Advances in Brief:

Mutation in the ATP-binding Pocket of the ABL Kinase Domain in an STI571-resistant BCR/ABL-positive Cell Line

Clara Ricci, Barbara Scappini, Vladimir Divoky, Simona Gatto, Francesco Onida, Srdan Verstovsek, Hagop M. Kantarjian, and Miloslav Beran
Cancer Res 2002 62: 5995-5998. [Abstract] [Full Text] [PDF]  

Identification from Public Data of Molecular Markers of Adenocarcinoma Characteristic of the Site of Origin

Jayne L. Dennis, J. Keith Vass, Ernst C. Wit, W. Nicol Keith, and Karin A. Oien
Cancer Res 2002 62: 5999-6005. [Abstract] [Full Text] [PDF] Supplementary Data  

Novel Detection and Differential Utilization of a c-myc Transcriptional Block in Colon Cancer Chemoprevention

Andrew J. Wilson, Anna Velcich, Diego Arango, Amy R. Kurland, Shailesh M. Shenoy, Rossanna C. Pezo, Jeffrey M. Levsky, Robert H. Singer, and Leonard H. Augenlicht
Cancer Res 2002 62: 6006-6010. [Abstract] [Full Text] [PDF]  

Morphological and Molecular Heterogeneity within Nonmicrosatellite Instability-High Colorectal Cancer

Vicki L. J. Whitehall, Coral V. A. Wynter, Michael D. Walsh, Lisa A. Simms, David Purdie, Nirmala Pandeya, Joanne Young, Stephen J. Meltzer, Barbara A. Leggett, and Jeremy R. Jass
Cancer Res 2002 62: 6011-6014. [Abstract] [Full Text] [PDF]  

Alendronate Inhibits Lysophosphatidic Acid-induced Migration of Human Ovarian Cancer Cells by Attenuating the Activation of Rho

Kenjiro Sawada, Ken-ichirou Morishige, Masahiro Tahara, Rikako Kawagishi, Yoshihide Ikebuchi, Keiichi Tasaka, and Yuji Murata
Cancer Res 2002 62: 6015-6020. [Abstract] [Full Text] [PDF]  

Inhibition of Transforming Growth Factor-ß Activity Decreases Angiogenesis in a Human Prostate Cancer-reactive Stroma Xenograft Model

Jennifer A. Tuxhorn, Stephanie J. McAlhany, Feng Yang, Truong D. Dang, and David R. Rowley
Cancer Res 2002 62: 6021-6025. [Abstract] [Full Text] [PDF]  

Functional Alterations of Human Exonuclease 1 Mutants Identified in Atypical Hereditary Nonpolyposis Colorectal Cancer Syndrome

Xuemin Sun, Li Zheng, and Binghui Shen
Cancer Res 2002 62: 6026-6030. [Abstract] [Full Text] [PDF]  

Ku Affects the CHK1-dependent G₂ Checkpoint after Ionizing Radiation

Xiang Wang, Gloria C. Li, George Iliakis, and Ya Wang
Cancer Res 2002 62: 6031-6034. [Abstract] [Full Text] [PDF]  

Constitutive Activation of Insulin Receptor Substrate 1 Is a Frequent Event in Human Tumors: Therapeutic Implications

Qing Chang, Yu Li, Morris F. White, Jonathan A. Fletcher, and Sheng Xiao
Cancer Res 2002 62: 6035-6038. [Abstract] [Full Text] [PDF]  

Biochemistry and Biophysics:

Activation of Mitogen-activated Protein Kinase Pathway by the Antiandrogen Hydroxyflutamide in Androgen Receptor-negative Prostate Cancer Cells

Yi-Fen Lee, Wen-Jye Lin, Jiaoti Huang, Edward M. Messing, Franky L. Chan, George Wilding, and Chawnshang Chang
Cancer Res 2002 62: 6039-6044. [Abstract] [Full Text] [PDF]  

Restoration of Transforming Growth Factor ß Signaling by Functional Expression of Smad4 Induces Anoikis

Murali Ramachandra, Isabella Atencio, Amena Rahman, Mei Vaillancourt, Aihua Zou, Jenny Avanzini, Ken Wills, Robert Bookstein, and Paul Shabram
Cancer Res 2002 62: 6045-6051. [Abstract] [Full Text] [PDF]  

Carcinogenesis:

Mutations in Tetranucleotide Repeats following DNA Damage Depend on Repeat Sequence and Carcinogenic Agent

Robbert J. C. Slebos, Daniel S. Oh, David M. Umbach, and Jack A. Taylor
Cancer Res 2002 62: 6052-6060. [Abstract] [Full Text] [PDF]  

Induction of a Low Level of Microsatellite Instability by Overexpression of DNA Polymerase ß

Nazumi A. Yamada and Rosann A. Farber
Cancer Res 2002 62: 6061-6064. [Abstract] [Full Text] [PDF]  

Mesothelial Cell Transformation Requires Increased AP-1 Binding Activity and ERK-dependent Fra-1 Expression

Maria E. Ramos-Nino, Cynthia R. Timblin, and Brooke T. Mossman
Cancer Res 2002 62: 6065-6069. [Abstract] [Full Text] [PDF]  

Clinical Investigations:

Hepatic Arterial Infusion of a Replication-selective Oncolytic Adenovirus (dl1520): Phase II Viral, Immunologic, and Clinical Endpoints

Tony Reid, Eva Galanis, James Abbruzzese, Dan Sze, Lawrence M. Wein, James Andrews, Britta Randlev, Carla Heise, Margaret Uprichard, Michael Hatfield, Larry Rome, Joseph Rubin, and David Kirn
Cancer Res 2002 62: 6070-6079. [Abstract] [Full Text] [PDF]  

Experimental Therapeutics:

Double Blockade of Cell Cycle at G₁-S Transition and M Phase by 3-Iodoacetamido Benzoyl Ethyl Ester, a New Type of Tubulin Ligand

Jian-Dong Jiang, Larry Denner, Yi-He Ling, Jian-Nong Li, Ashley Davis, Yue Wang, Yan Li, Julia Roboz, Long-Gui Wang, Roman Perez-Soler, Marco Marcelli, George Bekesi, and James F. Holland
Cancer Res 2002 62: 6080-6088. [Abstract] [Full Text] [PDF]  

Enzyme-activated Prodrug Therapy Enhances Tumor-specific Replication of Adenovirus Vectors

Kathrin M. Bernt, Dirk S. Steinwaerder, Shaoheng Ni, Zong-Yi Li, Steve R. Roffler, and André Lieber
Cancer Res 2002 62: 6089-6098. [Abstract] [Full Text] [PDF]  

Gene Transfer in Ovarian Cancer Cells: A Comparison between Retroviral and Lentiviral Vectors

Stefano Indraccolo, Walter Habeler, Veronica Tisato, Laura Stievano, Erich Piovan, Valeria Tosello, Giovanni Esposito, Ralf Wagner, Klaus Uberla, Luigi Chieco-Bianchi, and Alberto Amadori
Cancer Res 2002 62: 6099-6107. [Abstract] [Full Text] [PDF]  

MS-27-275, an Inhibitor of Histone Deacetylase, Has Marked in Vitro and in Vivo Antitumor Activity against Pediatric Solid Tumors

Jerry Jaboin, Jason Wild, Habib Hamidi, Chand Khanna, Chong Jai Kim, Robert Robey, Susan E. Bates, and Carol J. Thiele
Cancer Res 2002 62: 6108-6115. [Abstract] [Full Text] [PDF]  

Sulfonamide Derivative, E7820, Is a Unique Angiogenesis Inhibitor Suppressing an Expression of Integrin 2 Subunit on Endothelium

Yasuhiro Funahashi, Naoko Hata Sugi, Taro Semba, Yuji Yamamoto, Shinichi Hamaoka, Naoko Tsukahara-Tamai, Yoichi Ozawa, Akihiko Tsuruoka, Kazumasa Nara, Keiko Takahashi, Tadashi Okabe, Junichi Kamata, Takashi Owa, Norihiro Ueda, Toru Haneda, Masahiro Yonaga, Kentaro Yoshimatsu, and Toshiaki Wakabayashi
Cancer Res 2002 62: 6116-6123. [Abstract] [Full Text] [PDF]  

Antitumor Effect of in Vivo Somatostatin Receptor Subtype 2 Gene Transfer in Primary and Metastatic Pancreatic Cancer Models

Fabienne Vernejoul, Patrick Faure, Naoual Benali, Denis Calise, Gérard Tiraby, Lucien Pradayrol, Christiane Susini, and Louis Buscail
Cancer Res 2002 62: 6124-6131. [Abstract] [Full Text] [PDF]  

Increased Exposure of Anionic Phospholipids on the Surface of Tumor Blood Vessels

Sophia Ran, Amber Downes, and Philip E. Thorpe
Cancer Res 2002 62: 6132-6140. [Abstract] [Full Text] [PDF]  

Inhibitors of mTOR Reverse Doxorubicin Resistance Conferred by PTEN Status in Prostate Cancer Cells

Viktor Grünwald, Linda DeGraffenried, Douglas Russel, William E. Friedrichs, Ratna B. Ray, and Manuel Hidalgo
Cancer Res 2002 62: 6141-6145. [Abstract] [Full Text] [PDF]  

Tumor Targeting with Radiolabeled _vß₃ Integrin Binding Peptides in a Nude Mouse Model

Marcel L. Janssen, Wim J. Oyen, Ingrid Dijkgraaf, Leon F. Massuger, Cathelijne Frielink, D. Scott Edwards, Milind Rajopadhye, Henk Boonstra, Frans H. Corstens, and Otto C. Boerman
Cancer Res 2002 62: 6146-6151. [Abstract] [Full Text] [PDF]  

Defibrotide in Combination with Granulocyte Colony-stimulating Factor Significantly Enhances the Mobilization of Primitive and Committed Peripheral Blood Progenitor Cells in Mice

Carmelo Carlo-Stella, Massimo Di Nicola, Michele Magni, Paolo Longoni, Marco Milanesi, Claudio Stucchi, Loredana Cleris, Franca Formelli, and Massimo A. Gianni
Cancer Res 2002 62: 6152-6157. [Abstract] [Full Text] [PDF]  

Low Systemic Exposure of Oral Docetaxel in Mice Resulting from Extensive First-Pass Metabolism Is Boosted by Ritonavir

Heleen A. Bardelmeijer, Mariët Ouwehand, Tessa Buckle, Maarten T. Huisman, Jan H. M. Schellens, Jos H. Beijnen, and Olaf van Tellingen
Cancer Res 2002 62: 6158-6164. [Abstract] [Full Text] [PDF]  

Conditionally Replicative Adenovirus Expressing p53 Exhibits Enhanced Oncolytic Potency

Victor W. van Beusechem, Petra B. van den Doel, Jacques Grill, Herbert M. Pinedo, and Winald R. Gerritsen
Cancer Res 2002 62: 6165-6171. [Abstract] [Full Text] [PDF]  

Characterization of the Drug Resistance and Transport Properties of Multidrug Resistance Protein 6 (MRP6, ABCC6)

Martin G. Belinsky, Zhe-Sheng Chen, Irina Shchaveleva, Hao Zeng, and Gary D. Kruh
Cancer Res 2002 62: 6172-6177. [Abstract] [Full Text] [PDF]  

Immunology:

Major Histocompatibility Complex Class I-related Chain A and UL16-Binding Protein Expression on Tumor Cell Lines of Different Histotypes: Analysis of Tumor Susceptibility to NKG2D-dependent Natural Killer Cell Cytotoxicity

Daniela Pende, Paola Rivera, Stefania Marcenaro, Chien-Chung Chang, Roberto Biassoni, Romana Conte, Marek Kubin, David Cosman, Soldano Ferrone, Lorenzo Moretta, and Alessandro Moretta
Cancer Res 2002 62: 6178-6186. [Abstract] [Full Text] [PDF]  

Antitumor Efficacy of Wild-Type p53-specific CD4⁺ T-Helper Cells

Sander Zwaveling, Michel P. M. Vierboom, Sandra C. Ferreira Mota, Jennifer A. Hendriks, Marlies E. Ooms, Roger P. M. Sutmuller, Kees L. M. C. Franken, Hans W. Nijman, Ferry Ossendorp, Sjoerd H. van der Burg, Rienk Offringa, and Cornelis J. M. Melief
Cancer Res 2002 62: 6187-6193. [Abstract] [Full Text] [PDF]  

Loss of Brca2 and p53 Synergistically Promotes Genomic Instability and Deregulation of T-cell Apoptosis

Alison M. Y. Cheung, M. Prakash Hande, Farid Jalali, Ming-Sound Tsao, Brian Skinnider, Atsushi Hirao, J. Peter McPherson, Jana Karaskova, Akira Suzuki, Andrew Wakeham, Annick You-Ten, Andrew Elia, Jeremy Squire, Rob Bristow, Razqallah Hakem, and Tak W. Mak
Cancer Res 2002 62: 6194-6204. [Abstract] [Full Text] [PDF]  

Molecular Biology and Genetics:

Genetic Aberrations Defined by Comparative Genomic Hybridization Distinguish Long-Term from Typical Survivors of Glioblastoma

Eric C. Burton, Kathleen R. Lamborn, Burt G. Feuerstein, Michael Prados, James Scott, Peter Forsyth, Sandra Passe, Robert B. Jenkins, and Ken D. Aldape
Cancer Res 2002 62: 6205-6210. [Abstract] [Full Text] [PDF]  

Amplicon Mapping and Transcriptional Analysis Pinpoint Cyclin L as a Candidate Oncogene in Head and Neck Cancer

Richard Redon, Thomas Hussenet, Gaétan Bour, Krishna Caulee, Bernard Jost, Danièle Muller, Joseph Abecassis, and Stanislas du Manoir
Cancer Res 2002 62: 6211-6217. [Abstract] [Full Text] [PDF]  

Genomic and Expression Analysis of the 12p11-p12 Amplicon Using EST Arrays Identifies Two Novel Amplified and Overexpressed Genes

Véronique Bourdon, Félix Naef, Pulivarthi H. Rao, Victor Reuter, Samuel C. Mok, George J. Bosl, Sanjay Koul, Vundaralli V. V. S. Murty, Raju S. Kucherlapati, and R. S. K. Chaganti
Cancer Res 2002 62: 6218-6223. [Abstract] [Full Text] [PDF]  

Characterization of t(3;6)(q27;p21) Breakpoints in B-Cell Non-Hodgkin’s Lymphoma and Construction of the Histone H4/BCL6 Fusion Gene, Leading to Altered Expression of Bcl-6

Masayuki Kurata, Yoshitomo Maesako, Chiyoko Ueda, Momoko Nishikori, Takashi Akasaka, Takashi Uchiyama, and Hitoshi Ohno
Cancer Res 2002 62: 6224-6230. [Abstract] [Full Text] [PDF]  

Down-Regulation of p300/CBP Histone Acetyltransferase Activates a Senescence Checkpoint in Human Melanocytes

Debdutta Bandyopadhyay, Nihal A. Okan, Elise Bales, Lucia Nascimento, Philip A. Cole, and Estela E. Medrano
Cancer Res 2002 62: 6231-6239. [Abstract] [Full Text] [PDF]  

Impact of DNA Amplification on Gene Expression Patterns in Breast Cancer

Elizabeth Hyman, Päivikki Kauraniemi, Sampsa Hautaniemi, Maija Wolf, Spyro Mousses, Ester Rozenblum, Markus Ringnér, Guido Sauter, Outi Monni, Abdel Elkahloun, Olli-P. Kallioniemi, and Anne Kallioniemi
Cancer Res 2002 62: 6240-6245. [Abstract] [Full Text] [PDF] Supplementary Data  

Gene Expression after Treatment with Hydrogen Peroxide, Menadione, or t-Butyl Hydroperoxide in Breast Cancer Cells

Yao-Yu Eric Chuang, Yidong Chen, Gadisetti, V. R. Chandramouli, John A. Cook, Deborah Coffin, Mong-Hsun Tsai, William DeGraff, Hailing Yan, Shuping Zhao, Angelo Russo, Edison T. Liu, and James B. Mitchell
Cancer Res 2002 62: 6246-6254. [Abstract] [Full Text] [PDF]  

Characterization of Epithelial Senescence by Serial Analysis of Gene Expression: Identification of Genes Potentially Involved in Prostate Cancer

Gerold Untergasser, Heike B. Koch, Antje Menssen, and Heiko Hermeking
Cancer Res 2002 62: 6255-6262. [Abstract] [Full Text] [PDF] Supplementary Data  

Clustered DNA Damage Leads to Complex Genetic Changes in Irradiated Human Cells

Belinda K. Singleton, Carol S. Griffin, and John Thacker
Cancer Res 2002 62: 6263-6269. [Abstract] [Full Text] [PDF]  

Tumor Biology:

Secreted Protein Acidic and Rich in Cysteine Promotes Glioma Invasion and Delays Tumor Growth in Vivo

Chad Schultz, Nancy Lemke, Shugang Ge, William A. Golembieski, and Sandra A. Rempel
Cancer Res 2002 62: 6270-6277. [Abstract] [Full Text] [PDF]  

Single Cell Behavior in Metastatic Primary Mammary Tumors Correlated with Gene Expression Patterns Revealed by Molecular Profiling

Weigang Wang, Jeffrey B. Wyckoff, Victoria Centonze Frohlich, Yuri Oleynikov, Stefan Hüttelmaier, Jiri Zavadil, Lukas Cermak, Erwin P. Bottinger, Robert H. Singer, John G. White, Jeffrey E. Segall, and John S. Condeelis
Cancer Res 2002 62: 6278-6288. [Abstract] [Full Text] [PDF] Supplementary Data  

Roles of Cell Adhesion Molecules in Tumor Angiogenesis Induced by Cotransplantation of Cancer and Endothelial Cells to Nude Rats

Kou Tei, Naoko Kawakami-Kimura, Osamu Taguchi, Kensuke Kumamoto, Shigeki Higashiyama, Naoyuki Taniguchi, Ken’ichi Toda, Ryo Kawata, Yasuo Hisa, and Reiji Kannagi
Cancer Res 2002 62: 6289-6296. [Abstract] [Full Text] [PDF]  

Bcl-2 Determines Susceptibility to Induction of Lung Cancer by Oncogenic CRaf

Lev M. Fedorov, Oleg Yu. Tyrsin, Thomas Papadopoulos, Guadalupe Camarero, Rudolf Götz, and Ulf R. Rapp
Cancer Res 2002 62: 6297-6303. [Abstract] [Full Text] [PDF] Supplementary Data  

Regulation of Cellular Proliferation, Cytoskeletal Function, and Signal Transduction through CXCR4 and c-Kit in Small Cell Lung Cancer Cells

Takashi Kijima, Gautam Maulik, Patrick C. Ma, Elena V. Tibaldi, Ross E. Turner, Barrett Rollins, Martin Sattler, Bruce E. Johnson, and Ravi Salgia
Cancer Res 2002 62: 6304-6311. [Abstract] [Full Text] [PDF]  

Extracellular Membrane Vesicles from Tumor Cells Promote Angiogenesis via Sphingomyelin

Chan Woo Kim, Hwan Myung Lee, Tae Hoon Lee, Chulhun Kang, Hynda K. Kleinman, and Yong Song Gho
Cancer Res 2002 62: 6312-6317. [Abstract] [Full Text] [PDF]  

PTEN Suppresses Hyaluronic Acid-induced Matrix Metalloproteinase-9 Expression in U87MG Glioblastoma Cells through Focal Adhesion Kinase Dephosphorylation

Myung-Jin Park, Mi-Suk Kim, In-Chul Park, Hee-Seok Kang, Heon Yoo, Seok Hee Park, Chang Hun Rhee, Seok-Il Hong, and Seung-Hoon Lee
Cancer Res 2002 62: 6318-6322. [Abstract] [Full Text] [PDF]  

Cyclooxygenase-2 Overexpression Reduces Apoptotic Susceptibility by Inhibiting the Cytochrome c-dependent Apoptotic Pathway in Human Colon Cancer Cells

Yunjie Sun, Xi Ming Tang, Elizabeth Half, M. Tien Kuo, and Frank A. Sinicrope
Cancer Res 2002 62: 6323-6328. [Abstract] [Full Text] [PDF]  

Lysophosphatidic Acid-induced Squamous Cell Carcinoma Cell Proliferation and Motility Involves Epidermal Growth Factor Receptor Signal Transactivation

Andreas Gschwind, Norbert Prenzel, and Axel Ullrich
Cancer Res 2002 62: 6329-6336. [Abstract] [Full Text] [PDF]  

Epstein-Barr Virus Latent Membrane Protein 1 Induces and Causes Release of Fibroblast Growth Factor-2

Naohiro Wakisaka, Shigeyuki Murono, Tomokazu Yoshizaki, Mitsuru Furukawa, and Joseph S. Pagano
Cancer Res 2002 62: 6337-6344. [Abstract] [Full Text] [PDF]  

Letters to the Editor:

Correspondence re: D. Zimonjic et al., Derivation of Human Tumor Cells in Vitro without Widespread Genomic Instability. Cancer Res., 61: 8838–8844, 2001.

Ruhong Li, David Rasnick, Peter Duesberg, Drazen B. Zimonjic, Mary W. Brooks, Nicholas Popescu, Robert A. Weinberg, and William C. Hahn
Cancer Res 2002 62: 6345-6349. [Full Text] [PDF]  

Correspondence re: G. Anderson et al., Intrachromosomal Genomic Instability in Human Sporadic Colorectal Cancer Measured by Genome-Wide Allelotyping and Inter-(Simple Sequence Repeat) PCR. Cancer Res., 61: 8274–8283, 2001.

Harry Rubin and Garth R. Anderson
Cancer Res 2002 62: 6350-6351. [Full Text] [PDF]  

To see an article, click its [Full Text] link. To review many abstracts, check the boxes to the left of the titles you want, and click the 'Get All Checked Abstract(s)' button. To see one abstract at a time, click its [Abstract] link.