Review:

Mutations at Coding Repeat Sequences in Mismatch Repair-deficient Human Cancers: Toward a New Concept of Target Genes for Instability

Alex Duval and Richard Hamelin
Cancer Res 2002 62: 2447-2454. [Abstract] [Full Text] [PDF]  

Advances in Brief:

Endogenous Reactivation of the RARß2 Tumor Suppressor Gene Epigenetically Silenced in Breast Cancer

Silvia M. Sirchia, Mingqiang Ren, Roberto Pili, Elena Sironi, Giulia Somenzi, Riccardo Ghidoni, Salvatore Toma, Guido Nicolò, and Nicoletta Sacchi
Cancer Res 2002 62: 2455-2461. [Abstract] [Full Text] [PDF]  

Regulation of Microtubule Stability and Mitotic Progression by Survivin

Alessandra Giodini, Marko J. Kallio, Nathan R. Wall, Gary J. Gorbsky, Simona Tognin, Pier Carlo Marchisio, Marc Symons, and Dario C. Altieri
Cancer Res 2002 62: 2462-2467. [Abstract] [Full Text] [PDF]  

Platelet-derived Growth Factor D: Tumorigenicity in Mice and Dysregulated Expression in Human Cancer

William J. LaRochelle, Michael Jeffers, Jose R. F. Corvalan, Xiao-Chi Jia, Xiao Feng, Sandra Vanegas, Justin D. Vickroy, Xiao-Dong Yang, Francine Chen, Gadi Gazit, Jane Mayotte, Jennifer Macaluso, Beth Rittman, Frank Wu, Mohan Dhanabal, John Herrmann, and Henri S. Lichenstein
Cancer Res 2002 62: 2468-2473. [Abstract] [Full Text] [PDF]  

Dietary Genistein Negates the Inhibitory Effect of Tamoxifen on Growth of Estrogen-dependent Human Breast Cancer (MCF-7) Cells Implanted in Athymic Mice

Young H. Ju, Daniel R. Doerge, Kimberly F. Allred, Clinton D. Allred, and William G. Helferich
Cancer Res 2002 62: 2474-2477. [Abstract] [Full Text] [PDF]  

Geldanamycin Induces Degradation of Hypoxia-inducible Factor 1 Protein via the Proteosome Pathway in Prostate Cancer Cells

Nicola J. Mabjeesh, Dawn E. Post, Margaret T. Willard, Balveen Kaur, Erwin G. Van Meir, Jonathan W. Simons, and Hua Zhong
Cancer Res 2002 62: 2478-2482. [Abstract] [Full Text] [PDF]  

Ku Affects the Ataxia and Rad 3-related/CHK1-dependent S Phase Checkpoint Response after Camptothecin Treatment

Hongyan Wang, Xiang Wang, Xiang-Yang Zhou, David J. Chen, Gloria C. Li, George Iliakis, and Ya Wang
Cancer Res 2002 62: 2483-2487. [Abstract] [Full Text] [PDF]  

Resveratrol Induces Prostate Cancer Cell Entry into S Phase and Inhibits DNA Synthesis

Nafisa Kuwajerwala, Eugenia Cifuentes, Subhash Gautam, Mani Menon, Evelyn R. Barrack, and G. Prem Veer Reddy
Cancer Res 2002 62: 2488-2492. [Abstract] [Full Text] [PDF]  

Hypoxia-inducible Factors HIF-1 and HIF-2 in Head and Neck Cancer: Relationship to Tumor Biology and Treatment Outcome in Surgically Resected Patients

Nigel J. P. Beasley, Russell Leek, Mohammed Alam, Helen Turley, Graham J. Cox, Kevin Gatter, Peter Millard, Sue Fuggle, and Adrian L. Harris
Cancer Res 2002 62: 2493-2497. [Abstract] [Full Text] [PDF]  

Deficiency of Retinoblastoma Gene in Mouse Embryonic Stem Cells Leads to Genetic Instability

Lei Zheng, Andrea Flesken-Nikitin, Phang-Lang Chen, and Wen-Hwa Lee
Cancer Res 2002 62: 2498-2502. [Abstract] [Full Text] [PDF]  

Biochemistry and Biophysics:

Neural Wiskott-Aldrich Syndrome Protein Is Involved in Hepatocyte Growth Factor-induced Migration, Invasion, and Tubulogenesis of Epithelial Cells

Hideki Yamaguchi, Hiroaki Miki, and Tadaomi Takenawa
Cancer Res 2002 62: 2503-2509. [Abstract] [Full Text] [PDF]  

Forced Expression of the Interferon Regulatory Factor 2 Oncoprotein Causes Polyploidy and Cell Death in FDC-P1 Myeloid Hematopoietic Progenitor Cells

Rong-Lin Xie, Andre J. van Wijnen, Caroline M. van der Meijden, Janet L. Stein, and Gary S. Stein
Cancer Res 2002 62: 2510-2515. [Abstract] [Full Text] [PDF]  

Carcinogenesis:

Cyclooxygenase-2 Overexpression in the Skin of Transgenic Mice Results in Suppression of Tumor Development

David K. Bol, R. Bruce Rowley, Ching-Ping Ho, Brigette Pilz, Janet Dell, Mavis Swerdel, Kaoru Kiguchi, Stephanie Muga, Russell Klein, and Susan M. Fischer
Cancer Res 2002 62: 2516-2521. [Abstract] [Full Text] [PDF]  

Retinoids and Carnosol Suppress Cyclooxygenase-2 Transcription by CREB-binding Protein/p300-dependent and -independent Mechanisms

Kotha Subbaramaiah, Philip A. Cole, and Andrew J. Dannenberg
Cancer Res 2002 62: 2522-2530. [Abstract] [Full Text] [PDF]  

Involvement of Membrane Signaling in the Bystander Effect in Irradiated Cells

Hatsumi Nagasawa, Aida Cremesti, Richard Kolesnick, Zvi Fuks, and John B. Little
Cancer Res 2002 62: 2531-2534. [Abstract] [Full Text] [PDF]  

Clinical Investigations:

Expression of 90K (Mac-2 BP) Correlates with Distant Metastasis and Predicts Survival in Stage I Non-Small Cell Lung Cancer Patients

Antonio Marchetti, Nicola Tinari, Fiamma Buttitta, Antonio Chella, Carlo Alberto Angeletti, Rocco Sacco, Felice Mucilli, Axel Ullrich, and Stefano Iacobelli
Cancer Res 2002 62: 2535-2539. [Abstract] [Full Text] [PDF]  

Epidemiology and Prevention:

Selenium Modulation of Cell Proliferation and Cell Cycle Biomarkers in Human Prostate Carcinoma Cell Lines

Vasundara Venkateswaran, Laurence H. Klotz, and Neil E. Fleshner
Cancer Res 2002 62: 2540-2545. [Abstract] [Full Text] [PDF]  

Experimental Therapeutics:

Prostate Stem Cell Antigen as Therapy Target: Tissue Expression and in Vivo Efficacy of an Immunoconjugate

Sarajane Ross, Susan D. Spencer, Ilona Holcomb, Christine Tan, JoAnne Hongo, Brigitte Devaux, Linda Rangell, Gilbert A. Keller, Peter Schow, Rita M. Steeves, Robert J. Lutz, Gretchen Frantz, Kenneth Hillan, Franklin Peale, Patti Tobin, David Eberhard, Mark A. Rubin, Laurence A. Lasky, and Hartmut Koeppen
Cancer Res 2002 62: 2546-2553. [Abstract] [Full Text] [PDF]  

ZD1839 (Iressa) Induces Antiangiogenic Effects through Inhibition of Epidermal Growth Factor Receptor Tyrosine Kinase

Akira Hirata, Soh-ichiro Ogawa, Takuro Kometani, Takashi Kuwano, Seiji Naito, Michihiko Kuwano, and Mayumi Ono
Cancer Res 2002 62: 2554-2560. [Abstract] [Full Text] [PDF]  

Antivasculature Effects of Doxorubicin-containing Liposomes in an Intracranial Rat Brain Tumor Model

Rong Zhou, Richard Mazurchuk, and Robert M. Straubinger
Cancer Res 2002 62: 2561-2566. [Abstract] [Full Text] [PDF]  

Selective Targeting of Angiogenic Tumor Vasculature by Vascular Endothelial-cadherin Antibody Inhibits Tumor Growth without Affecting Vascular Permeability

Fang Liao, Jacqueline F. Doody, Jay Overholser, Bridget Finnerty, Rajiv Bassi, Yan Wu, Elisabetta Dejana, Paul Kussie, Peter Bohlen, and Daniel J. Hicklin
Cancer Res 2002 62: 2567-2575. [Abstract] [Full Text] [PDF] Supplementary Data  

Prostate-specific Expression of the Diphtheria Toxin A Chain (DT-A): Studies of Inducibility and Specificity of Expression of Prostate-specific Antigen Promoter-driven DT-A Adenoviral-mediated Gene Transfer

Ying Li, John McCadden, Fernando Ferrer, Mark Kruszewski, Michael Carducci, Jonathan Simons, and Ronald Rodriguez
Cancer Res 2002 62: 2576-2582. [Abstract] [Full Text] [PDF]  

Immunology:

Glioma-associated Hyaluronan Induces Apoptosis in Dendritic Cells via Inducible Nitric Oxide Synthase: Implications for the Use of Dendritic Cells for Therapy of Gliomas

Tianbing Yang, Timothy F. Witham, Lorissa Villa, Melanie Erff, Jason Attanucci, Simon Watkins, Douglas Kondziolka, Hideho Okada, Ian F. Pollack, and William H. Chambers
Cancer Res 2002 62: 2583-2591. [Abstract] [Full Text] [PDF]  

Identification of CD70-mediated Apoptosis of Immune Effector Cells as a Novel Immune Escape Pathway of Human Glioblastoma

Jörg Wischhusen, Gundram Jung, Ivan Radovanovic, Christoph Beier, Joachim P. Steinbach, Andreas Rimner, Huatao Huang, Jörg B. Schulz, Hiroko Ohgaki, Adriano Aguzzi, Hans-Georg Rammensee, and Michael Weller
Cancer Res 2002 62: 2592-2599. [Abstract] [Full Text] [PDF]  

Identification of HLA DR7-restricted Epitopes from Human Telomerase Reverse Transcriptase Recognized by CD4+ T-Helper Cells

Roland Schroers, Xue F. Huang, Juergen Hammer, Jingwu Zhang, and Si-Yi Chen
Cancer Res 2002 62: 2600-2605. [Abstract] [Full Text] [PDF]  

Immunotherapy with Interleukin-10 Depends on the CXC Chemokines Inducible Protein-10 and Monokine Induced by IFN-

Russell Dorsey, Namita Kundu, Qingyuan Yang, Charles S. Tannenbaum, Hui Sun, Thomas A. Hamilton, and Amy M. Fulton
Cancer Res 2002 62: 2606-2610. [Abstract] [Full Text] [PDF]  

Human CD4+ Effector T Cells Mediate Indirect Interleukin-12- and Interferon--dependent Suppression of Autologous HLA-negative Lung Tumor Xenografts in Severe Combined Immunodeficient Mice

Nejat K. Egilmez, Stephen D. Hess, Fang-An Chen, Hiroshi Takita, Thomas F. Conway, and Richard B. Bankert
Cancer Res 2002 62: 2611-2617. [Abstract] [Full Text] [PDF]  

Molecular Biology & Genetics:

Expression of Mitotic Spindle Checkpoint Protein hsMAD1 Correlates with Cellular Proliferation and Is Activated by a Gain-of-Function p53 Mutant

Yoichi Iwanaga and Kuan-Teh Jeang
Cancer Res 2002 62: 2618-2624. [Abstract] [Full Text] [PDF]  

Targets of Gene Amplification and Overexpression at 17q in Gastric Cancer

Asta Varis, Maija Wolf, Outi Monni, Marja-Leena Vakkari, Arto Kokkola, Chris Moskaluk, Henry Frierson, Jr., Steven M. Powell, Sakari Knuutila, Anne Kallioniemi, and Wa’el El-Rifai
Cancer Res 2002 62: 2625-2629. [Abstract] [Full Text] [PDF]  

RhoA-dependent Murine Prostate Cancer Cell Proliferation and Apoptosis: Role of Protein Kinase C

Paramita M. Ghosh, Roble Bedolla, Margharita Mikhailova, and Jeffrey I. Kreisberg
Cancer Res 2002 62: 2630-2636. [Abstract] [Full Text] [PDF]  

Semaphorin 3F Gene from Human 3p21.3 Suppresses Tumor Formation in Nude Mice

RuiHua Xiang, Albert R. Davalos, Charles H. Hensel, Xiao-Jun Zhou, Christin Tse, and Susan L. Naylor
Cancer Res 2002 62: 2637-2643. [Abstract] [Full Text] [PDF]  

The Role of Thymidylate Synthase Induction in Modulating p53-regulated Gene Expression in Response to 5-Fluorouracil and Antifolates

Daniel B. Longley, John Boyer, Wendy L. Allen, Tariq Latif, Paul R. Ferguson, Pamela J. Maxwell, Ultan McDermott, Maria Lynch, D. Paul Harkin, and Patrick G. Johnston
Cancer Res 2002 62: 2644-2649. [Abstract] [Full Text] [PDF]  

Point Mutations and Deletions in the Znfn1a1/Ikaros Gene in Chemically Induced Murine Lymphomas

Anneli Karlsson, Peter Söderkvist, and Shi-Mei Zhuang
Cancer Res 2002 62: 2650-2653. [Abstract] [Full Text] [PDF]  

Occurrence of NKX3.1 C154T Polymorphism in Men with and without Prostate Cancer and Studies of Its Effect on Protein Function

Edward P. Gelmann, David J. Steadman, Jing Ma, Natalie Ahronovitz, H. James Voeller, Sheridan Swope, Mohammed Abbaszadegan, Kevin M. Brown, Kate Strand, Richard B. Hayes, and Meir J. Stampfer
Cancer Res 2002 62: 2654-2659. [Abstract] [Full Text] [PDF]  

Tumor Biology:

Tenascin-C Promotes Microvascular Cell Migration and Phosphorylation of Focal Adhesion Kinase

David Zagzag, Bronya Shiff, George I. Jallo, M. Alba Greco, Cy Blanco, Henry Cohen, Juliette Hukin, Jeffrey C. Allen, and David R. Friedlander
Cancer Res 2002 62: 2660-2668. [Abstract] [Full Text] [PDF]  

Increased Src Activity Disrupts Cadherin/Catenin-mediated Homotypic Adhesion in Human Colon Cancer and Transformed Rodent Cells

Rosalyn B. Irby and Timothy J. Yeatman
Cancer Res 2002 62: 2669-2674. [Abstract] [Full Text] [PDF]  

Multivariate Analysis of Chromosomal Imbalances in Breast Cancer Delineates Cytogenetic Pathways and Reveals Complex Relationships among Imbalances

Mattias Höglund, David Gisselsson, Gunnar B. Hansen, Torbjörn Säll, and Felix Mitelman
Cancer Res 2002 62: 2675-2680. [Abstract] [Full Text] [PDF]  

Comparison of Accumulated Allele Loss between Primary Tumor and Lymph Node Metastasis in Stage II Non-small Cell Lung Carcinoma: Implications for the Timing of Lymph Node Metastasis and Prognostic Value

Eizaburo Sasatomi, Sydney D. Finkelstein, Jeffrey D. Woods, Anke Bakker, Patricia A. Swalsky, James D. Luketich, Hiran C. Fernando, and Samuel A. Yousem
Cancer Res 2002 62: 2681-2689. [Abstract] [Full Text] [PDF]  

Partial Depletion of Intracellular ATP Mediates the Stress-Survival Function of the PCPH Oncoprotein

Juán A. Recio, J. Guillermo Páez, Sean Sanders, Toshiaki Kawakami, and Vicente Notario
Cancer Res 2002 62: 2690-2694. [Abstract] [Full Text] [PDF]  

DD3^PCA3, a Very Sensitive and Specific Marker to Detect Prostate Tumors

Jacques B. de Kok, Gerald W. Verhaegh, Rian W. Roelofs, Daphne Hessels, Lambertus A. Kiemeney, Tilly W. Aalders, Dorine W. Swinkels, and Jack A. Schalken
Cancer Res 2002 62: 2695-2698. [Abstract] [Full Text] [PDF]  

Focal Adhesion Kinase Enhances Signaling through the Shc/Extracellular Signal-regulated Kinase Pathway in Anaplastic Astrocytoma Tumor Biopsy Samples

Timothy P. Hecker, J. Robert Grammer, G. Yancey Gillespie, Jerry Stewart, Jr., and Candece L. Gladson
Cancer Res 2002 62: 2699-2707. [Abstract] [Full Text] [PDF]  

Alendronate Inhibits Invasion of PC-3 Prostate Cancer Cells by Affecting the Mevalonate Pathway

Sanna S. Virtanen, H. Kalervo Väänänen, Pirkko L. Härkönen, and Päivi T. Lakkakorpi
Cancer Res 2002 62: 2708-2714. [Abstract] [Full Text] [PDF]  

Expression of Several Genes in the Human Chromosome 3p21.3 Homozygous Deletion Region by an Adenovirus Vector Results in Tumor Suppressor Activities in Vitro and in Vivo

Lin Ji, Masahiko Nishizaki, Boning Gao, David Burbee, Masashi Kondo, Craig Kamibayashi, Kai Xu, Nancy Yen, E. Neely Atkinson, Bingliang Fang, Michael I. Lerman, Jack A. Roth, and John D. Minna
Cancer Res 2002 62: 2715-2720. [Abstract] [Full Text] [PDF]  

Mechanisms Controlling Cell Cycle Arrest and Induction of Apoptosis after 12-Lipoxygenase Inhibition in Prostate Cancer Cells

Graham. P. Pidgeon, Mustapha Kandouz, Anthony Meram, and Kenneth V. Honn
Cancer Res 2002 62: 2721-2727. [Abstract] [Full Text] [PDF]  

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