Editorial:

The Year Ahead

Frank J. Rauscher, III
Cancer Res 2002 62: 1 [Full Text] [PDF]  

Advances in Brief:

Inhibition of Benzo(a)pyrene-induced Lung Tumorigenesis in A/J Mice by Dietary N-Acetylcysteine Conjugates of Benzyl and Phenethyl Isothiocyanates during the Postinitiation Phase Is Associated with Activation of Mitogen-activated Protein Kinases and p53 Activity and Induction of Apoptosis

Yang-Ming Yang, C. Clifford Conaway, J. W. Chiao, Chung-Xiou Wang, Shantu Amin, John Whysner, Wei Dai, Joel Reinhardt, and Fung-Lung Chung
Cancer Res 2002 62: 2-7. [Abstract] [Full Text] [PDF]  

Systemic Tumor Suppression by the Proapoptotic Gene bik

Yiyu Zou, Hua Peng, Binhua Zhou, Yong Wen, Shao-Chun Wang, Eing-Mei Tsai, and Mien-Chie Hung
Cancer Res 2002 62: 8-12. [Abstract] [Full Text] [PDF]  

Genetic and Epigenetic Inactivation of Mitotic Checkpoint Genes hBUB1 and hBUBR1 and Their Relationship to Survival

Masayoshi Shichiri, Keigo Yoshinaga, Hisashi Hisatomi, Kenichi Sugihara, and Yukio Hirata
Cancer Res 2002 62: 13-17. [Abstract] [Full Text] [PDF]  

Smac Is Required for Cytochrome c-induced Apoptosis in Prostate Cancer LNCaP Cells

Jonathan P. Carson, Marcelina Behnam, Jennifer N. Sutton, Chunying Du, Xiaodong Wang, Donald F. Hunt, Michael J. Weber, and George Kulik
Cancer Res 2002 62: 18-23. [Abstract] [Full Text] [PDF]  

Development of Spontaneous Uterine Tumors in Low Molecular Mass Polypeptide-2 Knockout Mice

Takuma Hayashi and Denise L. Faustman
Cancer Res 2002 62: 24-27. [Abstract] [Full Text] [PDF]  

Involvement of Prostaglandin E Receptor Subtype EP₄ in Colon Carcinogenesis

Michihiro Mutoh, Kouji Watanabe, Tomohiro Kitamura, Yutaka Shoji, Mami Takahashi, Toshihiko Kawamori, Kousuke Tani, Michiyoshi Kobayashi, Takayuki Maruyama, Kaoru Kobayashi, Shuichi Ohuchida, Yukihiko Sugimoto, Shuh Narumiya, Takashi Sugimura, and Keiji Wakabayashi
Cancer Res 2002 62: 28-32. [Abstract] [Full Text] [PDF]  

The HOXD11 Gene Is Fused to the NUP98 Gene in Acute Myeloid Leukemia with t(2;11)(q31;p15)

Takeshi Taketani, Tomohiko Taki, Noriko Shibuya, Etsuro Ito, Junichi Kitazawa, Kiminori Terui, and Yasuhide Hayashi
Cancer Res 2002 62: 33-37. [Abstract] [Full Text] [PDF]  

Mutational Analysis of Promoters of Mismatch Repair Genes hMSH2 and hMLH1 in Hereditary Nonpolyposis Colorectal Cancer and Early Onset Colorectal Cancer Patients: Identification of Three Novel Germ-line Mutations in Promoter of the hMSH2 Gene

Ki-Hyuk Shin, Joo-Ho Shin, Jung-Hwa Kim, and Jae-Gahb Park
Cancer Res 2002 62: 38-42. [Abstract] [Full Text] [PDF]  

Psoriasin Expression in Mammary Epithelial Cells in Vitro and in Vivo

Charlotta Enerbäck, Dale A. Porter, Pankaj Seth, Dennis Sgroi, Justine Gaudet, Stanislawa Weremowicz, Cynthia C. Morton, Stuart Schnitt, Robert L. Pitts, Jason Stampl, Kerry Barnhart, and Kornelia Polyak
Cancer Res 2002 62: 43-47. [Abstract] [Full Text] [PDF]  

Tumor-associated Zinc Finger Mutations in the CTCF Transcription Factor Selectively Alter Its DNA-binding Specificity

Galina N. Filippova, Chen-Feng Qi, Jonathan E. Ulmer, James M. Moore, Michael D. Ward, Ying J. Hu, Dmitri I. Loukinov, Elena M. Pugacheva, Elena M. Klenova, Paul E. Grundy, Andrew P. Feinberg, Anne-Marie Cleton-Jansen, Elna W. Moerland, Cees J. Cornelisse, Hiroyoshi Suzuki, Akira Komiya, Annika Lindblom, Françoise Dorion-Bonnet, Paul E. Neiman, Herbert C. Morse, III, Steven J. Collins, and Victor V. Lobanenkov
Cancer Res 2002 62: 48-52. [Abstract] [Full Text] [PDF]  

Low-Level Microsatellite Instability Occurs in Most Colorectal Cancers and Is a Nonrandomly Distributed Quantitative Trait

Sarah Halford, Peter Sasieni, Andrew Rowan, Harpreet Wasan, Walter Bodmer, Ian Talbot, Nicholas Hawkins, Robyn Ward, and Ian Tomlinson
Cancer Res 2002 62: 53-57. [Abstract] [Full Text] [PDF]  

Primary Prostate Stromal Cells Modulate the Morphology and Migration of Primary Prostate Epithelial Cells in Type 1 Collagen Gels

June A. Hall, Norman J. Maitland, Mike Stower, and Shona H. Lang
Cancer Res 2002 62: 58-62. [Abstract] [Full Text] [PDF]  

Gene Transfer of Thromboxane A₂ Synthase and Prostaglandin I₂ Synthase Antithetically Altered Tumor Angiogenesis and Tumor Growth

Prasenohadi Pradono, Ryushi Tazawa, Makoto Maemondo, Masashi Tanaka, Kazuhiro Usui, Yasuo Saijo, Koichi Hagiwara, and Toshihiro Nukiwa
Cancer Res 2002 62: 63-66. [Abstract] [Full Text] [PDF]  

Biochemistry and Biophysics:

Deregulation of Polyamine Biosynthesis Alters Intrinsic Histone Acetyltransferase and Deacetylase Activities in Murine Skin and Tumors

Cheryl A. Hobbs, Barry A. Paul, and Susan K. Gilmour
Cancer Res 2002 62: 67-74. [Abstract] [Full Text] [PDF]  

Ser-10 Phosphorylation of Histone H3 and Immediate Early Gene Expression in Oncogene-transformed Mouse Fibroblasts

Ileana S. Strelkov and James R. Davie
Cancer Res 2002 62: 75-78. [Abstract] [Full Text] [PDF]  

Carcinogenesis:

Effect of Normal Endometrial Stroma on Growth and Differentiation in Ishikawa Endometrial Adenocarcinoma Cells

Julia T. Arnold, Bruce A. Lessey, Markku Seppälä, and David G. Kaufman
Cancer Res 2002 62: 79-88. [Abstract] [Full Text] [PDF]  

Growth Factor Requirements and Basal Phenotype of an Immortalized Mammary Epithelial Cell Line

James DiRenzo, Sabina Signoretti, Noriaki Nakamura, Ramon Rivera-Gonzalez, William Sellers, Massimo Loda, and Myles Brown
Cancer Res 2002 62: 89-98. [Abstract] [Full Text] [PDF]  

Distinct Spectrum of Mutations Induced by Crocidolite Asbestos: Clue for 8-Hydroxydeoxyguanosine-dependent Mutagenesis in Vivo

Klaus Unfried, Claudia Schürkes, and Josef Abel
Cancer Res 2002 62: 99-104. [Abstract] [Full Text] [PDF]  

Comparative Aflatoxin B₁ Activation and Cytotoxicity in Human Bronchial Cells Expressing Cytochromes P450 1A2 and 3A4

Terry R. Van Vleet, Katherine Macé, and Roger A. Coulombe, Jr.
Cancer Res 2002 62: 105-112. [Abstract] [Full Text] [PDF]  

Activation of the Aromatic Hydrocarbon Receptor Pathway Is Not Sufficient for Transcriptional Repression of BRCA-1: Requirements for Metabolism of Benzo[a]pyrene to 7r,8t-Dihydroxy-9t,10-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene

Brandon D. Jeffy, Ryan B. Chirnomas, Eddy J. Chen, Jean M. Gudas, and Donato F. Romagnolo
Cancer Res 2002 62: 113-121. [Abstract] [Full Text] [PDF]  

Effect of Epidermal Growth Factor Receptor Tyrosine Kinase Inhibition on Epithelial Proliferation in Normal and Premalignant Breast

Kai C. Chan, W. Fiona Knox, Julia M. Gee, Julie Morris, Robert I. Nicholson, Christopher S. Potten, and Nigel J. Bundred
Cancer Res 2002 62: 122-128. [Abstract] [Full Text] [PDF]  

Quantitation of Metabolites of 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone after Cessation of Smokeless Tobacco Use

Stephen S. Hecht, Steven G. Carmella, Ming Ye, Ky-anh Le, Joni A. Jensen, Cheryl L. Zimmerman, and Dorothy K. Hatsukami
Cancer Res 2002 62: 129-134. [Abstract] [Full Text] [PDF]  

Clinical Investigations:

Impact of SYT-SSX Fusion Type on the Clinical Behavior of Synovial Sarcoma: A Multi-Institutional Retrospective Study of 243 Patients

Marc Ladanyi, Cristina R. Antonescu, Denis H. Leung, James M. Woodruff, Akira Kawai, John H. Healey, Murray F. Brennan, Julia A. Bridge, James R. Neff, Frederic G. Barr, Jeffrey D. Goldsmith, John S. J. Brooks, John R. Goldblum, Syed Z. Ali, Janet Shipley, Colin S. Cooper, Cyril Fisher, Björn Skytting, and Olle Larsson
Cancer Res 2002 62: 135-140. [Abstract] [Full Text] [PDF]  

Endocrinology:

p300 Modulates the BRCA1 Inhibition of Estrogen Receptor Activity

Saijun Fan, Yong Xian Ma, Chenguang Wang, Ren-Qi Yuan, Qinghui Meng, Ji-An Wang, Michael Erdos, Itzhak D. Goldberg, Paul Webb, Peter J. Kushner, Richard G. Pestell, and Eliot M. Rosen
Cancer Res 2002 62: 141-151. [Abstract] [Full Text] [PDF]  

Epidemiology and Prevention:

The XRCC1 Arg399Gln Polymorphism, Sunburn, and Non-melanoma Skin Cancer: Evidence of Gene-Environment Interaction

Heather H. Nelson, Karl T. Kelsey, Leila A. Mott, and Margaret R. Karagas
Cancer Res 2002 62: 152-155. [Abstract] [Full Text] [PDF]  

Mechanisms of Cell Cycle Arrest by Methylseleninic Acid

Zongjian Zhu, Weiqin Jiang, Howard E. Ganther, and Henry J. Thompson
Cancer Res 2002 62: 156-164. [Abstract] [Full Text] [PDF]  

Chemopreventive Properties of a Selective Inducible Nitric Oxide Synthase Inhibitor in Colon Carcinogenesis, Administered Alone or in Combination with Celecoxib, a Selective Cyclooxygenase-2 Inhibitor

Chinthalapally V. Rao, Cooma Indranie, Barbara Simi, Pamela T. Manning, Jane R. Connor, and Bandaru S. Reddy
Cancer Res 2002 62: 165-170. [Abstract] [Full Text] [PDF]  

Experimental Therapeutics:

Tumor-targeted Gene Therapy for Nasopharyngeal Carcinoma

Jian-Hua Li, Marie Chia, Wei Shi, D. Ngo, Craig A. Strathdee, Dolly Huang, Henry Klamut, and Fei-Fei Liu
Cancer Res 2002 62: 171-178. [Abstract] [Full Text] [PDF]  

Intestinal Alkalization As a Possible Preventive Mechanism in Irinotecan (CPT-11)-induced Diarrhea

Tadashi Ikegami, Linan Ha, Kazuhiko Arimori, Patricia Latham, Kunihiko Kobayashi, Susan Ceryak, Yasushi Matsuzaki, and Bernard Bouscarel
Cancer Res 2002 62: 179-187. [Abstract] [Full Text] [PDF]  

Pharmacologic Mitogen-activated Protein/Extracellular Signal-regulated Kinase Kinase/Mitogen-activated Protein Kinase Inhibitors Interact Synergistically with STI571 to Induce Apoptosis in Bcr/Abl-expressing Human Leukemia Cells

Chunrong Yu, Geoffrey Krystal, Lyuba Varticovksi, Robert McKinstry, Mohamed Rahmani, Paul Dent, and Steven Grant
Cancer Res 2002 62: 188-199. [Abstract] [Full Text] [PDF]  

Insulin-like Growth Factor Receptor I Mediates Resistance to Anti-Epidermal Growth Factor Receptor Therapy in Primary Human Glioblastoma Cells through Continued Activation of Phosphoinositide 3-Kinase Signaling

Arnab Chakravarti, Jay S. Loeffler, and Nicholas J. Dyson
Cancer Res 2002 62: 200-207. [Abstract] [Full Text] [PDF]  

Immunology:

Down-Regulation of Antihost Alloreactivity after Bone Marrow Transplant Permits Relapse of Hematological Malignancy

Jun Wang, Joanne L. Shaw, and Craig A. Mullen
Cancer Res 2002 62: 208-212. [Abstract] [Full Text] [PDF]  

NY-ESO-1 119–143 Is a Promiscuous Major Histocompatibility Complex Class II T-Helper Epitope Recognized by Th1- and Th2-Type Tumor-reactive CD4+ T Cells

Hassane M. Zarour, Bernard Maillere, Vladimir Brusic, Kara Coval, Eileen Williams, Sandra Pouvelle-Moratille, Florence Castelli, Stephanie Land, Jaafar Bennouna, Theodore Logan, and John M. Kirkwood
Cancer Res 2002 62: 213-218. [Abstract] [Full Text] [PDF]  

Molecular Biology and Genetics:

Elevated Levels of Rad51 Recombination Protein in Tumor Cells

Elke Raderschall, Karen Stout, Susanne Freier, Vanessa Suckow, Susann Schweiger, and Thomas Haaf
Cancer Res 2002 62: 219-225. [Abstract] [Full Text] [PDF]  

Osteonectin/SPARC Induction by Ectopic ß₃ Integrin in Human Radial Growth Phase Primary Melanoma Cells

Richard A. Sturm, Kapaeth Satyamoorthy, Freidegund Meier, Brooke B. Gardiner, Darren J. Smit, Bhavesh Vaidya, and Meenhard Herlyn
Cancer Res 2002 62: 226-232. [Abstract] [Full Text] [PDF]  

Global Gene Expression Analysis of Gastric Cancer by Oligonucleotide Microarrays

Yoshitaka Hippo, Hirokazu Taniguchi, Shuichi Tsutsumi, Naoko Machida, Ja-Mun Chong, Masashi Fukayama, Tatsuhiko Kodama, and Hiroyuki Aburatani
Cancer Res 2002 62: 233-240. [Abstract] [Full Text] [PDF] Supplementary Data  

Abolishment of the Tyr-15 Inhibitory Phosphorylation Site on cdc2 Reduces the Radiation-induced G₂ Delay, Revealing a Potential Checkpoint in Early Mitosis

Lynda Fletcher, Yi Cheng, and Ruth J. Muschel
Cancer Res 2002 62: 241-250. [Abstract] [Full Text] [PDF]  

Heterogeneous Expression of MAGE-A Genes in Occult Disseminated Tumor Cells: A Novel Multimarker Reverse Transcription-Polymerase Chain Reaction for Diagnosis of Micrometastatic Disease

Peter Kufer, Alfred Zippelius, Ralf Lutterbüse, Ingo Mecklenburg, Thomas Enzmann, Anthony Montag, Dorothea Weckermann, Bernward Passlick, Nadja Prang, Peter Reichardt, Martin Dugas, Manfred W. Köllermann, Klaus Pantel, and Gert Riethmüller
Cancer Res 2002 62: 251-261. [Abstract] [Full Text] [PDF]  

Identification of Underexpressed Genes in Early- and Late-Stage Primary Ovarian Tumors by Suppression Subtraction Hybridization

Viji Shridhar, Ami Sen, Jeremy Chien, Julie Staub, Rajeswari Avula, Steve Kovats, John Lee, Jim Lillie, and David I. Smith
Cancer Res 2002 62: 262-270. [Abstract] [Full Text] [PDF]  

Identification of Frequent G₂ Checkpoint Impairment and a Homozygous Deletion of 14-3-3 at 17p13.3 in Small Cell Lung Cancers

Hiroyuki Konishi, Taku Nakagawa, Tomoko Harano, Kotaro Mizuno, Hiroko Saito, Akira Masuda, Hikaru Matsuda, Hirotaka Osada, and Takashi Takahashi
Cancer Res 2002 62: 271-276. [Abstract] [Full Text] [PDF]  

Wnt-1 but not Epidermal Growth Factor Induces ß-Catenin/T-Cell Factor-dependent Transcription in Esophageal Cancer Cells

Takaaki Mizushima, Hiroshi Nakagawa, Yana G. Kamberov, Elizabeth L. Wilder, Peter S. Klein, and Anil K. Rustgi
Cancer Res 2002 62: 277-282. [Abstract] [Full Text] [PDF]  

Tumor Biology:

Cancer Cell-associated Fibronectin Induces Release of Matrix Metalloproteinase-2 from Normal Fibroblasts

Sonia Saad, David J. Gottlieb, Kenneth F. Bradstock, Christopher M. Overall, and Linda J. Bendall
Cancer Res 2002 62: 283-289. [Abstract] [Full Text] [PDF]  

TSP50, A Possible Protease in Human Testes, Is Activated in Breast Cancer Epithelial Cells

Jidong Shan, Liming Yuan, Qianxun Xiao, Nicholas Chiorazzi, Daniel Budman, Saul Teichberg, and Hao-peng Xu
Cancer Res 2002 62: 290-294. [Abstract] [Full Text] [PDF]  

Human Kallikrein 11: A New Biomarker of Prostate and Ovarian Carcinoma

Eleftherios P. Diamandis, Akira Okui, Shinichii Mitsui, Liu-Ying Luo, Antoninus Soosaipillai, Linda Grass, Terukazu Nakamura, David J. C. Howarth, and Nozomi Yamaguchi
Cancer Res 2002 62: 295-300. [Abstract] [Full Text] [PDF]  

Id2 Is Critical for Cellular Proliferation and Is the Oncogenic Effector of N-Myc in Human Neuroblastoma

Anna Lasorella, Renata Boldrini, Carlo Dominici, Alberto Donfrancesco, Yoshifumi Yokota, Alessandro Inserra, and Antonio Iavarone
Cancer Res 2002 62: 301-306. [Abstract] [Full Text] [PDF]  

Noninvasive Imaging of Tumor Redox Status and Its Modification by Tissue Glutathione Levels

Periannan Kuppusamy, Haiquan Li, Govindasamy Ilangovan, Arturo J. Cardounel, Jay L. Zweier, Kenichi Yamada, Murali C. Krishna, and James B. Mitchell
Cancer Res 2002 62: 307-312. [Abstract] [Full Text] [PDF]  

Sigma-2 Receptor Agonists Activate a Novel Apoptotic Pathway and Potentiate Antineoplastic Drugs in Breast Tumor Cell Lines

Keith W. Crawford and Wayne D. Bowen
Cancer Res 2002 62: 313-322. [Abstract] [Full Text] [PDF]  

Meeting Report:

The Role of INI1 and the SWI/SNF Complex in the Development of Rhabdoid Tumors: Meeting Summary from the Workshop on Childhood Atypical Teratoid/Rhabdoid Tumors

Jaclyn A. Biegel, Ganjarn Kalpana, Erik S. Knudsen, Roger J. Packer, Charles W. M. Roberts, Carol J. Thiele, Bernard Weissman, and Malcolm Smith
Cancer Res 2002 62: 323-328. [Abstract] [PDF]  

Correction:

J. A. Loncaster et al., 61: 6394–6399, 2001.

Cancer Res 2002 62: 330 [Full Text] [PDF]  

T. L. Frandsen et al., 61: 532–537, 2001.

Cancer Res 2002 62: 330 [Full Text] [PDF]  

Errata:

B. Pasche et al., 61: 8351–8352, 2001.

Cancer Res 2002 62: 330 [Full Text] [PDF]  

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