Advances in Brief:

Enhanced Chemosensitivity to CPT-11 with Proteasome Inhibitor PS-341:: Implications for Systemic Nuclear Factor-B Inhibition

James C. Cusack, Jr., Rong Liu, Michael Houston, Karin Abendroth, Peter J. Elliott, Julian Adams, and Albert S. Baldwin, Jr.
Cancer Res 2001 61: 3535-3540. [Abstract] [Full Text] [PDF]  

Mutations in Fibroblast Growth Factor Receptor 2 and Fibroblast Growth Factor Receptor 3 Genes Associated with Human Gastric and Colorectal Cancers

Jun-Hyeog Jang, Ki-Hyuk Shin, and Jae-Gahb Park
Cancer Res 2001 61: 3541-3543. [Abstract] [Full Text] [PDF]  

Alterations of Gene Expression during Colorectal Carcinogenesis Revealed by cDNA Microarrays after Laser-Capture Microdissection of Tumor Tissues and Normal Epithelia

Osamu Kitahara, Yoichi Furukawa, Toshihiro Tanaka, Chikashi Kihara, Kenji Ono, Renpei Yanagawa, Marcelo E. Nita, Toshihisa Takagi, Yusuke Nakamura, and Tatsuhiko Tsunoda
Cancer Res 2001 61: 3544-3549. [Abstract] [Full Text] [PDF]  

Amplification and Overexpression of Androgen Receptor Gene in Hormone-Refractory Prostate Cancer

Marika J. Linja, Kimmo J. Savinainen, Outi R. Saramäki, Teuvo L. J. Tammela, Robert L. Vessella, and Tapio Visakorpi
Cancer Res 2001 61: 3550-3555. [Abstract] [Full Text] [PDF]  

A Genetically Tractable Model of Human Glioma Formation

Jeremy N. Rich, Chuanhai Guo, Roger E. McLendon, Darell D. Bigner, Xiao-Fan Wang, and Christopher M. Counter
Cancer Res 2001 61: 3556-3560. [Abstract] [Full Text] [PDF]  

Erythropoietin and Erythropoietin Receptor Expression in Human Cancer

Geza Acs, Peter Acs, Susan M. Beckwith, Richard L. Pitts, Emily Clements, Kondi Wong, and Ajay Verma
Cancer Res 2001 61: 3561-3565. [Abstract] [Full Text] [PDF]  

CYP2C9 and UGT1A6 Genotypes Modulate the Protective Effect of Aspirin on Colon Adenoma Risk

Jeannette Bigler, John Whitton, Johanna W. Lampe, Lisa Fosdick, Roberd M. Bostick, and John D. Potter
Cancer Res 2001 61: 3566-3569. [Abstract] [Full Text] [PDF]  

Mutations in the Nijmegen Breakage Syndrome Gene (NBS1) in Childhood Acute Lymphoblastic Leukemia (ALL)

Raymonda Varon, André Reis, Günter Henze, Hagen Graf v. Einsiedel, Karl Sperling, and Karlheinz Seeger
Cancer Res 2001 61: 3570-3572. [Abstract] [Full Text] [PDF]  

Accelerated Age-related CpG Island Methylation in Ulcerative Colitis

Jean-Pierre J. Issa, Nita Ahuja, Minoru Toyota, Mary P. Bronner, and Teresa A. Brentnall
Cancer Res 2001 61: 3573-3577. [Abstract] [Full Text] [PDF]  

Loss of Heterozygosity Events Impeding Breast Cancer Metastasis Contain the MTA1 Gene

Michelle D. Martin, Kathy Fischbach, C. Kent Osborne, Syed K. Mohsin, D. Craig Allred, and Peter O’Connell
Cancer Res 2001 61: 3578-3580. [Abstract] [Full Text] [PDF]  

5' CpG Island Methylation of the FHIT Gene Is Correlated with Loss of Gene Expression in Lung and Breast Cancer

Sabine Zöchbauer-Müller, Kwun M. Fong, Anirban Maitra, Stephen Lam, Joseph Geradts, Raheela Ashfaq, Arvind K. Virmani, Sarah Milchgrub, Adi F. Gazdar, and John D. Minna
Cancer Res 2001 61: 3581-3585. [Abstract] [Full Text] [PDF]  

Oncogenic TLS/ERG and EWS/Fli-1 Fusion Proteins Inhibit RNA Splicing Mediated by YB-1 Protein

Howard A. Chansky, Ming Hu, Dennis D. Hickstein, and Liu Yang
Cancer Res 2001 61: 3586-3590. [Abstract] [Full Text] [PDF]  

The Histone Deacetylase Inhibitor, CBHA, Inhibits Growth of Human Neuroblastoma Xenografts in Vivo, Alone and Synergistically with All-Trans Retinoic Acid

Dennis C. Coffey, Martha C. Kutko, Richard D. Glick, Lisa M. Butler, Glenn Heller, Richard A. Rifkind, Paul A. Marks, Victoria M. Richon, and Michael P. La Quaglia
Cancer Res 2001 61: 3591-3594. [Abstract] [Full Text] [PDF]  

Biochemistry and Biophysics:

Active Ras Induces Heterodimerization of cRaf and BRaf

Christoph K. Weber, Joseph R. Slupsky, H. Andreas Kalmes, and Ulf R. Rapp
Cancer Res 2001 61: 3595-3598. [Abstract] [Full Text] [PDF]  

Detection of Increased Choline Compounds with Proton Nuclear Magnetic Resonance Spectroscopy Subsequent to Malignant Transformation of Human Prostatic Epithelial Cells

Ellen Ackerstaff, Beth R. Pflug, Joel B. Nelson, and Zaver M. Bhujwalla
Cancer Res 2001 61: 3599-3603. [Abstract] [Full Text] [PDF]  

Mechanism of Attenuation of Skeletal Muscle Protein Catabolism in Cancer Cachexia by Eicosapentaenoic Acid

Alison S. Whitehouse, Helen J. Smith, Joanne L. Drake, and Michael J. Tisdale
Cancer Res 2001 61: 3604-3609. [Abstract] [Full Text] [PDF]  

Tissue Inhibitor of Metalloproteinases-4 Inhibits But Does Not Support the Activation of Gelatinase A via Efficient Inhibition of Membrane Type 1-Matrix Metalloproteinase

Heather F. Bigg, Charlotte J. Morrison, Georgina S. Butler, Marie A. Bogoyevitch, Zhiping Wang, Paul D. Soloway, and Christopher M. Overall
Cancer Res 2001 61: 3610-3618. [Abstract] [Full Text] [PDF]  

Carcinogenesis:

Targeted Expression of bcl-2 to Murine Basal Epidermal Keratinocytes Results in Paradoxical Retardation of Ultraviolet- and Chemical-induced Tumorigenesis

Heidemarie Rossiter, Stefan Beissert, Christoph Mayer, Michael P. Schön, B. Gregor Wienrich, Erwin Tschachler, and Thomas S. Kupper
Cancer Res 2001 61: 3619-3626. [Abstract] [Full Text] [PDF]  

Evidence of DNA Repair/Processing Defects in Cultured Skin Fibroblasts from Breast Cancer Patients

Mohammed A. Hannan, Yunus Siddiqui, Assem Rostom, Mohammed N. Al-Ahdal, Mohammad A. Chaudhary, and Mohammed Kunhi
Cancer Res 2001 61: 3627-3631. [Abstract] [Full Text] [PDF]  

Endocrinology:

Silencing and Reactivation of the Selective Estrogen Receptor Modulator-Estrogen Receptor Complex

Hong Liu, Eun-Sook Lee, Alexander De Los Reyes, James W. Zapf, and V. Craig Jordan
Cancer Res 2001 61: 3632-3639. [Abstract] [Full Text] [PDF]  

Transcriptional Activation of the Thyroglobulin Promoter Directing Suicide Gene Expression by Thyroid Transcription Factor-1 in Thyroid Cancer Cells

Hiroki Shimura, Hideyo Suzuki, Asako Miyazaki, Fumihiko Furuya, Kazuyasu Ohta, Kazutaka Haraguchi, Toyoshi Endo, and Toshimasa Onaya
Cancer Res 2001 61: 3640-3646. [Abstract] [Full Text] [PDF]  

Epidemiology and Prevention:

Chemoprevention of Colon Cancer by a Glutathione Conjugate of 1,4-Phenylenebis(methylene)selenocyanate, a Novel Organoselenium Compound with Low Toxicity

Chinthalapally V. Rao, C-Q. Wang, Barbara Simi, Jose G. Rodriguez, Indranie Cooma, Karam El-Bayoumy, and Bandaru S. Reddy
Cancer Res 2001 61: 3647-3652. [Abstract] [Full Text] [PDF]  

Experimental Therapeutics:

A Strategy for Antitumor Vascular Therapy by Targeting the Vascular Endothelial Growth Factor: Receptor Complex

S. P. Cooke, G. M. Boxer, L. Lawrence, R. B. Pedley, D. I. R. Spencer, R. H. J. Begent, and K. A. Chester
Cancer Res 2001 61: 3653-3659. [Abstract] [Full Text] [PDF]  

Indolinone Tyrosine Kinase Inhibitors Block Kit Activation and Growth of Small Cell Lung Cancer Cells

Geoffrey W. Krystal, Sittisak Honsawek, David Kiewlich, Congxin Liang, Stefan Vasile, Li Sun, Gerald McMahon, and Kenneth E. Lipson
Cancer Res 2001 61: 3660-3668. [Abstract] [Full Text] [PDF]  

Lipid Association Improves the Therapeutic Index of Lomustine [1-(2-Chloroethyl)-3-cyclohexyl-1-nitrosourea] to Suppress 36B-10 Tumor Growth in Rats

Claudette R. Bethune, Russell J. Geyer, Alexander M. Spence, and Rodney J. Y. Ho
Cancer Res 2001 61: 3669-3674. [Abstract] [Full Text] [PDF]  

Modulation of Both Endogenous Folates and Thymidine Enhance the Therapeutic Efficacy of Thymidylate Synthase Inhibitors

Clasina L. van der Wilt, Harold H. J. Backus, Kees Smid, Lizzy Comijn, Gijsbert Veerman, Dorine Wouters, Daphne A. Voorn, David G. Priest, Marlene A. Bunni, Fraser Mitchell, Ann L. Jackman, Gerrit Jansen, and Godefridus J. Peters
Cancer Res 2001 61: 3675-3681. [Abstract] [Full Text] [PDF]  

Immunology:

Intersection of Interferon and Hypoxia Signal Transduction Pathways in Nitric Oxide-induced Tumor Apoptosis

Drory S. Tendler, Clare Bao, Tianhong Wang, Eric L. Huang, Edward A. Ratovitski, Drew A. Pardoll, and Charles J. Lowenstein
Cancer Res 2001 61: 3682-3688. [Abstract] [Full Text] [PDF]  

Cyclophosphamide, Doxorubicin, and Paclitaxel Enhance the Antitumor Immune Response of Granulocyte/Macrophage-Colony Stimulating Factor-secreting Whole-Cell Vaccines in HER-2/neu Tolerized Mice

Jean-Pascal H. Machiels, R. Todd Reilly, Leisha A. Emens, Anne M. Ercolini, Rachel Y. Lei, Diane Weintraub, Francesca I. Okoye, and Elizabeth M. Jaffee
Cancer Res 2001 61: 3689-3697. [Abstract] [Full Text] [PDF]  

Cancer Immunotherapy Using a DNA Vaccine Encoding the Translocation Domain of a Bacterial Toxin Linked to a Tumor Antigen

Chien-Fu Hung, Wen-Fang Cheng, Keng-Fu Hsu, Chee-Yin Chai, Liangmei He, Morris Ling, and T-C. Wu
Cancer Res 2001 61: 3698-3703. [Abstract] [Full Text] [PDF]  

Targeting Dendritic Cells to Enhance DNA Vaccine Potency

Zhaoyang You, Xue Huang, Jenny Hester, Han Chong Toh, and Si-Yi Chen
Cancer Res 2001 61: 3704-3711. [Abstract] [Full Text] [PDF]  

Immunoscintigraphy with Positron Emission Tomography: Gallium-68 Chelate Imaging of Breast Cancer Pretargeted with Bispecific Anti-MUC1/Anti-Ga Chelate Antibodies

Jochen Schuhmacher, Sepp Kaul, Gabor Klivényi, Hans Junkermann, Achim Magener, Marcus Henze, Josef Doll, Uwe Haberkorn, Folker Amelung, and Gunther Bastert
Cancer Res 2001 61: 3712-3717. [Abstract] [Full Text] [PDF]  

High Frequency of Cytolytic T Lymphocytes Directed against a Tumor-specific Mutated Antigen Detectable with HLA Tetramers in the Blood of a Lung Carcinoma Patient with Long Survival

Vaios Karanikas, Didier Colau, Jean-François Baurain, Rita Chiari, Joëlle Thonnard, Ilse Gutierrez-Roelens, Céline Goffinet, Emile Van Schaftingen, Patrick Weynants, Thierry Boon, and Pierre G. Coulie
Cancer Res 2001 61: 3718-3724. [Abstract] [Full Text] [PDF]  

Enhanced Activation of Human T Cells via Avipox Vector-mediated Hyperexpression of a Triad of Costimulatory Molecules in Human Dendritic Cells

MingZhu Zhu, Hiroshi Terasawa, James Gulley, Dennis Panicali, Philip Arlen, Jeffrey Schlom, and Kwong Y. Tsang
Cancer Res 2001 61: 3725-3734. [Abstract] [Full Text] [PDF]  

Interleukin 18 Transfection Enhances Antitumor Immunity Induced by Dendritic Cell-Tumor Cell Conjugates

Dian Wen Ju, Qun Tao, Guoliang Lou, Min Bai, Long He, Yili Yang, and Xuetao Cao
Cancer Res 2001 61: 3735-3740. [Abstract] [Full Text] [PDF]  

Molecular and Biology and Genetics:

Growth and Gene Expression Profile Analyses of Endometrial Cancer Cells Expressing Exogenous PTEN

Mieko Matsushima-Nishiu, Motoko Unoki, Kenji Ono, Tatsuhiko Tsunoda, Takeo Minaguchi, Hiroyuki Kuramoto, Masato Nishida, Toyomi Satoh, Toshihiro Tanaka, and Yusuke Nakamura
Cancer Res 2001 61: 3741-3749. [Abstract] [Full Text] [PDF]  

Metastasis-associated Differences in Gene Expression in a Murine Model of Osteosarcoma

Chand Khanna, Javed Khan, Phoungmai Nguyen, Jennifer Prehn, Jana Caylor, Choh Yeung, Jane Trepel, Paul Meltzer, and Lee Helman
Cancer Res 2001 61: 3750-3759. [Abstract] [Full Text] [PDF]  

Trp-p8, a Novel Prostate-specific Gene, Is Up-Regulated in Prostate Cancer and Other Malignancies and Shares High Homology with Transient Receptor Potential Calcium Channel Proteins

Larisa Tsavaler, Michael H. Shapero, Stan Morkowski, and Reiner Laus
Cancer Res 2001 61: 3760-3769. [Abstract] [Full Text] [PDF]  

Tumor Necrosis Factor Polymorphism Associated with Increased Susceptibility to Development of Adult T-Cell Leukemia/Lymphoma in Human T-lymphotropic Virus Type 1 Carriers

Kunihiro Tsukasaki, Carl W. Miller, Tetsuya Kubota, Seisho Takeuchi, Takeshi Fujimoto, Shuichi Ikeda, Masao Tomonaga, and H. Philip Koeffler
Cancer Res 2001 61: 3770-3774. [Abstract] [Full Text] [PDF]  

Hypermutability to Ionizing Radiation in Mismatch Repair-deficient, Pms2 Knockout Mice

Xiaoxin S. Xu, Latha Narayanan, Brady Dunklee, R. Michael Liskay, and Peter M. Glazer
Cancer Res 2001 61: 3775-3780. [Abstract] [Full Text] [PDF]  

Ablation of p21waf1cip1 Expression Enhances the Capacity of p53-deficient Human Tumor Cells to Repair UVB-induced DNA Damage

Jean-Philippe Therrien, Martin Loignon, Régen Drouin, and Elliot A. Drobetsky
Cancer Res 2001 61: 3781-3786. [Abstract] [Full Text] [PDF]  

Antitumor Drug Adozelesin Differentially Affects Active and Silent Origins of DNA Replication in Yeast Checkpoint Kinase Mutants

Yangzhou Wang, Terry A. Beerman, and David Kowalski
Cancer Res 2001 61: 3787-3794. [Abstract] [Full Text] [PDF]  

Genome-wide Allelotyping Analysis Reveals Multiple Sites of Allelic Loss in Gallbladder Carcinoma

Ignacio I. Wistuba, Moying Tang, Anirban Maitra, Hector Alvarez, Pablo Troncoso, Fernando Pimentel, and Adi F. Gazdar
Cancer Res 2001 61: 3795-3800. [Abstract] [Full Text] [PDF]  

Short Mononucleotide Repeat Sequence Variability in Mismatch Repair-deficient Cancers

Lin Zhang, Jian Yu, James K. V. Willson, Sanford D. Markowitz, Kenneth W. Kinzler, and Bert Vogelstein
Cancer Res 2001 61: 3801-3805. [Abstract] [Full Text] [PDF]  

Tumor Biology:

Isolation of a Novel Candidate Oncogene within a Frequently Amplified Region at 3q26 in Ovarian Cancer

Xin-Yuan Guan, Jonathan S. T. Sham, Terence C-M. Tang, Yan Fang, Ke-Ke Huo, and Jin-Ming Yang
Cancer Res 2001 61: 3806-3809. [Abstract] [Full Text] [PDF]  

Roles of IKK Kinases and Protein Kinase CK2 in Activation of Nuclear Factor-B in Breast Cancer

Raphaëlle Romieu-Mourez, Esther Landesman-Bollag, David C. Seldin, Abdulmaged M. Traish, Frank Mercurio, and Gail E. Sonenshein
Cancer Res 2001 61: 3810-3818. [Abstract] [Full Text] [PDF]  

N-Cadherin-mediated Intercellular Interactions Promote Survival and Migration of Melanoma Cells

Gang Li, Kapaettu Satyamoorthy, and Meenhard Herlyn
Cancer Res 2001 61: 3819-3825. [Abstract] [Full Text] [PDF]  

Astrocyte-specific Expression of Activated p21-ras Results in Malignant Astrocytoma Formation in a Transgenic Mouse Model of Human Gliomas

Hao Ding, Luba Roncari, Patrick Shannon, Xiaoli Wu, Nelson Lau, Jana Karaskova, David H. Gutmann, Jeremy A. Squire, Andras Nagy, and Abhijit Guha
Cancer Res 2001 61: 3826-3836. [Abstract] [Full Text] [PDF]  

Virology:

Human Papillomavirus Type 16 E6 and E7 Cooperate to Increase Epidermal Growth Factor Receptor (EGFR) mRNA Levels, Overcoming Mechanisms by which Excessive EGFR Signaling Shortens the Life Span of Normal Human Keratinocytes

Gregory S. Akerman, William H. Tolleson, Kim L. Brown, Li Li Zyzak, Elena Mourateva, Timur S. W. Engin, Anamaria Basaraba, Ann L. Coker, Kim E. Creek, and Lucia Pirisi
Cancer Res 2001 61: 3837-3843. [Abstract] [Full Text] [PDF]  

Meeting Report:

Epithelial-Stromal Interactions and Tumor Progression: Meeting Summary and Future Directions

Lynn M. Matrisian, Gerald R. Cunha, and Suresh Mohla
Cancer Res 2001 61: 3844-3846. [Abstract] [Full Text] [PDF]  

Obituary:

In Memoriam: James A. Miller (1915–2000)

Allan H. Conney
Cancer Res 2001 61: 3847-3848. [Full Text] [PDF]  

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