338. [Abstract] [Full Text] [PDF]  

Cloning and Characterization of Human Adenosine 5'-triphosphate-binding Cassette, Sub-family A, Transporter 2 (ABCA2)

Bojana Vulevic,, Zhijian Chen, Jonathan T. Boyd, Warren Davis, Jr., Eileen S. Walsh, Martin G. Belinsky, and Kenneth D. Tew
Cancer Res 2001 61: 3339-3347. [Abstract] [Full Text] [PDF]  

Hypoxia in Radiation-induced Blood-Spinal Cord Barrier Breakdown

Yu-Qing Li, James R. Ballinger, Robert A. Nordal, Zi-Fen Su, and C. Shun Wong
Cancer Res 2001 61: 3348-3354. [Abstract] [Full Text] [PDF]  

Preemptive Control of Graft-versus-Host Disease in a Murine Allogeneic Transplant Model Using Retrovirally Transduced Murine Suicidal Lymphocytes

Steven M. Kornblau, Irina Stiouf, Virginia Snell, Donna Przepiorka, L. Clifton Stephens, Richard Champlin, and Frank C. Marini, III
Cancer Res 2001 61: 3355-3360. [Abstract] [Full Text] [PDF]  

24-Oxo Metabolites of Vitamin D₃ Analogues: Disassociation of Their Prominent Antileukemic Effects from Their Lack of Calcium Modulation

Masaaki Shiohara, Milan Uskokovic, Junichi Hisatake, Yasuko Hisatake, Kenichi Koike, Atsushi Komiyama, and H. Phillip Koeffler
Cancer Res 2001 61: 3361-3368. [Abstract] [Full Text] [PDF]  

The Antiangiogenic Property of Docetaxel Is Synergistic with a Recombinant Humanized Monoclonal Antibody against Vascular Endothelial Growth Factor or 2-Methoxyestradiol but Antagonized by Endothelial Growth Factors

Christopher J. Sweeney, Kathy D. Miller, Sean E. Sissons, Shinichi Nozaki, Douglas K. Heilman, Jianzhao Shen, and George W. Sledge, Jr.
Cancer Res 2001 61: 3369-3372. [Abstract] [Full Text] [PDF]  

p53/p21^CIP1 Cooperate in Enforcing Rapamycin-induced G₁ Arrest and Determine the Cellular Response to Rapamycin

Shile Huang, Linda N. Liu, Hajime Hosoi, Michael B. Dilling, Takuma Shikata, and Peter J. Houghton
Cancer Res 2001 61: 3373-3381. [Abstract] [Full Text] [PDF]  

Attenuation of Doxorubicin Chronic Toxicity in Metallothionein-overexpressing Transgenic Mouse Heart

Xiuhua Sun, Zhanxiang Zhou, and Y. James Kang
Cancer Res 2001 61: 3382-3387. [Abstract] [Full Text] [PDF]  

Human Dendritic Cells Transfected with Renal Tumor RNA Stimulate Polyclonal T-Cell Responses against Antigens Expressed by Primaryand Metastatic Tumors

Axel Heiser, Margaret A. Maurice, Donna R. Yancey, Doris M. Coleman, Philipp Dahm, and Johannes Vieweg
Cancer Res 2001 61: 3388-3393. [Abstract] [Full Text] [PDF]  

E1A Sensitizes HER2/neu-overexpressing Ewing’s Sarcoma Cells to Topoisomerase II-targeting Anticancer Drugs

Zhichao Zhou, Shu-Fang Jia, Mien-Chie Hung, and Eugenie S. Kleinerman
Cancer Res 2001 61: 3394-3398. [Abstract] [Full Text] [PDF]  

Immunology:

A Role of Interferon- (IFN-) in Tumor Immunity: T Cells with the Capacity to Reject Tumor Cells Are Generated But Fail to Migrate to Tumor Sitesin IFN--deficient Mice

Chigusa Nakajima, Yasuhiro Uekusa, Masayuki Iwasaki, Nobuya Yamaguchi, Takao Mukai, Ping Gao, Michio Tomura, Shiro Ono, Takahiro Tsujimura, Hiromi Fujiwara, and Toshiyuki Hamaoka
Cancer Res 2001 61: 3399-3405. [Abstract] [Full Text] [PDF]  

Molecular Biology and Genetics:

ß-Catenin Mutations in Biliary Tract Cancers: A Population-based Study in China

Asif Rashid, Yu-Tang Gao, Sapna Bhakta, Ming-Chang Shen, Bing-Sheng Wang, Jie Deng, Joseph F. Fraumeni, Jr., and Ann W. Hsing
Cancer Res 2001 61: 3406-3409. [Abstract] [Full Text] [PDF]  

Epigenetic Patterns in the Progression of Esophageal Adenocarcinoma

Cindy A. Eads, Reginald V. Lord, Kumari Wickramasinghe, Tiffany I. Long, Soudamini K. Kurumboor, Leslie Bernstein, Jeffrey H. Peters, Steven R. DeMeester, Tom R. DeMeester, Kristin A. Skinner, and Peter W. Laird
Cancer Res 2001 61: 3410-3418. [Abstract] [Full Text] [PDF]  

p16^INK4a and Histology-specific Methylation of CpG Islands by Exposure to Tobacco Smoke in Non-Small Cell Lung Cancer

Duk-Hwan Kim, Heather H. Nelson, John K. Wiencke, Shichun Zheng, David C. Christiani, John C. Wain, Eugene J. Mark, and Karl T. Kelsey
Cancer Res 2001 61: 3419-3424. [Abstract] [Full Text] [PDF]  

Cloning of a New Member of the Human Kallikrein Gene Family, KLK14, Which Is Down-Regulated in Different Malignancies

George M. Yousef, Angeliki Magklara, Albert Chang, Klaus Jung, Dionyssios Katsaros, and Eleftherios P. Diamandis
Cancer Res 2001 61: 3425-3431. [Abstract] [Full Text] [PDF]  

Gestational Age and Gender-specific In Utero V(D)J Recombinase-mediated Deletions

Makoto Yoshioka, J. Patrick O’Neill, Pamela M. Vacek, and Barry A. Finette
Cancer Res 2001 61: 3432-3438. [Abstract] [Full Text] [PDF]  

Partial Deletions of the Long and Short Arm of Chromosome 3 Point to Two Tumor Suppressor Genes in Uveal Melanoma

Frank Tschentscher, Gabriele Prescher, Douglas E. Horsman, Valerie A. White, Harald Rieder, Gerasimos Anastassiou, Harald Schilling, Norbert Bornfeld, Karl Ulrich Bartz-Schmidt, Bernhard Horsthemke, Dietmar R. Lohmann, and Michael Zeschnigk
Cancer Res 2001 61: 3439-3442. [Abstract] [Full Text] [PDF]  

Tumor Biology:

Beclin 1 Contains a Leucine-rich Nuclear Export Signal That Is Required for Its Autophagy and Tumor Suppressor Function

Xiao Huan Liang, Jie Yu, Kristy Brown, and Beth Levine
Cancer Res 2001 61: 3443-3449. [Abstract] [Full Text] [PDF]  

Down-Regulation of Vascular Endothelial Growth Factor by Tissue Inhibitor of Metalloproteinase-2: Effect on in Vivo Mammary Tumor Growth and Angiogenesis

Amin Hajitou, Nor-Eddine Sounni, Laetitia Devy, Christine Grignet-Debrus, Jean-Marc Lewalle, Hong Li, Christophe F. Deroanne, He Lu, Alain Colige, Betty V. Nusgens, Francis Frankenne, Anne Maron, Patrice Yeh, Michel Perricaudet, Yawen Chang, Claudine Soria, Claire-Michelle Calberg-Bacq, Jean-Michel Foidart, and Agnès Noël
Cancer Res 2001 61: 3450-3457. [Abstract] [Full Text] [PDF]  

Subcellular Localization and Distribution of the Breast Cancer Resistance Protein Transporter in Normal Human Tissues

Marc Maliepaard, George L. Scheffer, Ian F. Faneyte, Margôt A. van Gastelen, Adriana C. L. M. Pijnenborg, Alfred H. Schinkel, Marc J. van de Vijver, Rik J. Scheper, and Jan H. M. Schellens
Cancer Res 2001 61: 3458-3464. [Abstract] [Full Text] [PDF]  

Down-Regulation of ß-Catenin TCF Signaling Is Linked to Colonic Epithelial Cell Differentiation

John M. Mariadason, Michael Bordonaro, Fauzia Aslam, Li Shi, Mari Kuraguchi, Anna Velcich, and Leonard H. Augenlicht
Cancer Res 2001 61: 3465-3471. [Abstract] [Full Text] [PDF]  

Mouse Intestinal Goblet Cells Expressing SV40 T Antigen Directed by the MUC2 Mucin Gene Promoter Undergo Apoptosis upon Migration to the Villi

James. R. Gum, Jr., James. W. Hicks, Anne Marie Gillespie, Jose L. Rius, Patrick A. Treseler, Scott C. Kogan, Elaine J. Carlson, Charles J. Epstein, and Young S. Kim
Cancer Res 2001 61: 3472-3479. [Abstract] [Full Text] [PDF]  

Genetic Background Affects Susceptibility to Mammary Hyperplasias and Carcinomas in Apc^Min/+ Mice

Amy Rapaich Moser, Laura F. Hegge, and Robert D. Cardiff
Cancer Res 2001 61: 3480-3485. [Abstract] [Full Text] [PDF]  

Increased Activator Protein 1 Activity as Well as Resistance to Heat-induced Radiosensitization, Hydrogen Peroxide, and Cisplatin Are Inhibited by Indomethacin in Oxidative Stress-resistant Cells

C. Matthew Bradbury, Jacob E. Locke, S. Jack Wei, Luis M. Rene, Shervin Karimpour, Clayton Hunt, Douglas R. Spitz, and David Gius
Cancer Res 2001 61: 3486-3492. [Abstract] [Full Text] [PDF]  

An Intracellular Form of Cathepsin B Contributes to Invasiveness in Cancer

Anna M. Szpaderska and Allen Frankfater
Cancer Res 2001 61: 3493-3500. [Abstract] [Full Text] [PDF]  

Viruses as Antitumor Weapons: Defining Conditions for Tumor Remission

Dominik Wodarz
Cancer Res 2001 61: 3501-3507. [Abstract] [Full Text] [PDF]  

Down-Regulation of E-Cadherin Gene Expression by Collagen Type I and Type III in Pancreatic Cancer Cell Lines

Andre Menke, Christian Philippi, Roger Vogelmann, Bjoern Seidel, Manfred P. Lutz, Guido Adler, and Doris Wedlich
Cancer Res 2001 61: 3508-3517. [Abstract] [Full Text] [PDF]  

Virology:

Interleukin 12-activated Lymphocytes Influence Tumor Genetic Programs

Federica Cavallo, Elena Quaglino, Loredana Cifaldi, Emma Di Carlo, Alessandra André, Paola Bernabei, Piero Musiani, Guido Forni, and Raffaele A. Calogero
Cancer Res 2001 61: 3518-3523. [Abstract] [Full Text] [PDF]  

Meeting Report:

Third International Dresden Symposium on Immunotherapy of Cancer

Marc Schmitz, Martin Bornhauser, Detlef Ockert, and Ernst Peter Rieber
Cancer Res 2001 61: 3524-3528. [Full Text] [PDF]  

Erratum:

D. Li et. al., Cancer Res., 61: 1445–1450, 2001

Cancer Res 2001 61: 3531 [Full Text]  

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