Advances in Brief:

3-Deoxy-3-[¹⁸F]Fluorothymidine-Positron Emission Tomography for Noninvasive Assessment of Proliferation in Pulmonary Nodules

Andreas K. Buck, Holger Schirrmeister, Martin Hetzel, Mareike von der Heide, Gisela Halter, Gerhard Glatting, Torsten Mattfeldt, Florian Liewald, Sven N. Reske, and Bernd Neumaier
Cancer Res 2002 62: 3331-3334. [Abstract] [Full Text] [PDF]  

Mutant Epidermal Growth Factor Receptor Up-Regulates Molecular Effectors of Tumor Invasion

Anita Lal, Chad A. Glazer, Holly M. Martinson, Henry S. Friedman, Gary E. Archer, John H. Sampson, and Gregory J. Riggins
Cancer Res 2002 62: 3335-3339. [Abstract] [Full Text] [PDF]  

A Preliminary Transcriptome Map of Non-Small Cell Lung Cancer

Takeshi Fujii, Tatiana Dracheva, Audrey Player, Susan Chacko, Robert Clifford, Robert L. Strausberg, Kenneth Buetow, Norio Azumi, William D. Travis, and Jin Jen
Cancer Res 2002 62: 3340-3346. [Abstract] [Full Text] [PDF]  

Human Cytomegalovirus Infection and Expression in Human Malignant Glioma

Charles S. Cobbs, Lualhati Harkins, Minu Samanta, G. Yancey Gillespie, Suman Bharara, Peter H. King, L. Burt Nabors, C. Glenn Cobbs, and William J. Britt
Cancer Res 2002 62: 3347-3350. [Abstract] [Full Text] [PDF]  

Constitutive Activation of Signal Transducers and Activators of Transcription 3 Correlates with Cyclin D1 Overexpression and May Provide a Novel Prognostic Marker in Head and Neck Squamous Cell Carcinoma

Muneyuki Masuda, Masumi Suzui, Ryuji Yasumatu, Torahiko Nakashima, Yuichiro Kuratomi, Kaoru Azuma, Kichinobu Tomita, Sohtaro Komiyama, and I. Bernard Weinstein
Cancer Res 2002 62: 3351-3355. [Abstract] [Full Text] [PDF]  

Peloruside A, a Novel Antimitotic Agent with Paclitaxel-like Microtubule- stabilizing Activity

Kylie A. Hood, Lyndon M. West, Berber Rouwé, Peter T. Northcote, Michael V. Berridge, St. John Wakefield, and John H. Miller
Cancer Res 2002 62: 3356-3360. [Abstract] [Full Text] [PDF]  

Thymidylate Synthase Promoter Polymorphism, Interaction with Folate Intake, and Risk of Colorectal Adenomas

Cornelia M. Ulrich, Jeannette Bigler, Roberd Bostick, Lisa Fosdick, and John D. Potter
Cancer Res 2002 62: 3361-3364. [Abstract] [Full Text] [PDF]  

Detection of Telomerase Inhibitors Based on G-Quadruplex Ligands by a Modified Telomeric Repeat Amplification Protocol Assay

Dennis Gomez, Jean-Louis Mergny, and Jean-François Riou
Cancer Res 2002 62: 3365-3368. [Abstract] [Full Text] [PDF]  

Influence of Cytokine Gene Polymorphisms on the Development of Prostate Cancer

Sarah L. McCarron, Stephen Edwards, Philip R. Evans, Roz Gibbs, David P. Dearnaley, Anna Dowe, Christine Southgate, Douglas F. Easton, Rosalind A. Eeles, and W. Martin Howell
Cancer Res 2002 62: 3369-3372. [Abstract] [Full Text] [PDF]  

Critical Requirement of BAX for Manifestation of Apoptosis Induced by Multiple Stimuli in Human Epithelial Cancer Cells

Paul Theodorakis, Elena Lomonosova, and G. Chinnadurai
Cancer Res 2002 62: 3373-3376. [Abstract] [Full Text] [PDF]  

Ecteinascidin-743 Inhibits Activated but not Constitutive Transcription

Debbie Friedman, Zhen Hu, E. Anders Kolb, Barbara Gorfajn, and Kathleen W. Scotto
Cancer Res 2002 62: 3377-3381. [Abstract] [Full Text] [PDF]  

Aberrant Methylation of the CDH13 (H-cadherin) Promoter Region in Colorectal Cancers and Adenomas

Shinichi Toyooka, Kiyomi O. Toyooka, Kenichi Harada, Kuniharu Miyajima, Prakash Makarla, Ubaradka G. Sathyanarayana, Jing Yin, Fumiaki Sato, Narayan Shivapurkar, Stephen J. Meltzer, and Adi F. Gazdar
Cancer Res 2002 62: 3382-3386. [Abstract] [Full Text] [PDF]  

Biochemistry and Biophysics:

Hypoxia-inducible Factor-1-dependent Regulation of the Multidrug Resistance (MDR1) Gene

Katrina M. Comerford, Timothy J. Wallace, Jörn Karhausen, Nancy A. Louis, Michael C. Montalto, and Sean P. Colgan
Cancer Res 2002 62: 3387-3394. [Abstract] [Full Text] [PDF]  

Carcinogenesis:

Deficiency of Either Cyclooxygenase (COX)-1 or COX-2 Alters Epidermal Differentiation and Reduces Mouse Skin Tumorigenesis

Howard F. Tiano, Charles D. Loftin, Jackie Akunda, Christopher A. Lee, Judson Spalding, Alisha Sessoms, David B. Dunson, Eleanor G. Rogan, Scott G. Morham, Robert C. Smart, and Robert Langenbach
Cancer Res 2002 62: 3395-3401. [Abstract] [Full Text] [PDF]  

A Critical Role for ras-mediated, Epidermal Growth Factor Receptor-dependent Angiogenesis in Mouse Skin Carcinogenesis

M. Llanos Casanova, Fernando Larcher, Benito Casanova, Rodolfo Murillas, M. Jesús Fernández-Aceñero, Concepción Villanueva, Jesús Martínez-Palacio, Axel Ullrich, Claudio J. Conti, and Jose Luis Jorcano
Cancer Res 2002 62: 3402-3407. [Abstract] [Full Text] [PDF]  

Clinical Investigations:

A Phase I Pharmacokinetic and Translational Study of the Novel Vascular Targeting Agent Combretastatin A-4 Phosphate on a Single-Dose Intravenous Schedule in Patients with Advanced Cancer

Afshin Dowlati, Kelly Robertson, Matthew Cooney, William P. Petros, Michael Stratford, John Jesberger, Niusha Rafie, Beth Overmoyer, Vinit Makkar, Bruce Stambler, Anne Taylor, John Waas, Jonathan S. Lewin, Keith R. McCrae, and Scot C. Remick
Cancer Res 2002 62: 3408-3416. [Abstract] [Full Text] [PDF]  

Prognostic Significance of the Metastasis-associated Protein Osteopontin in Human Breast Cancer

Philip S. Rudland, Angela Platt-Higgins, Mohamed El-Tanani, Suzete de Silva Rudland, Roger Barraclough, John H. R. Winstanley, Rachel Howitt, and Christopher R. West
Cancer Res 2002 62: 3417-3427. [Abstract] [Full Text] [PDF]  

Endocrinology:

Association of Interferon Regulatory Factor-1, Nucleophosmin, Nuclear Factor-B, and Cyclic AMP Response Element Binding with Acquired Resistance to Faslodex (ICI 182,780)

Zhiping Gu, Richard Y. Lee, Todd C. Skaar, Kerrie B. Bouker, James N. Welch, Jianping Lu, Aiyi Liu, Yuelin Zhu, Natalie Davis, Fabio Leonessa, Nils Brünner, Yue Wang, and Robert Clarke
Cancer Res 2002 62: 3428-3437. [Abstract] [Full Text] [PDF]  

Experimental Therapeutics:

An E2F-responsive Replication-selective Adenovirus Targeted to the Defective Cell Cycle in Cancer Cells: Potent Antitumoral Efficacy but No Toxicity to Normal Cell

Kazunori Tsukuda, Rainer Wiewrodt, Katherine Molnar-Kimber, Vuk P. Jovanovic, and Kunjlata Manibhai Amin
Cancer Res 2002 62: 3438-3447. [Abstract] [Full Text] [PDF]  

Lack of Promotion of Estrogen-dependent Mammary Gland Tumors in vivo by an Isopropanolic Cimicifuga racemosa Extract

Johannes Freudenstein, Clemens Dasenbrock, and Thomas Nißlein
Cancer Res 2002 62: 3448-3452. [Abstract] [Full Text] [PDF]  

Immunology:

Interferon Stimulated Gene 15 Constitutively Produced by Melanoma Cells Induces E-Cadherin Expression on Human Dendritic Cells

Elisabetta Padovan, Luigi Terracciano, Ulrich Certa, Barbara Jacobs, Anca Reschner, Martin Bolli, Giulio C. Spagnoli, Ernest C. Borden, and Michael Heberer
Cancer Res 2002 62: 3453-3458. [Abstract] [Full Text] [PDF]  

Anti-4-1BB Monoclonal Antibody Enhances Rejection of Large Tumor Burden by Promoting Survival but not Clonal Expansion of Tumor-specific CD8⁺ T Cells

Kenneth F. May, Jr., Lieping Chen, Pan Zheng, and Yang Liu
Cancer Res 2002 62: 3459-3465. [Abstract] [Full Text] [PDF]  

Molecular Biology and Genetics:

Parallel Analysis of Sporadic Primary Ovarian Carcinomas by Spectral Karyotyping, Comparative Genomic Hybridization, and Expression Microarrays

Jane Bayani, James D. Brenton, Pascale F. Macgregor, Ben Beheshti, Monique Albert, Dhani Nallainathan, Jana Karaskova, Barry Rosen, Joan Murphy, Stephanie Laframboise, Brent Zanke, and Jeremy A. Squire
Cancer Res 2002 62: 3466-3476. [Abstract] [Full Text] [PDF] Supplementary Data  

Identification of Unstable Sequences within the Common Fragile Site at 3p14.2: Implications for the Mechanism of Deletions within Fragile Histidine Triad Gene/Common Fragile Site at 3p14.2 in Tumors

Shantel Corbin, Mary E. Neilly, Rafael Espinosa, III, Elizabeth M. Davis, Timothy W. McKeithan, and Michelle M. Le Beau
Cancer Res 2002 62: 3477-3484. [Abstract] [Full Text] [PDF]  

Evaluation of Microsatellite Instability and Immunohistochemistry for the Prediction of Germ-Line MSH2 and MLH1 Mutations in Hereditary Nonpolyposis Colon Cancer Families

Siobhan S. Wahlberg, James Schmeits, George Thomas, Massimo Loda, Judy Garber, Sapna Syngal, Richard D. Kolodner, and Edward Fox
Cancer Res 2002 62: 3485-3492. [Abstract] [Full Text] [PDF]  

Artificial Neural Networks and Gene Filtering Distinguish Between Global Gene Expression Profiles of Barrett’s Esophagus and Esophageal Cancer

Yan Xu, Florin M. Selaru, Jing Yin, Tong Tong Zou, Valentina Shustova, Yuriko Mori, Fumiaki Sato, Thomas C. Liu, Andreea Olaru, Suna Wang, Martha C. Kimos, Kellie Perry, Kena Desai, Bruce D. Greenwald, Mark J. Krasna, David Shibata, John M. Abraham, and Stephen J. Meltzer
Cancer Res 2002 62: 3493-3497. [Abstract] [Full Text] [PDF]  

The RASSF1A Tumor Suppressor Gene Is Inactivated in Prostate Tumors and Suppresses Growth of Prostate Carcinoma Cells

Igor Kuzmin, John W. Gillespie, Alexei Protopopov, Laura Geil, Koen Dreijerink, Youfeng Yang, Cathy D. Vocke, Fuh-Mei Duh, Eugene Zabarovsky, John D. Minna, Johng S. Rhim, Michael R. Emmert-Buck, W. Marston Linehan, and Michael I. Lerman
Cancer Res 2002 62: 3498-3502. [Abstract] [Full Text] [PDF]  

ß-Catenin Mutation Is a Frequent Cause of Wnt Pathway Activation in Gastric Cancer

Wilson M. Clements, Jiang Wang, Amod Sarnaik, On Ja Kim, Jack MacDonald, Cecilia Fenoglio-Preiser, Joanna Groden, and Andrew M. Lowy
Cancer Res 2002 62: 3503-3506. [Abstract] [Full Text] [PDF]  

Omomyc, a Potential Myc Dominant Negative, Enhances Myc-induced Apoptosis

Laura Soucek, Richard Jucker, Laura Panacchia, Ruggero Ricordy, Franco Tatò, and Sergio Nasi
Cancer Res 2002 62: 3507-3510. [Abstract] [Full Text] [PDF]  

Deregulated DNA Polymerase ß Induces Chromosome Instability and Tumorigenesis

Valérie Bergoglio, Marie-Jeanne Pillaire, Magali Lacroix-Triki, Brigitte Raynaud-Messina, Yvan Canitrot, Anne Bieth, Michèle Garès, Michel Wright, Georges Delsol, Lawrence A. Loeb, Christophe Cazaux, and Jean-Sébastien Hoffmann
Cancer Res 2002 62: 3511-3514. [Abstract] [Full Text] [PDF]  

Genotoxic Exposure Is Associated with Alterations in Glucose Uptake and Metabolism

Rixin Zhou, Matthew G. Vander Heiden, and Charles M. Rudin
Cancer Res 2002 62: 3515-3520. [Abstract] [Full Text] [PDF]  

Tumor Biology:

Frequencies of Tetramer⁺ T Cells Specific for the Wild-Type Sequence p53_264–272 Peptide in the Circulation of Patients with Head and Neck Cancer

Thomas K. Hoffmann, Albert D. Donnenberg, Sydney D. Finkelstein, Vera S. Donnenberg, Ulrike Friebe-Hoffmann, Eugene N. Myers, Ettore Appella, Albert B. DeLeo, and Theresa L. Whiteside
Cancer Res 2002 62: 3521-3529. [Abstract] [Full Text] [PDF]  

Insulin-like Growth Factor Binding Protein-3 Inhibits the Growth of Non-Small Cell Lung Cancer

Ho-Young Lee, Kyung-Hee Chun, Bingrong Liu, Sandra A. Wiehle, Richard J. Cristiano, Waun Ki Hong, Pinchas Cohen, and Jonathan M. Kurie
Cancer Res 2002 62: 3530-3537. [Abstract] [Full Text] [PDF]  

Transformation of Mammary Epithelial Cells by 3-Phosphoinositide-dependent Protein Kinase-1 (PDK1) Is Associated with the Induction of Protein Kinase C

Xiao Zeng, Hangmin Xu, and Robert I. Glazer
Cancer Res 2002 62: 3538-3543. [Abstract] [Full Text] [PDF]  

Ciliary Neurotrophic Factor (CNTF) in Combination with Its Soluble Receptor (CNTFR) Increases Connexin43 Expression and Suppresses Growth of C6 Glioma Cells

Mark A. Ozog, John F. Bechberger, and Christian C. G. Naus
Cancer Res 2002 62: 3544-3548. [Abstract] [Full Text] [PDF]  

The B16F10 Cell Receptor for a Metastasis-promoting Site on Laminin-1 Is a Heparan Sulfate/Chondroitin Sulfate-containing Proteoglycan

Jean A. Engbring, Matthew P. Hoffman, Arezo J. Karmand, and Hynda K. Kleinman
Cancer Res 2002 62: 3549-3554. [Abstract] [Full Text] [PDF]  

Insulin Increases the Sensitivity of Tumors to Irradiation: Involvement of an Increase in Tumor Oxygenation Mediated by a Nitric Oxide-dependent Decrease of the Tumor Cells Oxygen Consumption

Bénédicte F. Jordan, Vincent Grégoire, Roger J. Demeure, Pierre Sonveaux, Olivier Feron, Julia O’Hara, Valérie P. Vanhulle, Nathalie Delzenne, and Bernard Gallez
Cancer Res 2002 62: 3555-3561. [Abstract] [Full Text] [PDF]  

Virology:

Transcription Profile of Cells Infected with Human T-cell Leukemia Virus Type I Compared with Activated Lymphocytes

Cynthia A. Pise-Masison, Michael Radonovich, Renaud Mahieux, Pramita Chatterjee, Craig Whiteford, Janet Duvall, Claire Guillerm, Antoine Gessain, and John N. Brady
Cancer Res 2002 62: 3562-3571. [Abstract] [Full Text] [PDF] Supplementary Data  

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