Advances in Brief:

Antitumor Effects in Mice of Low-dose (Metronomic) Cyclophosphamide Administered Continuously through the Drinking Water

Shan Man, Guido Bocci, Giulio Francia, Shane K. Green, Serge Jothy, Douglas Hanahan, Peter Bohlen, Daniel J. Hicklin, Gabriele Bergers, and Robert S. Kerbel
Cancer Res 2002 62: 2731-2735. [Abstract] [Full Text] [PDF]  

Identification of a Novel Breast- and Salivary Gland-specific, Mucin-like Gene Strongly Expressed in Normal and Tumor Human Mammary Epithelium

Richard J. Miksicek, Yvonne Myal, Peter H. Watson, Christina Walker, Leigh C. Murphy, and Etienne Leygue
Cancer Res 2002 62: 2736-2740. [Abstract] [Full Text] [PDF]  

Selective Loss of Heterozygosity in Multiple Breast Cancers from a Carrier of Mutations in Both BRCA1 and BRCA2

Daphne W. Bell, John Erban, Dennis C. Sgroi, and Daniel A. Haber
Cancer Res 2002 62: 2741-2743. [Abstract] [Full Text] [PDF]  

Oncogenic ß-Catenin Is Required for Bone Morphogenetic Protein 4 Expression in Human Cancer Cells

Jung-Sik Kim, Heather Crooks, Tatiana Dracheva, Tagvor G. Nishanian, Baljit Singh, Jin Jen, and Todd Waldman
Cancer Res 2002 62: 2744-2748. [Abstract] [Full Text] [PDF]  

Placental Growth Factor Is a Survival Factor for Tumor Endothelial Cells and Macrophages

Avner Adini, Tad Kornaga, Farshid Firoozbakht, and Laura E. Benjamin
Cancer Res 2002 62: 2749-2752. [Abstract] [Full Text] [PDF]  

Prolonged Survival and Decreased Invasive Activity Attributable to Dipeptidyl Peptidase IV Overexpression in Ovarian Carcinoma

Hiroaki Kajiyama, Fumitaka Kikkawa, Takahiro Suzuki, Kiyosumi Shibata, Kazuhiko Ino, and Shigehiko Mizutani
Cancer Res 2002 62: 2753-2757. [Abstract] [Full Text] [PDF]  

Microsatellite Instability of Germ Cell Tumors Is Associated with Resistance to Systemic Treatment

Frank Mayer, Ad J. M. Gillis, Winand Dinjens, J. Wolter Oosterhuis, Carsten Bokemeyer, and Leendert H. J. Looijenga
Cancer Res 2002 62: 2758-2760. [Abstract] [Full Text] [PDF]  

p16^INK4a and p53 Deficiency Cooperate in Tumorigenesis

Norman E. Sharpless, Scott Alson, Suzanne Chan, Daniel P. Silver, Diego H. Castrillon, and Ronald A. DePinho
Cancer Res 2002 62: 2761-2765. [Abstract] [Full Text] [PDF]  

The BLM Helicase Is Necessary for Normal DNA Double-Strand Break Repair

Gregory Langland, James Elliott, Yuling Li, Jenette Creaney, Kathleen Dixon, and Joanna Groden
Cancer Res 2002 62: 2766-2770. [Abstract] [Full Text] [PDF]  

Biochemistry and Biophysics:

Chemotherapy Inhibits Skeletal Muscle Ubiquitin-Proteasome-dependent Proteolysis

Thomas Tilignac, Sandrine Temparis, Lydie Combaret, Daniel Taillandier, Marie-Noëlle Pouch, Matjaz Cervek, Diana M. Cardenas, Thierry Le Bricon, Eric Debiton, Susan E. Samuels, Jean-Claude Madelmont, and Didier Attaix
Cancer Res 2002 62: 2771-2777. [Abstract] [Full Text] [PDF]  

Carcinogenesis:

Transforming Growth Factor ß Signaling Is Disabled Early in Human Endometrial Carcinogenesis Concomitant with Loss of Growth Inhibition

Trilok V. Parekh, Patricia Gama, Xie Wen, Rita Demopoulos, John S. Munger, Maria-Luisa Carcangiu, Michael Reiss, and Leslie I. Gold
Cancer Res 2002 62: 2778-2790. [Abstract] [Full Text] [PDF]  

Myeloid Leukemias Have Increased Activity of the Nonhomologous End-Joining Pathway and Concomitant DNA Misrepair that Is Dependent on the Ku70/86 Heterodimer

Terry J. Gaymes, Ghulam J. Mufti, and Feyruz V. Rassool
Cancer Res 2002 62: 2791-2797. [Abstract] [Full Text] [PDF]  

Lack of Ductal Development in the Absence of Functional Estrogen Receptor Delays Mammary Tumor Formation Induced by Transgenic Expression of ErbB2/neu

Sylvia Curtis Hewitt, Wayne P. Bocchinfuso, Jun Zhai, Chuck Harrell, Linwood Koonce, James Clark, Page Myers, and Kenneth S. Korach
Cancer Res 2002 62: 2798-2805. [Abstract] [Full Text] [PDF]  

Connexin 43 Suppresses Human Glioblastoma Cell Growth by Down-Regulation of Monocyte Chemotactic Protein 1, as Discovered Using Protein Array Technology

Ruochun Huang, Ying Lin, Cheng C. Wang, Jacob Gano, Biaoyang Lin, Qian Shi, Alton Boynton, Jocelyn Burke, and Ruo-Pan Huang
Cancer Res 2002 62: 2806-2812. [Abstract] [Full Text] [PDF]  

Epidemiology and Prevention:

Chromosome Instability in Lymphocytes: A Potential Indicator of Predisposition to Oral Premalignant Lesions

Xifeng Wu, Scott M. Lippman, J. Jack Lee, Yong Zhu, Q. Victoria Wei, Margaret Thomas, Waun Ki Hong, and Margaret R. Spitz
Cancer Res 2002 62: 2813-2818. [Abstract] [Full Text] [PDF]  

Combinations of the Variant Genotypes of GSTP1, GSTM1, and p53 Are Associated with an Increased Lung Cancer Risk

David P. Miller, Geoffrey Liu, Immaculata De Vivo, Thomas J. Lynch, John C. Wain, Li Su, and David C. Christiani
Cancer Res 2002 62: 2819-2823. [Abstract] [Full Text] [PDF]  

Experimental Therapeutics:

Multiple Roles for Platelet GPIIb/IIIa and vß3 Integrins in Tumor Growth, Angiogenesis, and Metastasis

Mohit Trikha, Zhao Zhou, Jozsef Timar, Erzebet Raso, Margaret Kennel, Eva Emmell, and Marian T. Nakada
Cancer Res 2002 62: 2824-2833. [Abstract] [Full Text] [PDF]  

Suppression of Thymidine Phosphorylase-mediated Angiogenesis and Tumor Growth by 2-Deoxy-L-ribose

Hiroshi Uchimiya, Tatsuhiko Furukawa, Masahiro Okamoto, Yuichi Nakajima, Shigeto Matsushita, Ryuji Ikeda, Takenari Gotanda, Misako Haraguchi, Tomoyuki Sumizawa, Mayumi Ono, Michihiko Kuwano, Tamotsu Kanzaki, and Shin-ichi Akiyama
Cancer Res 2002 62: 2834-2839. [Abstract] [Full Text] [PDF]  

Antibody Targeting of the EphA2 Tyrosine Kinase Inhibits Malignant Cell Behavior

Kelly Carles-Kinch, Katherine E. Kilpatrick, Jane C. Stewart, and Michael S. Kinch
Cancer Res 2002 62: 2840-2847. [Abstract] [Full Text] [PDF]  

A Recombinant CD7-specific Single-Chain Immunotoxin Is a Potent Inducer of Apoptosis in Acute Leukemic T Cells

Matthias Peipp, Heide Küpers, Domenica Saul, Beate Schlierf, Johann Greil, Susan J. Zunino, Martin Gramatzki, and Georg H. Fey
Cancer Res 2002 62: 2848-2855. [Abstract] [Full Text] [PDF]  

Immunology:

Increased Tumorigenicity, but Unchanged Immunogenicity, of Transporter for Antigen Presentation 1-deficient Tumors

Zhihai Qin, Christina Harders, Xuetao Cao, Christoph Huber, Thomas Blankenstein, and Barbara Seliger
Cancer Res 2002 62: 2856-2860. [Abstract] [Full Text] [PDF]  

Induction of Leukemia-specific Cytotoxic Response by Cross-Presentation of Late-Apoptotic Leukemic Blasts by Autologous Dendritic Cells of Nonleukemic Origin

Radek Spisek, Patrice Chevallier, Nadine Morineau, Noël Milpied, Herve Avet-Loiseau, Jean-Luc Harousseau, Khaled Meflah, and Marc Gregoire
Cancer Res 2002 62: 2861-2868. [Abstract] [Full Text] [PDF]  

Glycolipid-anchored IL-12 Expressed on Tumor Cell Surface Induces Antitumor Immune Response

Shanmugam Nagarajan and Periasamy Selvaraj
Cancer Res 2002 62: 2869-2874. [Abstract] [Full Text] [PDF]  

Expression of the Proteasome Activator PA28 Rescues the Presentation of a Cytotoxic T Lymphocyte Epitope on Melanoma Cells

Yuansheng Sun, Alice J. A. M. Sijts, Mingxia Song, Katharina Janek, Alexander K. Nussbaum, Sylvie Kral, Markus Schirle, Stefan Stevanovic, Annette Paschen, Hansjörg Schild, Peter-M. Kloetzel, and Dirk Schadendorf
Cancer Res 2002 62: 2875-2882. [Abstract] [Full Text] [PDF]  

Molecular Biology and Genetics:

p53AIP1 Regulates the Mitochondrial Apoptotic Pathway

Koichi Matsuda, Koji Yoshida, Yoichi Taya, Kozo Nakamura, Yusuke Nakamura, and Hirofumi Arakawa
Cancer Res 2002 62: 2883-2889. [Abstract] [Full Text] [PDF]  

Identification of Differentially Expressed Genes in Pancreatic Cancer Cells Using cDNA Microarray

Haiyong Han, David J. Bearss, L. Walden Browne, Robert Calaluce, Raymond B. Nagle, and Daniel D. Von Hoff
Cancer Res 2002 62: 2890-2896. [Abstract] [Full Text] [PDF]  

Initiation of Human Astrocytoma by Clonal Evolution of Cells with Progressive Loss of p53 Functions in a Patient with a 283H TP53 Germ-line Mutation: Evidence for a Precursor Lesion

Giulia Fulci, Nobuaki Ishii, Daniela Maurici, Kim M. Gernert, Pierre Hainaut, Balveen Kaur, and Erwin G. Van Meir
Cancer Res 2002 62: 2897-2905. [Abstract] [Full Text] [PDF]  

Cooperative Function of Aml1-ETO Corepressor Recruitment Domains in the Expansion of Primary Bone Marrow Cells

Bruce A. Hug, Samuel Y. D. Lee, Erron L. Kinsler, Jinsong Zhang, and Mitchell A. Lazar
Cancer Res 2002 62: 2906-2912. [Abstract] [Full Text] [PDF]  

Histone Deacetylase 5 Is Not a p53 Target Gene, But Its Overexpression Inhibits Tumor Cell Growth and Induces Apoptosis

Yuanhui Huang, Mingjia Tan, Mark Gosink, Kevin K. W. Wang, and Yi Sun
Cancer Res 2002 62: 2913-2922. [Abstract] [Full Text] [PDF]  

Development of a Highly Specialized cDNA Array for the Study and Diagnosis of Epithelial Ovarian Cancer

G. Peter Sawiris, Cheryl A. Sherman-Baust, Kevin G. Becker, Chris Cheadle, Diane Teichberg, and Patrice J. Morin
Cancer Res 2002 62: 2923-2928. [Abstract] [Full Text] [PDF]  

Tumor Biology:

Role of the von Hippel-Lindau Tumor Suppressor Gene in the Formation of ß1-Integrin Fibrillar Adhesions

Miguel A. Esteban-Barragán, Pilar Ávila, Miguel Álvarez-Tejado, M. Dolores Gutiérrez, Ángeles García-Pardo, Francisco Sánchez-Madrid, and Manuel O. Landázuri
Cancer Res 2002 62: 2929-2936. [Abstract] [Full Text] [PDF]  

Expression of Chemokine Receptor CCR7 Is Associated with Lymph Node Metastasis of Gastric Carcinoma

Kohjiro Mashino, Noriaki Sadanaga, Hiroshi Yamaguchi, Fumiaki Tanaka, Mitsuhiko Ohta, Kenji Shibuta, Hiroshi Inoue, and Masaki Mori
Cancer Res 2002 62: 2937-2941. [Abstract] [Full Text] [PDF]  

Expression of the Type 1 Insulin-like Growth Factor Receptor Is Up-Regulated in Primary Prostate Cancer and Commonly Persists in Metastatic Disease

Giles O. Hellawell, Gareth D. H. Turner, David R. Davies, Richard Poulsom, Simon F. Brewster, and Valentine M. Macaulay
Cancer Res 2002 62: 2942-2950. [Abstract] [Full Text] [PDF]  

Constitutive c-Met Signaling through a Nonautocrine Mechanism Promotes Metastasis in a Transgenic Transplantation Model

Yanlin Yu and Glenn Merlino
Cancer Res 2002 62: 2951-2956. [Abstract] [Full Text] [PDF]  

Expression of Hypoxia-inducible Factors in Human Renal Cancer: Relationship to Angiogenesis and to the von Hippel-Lindau Gene Mutation

Kevin J. Turner, John W. Moore, Adam Jones, Claire F. Taylor, Darren Cuthbert-Heavens, Cheng Han, Russell D. Leek, Kevin C. Gatter, Patrick H. Maxwell, Peter J. Ratcliffe, David Cranston, and Adrian L. Harris
Cancer Res 2002 62: 2957-2961. [Abstract] [Full Text] [PDF]  

Rescue of Hypoxia-inducible Factor-1-deficient Tumor Growth by Wild-Type Cells Is Independent of Vascular Endothelial Growth Factor

Gisele Höpfl, Roland H. Wenger, Urs Ziegler, Thomas Stallmach, Olivier Gardelle, Roger Achermann, Melanie Wergin, Barbara Kaser-Hotz, H. Mark Saunders, Kaye J. Williams, Ian J. Stratford, Max Gassmann, and Isabelle Desbaillets
Cancer Res 2002 62: 2962-2970. [Abstract] [Full Text] [PDF]  

Critical Involvement of the Phosphatidylinositol 3-Kinase/Akt Pathway in Anchorage-independent Growth and Hematogeneous Intrahepatic Metastasis of Liver Cancer

Kazuaki Nakanishi, Michiie Sakamoto, Jun Yasuda, Masaaki Takamura, Naoya Fujita, Takashi Tsuruo, Satoru Todo, and Setsuo Hirohashi
Cancer Res 2002 62: 2971-2975. [Abstract] [Full Text] [PDF]  

Identification and Characterization of Bim, a Novel Proapoptotic BH3-only Splice Variant of Bim

Jun-Wei Liu, Dhyan Chandra, Shao-Hua Tang, Dharam Chopra, and Dean G. Tang
Cancer Res 2002 62: 2976-2981. [Abstract] [Full Text] [PDF]  

Virology:

Adeno-associated Virus Protects the Retinoblastoma Family of Proteins from Adenoviral-induced Functional Inactivation

Ramesh B. Batchu, Masood A. Shammas, Jing Yi Wang, John Freeman, Nancy Rosen, and Nikhil C. Munshi
Cancer Res 2002 62: 2982-2985. [Abstract] [Full Text] [PDF]  

Letters to the Editor:

Correspondence re: J. Mora et al., Neuroblastic and Schwannian Stromal Cells of Neuroblastoma Are Derived from a Tumoral Progenitor Cell. Cancer Res., 61: 6892–6898, 2001.

Ingeborg M. Ambros, Gabriele Amann, Peter F. Ambros, Hiroyuki Shimada, Jaume Mora, Nai-Kong Cheung, Peter Illei, Marc Ladanyi, Carlos Cordon-Cardo, and William L. Gerald
Cancer Res 2002 62: 2986-2989. [Full Text] [PDF]  

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