Review:

What Do Oncogenic Mutations Have To Do with Angiogenesis/Vascular Dependence of Tumors?

Janusz Rak, Joanne L. Yu, Robert S. Kerbel, and Brenda L. Coomber
Cancer Res 2002 62: 1931-1934. [Full Text] [PDF]  

Advances in Brief:

Differential Mitotic Responses to Microtubule-stabilizing and -destabilizing Drugs

Jie-Guang Chen and Susan Band Horwitz
Cancer Res 2002 62: 1935-1938. [Abstract] [Full Text] [PDF]  

Biallelic Inactivation of the Thyroid Hormone Receptor ß1 Gene in Early Stage Breast Cancer

Zheng Li, Zhen Hang Meng, Raman Chandrasekaran, Wen-Lin Kuo, Colin C. Collins, Joe W. Gray, and Shanaz H. Dairkee
Cancer Res 2002 62: 1939-1943. [Abstract] [Full Text] [PDF]  

Endostatin Regulates Endothelial Cell Adhesion and Cytoskeletal Organization

Johan Dixelius, Michael Cross, Taro Matsumoto, Takako Sasaki, Rupert Timpl, and Lena Claesson-Welsh
Cancer Res 2002 62: 1944-1947. [Abstract] [Full Text] [PDF]  

Hormonal Regulation of VEGF in Orthotopic MCF7 Human Breast Cancer

Liora Bogin and Hadassa Degani
Cancer Res 2002 62: 1948-1951. [Abstract] [Full Text] [PDF]  

High Frequency Loss of Heterozygosity in von Hippel-Lindau (VHL)-associated and Sporadic Pancreatic Islet Cell Tumors: Evidence for a Stepwise Mechanism for Malignant Conversion in VHL Tumorigenesis

Steven T. Lott, Dawn S. Chandler, Steven A. Curley, Carolyn J. Foster, Adel El-Naggar, Marsha Frazier, Louise C. Strong, Mercedes Lovell, and Ann McNeill Killary
Cancer Res 2002 62: 1952-1955. [Abstract] [Full Text] [PDF]  

Lack of Mutation Induction with Exposure to 1.5 GHz Electromagnetic Near Fields Used for Cellular Phones in Brains of Big Blue Mice

Satoru Takahashi, Shingo Inaguma, Young-Man Cho, Katsumi Imaida, Jianqing Wang, Osamu Fujiwara, and Tomoyuki Shirai
Cancer Res 2002 62: 1956-1960. [Abstract] [Full Text] [PDF]  

Biochemistry and Biophysics:

Low Mutation Incidence in Polymorphic Noncoding Short Mononucleotide Repeats in Gastrointestinal Cancer of the Microsatellite Mutator Phenotype Pathway

Koichi Suzuki, Tomoko Dai, Ikuko Suzuki, Yuichi Dai, Kentaro Yamashita, and Manuel Perucho
Cancer Res 2002 62: 1961-1965. [Abstract] [Full Text] [PDF]  

Metabolic Markers of Breast Cancer: Enhanced Choline Metabolism and Reduced Choline-Ether-Phospholipid Synthesis

Rachel Katz-Brull, Dalia Seger, Dalia Rivenson-Segal, Edna Rushkin, and Hadassa Degani
Cancer Res 2002 62: 1966-1970. [Abstract] [Full Text] [PDF]  

Carcinogenesis:

Lack of Tumorigenesis in the Mouse Liver after Adenovirus-mediated Expression of a Dominant Stable Mutant of ß-Catenin

Naomoto Harada, Hiroyuki Miyoshi, Naomi Murai, Hiroko Oshima, Yoshitaka Tamai, Masanobu Oshima, and Makoto M. Taketo
Cancer Res 2002 62: 1971-1977. [Abstract] [Full Text] [PDF]  

Characterization of Benzo(a)pyrene-trans-7,8-dihydrodiol Glucuronidation by Human Tissue Microsomes and Overexpressed UDP-glucuronosyltransferase Enzymes

Jia-Long Fang, Frederick A. Beland, Daniel R. Doerge, Doris Wiener, Chantal Guillemette, M. Matilde Marques, and Philip Lazarus
Cancer Res 2002 62: 1978-1986. [Abstract] [Full Text] [PDF]  

Epidemiology and Prevention:

Prevalence and Spectrum of p53 Mutations Associated with Smoking in Breast Cancer

Kathleen Conway, Sharon N. Edmiston, Lisa Cui, S. Scott Drouin, Jingzhong Pang, Mei He, Chiu-Kit Tse, Joseph Geradts, Lynn Dressler, Edison T. Liu, Robert Millikan, and Beth Newman
Cancer Res 2002 62: 1987-1995. [Abstract] [Full Text] [PDF]  

Experimental Therapeutics:

Blockade of Vascular Endothelial Growth Factor Receptor and Epidermal Growth Factor Receptor Signaling for Therapy of Metastatic Human Pancreatic Cancer

Cheryl H. Baker, Carmen C. Solorzano, and Isaiah J. Fidler
Cancer Res 2002 62: 1996-2003. [Abstract] [Full Text] [PDF]  

Systemic Inhibition of Tumor Growth and Angiogenesis by Thrombospondin-2 Using Cell-based Antiangiogenic Gene Therapy

Michael Streit, Antonia E. Stephen, Thomas Hawighorst, Kant Matsuda, Bernhard Lange-Asschenfeldt, Lawrence F. Brown, Joseph P. Vacanti, and Michael Detmar
Cancer Res 2002 62: 2004-2012. [Abstract] [Full Text] [PDF]  

Antitumor Effect of TAT-Oxygen-dependent Degradation-Caspase-3 Fusion Protein Specifically Stabilized and Activated in Hypoxic Tumor Cells

Hiroshi Harada, Masahiro Hiraoka, and Shinae Kizaka-Kondoh
Cancer Res 2002 62: 2013-2018. [Abstract] [Full Text] [PDF]  

Soluble FLT-1 Expression Suppresses Carcinomatous Ascites in Nude Mice Bearing Ovarian Cancer

Yoko Hasumi, Hiroaki Mizukami, Masashi Urabe, Takahiro Kohno, Koichi Takeuchi, Akihiro Kume, Mikio Momoeda, Hiroyuki Yoshikawa, Takashi Tsuruo, Masabumi Shibuya, Yuji Taketani, and Keiya Ozawa
Cancer Res 2002 62: 2019-2023. [Abstract] [Full Text] [PDF]  

Tumor Genotype-specific Growth Inhibition in Vivo by Antisense Oligonucleotides against a Polymorphic Site of the Large Subunit of Human RNA Polymerase II

Kees Fluiter, Anneloor L. M. A. ten Asbroek, Marjon van Groenigen, Marleen Nooij, Maurice C. G. Aalders, and Frank Baas
Cancer Res 2002 62: 2024-2028. [Abstract] [Full Text] [PDF]  

Celecoxib Exhibits the Greatest Potency amongst Cyclooxygenase (COX) Inhibitors for Growth Inhibition of COX-2-negative Hematopoietic and Epithelial Cell Lines

Chris Waskewich, Rosalyn D. Blumenthal, Honglan Li, Rhona Stein, David M. Goldenberg, and Jack Burton
Cancer Res 2002 62: 2029-2033. [Abstract] [Full Text] [PDF]  

Combined Anti-Fetal Liver Kinase 1 Monoclonal Antibody and Continuous Low-Dose Doxorubicin Inhibits Angiogenesis and Growth of Human Soft Tissue Sarcoma Xenografts by Induction of Endothelial Cell Apoptosis

Lianglin Zhang, Dihua Yu, Daniel J. Hicklin, Jonathan A. F. Hannay, Lee M. Ellis, and Raphael E. Pollock
Cancer Res 2002 62: 2034-2042. [Abstract] [Full Text] [PDF]  

Immunology:

Synergistic Enhancement of Antitumor Immunity with Adoptively Transferred Tumor-specific CD4⁺ and CD8⁺ T Cells and Intratumoral Lymphotactin Transgene Expression

Hui Huang, Fang Li, John R. Gordon, and Jim Xiang
Cancer Res 2002 62: 2043-2051. [Abstract] [Full Text] [PDF]  

CD40-expressing Carcinoma Cells Induce Down-Regulation of CD40 Ligand (CD154) and Impair T-Cell Functions

Richard Batrla, Michael Linnebacher, Wolfgang Rudy, Susanne Stumm, Diethelm Wallwiener, and Brigitte Gückel
Cancer Res 2002 62: 2052-2057. [Abstract] [Full Text] [PDF]  

Toward Synthetic Combinatorial Peptide Libraries in Positional Scanning Format (PS-SCL)-based Identification of CD8⁺ Tumor-reactive T-Cell Ligands: A Comparative Analysis of PS-SCL Recognition by a Single Tumor-reactive CD8⁺ Cytolytic T-Lymphocyte Clone

Verena Rubio-Godoy, Clemencia Pinilla, Valerie Dutoit, Eva Borras, Richard Simon, Yingdong Zhao, Jean-Charles Cerottini, Pedro Romero, Richard Houghten, and Danila Valmori
Cancer Res 2002 62: 2058-2063. [Abstract] [Full Text] [PDF]  

Molecular Biology and Genetics:

Hepatocyte Growth Factor Induces Wnt-independent Nuclear Translocation of ß-Catenin after Met-ß-Catenin Dissociation in Hepatocytes

Satdarshan P. S. Monga, Wendy M. Mars, Peter Pediaditakis, Aaron Bell, Karen Mulé, William C. Bowen, Xue Wang, Reza Zarnegar, and George K. Michalopoulos
Cancer Res 2002 62: 2064-2071. [Abstract] [Full Text] [PDF]  

Epigenetic Inactivation of 14-3-3 in Oral Carcinoma: Association with p16^INK4a Silencing and Human Papillomavirus Negativity

Milena Gasco, Alexandra K. Bell, Victoria Heath, Alex Sullivan, Paul Smith, Louise Hiller, Isik Yulug, Gianmauro Numico, Marco Merlano, Paul J. Farrell, Mahvash Tavassoli, Barry Gusterson, and Tim Crook
Cancer Res 2002 62: 2072-2076. [Abstract] [Full Text] [PDF]  

Differential Effects of p21^WAF1/CIP1 Deficiency on MMTV-ras and MMTV-myc Mammary Tumor Properties

David J. Bearss, Richard J. Lee, Dean A. Troyer, Richard G. Pestell, and Jolene J. Windle
Cancer Res 2002 62: 2077-2084. [Abstract] [Full Text] [PDF]  

Comparative Gene Expression Profile Analysis of Neurofibromatosis 1-associated and Sporadic Pilocytic Astrocytomas

David H. Gutmann, Nicolé M. Hedrick, Jun Li, Rakesh Nagarajan, Arie Perry, and Mark A. Watson
Cancer Res 2002 62: 2085-2091. [Abstract] [Full Text] [PDF]  

Susceptibility of Msh2-deficient Mice to Inflammation-associated Colorectal Tumors

Maija R. J. Kohonen-Corish, Joseph J. Daniel, Hein te Riele, Gary D. Buffinton, and Jane E. Dahlstrom
Cancer Res 2002 62: 2092-2097. [Abstract] [Full Text] [PDF]  

Tumor Biology:

The Melanocyte-specific Isoform of the Microphthalmia Transcription Factor Affects the Phenotype of Human Melanoma

Edgar Selzer, Volker Wacheck, Trevor Lucas, Elisabeth Heere-Ress, Min Wu, Katherine N. Weilbaecher, Werner Schlegel, Peter Valent, Fritz Wrba, Hubert Pehamberger, David Fisher, and Burkhard Jansen
Cancer Res 2002 62: 2098-2103. [Abstract] [Full Text] [PDF]  

Limited Proliferation and Telomere Dysfunction following Telomerase Inhibition in Immortal Murine Fibroblasts

Jessica Boklan, Gouri Nanjangud, Karen L. MacKenzie, Chad May, Michel Sadelain, and Malcolm A. S. Moore
Cancer Res 2002 62: 2104-2114. [Abstract] [Full Text] [PDF]  

Rad6 Overexpression Induces Multinucleation, Centrosome Amplification, Abnormal Mitosis, Aneuploidy, and Transformation

Malathy P. V. Shekhar, Alex Lyakhovich, Daniel W. Visscher, Henry Heng, and Noelle Kondrat
Cancer Res 2002 62: 2115-2124. [Abstract] [Full Text] [PDF]  

Collective Cell Movement in Primary Melanoma Explants: Plasticity of Cell-Cell Interaction, ß1-Integrin Function, and Migration Strategies

Yael Hegerfeldt, Miriam Tusch, Eva-B. Bröcker, and Peter Friedl
Cancer Res 2002 62: 2125-2130. [Abstract] [Full Text] [PDF] [Supplementary Data: Videos]  

Suppression of Rac Activity Induces Apoptosis of Human Glioma Cells but not Normal Human Astrocytes

Donna L. Senger, Christopher Tudan, Marie-Christine Guiot, Irene E. Mazzoni, Gabriele Molenkamp, Richard LeBlanc, Jack Antel, Andre Olivier, G. Jackson Snipes, and David R. Kaplan
Cancer Res 2002 62: 2131-2140. [Abstract] [Full Text] [PDF]  

Human Non-Small Cell Lung Tumors and Cells Derived from Normal Lung Express Both Estrogen Receptor and ß and Show Biological Responses to Estrogen

Laura P. Stabile, Autumn L. Gaither Davis, Christopher T. Gubish, Toni M. Hopkins, James D. Luketich, Neil Christie, Sydney Finkelstein, and Jill M. Siegfried
Cancer Res 2002 62: 2141-2150. [Abstract] [Full Text] [PDF]  

Vascular Accumulation of a Novel Photosensitizer, MV6401, Causes Selective Thrombosis in Tumor Vessels after Photodynamic Therapy

Dennis E. J. G. J. Dolmans, Ananth Kadambi, John S. Hill, Christina A. Waters, Byron C. Robinson, Jeffrey P. Walker, Dai Fukumura, and Rakesh K. Jain
Cancer Res 2002 62: 2151-2156. [Abstract] [Full Text] [PDF]  

Tumor-specific Down-Regulation of the Tumor Necrosis Factor-related Apoptosis-inducing Ligand Decoy Receptors DcR1 and DcR2 Is Associated with Dense Promoter Hypermethylation

Max M. van Noesel, Saskia van Bezouw, Gajja S. Salomons, P. A. Voûte, Rob Pieters, Steve B. Baylin, James G. Herman, and Rogier Versteeg
Cancer Res 2002 62: 2157-2161. [Abstract] [Full Text] [PDF]  

Persistence of Solitary Mammary Carcinoma Cells in a Secondary Site: A Possible Contributor to Dormancy

George N. Naumov, Ian C. MacDonald, Pascal M. Weinmeister, Nancy Kerkvliet, Kishore V. Nadkarni, Sylvia M. Wilson, Vincent L. Morris, Alan C. Groom, and Ann F. Chambers
Cancer Res 2002 62: 2162-2168. [Abstract] [Full Text] [PDF]  

Growth Phase-dependent Expression of ICAD-L/DFF45 Modulates the Pattern of Apoptosis in Human Colonic Cancer Cells

Laetitia Charrier, Anne Jarry, Claire Toquet, Chantal Bou-Hanna, Marie Chedorge, Marc Denis, Geneviève Vallette, and Christian L. Laboisse
Cancer Res 2002 62: 2169-2174. [Abstract] [Full Text] [PDF]  

Antisense RNA Down-Regulation of bcl-xL Expression in Prostate Cancer Cells Leads to Diminished Rates of Cellular Proliferation and Resistance to Cytotoxic Chemotherapeutic Agents

Maria Vilenchik, Anthony J. Raffo, Luba Benimetskaya, David Shames, and C. A. Stein
Cancer Res 2002 62: 2175-2183. [Abstract] [Full Text] [PDF]  

Loss of Bax Alters Tumor Spectrum and Tumor Numbers in ARF-deficient Mice

Christine M. Eischen, Jerold E. Rehg, Stanley J. Korsmeyer, and John L. Cleveland
Cancer Res 2002 62: 2184-2191. [Abstract] [Full Text] [PDF]  

Letters to the Editor:

Correspondence re: A. Kumar et al., Cross-Resistance to the Synthetic Retinoid CD437 in a Paclitaxel-resistant Human Ovarian Carcinoma Cell Line Is Independent of the Overexpression of Retinoic Acid Receptor-. Cancer Res., 61: 7552–7555, 2001.

Enrico Garattini, Maurizio Gianni’, Mineko Terao, and H. K. Parekh
Cancer Res 2002 62: 2192-2194. [Full Text] [PDF]  

Meeting Report:

Special Conference of the American Association for Cancer Research on Molecular Imaging in Cancer: Linking Biology, Function, and Clinical Applications in Vivo

Gary D. Luker
Cancer Res 2002 62: 2195-2198. [Abstract] [Full Text] [PDF]  

Correction:

M. W. Jackson et al., 62: 854–859, 2002.

Cancer Res 2002 62: 2200 [Full Text] [PDF]  

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