Advances in Brief:

Kinnimulki Vijayachandra, Jessica Lee, and Adam B. Glick

Smad3 Regulates Senescence and Malignant Conversion in a Mouse Multistage Skin Carcinogenesis Model
Cancer Res 2003 63: 3447-3452. [Abstract] [Full Text] [PDF]  

Tae-Wook Chung, Young-Choon Lee, Jeong-Heon Ko, and Cheorl-Ho Kim

Hepatitis B Virus X Protein Modulates the Expression of PTEN by Inhibiting the Function of p53, a Transcriptional Activator in Liver Cells
Cancer Res 2003 63: 3453-3458. [Abstract] [Full Text] [PDF]  

Andrea Flesken-Nikitin, Kyung-Chul Choi, Jessica P. Eng, Elena N. Shmidt, and Alexander Yu. Nikitin

Induction of Carcinogenesis by Concurrent Inactivation of p53 and Rb1 in the Mouse Ovarian Surface Epithelium
Cancer Res 2003 63: 3459-3463. [Abstract] [Full Text] [PDF]  

Enrique C. Torchia, Sobha Jaishankar, and Suzanne J. Baker

Ewing Tumor Fusion Proteins Block the Differentiation of Pluripotent Marrow Stromal Cells
Cancer Res 2003 63: 3464-3468. [Abstract] [Full Text] [PDF]  

Saverio Bettuzzi, Maurizio Scaltriti, Andrea Caporali, Maurizio Brausi, Domenico D’Arca, Serenella Astancolle, Pierpaola Davalli, and Arnaldo Corti

Successful Prediction of Prostate Cancer Recurrence by Gene Profiling in Combination with Clinical Data: A 5-year Follow-up Study
Cancer Res 2003 63: 3469-3472. [Abstract] [Full Text] [PDF]  

Song-Ping Li, Melissa R. Junttila, Jiahuai Han, Veli-Matti Kähäri, and Jukka Westermarck

p38 Mitogen-activated Protein Kinase Pathway Suppresses Cell Survival by Inducing Dephosphorylation of Mitogen-activated Protein/Extracellular Signal-regulated Kinase Kinase1,2
Cancer Res 2003 63: 3473-3477. [Abstract] [Full Text] [PDF]  

Steven C. Fausch, Diane M. Da Silva, and W. Martin Kast

Differential Uptake and Cross-Presentation of Human Papillomavirus Virus-like Particles by Dendritic Cells and Langerhans Cells
Cancer Res 2003 63: 3478-3482. [Abstract] [Full Text] [PDF]  

Martina Willhauck, Carmen Scheibenbogen, Michael Pawlita, Thomas Möhler, Eckhard Thiel, and Ulrich Keilholz

Restricted T-Cell Receptor Repertoire in Melanoma Metastases Regressing after Cytokine Therapy
Cancer Res 2003 63: 3483-3485. [Abstract] [Full Text] [PDF]  

David C. Miller, S. Lilly Zheng, Rodney L. Dunn, Aruna V. Sarma, James E. Montie, Ethan M. Lange, Deborah A. Meyers, Jianfeng Xu, and Kathleen A. Cooney

Germ-line Mutations of the Macrophage Scavenger Receptor 1 Gene: Association with Prostate Cancer Risk in African-American Men
Cancer Res 2003 63: 3486-3489. [Abstract] [Full Text] [PDF]  

Marco Folini, Kristian Berg, Enrico Millo, Raffaella Villa, Lina Prasmickaite, Maria Grazia Daidone, Umberto Benatti, and Nadia Zaffaroni

Photochemical Internalization of a Peptide Nucleic Acid Targeting the Catalytic Subunit of Human Telomerase
Cancer Res 2003 63: 3490-3494. [Abstract] [Full Text] [PDF]  

Carcinogenesis:

Lyuba Levine, Joseph A. Lucci, III, Barbara Pazdrak, Ji-Zhong Cheng, Yan-Shi Guo, Courtney M. Townsend, Jr., and Mark R. Hellmich

Bombesin Stimulates Nuclear Factor B Activation and Expression of Proangiogenic Factors in Prostate Cancer Cells
Cancer Res 2003 63: 3495-3502. [Abstract] [Full Text] [PDF]  

Faith M. Strickland, Sen Pathak, Asha S. Multani, Ronald P. Pelley, and Cherrie K. Donawho

Molecular Characterization of New Melanoma Cell Lines from C3H Mice Induced by Ethanol plus Ultraviolet Radiation
Cancer Res 2003 63: 3503-3510. [Abstract] [Full Text] [PDF]  

Takeshi Tomonaga, Kazuyuki Matsushita, Seiko Yamaguchi, Tatsuya Oohashi, Hideaki Shimada, Takenori Ochiai, Kinya Yoda, and Fumio Nomura

Overexpression and Mistargeting of Centromere Protein-A in Human Primary Colorectal Cancer
Cancer Res 2003 63: 3511-3516. [Abstract] [Full Text] [PDF]  

Sharad Khare, Sonia Cerda, Ramesh K. Wali, Friederike C. von Lintig, Maria Tretiakova, Loren Joseph, Debra Stoiber, Greg Cohen, Kiran Nimmagadda, John Hart, Michael D. Sitrin, Gerry R. Boss, and Marc Bissonnette

Ursodeoxycholic Acid Inhibits Ras Mutations, Wild-type Ras Activation, and Cyclooxygenase-2 Expression in Colon Cancer
Cancer Res 2003 63: 3517-3523. [Abstract] [Full Text] [PDF]  

Konstantin Salnikow, Todd Davidson, Qunwei Zhang, Lung Chi Chen, Weichen Su, and Max Costa

The Involvement of Hypoxia-inducible Transcription Factor-1-dependent Pathway in Nickel Carcinogenesis
Cancer Res 2003 63: 3524-3530. [Abstract] [Full Text] [PDF]  

Sharon Y. James, Feng Lin, Siva Kumar Kolluri, Marcia I. Dawson, and Xiao-kun Zhang

Regulation of Retinoic Acid Receptor ß Expression by Peroxisome Proliferator-activated Receptor Ligands in Cancer Cells
Cancer Res 2003 63: 3531-3538. [Abstract] [Full Text] [PDF]  

Maria E. Ramos-Nino, Luca Scapoli, Marcella Martinelli, Susan Land, and Brooke T. Mossman

Microarray Analysis and RNA Silencing Link fra-1 to cd44 and c-met Expression in Mesothelioma
Cancer Res 2003 63: 3539-3545. [Abstract] [Full Text] [PDF]  

Endocrinology:

Yoshiyuki Kinoshita and Shiuan Chen

Induction of Aromatase (CYP19) Expression in Breast Cancer Cells through a Nongenomic Action of Estrogen Receptor
Cancer Res 2003 63: 3546-3555. [Abstract] [Full Text] [PDF]  

Epidemiology and Prevention:

Adam Wax, Changhuei Yang, Markus G. Müller, Ronald Nines, Charles W. Boone, Vernon E. Steele, Gary D. Stoner, Ramachandra R. Dasari, and Michael S. Feld

In Situ Detection of Neoplastic Transformation and Chemopreventive Effects in Rat Esophagus Epithelium Using Angle-resolved Low-coherence Interferometry
Cancer Res 2003 63: 3556-3559. [Abstract] [Full Text] [PDF]  

Stefano Landi, Victor Moreno, Lydie Gioia-Patricola, Elisabeth Guino, Matilde Navarro, Javier de Oca, Gabriel Capella, and Federico Canzian

Association of Common Polymorphisms in Inflammatory Genes Interleukin (IL)6, IL8, Tumor Necrosis Factor , NFKB1, and Peroxisome Proliferator-activated Receptor with Colorectal Cancer ,
Cancer Res 2003 63: 3560-3566. [Abstract] [Full Text] [PDF]  

Experimental Therapeutics:

Jun Fang, Tomohiro Sawa, Takaaki Akaike, Teruo Akuta, Sanjeeb K. Sahoo, Greish Khaled, Akinobu Hamada, and Hiroshi Maeda

In Vivo Antitumor Activity of Pegylated Zinc Protoporphyrin: Targeted Inhibition of Heme Oxygenase in Solid Tumor
Cancer Res 2003 63: 3567-3574. [Abstract] [Full Text] [PDF]  

Satoshi Kiyama, Kevin Morrison, Tobias Zellweger, Majid Akbari, Michael Cox, Duan Yu, Hideaki Miyake, and Martin E. Gleave

Castration-Induced Increases in Insulin-Like Growth Factor-Binding Protein 2 Promotes Proliferation of Androgen-independent Human Prostate LNCaP Tumors
Cancer Res 2003 63: 3575-3584. [Abstract] [Full Text] [PDF]  

Jing Dong Su, Lindsey D. Mayo, David B. Donner, and Donald L. Durden

PTEN and Phosphatidylinositol 3'-Kinase Inhibitors Up-Regulate p53 and Block Tumor-induced Angiogenesis: Evidence for an Effect on the Tumor and Endothelial Compartment
Cancer Res 2003 63: 3585-3592. [Abstract] [Full Text] [PDF]  

Kaiyi Li, Shiaw-Yih Lin, F. Charles Brunicardi, and Philip Seu

Use of RNA Interference to Target Cyclin E-overexpressing Hepatocellular Carcinoma
Cancer Res 2003 63: 3593-3597. [Abstract] [Full Text] [PDF]  

Michael T. Beck, Nian Y. Chen, Karl J. Franek, and Wen Y. Chen

Prolactin Antagonist-endostatin Fusion Protein as a Targeted Dual-Functional Therapeutic Agent for Breast Cancer
Cancer Res 2003 63: 3598-3604. [Abstract] [Full Text] [PDF]  

Oliver Ebert, Katsunori Shinozaki, Tian-Gui Huang, Mikko J. Savontaus, Adolfo García-Sastre, and Savio L. C. Woo

Oncolytic Vesicular Stomatitis Virus for Treatment of Orthotopic Hepatocellular Carcinoma in Immune-competent Rats
Cancer Res 2003 63: 3605-3611. [Abstract] [Full Text] [PDF]  

Davinder S. Theti, Vassilios Bavetsias, Lorraine A. Skelton, Jenny Titley, David Gibbs, Gerrit Jansen, and Ann L. Jackman

Selective Delivery of CB300638, a Cyclopenta[g]quinazoline-based Thymidylate Synthase Inhibitor into Human Tumor Cell Lines Overexpressing the -Isoform of the Folate Receptor
Cancer Res 2003 63: 3612-3618. [Abstract] [Full Text] [PDF]  

Ying Chen, Kersti Alm, Slavoljub Vujcic, Debora L. Kramer, Kristin Kee, Paula Diegelman, and Carl W. Porter

The Role of Mitogen-activated Protein Kinase Activation in Determining Cellular Outcomes in Polyamine Analogue-treated Human Melanoma Cells
Cancer Res 2003 63: 3619-3625. [Abstract] [Full Text] [PDF]  

Rita Nahta, Sally Trent, Chuanwei Yang, and Emmett V. Schmidt

Epidermal Growth Factor Receptor Expression Is a Candidate Target of the Synergistic Combination of Trastuzumab and Flavopiridol in Breast Cancer
Cancer Res 2003 63: 3626-3631. [Abstract] [Full Text] [PDF]  

Wenbiao Liu, Niels Reinmuth, Oliver Stoeltzing, Alexander A. Parikh, Carmen Tellez, Simon Williams, Young D. Jung, Fan Fan, Akihiko Takeda, Morihisa Akagi, Menashe Bar-Eli, Gary E. Gallick, and Lee M. Ellis

Cyclooxygenase-2 Is Up-Regulated by Interleukin-1ß in Human Colorectal Cancer Cells via Multiple Signaling Pathways
Cancer Res 2003 63: 3632-3636. [Abstract] [Full Text] [PDF]  

Roberto R. Rosato, Jorge A. Almenara, and Steven Grant

The Histone Deacetylase Inhibitor MS-275 Promotes Differentiation or Apoptosis in Human Leukemia Cells through a Process Regulated by Generation of Reactive Oxygen Species and Induction of p21^{CIP1/WAF1 1}
Cancer Res 2003 63: 3637-3645. [Abstract] [Full Text] [PDF]  

Yinghui Huang, Traci Tyler, Neshat Saadatmandi, Casey Lee, Per Borgstrom, and Ruth A. Gjerset

Enhanced Tumor Suppression by a p14ARF/p53 Bicistronic Adenovirus through Increased p53 Protein Translation and Stability
Cancer Res 2003 63: 3646-3653. [Abstract] [Full Text] [PDF]  

Michael Weiss, Simone Hettmer, Paul Smith, and Stephan Ladisch

Inhibition of Melanoma Tumor Growth by a Novel Inhibitor of Glucosylceramide Synthase
Cancer Res 2003 63: 3654-3658. [Abstract] [Full Text] [PDF]  

Yoshio Honma, Yuki Ishii, Yuri Yamamoto-Yamaguchi, Takeshi Sassa, and Ken-ichi Asahi

Cotylenin A, a Differentiation-inducing Agent, and IFN- Cooperatively Induce Apoptosis and Have an Antitumor Effect on Human Non-Small Cell Lung Carcinoma Cells in Nude Mice
Cancer Res 2003 63: 3659-3666. [Abstract] [Full Text] [PDF]  

James R. Bading, Paul B. Yoo, John D. Fissekis, Mian M. Alauddin, David Z. D’Argenio, and Peter S. Conti

Kinetic Modeling of 5-Fluorouracil Anabolism in Colorectal Adenocarcinoma: A Positron Emission Tomography Study in Rats
Cancer Res 2003 63: 3667-3674. [Abstract] [Full Text] [PDF]  

Immunology:

Kazuaki Chikamatsu, Andreas Albers, Joanna Stanson, William W. Kwok, Ettore Appella, Theresa L. Whiteside, and Albert B. DeLeo

p53_110–124-specific Human CD4⁺ T-helper Cells Enhance in Vitro Generation and Antitumor Function of Tumor-reactive CD8⁺ T Cells
Cancer Res 2003 63: 3675-3681. [Abstract] [Full Text] [PDF]  

Virginie Dangles-Marie, Sophie Richon, Mohamed El Behi, Hamid Echchakir, Guillaume Dorothée, Jérôme Thiery, Pierre Validire, Isabelle Vergnon, Jeanne Menez, Moncef Ladjimi, Salem Chouaib, Dominique Bellet, and Fathia Mami-Chouaib

A Three-Dimensional Tumor Cell Defect in Activating Autologous CTLs Is Associated with Inefficient Antigen Presentation Correlated with Heat Shock Protein-70 Down-Regulation
Cancer Res 2003 63: 3682-3687. [Abstract] [Full Text] [PDF]  

Annalisa Camporeale, Andrea Boni, Giandomenica Iezzi, Elena Degl’Innocenti, Matteo Grioni, Anna Mondino, and Matteo Bellone

Critical Impact of the Kinetics of Dendritic Cells Activation on the in Vivo Induction of Tumor-specific T Lymphocytes
Cancer Res 2003 63: 3688-3694. [Abstract] [Full Text] [PDF]  

Ingegerd Hellström, John Raycraft, Martha Hayden-Ledbetter, Jeffrey A. Ledbetter, Michèl Schummer, Martin McIntosh, Charles Drescher, Nicole Urban, and Karl Erik Hellström

The HE4 (WFDC2) Protein Is a Biomarker for Ovarian Carcinoma
Cancer Res 2003 63: 3695-3700. [Abstract] [Full Text] [PDF]  

Molecular Biology and Genetics:

Elizabeth A. Barnes, Lisa A. Porter, Jean-Luc Lenormand, Ryan W. Dellinger, and Daniel J. Donoghue

Human Spy1 Promotes Survival of Mammalian Cells following DNA Damage
Cancer Res 2003 63: 3701-3707. [Abstract] [Full Text] [PDF]  

Masayoshi Inoue, Petr Starostik, Andreas Zettl, Philipp Ströbel, Stephan Schwarz, Francesco Scaravilli, Kristin Henry, Nick Willcox, Hans-Konrad Müller-Hermelink, and Alexander Marx

Correlating Genetic Aberrations with World Health Organization-defined Histology and Stage across the Spectrum of Thymomas
Cancer Res 2003 63: 3708-3715. [Abstract] [Full Text] [PDF]  

Esther P. Black, Erich Huang, Holly Dressman, Rachel Rempel, Nina Laakso, Sylvia L. Asa, Seiichi Ishida, Mike West, and Joseph R. Nevins

Distinct Gene Expression Phenotypes of Cells Lacking Rb and Rb Family Members
Cancer Res 2003 63: 3716-3723. [Abstract] [Full Text] [PDF] Supplementary Data  

Tamotsu Kuroki, Francesco Trapasso, Sai Yendamuri, Ayumi Matsuyama, Hansjuerg Alder, Masaki Mori, and Carlo M. Croce

Allele Loss and Promoter Hypermethylation of VHL, RAR-ß, RASSF1A, and FHIT Tumor Suppressor Genes on Chromosome 3p in Esophageal Squamous Cell Carcinoma
Cancer Res 2003 63: 3724-3728. [Abstract] [Full Text] [PDF]  

Yoichiro Yoshida, Hiroto Izumi, Takayuki Torigoe, Hiroshi Ishiguchi, Hideaki Itoh, Dongchon Kang, and Kimitoshi Kohno

p53 Physically Interacts with Mitochondrial Transcription Factor A and Differentially Regulates Binding to Damaged DNA
Cancer Res 2003 63: 3729-3734. [Abstract] [Full Text] [PDF]  

Norihiro Sato, Noriyoshi Fukushima, Anirban Maitra, Hiroyuki Matsubayashi, Charles J. Yeo, John L. Cameron, Ralph H. Hruban, and Michael Goggins

Discovery of Novel Targets for Aberrant Methylation in Pancreatic Carcinoma Using High-Throughput Microarrays
Cancer Res 2003 63: 3735-3742. [Abstract] [Full Text] [PDF]  

Duk-Hwan Kim, Jin Seuk Kim, Yong-Ick Ji, Young Mog Shim, Hojoong Kim, Joungho Han, and Joobae Park

Hypermethylation of RASSF1A Promoter Is Associated with the Age at Starting Smoking and a Poor Prognosis in Primary Non-Small Cell Lung Cancer
Cancer Res 2003 63: 3743-3746. [Abstract] [Full Text] [PDF]  

Toshihiko Ezaki, Mamoru Watanabe, Nagamu Inoue, Takanori Kanai, Haruhiko Ogata, Yasushi Iwao, Hiromasa Ishii, and Toshifumi Hibi

A Specific Genetic Alteration on Chromosome 6 in Ulcerative Colitis-associated Colorectal Cancers
Cancer Res 2003 63: 3747-3749. [Abstract] [Full Text] [PDF]  

Tumor Biology:

Maria Laura Falchetti, Francesco Pierconti, Patrizia Casalbore, Nicola Maggiano, Andrea Levi, Luigi Maria Larocca, and Roberto Pallini

Glioblastoma Induces Vascular Endothelial Cells to Express Telomerase in Vitro
Cancer Res 2003 63: 3750-3754. [Abstract] [Full Text] [PDF]  

Amir Abdollahi, Kenneth E. Lipson, Xiaohong Han, Robert Krempien, Thuy Trinh, Klaus J. Weber, Philip Hahnfeldt, Lynn Hlatky, Juergen Debus, Anthony R. Howlett, and Peter E. Huber

SU5416 and SU6668 Attenuate the Angiogenic Effects of Radiation-induced Tumor Cell Growth Factor Production and Amplify the Direct Anti-endothelial Action of Radiation in Vitro
Cancer Res 2003 63: 3755-3763. [Abstract] [Full Text] [PDF]  

Moulay A. Alaoui-Jamali, Daniel J. Song, Naciba Benlimame, Lily Yen, Xiaoming Deng, Maite Hernandez-Perez, and Taiqi Wang

Regulation of Multiple Tumor Microenvironment Markers by Overexpression of Single or Paired Combinations of ErbB Receptors
Cancer Res 2003 63: 3764-3774. [Abstract] [Full Text] [PDF]  

Ruimin Huang, Zhigang Xing, Zhidong Luan, Tangming Wu, Xin Wu, and Gengxi Hu

A Specific Splicing Variant of SVH, a Novel Human Armadillo Repeat Protein, Is Up-Regulated in Hepatocellular Carcinomas
Cancer Res 2003 63: 3775-3782. [Abstract] [Full Text] [PDF]  

Jacqueline S. Jeruss, Charles D. Sturgis, Alfred W. Rademaker, and Teresa K. Woodruff

Down-Regulation of Activin, Activin Receptors, and Smads in High-Grade Breast Cancer
Cancer Res 2003 63: 3783-3790. [Abstract] [Full Text] [PDF]  

Henryk Barthel, Marcel C. Cleij, David R. Collingridge, O. Clyde Hutchinson, Safiye Osman, Qimin He, Sajinder K. Luthra, Frank Brady, Pat M. Price, and Eric O. Aboagye

3'-Deoxy-3'-[¹⁸F]Fluorothymidine as a New Marker for Monitoring Tumor Response to Antiproliferative Therapy in Vivo with Positron Emission Tomography
Cancer Res 2003 63: 3791-3798. [Abstract] [Full Text] [PDF]  

Ellen De Schrijver, Koen Brusselmans, Walter Heyns, Guido Verhoeven, and Johannes V. Swinnen

RNA Interference-mediated Silencing of the Fatty Acid Synthase Gene Attenuates Growth and Induces Morphological Changes and Apoptosis of LNCaP Prostate Cancer Cells
Cancer Res 2003 63: 3799-3804. [Abstract] [Full Text] [PDF]  

Vladislav V. Glinsky, Gennadi V. Glinsky, Olga V. Glinskii, Virginia H. Huxley, James R. Turk, Valeri V. Mossine, Susan L. Deutscher, Kenneth J. Pienta, and Thomas P. Quinn

Intravascular Metastatic Cancer Cell Homotypic Aggregation at the Sites of Primary Attachment to the Endothelium
Cancer Res 2003 63: 3805-3811. [Abstract] [Full Text] [PDF]  

Tak-Wah Wong, Erin Tracy, Allan R Oseroff, and Heinz Baumann

Photodynamic Therapy Mediates Immediate Loss of Cellular Responsiveness to Cytokines and Growth Factors
Cancer Res 2003 63: 3812-3818. [Abstract] [Full Text] [PDF]  

Sean L. Preston, Wai-Man Wong, Annie On-On Chan, Richard Poulsom, Rosemary Jeffery, Robert A. Goodlad, Nikki Mandir, George Elia, Marco Novelli, Walter F. Bodmer, Ian P. Tomlinson, and Nicholas A. Wright

Bottom-up Histogenesis of Colorectal Adenomas: Origin in the Monocryptal Adenoma and Initial Expansion by Crypt Fission
Cancer Res 2003 63: 3819-3825. [Abstract] [Full Text] [PDF]  

Kyung-Hee Chun, Doris M. Benbrook, K. Darrell Berlin, Waun Ki Hong, and Reuben Lotan

The Synthetic Heteroarotinoid SHetA2 Induces Apoptosis in Squamous Carcinoma Cells through a Receptor-independent and Mitochondria-dependent Pathway
Cancer Res 2003 63: 3826-3832. [Abstract] [Full Text] [PDF]  

Ingrid S. Zeelenberg, Lisette Ruuls-Van Stalle, and Ed Roos

The Chemokine Receptor CXCR4 Is Required for Outgrowth of Colon Carcinoma Micrometastases
Cancer Res 2003 63: 3833-3839. [Abstract] [Full Text] [PDF]  

Pamela P. McKenzie, Mary K. Danks, Richard W. Kriwacki, and Linda C. Harris

p21^Waf1/Cip1 Dysfunction in Neuroblastoma: A Novel Mechanism of Attenuating G₀-G₁ Cell Cycle Arrest
Cancer Res 2003 63: 3840-3844. [Abstract] [Full Text] [PDF]  

Retraction:

Retraction
Cancer Res 2003 63: 3846. [Full Text] [PDF]  

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