Advances in Brief:

Christopher B. Manning, Andrew B. Cummins, Michael W. Jung, Ingrid Berlanger, Cynthia R. Timblin, Cathy Palmer, Douglas J. Taatjes, David Hemenway, Pamela Vacek, and Brooke T. Mossman

A Mutant Epidermal Growth Factor Receptor Targeted to Lung Epithelium Inhibits Asbestos-induced Proliferation and Proto-Oncogene Expression
Cancer Res 2002 62: 4169-4175. [Abstract] [Full Text] [PDF]  

Akira Miyajima, Takeo Kosaka, Tomohiko Asano, Takako Asano, Kaori Seta, Toshiaki Kawai, and Masamichi Hayakawa

Angiotensin II Type I Antagonist Prevents Pulmonary Metastasis of Murine Renal Cancer by Inhibiting Tumor Angiogenesis
Cancer Res 2002 62: 4176-4179. [Abstract] [Full Text] [PDF]  

Rajani Ravi and Atul Bedi

Sensitization of Tumor Cells to Apo2 Ligand/TRAIL-induced Apoptosis by Inhibition of Casein Kinase II
Cancer Res 2002 62: 4180-4185. [Abstract] [Full Text] [PDF]  

Juping Yuan, Andrea Krämer, Frank Eckerdt, Manfred Kaufmann, and Klaus Strebhardt

Efficient Internalization of the Polo-Box of Polo-like Kinase 1 Fused to an Antennapedia Peptide Results in Inhibition of Cancer Cell Proliferation
Cancer Res 2002 62: 4186-4190. [Abstract] [Full Text] [PDF]  

H. Shuen Lo, Nan Hu, Sheryl Gere, Ning Lu, Hua Su, Alisa M. Goldstein, Philip R. Taylor, and Maxwell P. Lee

Identification of Somatic Mutations of the RNF6 Gene in Human Esophageal Squamous Cell Carcinoma
Cancer Res 2002 62: 4191-4193. [Abstract] [Full Text] [PDF]  

Jianing Zhang, Jun Nakayama, Chikara Ohyama, Masami Suzuki, Atsushi Suzuki, Minoru Fukuda, and Michiko N. Fukuda

Sialyl Lewis X-dependent Lung Colonization of B16 Melanoma Cells through a Selectin-like Endothelial Receptor Distinct from E- or P-Selectin
Cancer Res 2002 62: 4194-4198. [Abstract] [Full Text] [PDF]  

William T. Gunning, Paula M. Kramer, Vernon E. Steele, and Michael A. Pereira

Chemoprevention by Lipoxygenase and Leukotriene Pathway Inhibitors of Vinyl Carbamate-induced Lung Tumors in Mice
Cancer Res 2002 62: 4199-4201. [Abstract] [Full Text] [PDF]  

Young S. Lew, Andrew Kolozsvary, Stephen L. Brown, and Jae Ho Kim

Synergistic Interaction with Arsenic Trioxide and Fractionated Radiation in Locally Advanced Murine Tumor
Cancer Res 2002 62: 4202-4205. [Abstract] [Full Text] [PDF]  

Henrik Lövborg, Jacek Wojciechowski, Rolf Larsson, and Józefa Wesierska-Gadek

Action of a Novel Anticancer Agent, CHS 828, on Mouse Fibroblasts: Increased Sensitivity of Cells Lacking Poly (ADP-Ribose) Polymerase-1
Cancer Res 2002 62: 4206-4211. [Abstract] [Full Text] [PDF]  

Jenny M. Kim, Junjie Fang, Susan Rheingold, Richard Aplenc, Robert Wasserman, and Stephan A. Grupp

Cytoplasmic µ Heavy Chain Confers Sensitivity to Dexamethasone-induced Apoptosis in Early B-lineage Acute Lymphoblastic Leukemia
Cancer Res 2002 62: 4212-4216. [Abstract] [Full Text] [PDF]  

Su Hao Lo and Tung Bin Lo

Cten, a COOH-Terminal Tensin-like Protein with Prostate Restricted Expression, Is Down-Regulated in Prostate Cancer
Cancer Res 2002 62: 4217-4221. [Abstract] [Full Text] [PDF]  

Biochemistry and Biophysics:

Natsuko Chiba and Jeffrey D. Parvin

The BRCA1 and BARD1 Association with the RNA Polymerase II Holoenzyme
Cancer Res 2002 62: 4222-4228. [Abstract] [Full Text] [PDF]  

Tonko Buterin, Martin T. Hess, Daniela Gunz, Nicholas E. Geacintov, Leon H. Mullenders, and Hanspeter Naegeli

Trapping of DNA Nucleotide Excision Repair Factors by Nonrepairable Carcinogen Adducts
Cancer Res 2002 62: 4229-4235. [Abstract] [Full Text] [PDF]  

Bhushan Nagar, William G. Bornmann, Patricia Pellicena, Thomas Schindler, Darren R. Veach, W. Todd Miller, Bayard Clarkson, and John Kuriyan

Crystal Structures of the Kinase Domain of c-Abl in Complex with the Small Molecule Inhibitors PD173955 and Imatinib (STI-571)
Cancer Res 2002 62: 4236-4243. [Abstract] [Full Text] [PDF]  

Experimental Therapeutics:

David Wisniewski, Caryl L. Lambek, Chongyuan Liu, Annabel Strife, Darren R. Veach, Bhushan Nagar, Matthew A. Young, Thomas Schindler, William G. Bornmann, Joseph R. Bertino, John Kuriyan, and Bayard Clarkson

Characterization of Potent Inhibitors of the Bcr-Abl and the c-Kit Receptor Tyrosine Kinases
Cancer Res 2002 62: 4244-4255. [Abstract] [Full Text] [PDF]  

Sarah Donald, Richard D. Verschoyle, Richard Edwards, David J. Judah, Reginald Davies, Joan Riley, David Dinsdale, Luis Lopez Lazaro, Andrew G. Smith, Timothy W. Gant, Peter Greaves, and Andreas J. Gescher

Hepatobiliary Damage and Changes in Hepatic Gene Expression Caused by the Antitumor Drug Ecteinascidin-743 (ET-743) in the Female Rat
Cancer Res 2002 62: 4256-4262. [Abstract] [Full Text] [PDF]  

Patricia A. Burke, Sally J. DeNardo, Laird A. Miers, Kathleen R. Lamborn, Siegfried Matzku, and Gerald L. DeNardo

Cilengitide Targeting of _vß₃ Integrin Receptor Synergizes with Radioimmunotherapy to Increase Efficacy and Apoptosis in Breast Cancer Xenografts
Cancer Res 2002 62: 4263-4272. [Abstract] [Full Text] [PDF]  

Yosef S. Haviv, Jerry L. Blackwell, Anna Kanerva, Peter Nagi, Victor Krasnykh, Igor Dmitriev, Minghui Wang, Seiji Naito, Xiaosheng Lei, Akseli Hemminki, Delicia Carey, and David T. Curiel

Adenoviral Gene Therapy for Renal Cancer Requires Retargeting to Alternative Cellular Receptors
Cancer Res 2002 62: 4273-4281. [Abstract] [Full Text] [PDF]  

Chun Man Lee, Toshiyuki Tanaka, Toshiyuki Murai, Masayo Kondo, Junji Kimura, Wei Su, Toru Kitagawa, Toshinori Ito, Hikaru Matsuda, and Masayuki Miyasaka

Novel Chondroitin Sulfate-binding Cationic Liposomes Loaded with Cisplatin Efficiently Suppress the Local Growth and Liver Metastasis of Tumor Cells in Vivo
Cancer Res 2002 62: 4282-4288. [Abstract] [Full Text] [PDF]  

Dennis E. J. G. J. Dolmans, Ananth Kadambi, John S. Hill, Kevin R. Flores, Joseph N. Gerber, Jeffrey P. Walker, Inne H. M. Borel Rinkes, Rakesh K. Jain, and Dai Fukumura

Targeting Tumor Vasculature and Cancer Cells in Orthotopic Breast Tumor by Fractionated Photosensitizer Dosing Photodynamic Therapy
Cancer Res 2002 62: 4289-4294. [Abstract] [Full Text] [PDF]  

Wei R. Chen, Hong Liu, Jerry W. Ritchey, Kenneth E. Bartels, Michael D. Lucroy, and Robert E. Nordquist

Effect of Different Components of Laser Immunotherapy in Treatment of Metastatic Tumors in Rats
Cancer Res 2002 62: 4295-4299. [Abstract] [Full Text] [PDF]  

Shyh-Min Huang, Jing Li, Eric A. Armstrong, and Paul M. Harari

Modulation of Radiation Response and Tumor-induced Angiogenesis after Epidermal Growth Factor Receptor Inhibition by ZD1839 (Iressa)
Cancer Res 2002 62: 4300-4306. [Abstract] [Full Text] [PDF]  

Arnab Chakravarti, Abhijit Chakladar, Meaghan A. Delaney, Douglas E. Latham, and Jay S. Loeffler

The Epidermal Growth Factor Receptor Pathway Mediates Resistance to Sequential Administration of Radiation and Chemotherapy in Primary Human Glioblastoma Cells in a RAS-dependent Manner
Cancer Res 2002 62: 4307-4315. [Abstract] [Full Text] [PDF]  

Annamaria Rapisarda, Badarch Uranchimeg, Dominic A. Scudiero, Mike Selby, Edward A. Sausville, Robert H. Shoemaker, and Giovanni Melillo

Identification of Small Molecule Inhibitors of Hypoxia-inducible Factor 1 Transcriptional Activation Pathway
Cancer Res 2002 62: 4316-4324. [Abstract] [Full Text] [PDF]  

Marielle Fournel, Marie-Claude Trachy-Bourget, P. Theresa Yan, Ann Kalita, Claire Bonfils, Carole Beaulieu, Sylvie Frechette, Silvana Leit, Elie Abou-Khalil, Soon-Hyung Woo, Daniel Delorme, A. Robert MacLeod, Jeffrey M. Besterman, and Zuomei Li

Sulfonamide Anilides, a Novel Class of Histone Deacetylase Inhibitors, Are Antiproliferative against Human Tumors
Cancer Res 2002 62: 4325-4330. [Abstract] [Full Text] [PDF]  

Carcinogenesis:

Ahmad Besaratinia, Steven E. Bates, and Gerd P. Pfeifer

Mutational Signature of the Proximate Bladder Carcinogen N-Hydroxy-4-acetylaminobiphenyl: Inconsistency with the p53 Mutational Spectrum in Bladder Cancer
Cancer Res 2002 62: 4331-4338. [Abstract] [Full Text] [PDF]  

Lars O. Dragsted, Bahram Daneshvar, Ulla Vogel, Herman N. Autrup, Håkan Wallin, Lotte Risom, Peter Møller, Anne M. Mølck, Max Hansen, Henrik E. Poulsen, and Steffen Loft

A Sucrose-rich Diet Induces Mutations in the Rat Colon
Cancer Res 2002 62: 4339-4345. [Abstract] [Full Text] [PDF]  

Shiou-Hwei Yeh, Ching-Fung Chang, Wen-Yi Shau, Ya-Wen Chen, Hey-Chi Hsu, Po-Huang Lee, Ding-Shinn Chen, and Pei-Jer Chen

Dominance of Functional Androgen Receptor Allele with Longer CAG Repeat in Hepatitis B Virus-related Female Hepatocarcinogenesis
Cancer Res 2002 62: 4346-4351. [Abstract] [Full Text] [PDF]  

Clinical Investigations:

Karin Birkenkamp-Demtroder, Lise Lotte Christensen, Sanne Harder Olesen, Casper M. Frederiksen, Päivi Laiho, Lauri A. Aaltonen, Søren Laurberg, Flemming B. Sørensen, Rikke Hagemann, and Torben F. Ørntoft

Gene Expression in Colorectal Cancer
Cancer Res 2002 62: 4352-4363. [Abstract] [Full Text] [PDF] Supplementary Data  

Meena K. Tanwar, Mark R. Gilbert, and Eric C. Holland

Gene Expression Microarray Analysis Reveals YKL-40 to Be a Potential Serum Marker for Malignant Character in Human Glioma
Cancer Res 2002 62: 4364-4368. [Abstract] [Full Text] [PDF]  

Endocrinology:

Xihong Zhang and Douglas Yee

Insulin-like Growth Factor Binding Protein-1 (IGFBP-1) Inhibits Breast Cancer Cell Motility
Cancer Res 2002 62: 4369-4375. [Abstract] [Full Text] [PDF]  

Epidemiology and Prevention:

Peter S. Carlton, Rajaram Gopalakrishnan, Ashok Gupta, Beth W. Liston, Suzy Habib, Mark A. Morse, and Gary D. Stoner

Piroxicam Is an Ineffective Inhibitor of N-Nitrosomethylbenzylamine-induced Tumorigenesis in the Rat Esophagus
Cancer Res 2002 62: 4376-4382. [Abstract] [Full Text] [PDF]  

Patricia A. Masso-Welch, Danilo Zangani, Clement Ip, Mary M. Vaughan, Suzanne Shoemaker, Robert A. Ramirez, and Margot M. Ip

Inhibition of Angiogenesis by the Cancer Chemopreventive Agent Conjugated Linoleic Acid
Cancer Res 2002 62: 4383-4389. [Abstract] [Full Text] [PDF]  

Immunology:

Giorgia Gri, Claudia Chiodoni, Elena Gallo, Antonella Stoppacciaro, Foo Y. Liew, and Mario P. Colombo

Antitumor Effect of Interleukin (IL)-12 in the Absence of Endogenous IFN-: A Role for Intrinsic Tumor Immunogenicity and IL-15
Cancer Res 2002 62: 4390-4397. [Abstract] [Full Text] [PDF]  

Sara Ek, Carl-Magnus Högerkorp, Michael Dictor, Mats Ehinger, and Carl A. K. Borrebaeck

Mantle Cell Lymphomas Express a Distinct Genetic Signature Affecting Lymphocyte Trafficking and Growth Regulation as Compared with Subpopulations of Normal Human B Cells
Cancer Res 2002 62: 4398-4405. [Abstract] [Full Text] [PDF]  

Beth A. Pulaski, Mark J. Smyth, and Suzanne Ostrand-Rosenberg

Interferon--dependent Phagocytic Cells Are a Critical Component of Innate Immunity against Metastatic Mammary Carcinoma
Cancer Res 2002 62: 4406-4412. [Abstract] [Full Text] [PDF]  

Ryan A. Wilcox, Dallas B. Flies, Hao Wang, Koji Tamada, Aaron J. Johnson, Larry R. Pease, Moses Rodriguez, Yajun Guo, and Lieping Chen

Impaired Infiltration of Tumor-specific Cytolytic T Cells in the Absence of Interferon- despite Their Normal Maturation in Lymphoid Organs during CD137 Monoclonal Antibody Therapy
Cancer Res 2002 62: 4413-4418. [Abstract] [Full Text] [PDF]  

Molecular Biology and Genetics:

Anait S. Levenson, Kristen M. Svoboda, Katherine M. Pease, Scott A. Kaiser, Bin Chen, Laura A. Simons, Borko D. Jovanovic, Patricia A. Dyck, and V. Craig Jordan

Gene Expression Profiles with Activation of the Estrogen Receptor -Selective Estrogen Receptor Modulator Complex in Breast Cancer Cells Expressing Wild-Type Estrogen Receptor
Cancer Res 2002 62: 4419-4426. [Abstract] [Full Text] [PDF]  

Daniel R. Rhodes, Terrence R. Barrette, Mark A. Rubin, Debashis Ghosh, and Arul M. Chinnaiyan

Meta-Analysis of Microarrays: Interstudy Validation of Gene Expression Profiles Reveals Pathway Dysregulation in Prostate Cancer
Cancer Res 2002 62: 4427-4433. [Abstract] [Full Text] [PDF]  

Renu Wadhwa, Lorel Colgin, Tomoko Yaguchi, Kazunari Taira, Roger R. Reddel, and Sunil C. Kaul

Rhodacyanine Dye MKT-077 Inhibits in Vitro Telomerase Assay But Has No Detectable Effects on Telomerase Activity in Vivo
Cancer Res 2002 62: 4434-4438. [Abstract] [Full Text] [PDF]  

A. Hamid Boulares, Anna J. Zoltoski, Zaki A. Sherif, Alexander G. Yakovlev, and Mark E. Smulson

The Poly(ADP-ribose) Polymerase-1-regulated Endonuclease DNAS1L3 Is Required for Etoposide-induced Internucleosomal DNA Fragmentation and Increases Etoposide Cytotoxicity in Transfected Osteosarcoma Cells
Cancer Res 2002 62: 4439-4444. [Abstract] [Full Text] [PDF]  

Diego Vieyra, Tatsuya Toyama, Yasuo Hara, Donna Boland, Randal Johnston, and Karl Riabowol

ING1 Isoforms Differentially Affect Apoptosis in a Cell Age-dependent Manner
Cancer Res 2002 62: 4445-4452. [Abstract] [Full Text] [PDF]  

Guenhael Sanz, Lluis Mir, and Alain Jacquemin-Sablon

Bleomycin Resistance in Mammalian Cells Expressing a Genetic Suppressor Element Derived from the SRPK1 Gene
Cancer Res 2002 62: 4453-4458. [Abstract] [Full Text] [PDF]  

Maria R. De Miglio, Rosa M. Pascale, Maria M. Simile, Maria R. Muroni, Diego F. Calvisi, Patrizia Virdis, Giovanni M. Bosinco, Maddalena Frau, Maria A. Seddaiu, Sara Ladu, and Francesco Feo

Chromosome Mapping of Multiple Loci Affecting the Genetic Predisposition to Rat Liver Carcinogenesis
Cancer Res 2002 62: 4459-4463. [Abstract] [Full Text] [PDF]  

Molecular Biology & Genetics:

Maria Pik Wong, Wah Kit Lam, Elaine Wang, Shui Wah Chiu, Chi Leung Lam, and Lap Ping Chung

Primary Adenocarcinomas of the Lung in Nonsmokers Show a Distinct Pattern of Allelic Imbalance
Cancer Res 2002 62: 4464-4468. [Abstract] [Full Text] [PDF]  

Stefan Kaluz, Milota Kaluzová, Adrian Chrastina, Peggy L. Olive, Silvia Pastoreková, Jaromír Pastorek, Michael I. Lerman, and Eric J. Stanbridge

Lowered Oxygen Tension Induces Expression of the Hypoxia Marker MN/Carbonic Anhydrase IX in the Absence of Hypoxia-inducible Factor 1 Stabilization: A Role for Phosphatidylinositol 3'-Kinase
Cancer Res 2002 62: 4469-4477. [Abstract] [Full Text] [PDF]  

Tumor Biology:

Dawn A. Kirschmann, Elisabeth A. Seftor, Sheri F. T. Fong, Daniel R. C. Nieva, Colleen M. Sullivan, Elijah M. Edwards, Pascal Sommer, Katalin Csiszar, and Mary J. C. Hendrix

A Molecular Role for Lysyl Oxidase in Breast Cancer Invasion
Cancer Res 2002 62: 4478-4483. [Abstract] [Full Text] [PDF]  

Soichi Tsutsumi, Suresh K. Gupta, Victor Hogan, John G. Collard, and Avraham Raz

Activation of Small GTPase Rho Is Required for Autocrine Motility Factor Signaling
Cancer Res 2002 62: 4484-4490. [Abstract] [Full Text] [PDF]  

Kalpna Gupta, Smita Kshirsagar, Liming Chang, Robert Schwartz, Ping-Y. Law, Doug Yee, and Robert P. Hebbel

Morphine Stimulates Angiogenesis by Activating Proangiogenic and Survival-promoting Signaling and Promotes Breast Tumor Growth
Cancer Res 2002 62: 4491-4498. [Abstract] [Full Text] [PDF]  

Eva LaTulippe, Jaya Satagopan, Alex Smith, Howard Scher, Peter Scardino, Victor Reuter, and William L. Gerald

Comprehensive Gene Expression Analysis of Prostate Cancer Reveals Distinct Transcriptional Programs Associated with Metastatic Disease
Cancer Res 2002 62: 4499-4506. [Abstract] [Full Text] [PDF] Supplementary Data  

Hongzhen Li, Susana Velasco-Miguel, William C. Vass, Luis F. Parada, and Jeffrey E. DeClue

Epidermal Growth Factor Receptor Signaling Pathways Are Associated with Tumorigenesis in the Nf1:p53 Mouse Tumor Model
Cancer Res 2002 62: 4507-4513. [Abstract] [Full Text] [PDF]  

Roberto Diaz, Daniel Ahn, Lluis Lopez-Barcons, Marcos Malumbres, Ignacio Perez de Castro, Jeffrey Lue, Neus Ferrer-Miralles, Ramon Mangues, Jerry Tsong, Roberto Garcia, Roman Perez-Soler, and Angel Pellicer

The N-ras Proto-oncogene Can Suppress the Malignant Phenotype in the Presence or Absence of Its Oncogene
Cancer Res 2002 62: 4514-4518. [Abstract] [Full Text] [PDF]  

Maria F. Paz, Sonia Avila, Mario F. Fraga, Marina Pollan, Gabriel Capella, Miquel Angel Peinado, Montserrat Sanchez-Cespedes, James G. Herman, and Manel Esteller

Germ-Line Variants in Methyl-Group Metabolism Genes and Susceptibility to DNA Methylation in Normal Tissues and Human Primary Tumors
Cancer Res 2002 62: 4519-4524. [Abstract] [Full Text] [PDF]  

Virology:

Andrew G. Polson, David Wang, Joseph DeRisi, and Don Ganem

Modulation of Host Gene Expression by the Constitutively Active G Protein-coupled Receptor of Kaposi’s Sarcoma-associated Herpesvirus
Cancer Res 2002 62: 4525-4530. [Abstract] [Full Text] [PDF]  

Correction:

Correction for vol 62, p 2890
Cancer Res 2002 62: 4532. [Full Text] [PDF]  

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