Advances in Brief:

Cyclooxygenase-2 Inhibition by Celecoxib Reduces Proliferation and Induces Apoptosis in Angiogenic Endothelial Cells in Vivo

Kathleen M. Leahy, Richard L. Ornberg, Yu Wang, Ben S. Zweifel, Alane T. Koki, and Jaime L. Masferrer
Cancer Res 2002 62: 625-631. [Abstract] [Full Text] [PDF]  

Prognostic Significance of Elevated Cyclooxygenase-2 Expression in Breast Cancer

Ari Ristimäki, Anna Sivula, Johan Lundin, Mikael Lundin, Tiina Salminen, Caj Haglund, Heikki Joensuu, and Jorma Isola
Cancer Res 2002 62: 632-635. [Abstract] [Full Text] [PDF]  

Possible Oncogenic Potential of Np73: A Newly Identified Isoform of Human p73

Osamu Ishimoto, Chikashi Kawahara, Kentaro Enjo, Masuo Obinata, Toshihiro Nukiwa, and Shuntaro Ikawa
Cancer Res 2002 62: 636-641. [Abstract] [Full Text] [PDF]  

Role of the Phosphatidylinositol 3'-Kinase/PTEN/Akt Kinase Pathway in the Overexpression of Fatty Acid Synthase in LNCaP Prostate Cancer Cells

Tine Van de Sande, Ellen De Schrijver, Walter Heyns, Guido Verhoeven, and Johannes V. Swinnen
Cancer Res 2002 62: 642-646. [Abstract] [Full Text] [PDF]  

High Mobility Group Protein I(Y): A Candidate Architectural Protein for Chromosomal Rearrangements in Prostate Cancer Cells

Natsuki Takaha, Anita L. Hawkins, Constance A. Griffin, William B. Isaacs, and Donald S. Coffey
Cancer Res 2002 62: 647-651. [Abstract] [Full Text] [PDF]  

Green Tea Polyphenol Epigallocatechin-3 Gallate Inhibits Her-2/Neu Signaling, Proliferation, and Transformed Phenotype of Breast Cancer Cells

Stefania Pianetti, Shangqin Guo, Kathryn T. Kavanagh, and Gail E. Sonenshein
Cancer Res 2002 62: 652-655. [Abstract] [Full Text] [PDF]  

3-Methyladenine DNA Glycosylase-deficient Aag Null Mice Display Unexpected Bone Marrow Alkylation Resistance

Richard B. Roth and Leona D. Samson
Cancer Res 2002 62: 656-660. [Abstract] [Full Text] [PDF]  

Pulmonary and Lymph Node Metastasis Is Associated with Primary Tumor Interstitial Fluid Pressure in Human Melanoma Xenografts

Einar K. Rofstad, Siv H. Tunheim, Berit Mathiesen, Bjørn A. Graff, Ellen F. Halsør, Kristin Nilsen, and Kanthi Galappathi
Cancer Res 2002 62: 661-664. [Abstract] [Full Text] [PDF]  

Transendothelial Function of Human Metastatic Melanoma Cells: Role of the Microenvironment in Cell-Fate Determination

Mary J. C. Hendrix, Richard E. B. Seftor, Elisabeth A. Seftor, Lynn M. Gruman, Lisa M. L. Lee, Brian J. Nickoloff, Lucio Miele, Don D. Sheriff, and Gina C. Schatteman
Cancer Res 2002 62: 665-668. [Abstract] [Full Text] [PDF]  

Biochemistry and Biophysics:

Essential Role of Neural Wiskott-Aldrich Syndrome Protein in Podosome Formation and Degradation of Extracellular Matrix in src-transformed Fibroblasts

Kiyohito Mizutani, Hiroaki Miki, Hong He, Hiroshi Maruta, and Tadaomi Takenawa
Cancer Res 2002 62: 669-674. [Abstract] [Full Text] [PDF]  

Activation of Membrane-type Matrix Metalloproteinase 3 Zymogen by the Proprotein Convertase Furin in the trans-Golgi Network

Tiebang Kang, Hideaki Nagase, and Duanqing Pei
Cancer Res 2002 62: 675-681. [Abstract] [Full Text] [PDF]  

NAD(P)H and Collagen as in Vivo Quantitative Fluorescent Biomarkers of Epithelial Precancerous Changes

Irene Georgakoudi, Brian C. Jacobson, Markus G. Müller, Ellen E. Sheets, Kamran Badizadegan, David L. Carr-Locke, Christopher P. Crum, Charles W. Boone, Ramachandra R. Dasari, Jacques Van Dam, and Michael S. Feld
Cancer Res 2002 62: 682-687. [Abstract] [Full Text] [PDF]  

Metabolic Changes Detected by in Vivo Magnetic Resonance Studies of HEPA-1 Wild-Type Tumors and Tumors Deficient in Hypoxia-inducible Factor-1ß (HIF-1ß): Evidence of an Anabolic Role for the HIF-1 Pathway

John R. Griffiths, Paul M. J. McSheehy, Simon P. Robinson, Helen Troy, Yuen-Li Chung, Russell D. Leek, Kaye J. Williams, Ian J. Stratford, Adrian L. Harris, and Marion Stubbs
Cancer Res 2002 62: 688-695. [Abstract] [Full Text] [PDF]  

Carcinogenesis:

Germ-Line p53-targeted Disruption Inhibits Helicobacter-induced Premalignant Lesions and Invasive Gastric Carcinoma through Down-Regulation of Th1 Proinflammatory Responses

James G. Fox, Barbara J. Sheppard, Charles A. Dangler, Mark T. Whary, Melanie Ihrig, and Timothy C. Wang
Cancer Res 2002 62: 696-702. [Abstract] [Full Text] [PDF]  

Molecular Cloning and Functional Analysis of a Novel Cadmium-responsive Proto-oncogene

Pius Joseph, Yi-Xiong Lei, Wen-Zong Whong, and Tong-man Ong
Cancer Res 2002 62: 703-707. [Abstract] [Full Text] [PDF]  

Identification of Molecular Targets Associated with Selenium-induced Growth Inhibition in Human Breast Cells Using cDNA Microarrays

Yan Dong, Howard E. Ganther, Carleton Stewart, and Clement Ip
Cancer Res 2002 62: 708-714. [Abstract] [Full Text] [PDF]  

Clinical Investigations:

Biological and Prognostic Significance of Interphase Fluorescence in Situ Hybridization Detection of Chromosome 13 Abnormalities (13) in Multiple Myeloma: An Eastern Cooperative Oncology Group Study

Rafael Fonseca, David Harrington, Martin M. Oken, Gordon W. Dewald, Richard J. Bailey, Scott A. Van Wier, Kimberly J. Henderson, Emily A. Blood, S. Vincent Rajkumar, Neil E. Kay, Brian Van Ness, and Philip R. Greipp
Cancer Res 2002 62: 715-720. [Abstract] [Full Text] [PDF]  

Endocrinology:

AIbZIP, a Novel bZIP Gene Located on Chromosome 1q21.3 That Is Highly Expressed in Prostate Tumors and of Which the Expression Is Up-Regulated by Androgens in LNCaP Human Prostate Cancer Cells

Heng Qi, Catherine Fillion, Yvan Labrie, Josée Grenier, Andréa Fournier, Louise Berger, Mohamed El-Alfy, and Claude Labrie
Cancer Res 2002 62: 721-733. [Abstract] [Full Text] [PDF]  

Epidemiology and Prevention:

Manipulation of Pulmonary Prostacyclin Synthase Expression Prevents Murine Lung Cancer

Robert L. Keith, York E. Miller, Yasushi Hoshikawa, Mark D. Moore, Tracy L. Gesell, Bifeng Gao, Alvin M. Malkinson, Heiko A. Golpon, Raphael A. Nemenoff, and Mark W. Geraci
Cancer Res 2002 62: 734-740. [Abstract] [Full Text] [PDF]  

Experimental Therapeutics:

1,25-(OH)₂-D₃ and Its Synthetic Analogue Decrease Tumor Load in the Apc^min Mouse

Sergio Huerta, Ronald W. Irwin, David Heber, Vay Liang W. Go, H. Phillip Koeffler, Milan R. Uskokovic, and Diane M. Harris
Cancer Res 2002 62: 741-746. [Abstract] [Full Text] [PDF]  

Interleukin-12 Inhibits Angiogenesis and Growth of Transplanted but not in Situ Mouse Mammary Tumor Virus-induced Mammary Carcinomas

James C. Lee, David C. Kim, Michael S. Gee, H. Mark Saunders, Chandra M. Sehgal, Michael D. Feldman, Susan R. Ross, and William M. F. Lee
Cancer Res 2002 62: 747-755. [Abstract] [Full Text] [PDF]  

Suppression of Intracranial Human Glioma Growth after Intramuscular Administration of an Adeno-associated Viral Vector Expressing Angiostatin

Hsin-I Ma, Ping Guo, Juan Li, Shinn-Zong Lin, Yung-Hsiao Chiang, Xiao Xiao, and Shi-Yuan Cheng
Cancer Res 2002 62: 756-763. [Abstract] [Full Text] [PDF]  

Oncolytic Activity of the E1B-55 kDa-deleted Adenovirus ONYX-015 Is Independent of Cellular p53 Status in Human Malignant Glioma Xenografts

Birgit Geoerger, Jacques Grill, Paule Opolon, Jackie Morizet, Geneviève Aubert, Marie-José Terrier-Lacombe, Brigitte Bressac de-Paillerets, Michel Barrois, Jean Feunteun, David H. Kirn, and Gilles Vassal
Cancer Res 2002 62: 764-772. [Abstract] [Full Text] [PDF]  

Intratumoral 5-Fluorouracil Produced by Cytosine Deaminase/5-Fluorocytosine Gene Therapy Is Effective for Experimental Human Glioblastomas

C. Ryan Miller, Christopher R. Williams, Donald J. Buchsbaum, and G. Yancey Gillespie
Cancer Res 2002 62: 773-780. [Abstract] [Full Text] [PDF]  

Targeted Cytotoxic Somatostatin Analogue AN-238 Inhibits Somatostatin Receptor-positive Experimental Colon Cancers Independently of Their p53 Status

Karoly Szepeshazi, Andrew V. Schally, Gabor Halmos, Patricia Armatis, Francine Hebert, Baodong Sun, Anita Feil, Hippokratis Kiaris, and Attila Nagy
Cancer Res 2002 62: 781-788. [Abstract] [Full Text] [PDF]  

Antineoplastic Effects of Chemotherapeutic Agents Are Potentiated by NM-3, an Inhibitor of Angiogenesis

Corinne L. Reimer, Naoki Agata, Jennifer G. Tammam, Michael Bamberg, William M. Dickerson, George D. Kamphaus, Susan L. Rook, Michael Milhollen, Robert Fram, Raghu Kalluri, Donald Kufe, and Surender Kharbanda
Cancer Res 2002 62: 789-795. [Abstract] [Full Text] [PDF]  

Donor Leukocyte Infusion from Immunized Donors Increases Tumor Vaccine Efficacy after Allogeneic Bone Marrow Transplantation

Takanori Teshima, Chen Liu, Kathleen P. Lowler, Glenn Dranoff, and James L. M. Ferrara
Cancer Res 2002 62: 796-800. [Abstract] [Full Text] [PDF]  

Molecular Biology and Genetics:

The CLN3 Gene is a Novel Molecular Target for Cancer Drug Discovery

Svetlana N. Rylova, Andrea Amalfitano, Dixie-Ann Persaud-Sawin, Wei-Xing Guo, Jerry Chang, Paul J. Jansen, Alan D. Proia, and Rose-Mary Boustany
Cancer Res 2002 62: 801-808. [Abstract] [Full Text] [PDF]  

Occurrence of Chromosome 9 and p53 Alterations in Multifocal Dysplasia and Carcinoma in Situ of Human Urinary Bladder

Arndt Hartmann, Gudrun Schlake, Dirk Zaak, Edwin Hungerhuber, Alfons Hofstetter, Ferdinand Hofstaedter, and Ruth Knuechel
Cancer Res 2002 62: 809-818. [Abstract] [Full Text] [PDF]  

Relationships and Differentially Expressed Genes among Pancreatic Cancers Examined by Large-scale Serial Analysis of Gene Expression

Byungwoo Ryu, Jessa Jones, Natalie J. Blades, Giovanni Parmigiani, Michael A. Hollingsworth, Ralph H. Hruban, and Scott E. Kern
Cancer Res 2002 62: 819-826. [Abstract] [Full Text] [PDF]  

Early Growth Response-1 Gene Mediates Up-Regulation of Epidermal Growth Factor Receptor Expression during Hypoxia

Hirotaka Nishi, Katsura H. Nishi, and Alfred C. Johnson
Cancer Res 2002 62: 827-834. [Abstract] [Full Text] [PDF]  

Interglandular Cytogenetic Heterogeneity Detected by Comparative Genomic Hybridization in Pancreatic Cancer

Tomohiko Harada, Kiwamu Okita, Kei Shiraishi, Noriyoshi Kusano, Satoshi Kondoh, and Kohsuke Sasaki
Cancer Res 2002 62: 835-839. [Abstract] [Full Text] [PDF]  

Cancer Progression and Tumor Cell Motility Are Associated with the FGFR4 Arg³⁸⁸ Allele

Johannes Bange, Dieter Prechtl, Yuri Cheburkin, Katja Specht, Nadia Harbeck, Manfred Schmitt, Tatjana Knyazeva, Susanne Müller, Silvia Gärtner, Irmi Sures, Hongyang Wang, Evgeny Imyanitov, Hans-Ulrich Häring, Pjotr Knayzev, Stefano Iacobelli, Heinz Höfler, and Axel Ullrich
Cancer Res 2002 62: 840-847. [Abstract] [Full Text] [PDF]  

MSH2 in Contrast to MLH1 and MSH6 Is Frequently Inactivated by Exonic and Promoter Rearrangements in Hereditary Nonpolyposis Colorectal Cancer

Françoise Charbonnier, Sylviane Olschwang, Qing Wang, Cécile Boisson, Cosette Martin, Marie-Pierre Buisine, Alain Puisieux, and Thierry Frebourg
Cancer Res 2002 62: 848-853. [Abstract] [Full Text] [PDF]  

Tumor Biology:

A Potential Autocrine Role for Vascular Endothelial Growth Factor in Prostate Cancer

Michael W. Jackson, James S. Roberts, Susan E. Heckford, Carmela Ricciardelli, Jurgen Stahl, David J. Horsfall, and Wayne D. Tilley
Cancer Res 2002 62: 854-859. [Abstract] [Full Text] [PDF]  

Rapid Accumulation and Internalization of Radiolabeled Herceptin in an Inflammatory Breast Cancer Xenograft with Vasculogenic Mimicry Predicted by the Contrast-enhanced Dynamic MRI with the Macromolecular Contrast Agent G6-(1B4M-Gd)₂₅₆

Hisataka Kobayashi, Kazuo Shirakawa, Satomi Kawamoto, Tsuneo Saga, Noriko Sato, Akira Hiraga, Ichiro Watanabe, Yuji Heike, Kaori Togashi, Junji Konishi, Martin W. Brechbiel, and Hiro Wakasugi
Cancer Res 2002 62: 860-866. [Abstract] [Full Text] [PDF]  

Differential Binding of Drugs Containing the NGR Motif to CD13 Isoforms in Tumor Vessels, Epithelia, and Myeloid Cells

Flavio Curnis, Gianluigi Arrigoni, Angelina Sacchi, Lucia Fischetti, Wadih Arap, Renata Pasqualini, and Angelo Corti
Cancer Res 2002 62: 867-874. [Abstract] [Full Text] [PDF]  

-Melanocyte Stimulating Hormone Potentiates p16/CDKN2A Expression in Human Skin after Ultraviolet Irradiation

Sandra Pavey and Brian Gabrielli
Cancer Res 2002 62: 875-880. [Abstract] [Full Text] [PDF]  

Progesterone Inhibits Human Endometrial Cancer Cell Growth and Invasiveness: Down-Regulation of Cellular Adhesion Molecules through Progesterone B Receptors

Donghai Dai, Douglas M. Wolf, Elizabeth S. Litman, Michael J. White, and Kimberly K. Leslie
Cancer Res 2002 62: 881-886. [Abstract] [Full Text] [PDF]  

Activated Ras Regulates the Proliferation/Apoptosis Balance and Early Survival of Developing Micrometastases

Hemanth J. Varghese, Melanie T. M. Davidson, Ian C. MacDonald, Sylvia M. Wilson, Kishore V. Nadkarni, Alan C. Groom, and Ann F. Chambers
Cancer Res 2002 62: 887-891. [Abstract] [Full Text] [PDF]  

An MCL1-overexpressing Burkitt Lymphoma Subline Exhibits Enhanced Survival on Exposure to Serum Deprivation, Topoisomerase Inhibitors, or Staurosporine but Remains Sensitive to 1-ß-D-Arabinofuranosylcytosine

Julie A. Vrana, Christine K. Bieszczad, Emily S. Cleaveland, Yan Ma, Jonathan P. Park, Thuluvancheri K. Mohandas, and Ruth W. Craig
Cancer Res 2002 62: 892-900. [Abstract] [Full Text] [PDF]  

High Incidence of T-Cell Lymphomas in Mice Deficient in the Retinoid-related Orphan Receptor ROR

Eiichiro Ueda, Shogo Kurebayashi, Morito Sakaue, Michael Backlund, Beverly Koller, and Anton M. Jetten
Cancer Res 2002 62: 901-909. [Abstract] [Full Text] [PDF]  

Autocrine Production of Interleukin 1ß Confers Constitutive Nuclear Factor B Activity and Chemoresistance in Pancreatic Carcinoma Cell Lines

Alexander Arlt, Jens Vorndamm, Susanne Müerköster, Honggang Yu, Wolfgang E. Schmidt, Ulrich R. Fölsch, and Heiner Schäfer
Cancer Res 2002 62: 910-916. [Abstract] [Full Text] [PDF]  

Tumor-derived Platelet-derived Growth Factor-BB Plays a Critical Role in Osteosclerotic Bone Metastasis in an Animal Model of Human Breast Cancer

Bing Yi, Paul J. Williams, Marie Niewolna, Yakun Wang, and Toshiyuki Yoneda
Cancer Res 2002 62: 917-923. [Abstract] [Full Text] [PDF]  

Dysfunctional Apoptosome Activation in Ovarian Cancer: Implications for Chemoresistance

J. Rebecca Liu, Anthony W. Opipari, Lijun Tan, Yibin Jiang, Yujing Zhang, Huaijing Tang, and Gabriel Nuñez
Cancer Res 2002 62: 924-931. [Abstract] [Full Text] [PDF]  

Autocrine Interleukin-6 Production in Renal Cell Carcinoma: Evidence for the Involvement of p53

Laura S. Angelo, Moshe Talpaz, and Razelle Kurzrock
Cancer Res 2002 62: 932-940. [Abstract] [Full Text] [PDF]  

Chromogranin A Expression in Neoplastic Cells Affects Tumor Growth and Morphogenesis in Mouse Models

Barbara Colombo, Flavio Curnis, Chiara Foglieni, Antonella Monno, Gianluigi Arrigoni, and Angelo Corti
Cancer Res 2002 62: 941-946. [Abstract] [Full Text] [PDF]  

A Misspliced Form of the Cholecystokinin-B/Gastrin Receptor in Pancreatic Carcinoma: Role of Reduced Cellular U2AF35 and a Suboptimal 3'-Splicing Site Leading to Retention of the Fourth Intron

Wei-Qun Ding, Susan M. Kuntz, and Laurence J. Miller
Cancer Res 2002 62: 947-952. [Abstract] [Full Text] [PDF]  

Correction:

J. D. Geiger et al., 61: 8513–8519, 2001.

Cancer Res 2002 62: 954 [Full Text] [PDF]  

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