Perspectives in Cancer Research:

Csaba Kari, Tung O. Chan, Marlene Rocha de Quadros, and Ulrich Rodeck

Targeting the Epidermal Growth Factor Receptor in Cancer: Apoptosis Takes Center Stage
Cancer Res 2003 63: 1-5. [Abstract] [Full Text] [PDF]  

Advances in Brief:

John I. Risinger, G. Larry Maxwell, G. V. R. Chandramouli, Amir Jazaeri, Olga Aprelikova, Tricia Patterson, Andrew Berchuck, and J. Carl Barrett

Microarray Analysis Reveals Distinct Gene Expression Profiles among Different Histologic Types of Endometrial Cancer
Cancer Res 2003 63: 6-11. [Abstract] [Full Text] [PDF]  

I. Jolanda M. de Vries, Daniëlle J. E. B. Krooshoop, Nicole M. Scharenborg, W. Joost Lesterhuis, J. Heleen S. Diepstra, Goos N. P. van Muijen, Simon P. Strijk, Theo J. Ruers, Otto C. Boerman, Wim J. G. Oyen, Gosse J. Adema, Cornelis J. A. Punt, and Carl G. Figdor

Effective Migration of Antigen-pulsed Dendritic Cells to Lymph Nodes in Melanoma Patients Is Determined by Their Maturation State
Cancer Res 2003 63: 12-17. [Abstract] [Full Text] [PDF] Supplementary Data  

Masaharu Akiyama, Teru Hideshima, Toshiaki Hayashi, Yu-Tzu Tai, Constantine S. Mitsiades, Nicholas Mitsiades, Dharminder Chauhan, Paul Richardson, Nikhil C. Munshi, and Kenneth C. Anderson

Nuclear Factor-B p65 Mediates Tumor Necrosis Factor -induced Nuclear Translocation of Telomerase Reverse Transcriptase Protein
Cancer Res 2003 63: 18-21. [Abstract] [Full Text] [PDF]  

Jae Wan Lee, Steven M. Yannone, David J. Chen, and Lawrence F. Povirk

Requirement for XRCC4 and DNA Ligase IV in Alignment-based Gap Filling for Nonhomologous DNA End Joining in Vitro
Cancer Res 2003 63: 22-24. [Abstract] [Full Text] [PDF]  

Iris Lavon, Eli Pikarsky, Elena Gutkovich, Iris Goldberg, Jair Bar, Moshe Oren, and Yinon Ben-Neriah

Nuclear Factor-B Protects the Liver against Genotoxic Stress and Functions Independently of p53
Cancer Res 2003 63: 25-30. [Abstract] [Full Text] [PDF]  

Ethan A. Kohn, Carolyn J. Yoo, and Alan Eastman

The Protein Kinase C Inhibitor Gö6976 Is a Potent Inhibitor of DNA Damage-induced S and G₂ Cell Cycle Checkpoints
Cancer Res 2003 63: 31-35. [Abstract] [Full Text] [PDF]  

John C. Byrd, Lisa Smith, Marcy L. Hackbarth, Ian W. Flinn, Donn Young, John H. Proffitt, and Nyla A. Heerema

Interphase Cytogenetic Abnormalities in Chronic Lymphocytic Leukemia May Predict Response to Rituximab
Cancer Res 2003 63: 36-38. [Abstract] [Full Text] [PDF]  

Biochemistry and Biophysics:

Oleg Tikhomirov and Graham Carpenter

Identification of ErbB-2 Kinase Domain Motifs Required for Geldanamycin-induced Degradation
Cancer Res 2003 63: 39-43. [Abstract] [Full Text] [PDF]  

Epidemiology and Prevention:

Sara Frias, Paul Van Hummelen, Marvin L. Meistrich, Xiu R. Lowe, Fredrick B. Hagemeister, Michael D. Shelby, Jack B. Bishop, and Andrew J. Wyrobek

NOVP Chemotherapy for Hodgkin’s Disease Transiently Induces Sperm Aneuploidies Associated with the Major Clinical Aneuploidy Syndromes Involving Chromosomes X, Y, 18, and 21
Cancer Res 2003 63: 44-51. [Abstract] [Full Text] [PDF]  

Carcinogenesis:

Yan Dong, Haitao Zhang, Lesleyann Hawthorn, Howard E. Ganther, and Clement Ip

Delineation of the Molecular Basis for Selenium-induced Growth Arrest in Human Prostate Cancer Cells by Oligonucleotide Array
Cancer Res 2003 63: 52-59. [Abstract] [Full Text] [PDF]  

Clinical Investigations:

Tohru Kobayashi, Motoko Yamaguchi, Seungchan Kim, Jun Morikawa, Shoko Ogawa, Satoshi Ueno, Edward Suh, Edward Dougherty, Ilya Shmulevich, Hiroshi Shiku, and Wei Zhang

Microarray Reveals Differences in Both Tumors and Vascular Specific Gene Expression in de Novo CD5⁺ and CD5^- Diffuse Large B-Cell Lymphomas
Cancer Res 2003 63: 60-66. [Abstract] [Full Text] [PDF]  

Endocrinology:

Subhas Chakrabarty, Venugopal Radjendirane, Henry Appelman, and James Varani

Extracellular Calcium and Calcium Sensing Receptor Function in Human Colon Carcinomas: Promotion of E-Cadherin Expression and Suppression of ß-Catenin/TCF Activation
Cancer Res 2003 63: 67-71. [Abstract] [Full Text] [PDF]  

Experimental Therapeutics:

Melissa S. McGrath, Michael G. Rosenblum, Mark R. Philips, and David A. Scheinberg

Immunotoxin Resistance in Multidrug Resistant Cells
Cancer Res 2003 63: 72-79. [Abstract] [Full Text] [PDF]  

Fang-Xian Sun, Akiko Tohgo, Michael Bouvet, Shigeo Yagi, Rounak Nassirpour, Abdoul R. Moossa, and Robert M. Hoffman

Efficacy of Camptothecin Analog DX-8951f (Exatecan Mesylate) on Human Pancreatic Cancer in an Orthotopic Metastatic Model
Cancer Res 2003 63: 80-85. [Abstract] [Full Text] [PDF]  

Fabio Pastorino, Chiara Brignole, Danilo Marimpietri, Puja Sapra, Elaine H. Moase, Theresa M. Allen, and Mirco Ponzoni

Doxorubicin-loaded Fab' Fragments of Anti-disialoganglioside Immunoliposomes Selectively Inhibit the Growth and Dissemination of Human Neuroblastoma in Nude Mice
Cancer Res 2003 63: 86-92. [Abstract] [Full Text] [PDF]  

Sylvie Wittmann, Purva Bali, Sreenivasa Donapaty, Ramadevi Nimmanapalli, Fei Guo, Hirohito Yamaguchi, Mei Huang, Richard Jove, Hong Gang Wang, and Kapil Bhalla

Flavopiridol Down-Regulates Antiapoptotic Proteins and Sensitizes Human Breast Cancer Cells to Epothilone B-induced Apoptosis
Cancer Res 2003 63: 93-99. [Abstract] [Full Text] [PDF]  

Eugene Y. Krynetski, Natalia F. Krynetskaia, Marco E. Bianchi, and William E. Evans

A Nuclear Protein Complex Containing High Mobility Group Proteins B1 and B2, Heat Shock Cognate Protein 70, ERp60, and Glyceraldehyde-3-Phosphate Dehydrogenase Is Involved in the Cytotoxic Response to DNA Modified by Incorporation of Anticancer Nucleoside Analogues
Cancer Res 2003 63: 100-106. [Abstract] [Full Text] [PDF]  

Eiji Kikuchi, Yutaka Horiguchi, Jun Nakashima, Kenji Kuroda, Mototsugu Oya, Takashi Ohigashi, Nozomu Takahashi, Yutaka Shima, Kazuo Umezawa, and Masaru Murai

Suppression of Hormone-refractory Prostate Cancer by a Novel Nuclear Factor B Inhibitor in Nude Mice
Cancer Res 2003 63: 107-110. [Abstract] [Full Text] [PDF]  

Rhona Stein, Serengulam V. Govindan, M. Jules Mattes, Susan Chen, Linda Reed, Guy Newsome, Bill J. McBride, Gary L. Griffiths, Hans J. Hansen, and David M. Goldenberg

Improved Iodine Radiolabels for Monoclonal Antibody Therapy
Cancer Res 2003 63: 111-118. [Abstract] [Full Text] [PDF]  

Molecular Biology and Genetics:

Eigo Suyama, Hiroaki Kawasaki, Tatsuhiko Kasaoka, and Kazunari Taira

Identification of Genes Responsible for Cell Migration by a Library of Randomized Ribozymes
Cancer Res 2003 63: 119-124. [Abstract] [Full Text] [PDF]  

Nikos Tripodis and Peter Demant

Genetic Analysis of Three-dimensional Shape of Mouse Lung Tumors Reveals Eight Lung Tumor Shape-Determining (Ltsd) Loci That Are Associated with Tumor Heterogeneity and Symmetry
Cancer Res 2003 63: 125-131. [Abstract] [Full Text] [PDF]  

Chandan Kumar-Sinha, Kathleen Woods Ignatoski, Marc E. Lippman, Stephen P. Ethier, and Arul M. Chinnaiyan

Transcriptome Analysis of HER2 Reveals a Molecular Connection to Fatty Acid Synthesis
Cancer Res 2003 63: 132-139. [Abstract] [Full Text] [PDF]  

Roberto Hernan, Rami Fasheh, Christopher Calabrese, Adrian J. Frank, Kirsteen H. Maclean, David Allard, Roger Barraclough, and Richard J. Gilbertson

ERBB2 Up-Regulates S100A4 and Several other Prometastatic Genes in Medulloblastoma
Cancer Res 2003 63: 140-148. [Abstract] [Full Text] [PDF]  

Takahito Hara, Jun-ichi Miyazaki, Hideo Araki, Masuo Yamaoka, Naoyuki Kanzaki, Masami Kusaka, and Masaomi Miyamoto

Novel Mutations of Androgen Receptor: A Possible Mechanism of Bicalutamide Withdrawal Syndrome
Cancer Res 2003 63: 149-153. [Abstract] [Full Text] [PDF]  

Shantie Jagmohan-Changur, Taija Poikonen, Susa Vilkki, Virpi Launonen, Friedrik Wikman, Torben F. Orntoft, Pål Møller, Hans Vasen, Carli Tops, Richard D. Kolodner, Jukka-Pekka Mecklin, Heikki Järvinen, Stephen Bevan, Richard S. Houlston, Lauri A. Aaltonen, Riccardo Fodde, Juul Wijnen, and Auli Karhu

EXO1 Variants Occur Commonly in Normal Population: Evidence against a Role in Hereditary Nonpolyposis Colorectal Cancer
Cancer Res 2003 63: 154-158. [Abstract] [Full Text] [PDF]  

Daniel Hernandez-Saavedra and Joe M. McCord

Paradoxical Effects of Thiol Reagents on Jurkat Cells and a New Thiol-sensitive Mutant Form of Human Mitochondrial Superoxide Dismutase
Cancer Res 2003 63: 159-163. [Abstract] [Full Text] [PDF]  

Laurent Gros, Charlotte Delaporte, Stéphane Frey, Julien Decesse, Bruno Robert de Saint-Vincent, Laurent Cavarec, Anne Dubart, Andrei V. Gudkov, and Alain Jacquemin-Sablon

Identification of New Drug Sensitivity Genes Using Genetic Suppressor Elements: Protein Arginine N-Methyltransferase Mediates Cell Sensitivity to DNA-damaging Agents
Cancer Res 2003 63: 164-171. [Abstract] [Full Text] [PDF]  

Sonia L. Planey, Marc T. Abrams, Noreen M. Robertson, and Gerald Litwack

Role of Apical Caspases and Glucocorticoid-regulated Genes in Glucocorticoid-induced Apoptosis of Pre-B Leukemic Cells
Cancer Res 2003 63: 172-178. [Abstract] [Full Text] [PDF]  

Tumor Biology:

Jin Cheng, Hongying Huang, Joanne Pak, Ellen Shapiro, Tung-Tien Sun, Carlos Cordon-Cardo, Frederic M. Waldman, and Xue-Ru Wu

Allelic Loss of p53 Gene Is Associated with Genesis and Maintenance, but not Invasion, of Mouse Carcinoma in Situ of the Bladder
Cancer Res 2003 63: 179-185. [Abstract] [Full Text] [PDF]  

Louise Y. Y. Fong, Hideshi Ishii, Vu T. Nguyen, Andrea Vecchione, John L. Farber, Carlo M. Croce, and Kay Huebner

p53 Deficiency Accelerates Induction and Progression of Esophageal and Forestomach Tumors in Zinc-deficient Mice
Cancer Res 2003 63: 186-195. [Abstract] [Full Text] [PDF]  

M. Jane Arboleda, John F. Lyons, Fairooz F. Kabbinavar, Mark R. Bray, Bryan E. Snow, Raul Ayala, Mordechai Danino, Beth Y. Karlan, and Dennis J. Slamon

Overexpression of AKT2/Protein Kinase Bß Leads to Up-Regulation of ß1 Integrins, Increased Invasion, and Metastasis of Human Breast and Ovarian Cancer Cells
Cancer Res 2003 63: 196-206. [Abstract] [Full Text] [PDF]  

Naoko Seki, Yoshihiro Hayakawa, Alan D. Brooks, John Wine, Robert H. Wiltrout, Hideo Yagita, Jane E. Tanner, Mark J. Smyth, and Thomas J. Sayers

Tumor Necrosis Factor-related Apoptosis-inducing Ligand-mediated Apoptosis Is an Important Endogenous Mechanism for Resistance to Liver Metastases in Murine Renal Cancer
Cancer Res 2003 63: 207-213. [Abstract] [Full Text] [PDF]  

Pingfang Song, Harmanjatinder S. Sekhon, Yibing Jia, Jennifer A. Keller, Jan Krzysztof Blusztajn, Gregory P. Mark, and Eliot R. Spindel

Acetylcholine Is Synthesized by and Acts as an Autocrine Growth Factor for Small Cell Lung Carcinoma
Cancer Res 2003 63: 214-221. [Abstract] [Full Text] [PDF]  

Masahiko Katayama, Noriko Sanzen, Akihiro Funakoshi, and Kiyotoshi Sekiguchi

Laminin 2-Chain Fragment in the Circulation: A Prognostic Indicator of Epithelial Tumor Invasion
Cancer Res 2003 63: 222-229. [Abstract] [Full Text] [PDF]  

Nathan R. Wall, Daniel S. O’Connor, Janet Plescia, Yves Pommier, and Dario C. Altieri

Suppression of Survivin Phosphorylation on Thr³⁴ by Flavopiridol Enhances Tumor Cell Apoptosis
Cancer Res 2003 63: 230-235. [Abstract] [Full Text] [PDF]  

Nabendu Pore, Shuang Liu, Daphne A. Haas-Kogan, Donald M. O’Rourke, and Amit Maity

PTEN Mutation and Epidermal Growth Factor Receptor Activation Regulate Vascular Endothelial Growth Factor (VEGF) mRNA Expression in Human Glioblastoma Cells by Transactivating the Proximal VEGF Promoter
Cancer Res 2003 63: 236-241. [Abstract] [Full Text] [PDF]  

Soichi Tsutsumi, Victor Hogan, Ivan R. Nabi, and Avraham Raz

Overexpression of the Autocrine Motility Factor/Phosphoglucose Isomerase Induces Transformation and Survival of NIH-3T3 Fibroblasts
Cancer Res 2003 63: 242-249. [Abstract] [Full Text] [PDF]  

Hiromasa Tsuiki, Mehdi Tnani, Isamu Okamoto, Lawrence C. Kenyon, David R. Emlet, Marina Holgado-Madruga, Irene S. Lanham, Christopher J. Joynes, Kim T. Vo, and Albert J. Wong

Constitutively Active Forms of c-Jun NH₂-terminal Kinase Are Expressed in Primary Glial Tumors
Cancer Res 2003 63: 250-255. [Abstract] [Full Text] [PDF]  

Virology:

Jean Lu, Huey-Huey Chua, Shao-Yin Chen, Jen-Yang Chen, and Ching-Hwa Tsai

Regulation of Matrix Metalloproteinase-1 by Epstein-Barr Virus Proteins
Cancer Res 2003 63: 256-262. [Abstract] [Full Text] [PDF]  

Meeting Report:

Frank Stenner-Liewen and John C. Reed

Apoptosis and Cancer: Basic Mechanisms and Therapeutic Opportunities in the Postgenomic Era
Cancer Res 2003 63: 263-268. [Full Text] [PDF]  

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