Advances in Brief:

Requirement of BAX for TRAIL/Apo2L-induced Apoptosis of Colorectal Cancers: Synergism with Sulindac-mediated Inhibition of Bcl-x_L

Rajani Ravi and Atul Bedi
Cancer Res 2002 62: 1583-1587. [Abstract] [Full Text] [PDF]  

Doxycycline Decreases Tumor Burden in a Bone Metastasis Model of Human Breast Cancer

Wilhelmina C. M. Duivenvoorden, Snezana Vukmirovic Popovic, Sárka Lhoták, Eric Seidlitz, Holger W. Hirte, Richard G. Tozer, and Gurmit Singh
Cancer Res 2002 62: 1588-1591. [Abstract] [Full Text] [PDF]  

Selective Depletion of Human DNA-Methyltransferase DNMT1 Proteins by Sulfonate-derived Methylating Agents

Linda Shyue-Huey Chuang, Eileen Hwee-Hong Tan, Hue-Kian Oh, and Benjamin F-L. Li
Cancer Res 2002 62: 1592-1597. [Abstract] [Full Text] [PDF]  

An ATM-independent S-Phase Checkpoint Response Involves CHK1 Pathway

Xiang-Yang Zhou, Xiang Wang, Baocheng Hu, Jun Guan, George Iliakis, and Ya Wang
Cancer Res 2002 62: 1598-1603. [Abstract] [Full Text] [PDF]  

Generation of Effective Antitumor Vaccines Using Photodynamic Therapy

Sandra O. Gollnick, Lurine Vaughan, and Barbara W. Henderson
Cancer Res 2002 62: 1604-1608. [Abstract] [Full Text] [PDF]  

Target Gene Mutation Profile Differs between Gastrointestinal and Endometrial Tumors with Mismatch Repair Deficiency

Alex Duval, Maryline Reperant, Aurore Compoint, Raquel Seruca, Guglielmina N. Ranzani, Barry Iacopetta, and Richard Hamelin
Cancer Res 2002 62: 1609-1612. [Abstract] [Full Text] [PDF]  

The SLUG Zinc-Finger Protein Represses E-Cadherin in Breast Cancer

Karen M. Hajra, David Y-S. Chen, and Eric R. Fearon
Cancer Res 2002 62: 1613-1618. [Abstract] [Full Text] [PDF]  

Osteoprotegerin (OPG) Is a Survival Factor for Human Prostate Cancer Cells

Ingunn Holen, Peter I. Croucher, Freddie C. Hamdy, and Colby L. Eaton
Cancer Res 2002 62: 1619-1623. [Abstract] [Full Text] [PDF]  

Biochemistry and Biophysics:

Characterization of Human UMP/CMP Kinase and Its Phosphorylation of D- and L-Form Deoxycytidine Analogue Monophosphates

Jieh-Yuan Liou, Ginger E. Dutschman, Wing Lam, Zaoli Jiang, and Yung-Chi Cheng
Cancer Res 2002 62: 1624-1631. [Abstract] [Full Text] [PDF]  

Neurotensin Induces Protein Kinase C-dependent Protein Kinase D Activation and DNA Synthesis in Human Pancreatic Carcinoma Cell Line PANC-1

Sushovan Guha, Osvaldo Rey, and Enrique Rozengurt
Cancer Res 2002 62: 1632-1640. [Abstract] [Full Text] [PDF]  

Carcinogenesis:

Enhanced Skin Carcinogenesis in Cyclin D1-conditional Transgenic Mice: Cyclin D1 Alters Keratinocyte Response to Calcium-induced Terminal Differentiation

Hanako Yamamoto, Takahiro Ochiya, Fumitaka Takeshita, Hiroyasu Toriyama-Baba, Kotaro Hirai, Hideo Sasaki, Hiroki Sasaki, Hiromi Sakamoto, Teruhiko Yoshida, Izumu Saito, and Masaaki Terada
Cancer Res 2002 62: 1641-1647. [Abstract] [Full Text] [PDF]  

Nitric Oxide Inhibits Apoptosis Downstream of Cytochrome c Release by Nitrosylating Caspase 9

Natalie J. Török, Hajime Higuchi, Steven Bronk, and Gregory J. Gores
Cancer Res 2002 62: 1648-1653. [Abstract] [Full Text] [PDF]  

Retinol Metabolism and Lecithin:Retinol Acyltransferase Levels Are Reduced in Cultured Human Prostate Cancer Cells and Tissue Specimens

Xiaojia Guo, Beatrice S. Knudsen, Donna M. Peehl, Alberto Ruiz, Dean Bok, Robert R. Rando, Johng S. Rhim, David M. Nanus, and Lorraine J. Gudas
Cancer Res 2002 62: 1654-1661. [Abstract] [Full Text] [PDF]  

Significance of MAD2 Expression to Mitotic Checkpoint Control in Ovarian Cancer Cells

Xianghong Wang, Dong-Yan Jin, Raymond W. M. Ng, Huichen Feng, Yong C. Wong, Annie L. M. Cheung, and Sai W. Tsao
Cancer Res 2002 62: 1662-1668. [Abstract] [Full Text] [PDF]  

Clinical Investigations:

Vascular Endothelial Growth Factor-D Expression Is an Independent Prognostic Marker for Survival in Colorectal Carcinoma

Jeff D. White, Peter W. Hewett, Dennis Kosuge, Thomas McCulloch, Berndt C. Enholm, James Carmichael, and J. Clifford Murray
Cancer Res 2002 62: 1669-1675. [Abstract] [Full Text] [PDF]  

Cyclooxygenase-2 Expression in Human Breast Cancers and Adjacent Ductal Carcinoma in Situ

Elizabeth Half, Xi Ming Tang, Karin Gwyn, Aysegul Sahin, Kyle Wathen, and Frank A. Sinicrope
Cancer Res 2002 62: 1676-1681. [Abstract] [Full Text] [PDF]  

Endocrinology:

Endogenous von Hippel-Lindau Tumor Suppressor Protein Regulates Catecholaminergic Phenotype in PC12 Cells

Amy L. Bauer, Waltke R. Paulding, Justin B. Striet, Phillip O. Schnell, and Maria F. Czyzyk-Krzeska
Cancer Res 2002 62: 1682-1687. [Abstract] [Full Text] [PDF]  

Experimental Therapeutics:

Transcriptional Regulation of Mitotic Genes by Camptothecin-induced DNA Damage: Microarray Analysis of Dose- and Time-dependent Effects

Yi Zhou, Fuad G. Gwadry, William C. Reinhold, Lance D. Miller, Lawrence H. Smith, Uwe Scherf, Edison T. Liu, Kurt W. Kohn, Yves Pommier, and John N. Weinstein
Cancer Res 2002 62: 1688-1695. [Abstract] [Full Text] [PDF]  

Oncolytic Reovirus against Ovarian and Colon Cancer

Kensuke Hirasawa, Sandra G. Nishikawa, Kara L. Norman, Tommy Alain, Anna Kossakowska, and Patrick W. K. Lee
Cancer Res 2002 62: 1696-1701. [Abstract] [Full Text] [PDF]  

Simultaneous Inhibition of the Receptor Kinase Activity of Vascular Endothelial, Fibroblast, and Platelet-derived Growth Factors Suppresses Tumor Growth and Enhances Tumor Radiation Response

Robert J. Griffin, Brent W. Williams, Robert Wild, Julie M. Cherrington, Heonjoo Park, and Chang W. Song
Cancer Res 2002 62: 1702-1706. [Abstract] [Full Text] [PDF]  

Selective Sensitization of Transformed Cells to Flavopiridol-induced Apoptosis following Recruitment to S-Phase

Christian B. Matranga and Geoffrey I. Shapiro
Cancer Res 2002 62: 1707-1717. [Abstract] [Full Text] [PDF]  

The New Sulindac Derivative IND 12 Reverses Ras-induced Cell Transformation

Ioanna-Maria Karaguni, Peter Herter, Philip Debruyne, Slava Chtarbova, Alice Kasprzynski, Ulrike Herbrand, M-Reza Ahmadian, Karl-Heinz Glüsenkamp, Günther Winde, Marc Mareel, Tarik Möröy, and Oliver Müller
Cancer Res 2002 62: 1718-1723. [Abstract] [Full Text] [PDF]  

Three New Prodrugs for Suicide Gene Therapy Using Carboxypeptidase G2 Elicit Bystander Efficacy in Two Xenograft Models

Frank Friedlos, Lawrence Davies, Ian Scanlon, Lesley M. Ogilvie, Janet Martin, Stephen M. Stribbling, Robert A. Spooner, Ion Niculescu-Duvaz, Richard Marais, and Caroline J. Springer
Cancer Res 2002 62: 1724-1729. [Abstract] [Full Text] [PDF]  

A Diphtheria Toxin-Interleukin 3 Fusion Protein Is Cytotoxic to Primitive Acute Myeloid Leukemia Progenitors But Spares Normal Progenitors

Michaela Feuring-Buske, Arthur E. Frankel, Richard L. Alexander, Brigitte Gerhard, and Donna E. Hogge
Cancer Res 2002 62: 1730-1736. [Abstract] [Full Text] [PDF]  

Immunology:

Development of a Recombinant HSP110-HER-2/neu Vaccine Using the Chaperoning Properties of HSP110

Masoud H. Manjili, Robert Henderson, Xiang-Yang Wang, Xing Chen, Ying Li, Elizabeth Repasky, Latif Kazim, and John R. Subjeck
Cancer Res 2002 62: 1737-1742. [Abstract] [Full Text] [PDF]  

Circulating Tumor-reactive CD8⁺ T Cells in Melanoma Patients Contain a CD45RA⁺CCR7^- Effector Subset Exerting ex Vivo Tumor-specific Cytolytic Activity

Danila Valmori, Carmen Scheibenbogen, Valerie Dutoit, Dirk Nagorsen, Anne Marie Asemissen, Verena Rubio-Godoy, Donata Rimoldi, Philippe Guillaume, Pedro Romero, Dirk Schadendorf, Martin Lipp, Pierre-Yves Dietrich, Eckhard Thiel, Jean-Charles Cerottini, Danielle Liénard, and Ulrich Keilholz
Cancer Res 2002 62: 1743-1750. [Abstract] [Full Text] [PDF]  

Tumor-infiltrating B Lymphocytes as a Potential Source of Identifying Tumor Antigen in Human Lung Cancer

Manabu Yasuda, Mitsuhiro Takenoyama, Yuichi Obata, Masakazu Sugaya, Tomoko So, Takeshi Hanagiri, Kenji Sugio, and Kosei Yasumoto
Cancer Res 2002 62: 1751-1756. [Abstract] [Full Text] [PDF]  

Vaccination with DNA Encoding a Single-Chain TCR Fusion Protein Induces Anticlonotypic Immunity and Protects against T-Cell Lymphoma

Stephen M. Thirdborough, Joanna N. Radcliffe, Peter S. Friedmann, and Freda K. Stevenson
Cancer Res 2002 62: 1757-1760. [Abstract] [Full Text] [PDF]  

Molecular Biology and Genetics:

Novel Regions of Allelic Imbalance Identified by Genome-wide Analysis of Neuroblastoma

Jaume Mora, Nai-Kong V. Cheung, Sandra Oplanich, Lishi Chen, and William L. Gerald
Cancer Res 2002 62: 1761-1767. [Abstract] [Full Text] [PDF]  

In Lymphatic Cells Par-4 Sensitizes to Apoptosis by Down-Regulating Bcl-2 and Promoting Disruption of Mitochondrial Membrane Potential and Caspase Activation

Simone Boehrer, Kai U. Chow, Florian Beske, Natasa Kukoc-Zivojnov, Elena Puccetti, Martin Ruthardt, Christine Baum, Vivek M. Rangnekar, Dieter Hoelzer, Paris S. Mitrou, and Eckhart Weidmann
Cancer Res 2002 62: 1768-1775. [Abstract] [Full Text] [PDF]  

Adenovirus-mediated E2F-1 Gene Transfer Sensitizes Melanoma Cells to Apoptosis Induced by Topoisomerase II Inhibitors

Yan Bin Dong, Hai Liang Yang, Mary Jane Elliott, and Kelly M. McMasters
Cancer Res 2002 62: 1776-1783. [Abstract] [Full Text] [PDF]  

Joint Effect of HSD3B1 and HSD3B2 Genes Is Associated with Hereditary and Sporadic Prostate Cancer Susceptibility

Bao-li Chang, Siqun L. Zheng, Gregory A. Hawkins, Sarah D. Isaacs, Kathy E. Wiley, Aubrey Turner, John D. Carpten, Eugene R. Bleecker, Patrick C. Walsh, Jeffrey M. Trent, Deborah A. Meyers, William B. Isaacs, and Jianfeng Xu
Cancer Res 2002 62: 1784-1789. [Abstract] [Full Text] [PDF]  

DMBT1 Polymorphisms: Relationship to Malignant Glioma Tumorigenesis

Hikaru Sasaki, Rebecca A. Betensky, J. Gregory Cairncross, and David N. Louis
Cancer Res 2002 62: 1790-1796. [Abstract] [Full Text] [PDF]  

Chfr Regulates a Mitotic Stress Pathway through its RING-Finger Domain with Ubiquitin Ligase Activity

Priya Chaturvedi, Valery Sudakin, Matthew L. Bobiak, Paul W. Fisher, Michael R. Mattern, Sandra A. Jablonski, Mark R. Hurle, Yuan Zhu, Tim J. Yen, and Bin-Bing S. Zhou
Cancer Res 2002 62: 1797-1801. [Abstract] [Full Text] [PDF]  

Tumor Biology:

Expression of the Neurotrophin Receptor TrkA Down-Regulates Expression and Function of Angiogenic Stimulators in SH-SY5Y Neuroblastoma Cells

Angelika Eggert, Michael A. Grotzer, Naohiko Ikegaki, Xing-ge Liu, Audrey E. Evans, and Garrett M. Brodeur
Cancer Res 2002 62: 1802-1808. [Abstract] [Full Text] [PDF]  

Nuclear Factor B Dependency of Platelet-activating Factor-induced Angiogenesis

Hyun-Mi Ko, Kook Heon Seo, Su-Ji Han, Kyu Youn Ahn, Il-Hwan Choi, Gou Young Koh, Hern-Ku Lee, Myung Suk Ra, and Suhn-Young Im
Cancer Res 2002 62: 1809-1814. [Abstract] [Full Text] [PDF]  

Atypical Protein Kinase C as a Target for Chemosensitization of Tumor Cells

Rodolphe Filomenko, Florence Poirson-Bichat, Claire Billerey, Jean-Paul Belon, Carmen Garrido, Eric Solary, and Ali Bettaieb
Cancer Res 2002 62: 1815-1821. [Abstract] [Full Text] [PDF]  

Coamplification of DAD-R, SOX5, and EKI1 in Human Testicular Seminomas, with Specific Overexpression of DAD-R, Correlates with Reduced Levels of Apoptosis and Earlier Clinical Manifestation

Gaetano Zafarana, Ad J. M. Gillis, Ruud J. H. L. M. van Gurp, Per G. Olsson, Fons Elstrodt, Hans Stoop, José Luis Millán, J. Wolter Oosterhuis, and Leendert H. J. Looijenga
Cancer Res 2002 62: 1822-1831. [Abstract] [Full Text] [PDF]  

Use of the Stromal Cell-derived Factor-1/CXCR4 Pathway in Prostate Cancer Metastasis to Bone

Russell S. Taichman, Carlton Cooper, Evan T. Keller, Kenneth J. Pienta, Norton S. Taichman, and Laurie K. McCauley
Cancer Res 2002 62: 1832-1837. [Abstract] [Full Text] [PDF]  

Vascular Endothelial Growth Factor Isoform Expression as a Determinant of Blood Vessel Patterning in Human Melanoma Xenografts

Joanne L. Yu, Janusz W. Rak, Giannoula Klement, and Robert S. Kerbel
Cancer Res 2002 62: 1838-1846. [Abstract] [Full Text] [PDF]  

Hypoxia Promotes Lymph Node Metastasis in Human Melanoma Xenografts by Up-Regulating the Urokinase-Type Plasminogen Activator Receptor

Einar K. Rofstad, Heidi Rasmussen, Kanthi Galappathi, Berit Mathiesen, Kristin Nilsen, and Bjørn A. Graff
Cancer Res 2002 62: 1847-1853. [Abstract] [Full Text] [PDF]  

VEGF₁₂₁, VEGF₁₆₅ Overexpression Enhances Tumorigenicity in U251 MG but not in NG-1 Glioma Cells

Li Dao Ke, Yue-Xi Shi, and W. K. Alfred Yung
Cancer Res 2002 62: 1854-1861. [Abstract] [Full Text] [PDF]  

Noninvasive Imaging of Spontaneous Retinoblastoma Pathway-dependent Tumors in Mice

Marc Vooijs, Jos Jonkers, Scott Lyons, and Anton Berns
Cancer Res 2002 62: 1862-1867. [Abstract] [Full Text] [PDF]  

Identification of Hepatocarcinoma-Intestine-Pancreas/Pancreatitis-associated Protein I as a Biomarker for Pancreatic Ductal Adenocarcinoma by Protein Biochip Technology

Christophe Rosty, Laurence Christa, Scott Kuzdzal, William M. Baldwin, Marianna L. Zahurak, Françoise Carnot, Daniel W. Chan, Marcia Canto, Keith D. Lillemoe, John L. Cameron, Charles J. Yeo, Ralph H. Hruban, and Michael Goggins
Cancer Res 2002 62: 1868-1875. [Abstract] [Full Text] [PDF]  

DNA Damage Is Able to Induce Senescence in Tumor Cells in Vitro and in Vivo

Robert H. te Poele, Andrei L. Okorokov, Lesley Jardine, Jeffrey Cummings, and Simon P. Joel
Cancer Res 2002 62: 1876-1883. [Abstract] [Full Text] [PDF]  

Strategies for Antigen Loading of Dendritic Cells to Enhance the Antitumor Immune Response

Scott E. Strome, Stephen Voss, Ryan Wilcox, Tamekia L. Wakefield, Koji Tamada, Dallas Flies, Andrei Chapoval, Jun Lu, Jan L. Kasperbauer, Douglas Padley, Richard Vile, Dennis Gastineau, Peter Wettstein, and Lieping Chen
Cancer Res 2002 62: 1884-1889. [Abstract] [Full Text] [PDF]  

Melanoma Tumors Acquire a New Phospholipid Metabolism Phenotype under Cystemustine As Revealed by High-Resolution Magic Angle Spinning Proton Nuclear Magnetic Resonance Spectroscopy of Intact Tumor Samples

Daniel Morvan, Aicha Demidem, Janine Papon, Monique De Latour, and Jean Claude Madelmont
Cancer Res 2002 62: 1890-1897. [Abstract] [Full Text] [PDF]  

Fibroblast Growth Factor Receptor 1 Phosphotyrosine 766: Molecular Target for Prevention of Progression of Prostate Tumors to Malignancy

Fen Wang, Kerstin McKeehan, Chundong Yu, and Wallace L. McKeehan
Cancer Res 2002 62: 1898-1903. [Abstract] [Full Text] [PDF]  

Bag1 Proteins Regulate Growth and Survival of ZR-75-1 Human Breast Cancer Cells

Masafumi Kudoh, Deborah A. Knee, Shinichi Takayama, and John C. Reed
Cancer Res 2002 62: 1904-1909. [Abstract] [Full Text] [PDF]  

Regulation of Matrix Metalloproteinase-9 (MMP-9) by Translational Efficiency in Murine Prostate Carcinoma Cells

Yong Jiang and Ruth J. Muschel
Cancer Res 2002 62: 1910-1914. [Abstract] [Full Text] [PDF]  

Prevention of Irradiation-induced Glioma Cell Invasion by Temozolomide Involves Caspase 3 Activity and Cleavage of Focal Adhesion Kinase

Wolfgang Wick, Antje Wick, Jörg B. Schulz, Johannes Dichgans, Hans P. Rodemann, and Michael Weller
Cancer Res 2002 62: 1915-1919. [Abstract] [Full Text] [PDF]  

Virology:

Chemotherapy Induces Lytic EBV Replication and Confers Ganciclovir Susceptibility to EBV-positive Epithelial Cell Tumors

Wen-hai Feng, Bruce Israel, Nancy Raab-Traub, Pierre Busson, and Shannon C. Kenney
Cancer Res 2002 62: 1920-1926. [Abstract] [Full Text] [PDF]  

Correction:

R-H. Chen et al., 61: 4445–4449, 2001.

Cancer Res 2002 62: 1928 [Full Text] [PDF]  

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