A genome-wide screen, using comparative genomic hybridization, was performed to characterize tumors from long-term survivors (survival > 3 years following initial diagnosis) and to compare these with tumors from patients exhibiting typical survival times (1 year). The image demonstrates the frequency of genetic aberrations identified in 39 cases of long-term survivors of glioblastoma. Red lines to the right of the chromosome indicate gains, while green lines, to the left of the chromosome, indicate losses. Amplifications are represented as thick red bars. Where aberrations were frequent, a single line is present, with an indication of the number of tumors exhibiting that aberration. Key genetic lesions, (loss of 10q and gains of 7 and 19) were not only less frequent in the long-term survivors, but also tended to occur singly in this group of tumors. In contrast, they were frequently present in combination in the short-term survivors. Furthermore, some aberrations, such as losses of 19q (alone and in combination with 1p loss), were seen exclusively in the long-term survivors. The data point to genetic regions that may contribute to the clinical aggressiveness of these tumors. For details, see the article by Burton et al on page 6205 of this issue.