The figure shows Brain Tumour Stem Cells (BTSC) derived from a juvenile Pilocytic Astrocytoma. Undifferentiated BTSC grow as free suspension spheres and stain for the stem cell marker CD133 (lower panel) but not the mature astrocyte marker GFAP. When differentiated the BTSC lose CD133 staining, and differentiate into mature astrocytes staining for GFAP (upper panel), recapitulating the original tumour phenotype. For details, see the article by Singh et al. on p. 5821 of this issue.

[Table of Contents]