Advances in Brief:

Micro-magnetic Resonance Lymphangiography in Mice Using a Novel Dendrimer-based Magnetic Resonance Imaging Contrast Agent

Hisataka Kobayashi, Satomi Kawamoto, Robert A. Star, Thomas A. Waldmann, Yutaka Tagaya, and Martin W. Brechbiel
Cancer Res 2003 63: 271-276. [Abstract] [Full Text] [PDF]  

Overexpression of a Dominant Negative Type II Bone Morphogenetic Protein Receptor Inhibits the Growth of Human Breast Cancer Cells

Frédéric Pouliot, Alexandre Blais, and Claude Labrie
Cancer Res 2003 63: 277-281. [Abstract] [Full Text] [PDF]  

Increased Nuclear Phosphatase and Tensin Homologue Deleted on Chromosome 10 Is Associated with G₀-G₁ in MCF-7 Cells

Margaret E. Ginn-Pease and Charis Eng
Cancer Res 2003 63: 282-286. [Abstract] [Full Text] [PDF]  

Recombinant Osteoprotegerin Decreases Tumor Burden and Increases Survival in a Murine Model of Multiple Myeloma

Karin Vanderkerken, Evy De Leenheer, Claire Shipman, Kewal Asosingh, Angelo Willems, Ben Van Camp, and Peter Croucher
Cancer Res 2003 63: 287-289. [Abstract] [Full Text] [PDF]  

Apoptosis Caused by Chemotherapeutic Inhibition of Nuclear Factor-B Activation

Debajit K. Biswas, Katherine J. Martin, Cliona McAlister, Antonio P. Cruz, Edgard Graner, Sun-chun Dai, and Arthur B. Pardee
Cancer Res 2003 63: 290-295. [Abstract] [Full Text] [PDF]  

Insulin-like Growth Factor II Receptor Gene-167 Genotype Increases the Risk of Oral Squamous Cell Carcinoma in Humans

Athanasios I. Zavras, Waranuch Pitiphat, Tianxia Wu, Vassiliki Cartsos, Albert Lam, Chester W. Douglass, and Scott R. Diehl
Cancer Res 2003 63: 296-297. [Abstract] [Full Text] [PDF]  

Bcr and Abl Interaction: Oncogenic Activation of c-Abl by Sequestering Bcr

Xiaoyang Ling, Guozhen Ma, Tong Sun, Jiaxin Liu, and Ralph B. Arlinghaus
Cancer Res 2003 63: 298-303. [Abstract] [Full Text] [PDF]  

BRD4-NUT Fusion Oncogene: A Novel Mechanism in Aggressive Carcinoma

Christopher A. French, Isao Miyoshi, Ichiro Kubonishi, Holcombe E. Grier, Antonio R. Perez-Atayde, and Jonathan A. Fletcher
Cancer Res 2003 63: 304-307. [Abstract] [Full Text] [PDF]  

Prolonged Treatment with Angiostatin Reduces Metastatic Burden during Radiation Therapy

David H. Gorski, Helena J. Mauceri, Rabih M. Salloum, Arielle Halpern, Saraswathy Seetharam, and Ralph R. Weichselbaum
Cancer Res 2003 63: 308-311. [Abstract] [Full Text] [PDF]  

Biochemistry and Biophysics:

Inhibition of Glutathione Synthesis Reverses Bcl-2-mediated Cisplatin Resistance

Charles M. Rudin, Zejia Yang, Lisa M. Schumaker, David J. VanderWeele, Kenneth Newkirk, Merrill J. Egorin, Eleanor G. Zuhowski, and Kevin J. Cullen
Cancer Res 2003 63: 312-318. [Abstract] [Full Text] [PDF]  

Carcinogenesis:

Inducible Activation of Ras and Raf in Adult Epidermis

Masahito Tarutani, Ti Cai, Maya Dajee, and Paul A. Khavari
Cancer Res 2003 63: 319-323. [Abstract] [Full Text] [PDF]  

Characterization of a Novel Epigenetic Effect of Ionizing Radiation: The Death-Inducing Effect

Shruti Nagar, Leslie E. Smith, and William F. Morgan
Cancer Res 2003 63: 324-328. [Abstract] [Full Text] [PDF]  

A Novel Human Prostate-specific Gene-1 (HPG-1): Molecular Cloning, Sequencing, and Its Potential Involvement in Prostate Carcinogenesis

Elizabeth A. Herness and Rajesh K. Naz
Cancer Res 2003 63: 329-336. [Abstract] [Full Text] [PDF]  

Clinical Investigations:

The Prognostic Value of Polymorphonuclear Leukocyte Elastase in Patients with Primary Breast Cancer

John A. Foekens, Christian Ries, Maxime P. Look, Cornelia Gippner-Steppert, Jan G. M. Klijn, and Marianne Jochum
Cancer Res 2003 63: 337-341. [Abstract] [Full Text] [PDF]  

Epidemiology and Prevention:

BRCA1 and BRCA2 Mutation Status and Tumor Characteristics in Male Breast Cancer: A Population-based Study in Italy

Laura Ottini, Giovanna Masala, Cristina D’Amico, Biancamaria Mancini, Calogero Saieva, Gitana Aceto, Donella Gestri, Vania Vezzosi, Mario Falchetti, Manola De Marco, Milena Paglierani, Alessandro Cama, Simonetta Bianchi, Renato Mariani-Costantini, and Domenico Palli
Cancer Res 2003 63: 342-347. [Abstract] [Full Text] [PDF]  

Experimental Therapeutics:

Systemic Reovirus Therapy of Metastatic Cancer in Immune-competent Mice

Kensuke Hirasawa, Sandra G. Nishikawa, Kara L. Norman, Matthew C. Coffey, Bradley G. Thompson, Chang-Soon Yoon, David M. Waisman, and Patrick W. K. Lee
Cancer Res 2003 63: 348-353. [Abstract] [Full Text] [PDF]  

A Universal Pretargeting System for Cancer Detection and Therapy Using Bispecific Antibody

Robert M. Sharkey, William J. McBride, Habibe Karacay, Ken Chang, Gary L. Griffiths, Hans J. Hansen, and David M. Goldenberg
Cancer Res 2003 63: 354-363. [Abstract] [Full Text] [PDF]  

Insulin-like Growth Factor I-mediated Protection from Rapamycin-induced Apoptosis Is Independent of Ras-Erk1-Erk2 and Phosphatidylinositol 3'-Kinase-Akt Signaling Pathways

Kuntebommanahalli N. Thimmaiah, John Easton, Shile Huang, Karen A. Veverka, Glen S. Germain, Franklin C. Harwood, and Peter J. Houghton
Cancer Res 2003 63: 364-374. [Abstract] [Full Text] [PDF]  

SKI-606, a 4-Anilino-3-quinolinecarbonitrile Dual Inhibitor of Src and Abl Kinases, Is a Potent Antiproliferative Agent against Chronic Myelogenous Leukemia Cells in Culture and Causes Regression of K562 Xenografts in Nude Mice

Jennifer M. Golas, Kim Arndt, Carlo Etienne, Judy Lucas, Danielle Nardin, James Gibbons, Philip Frost, Fei Ye, Diane H. Boschelli, and Frank Boschelli
Cancer Res 2003 63: 375-381. [Abstract] [Full Text] [PDF]  

The Designed Angiostatic Peptide Anginex Synergistically Improves Chemotherapy and Antiangiogenesis Therapy with Angiostatin

Ruud P. M. Dings, Yumi Yokoyama, Sundaram Ramakrishnan, Arjan W. Griffioen, and Kevin H. Mayo
Cancer Res 2003 63: 382-385. [Abstract] [Full Text] [PDF]  

Antitumor Activity of the 16-kDa Prolactin Fragment in Prostate Cancer

Jeri Kim, Weiping Luo, Dung-Tsa Chen, Karen Earley, James Tunstead, Li-Yuan Yu-Lee, and Sue-Hwa Lin
Cancer Res 2003 63: 386-393. [Abstract] [Full Text] [PDF]  

Immunology:

CpG Oligonucleotides Enhance the Tumor Antigen-specific Immune Response of a Granulocyte Macrophage Colony-stimulating Factor-based Vaccine Strategy in Neuroblastoma

Anthony D. Sandler, Hiroshi Chihara, Gen Kobayashi, Xiaoyan Zhu, Michal A. Miller, David L. Scott, and Arthur M. Krieg
Cancer Res 2003 63: 394-399. [Abstract] [Full Text] [PDF]  

Association between Human Leukocyte Antigen Polymorphism and Human Papillomavirus 16-positive Vulval Intraepithelial Neoplasia in British Women

Emma J. Davidson, Judith A. Davidson, Jane C. Sterling, Peter J. W. Baldwin, Henry C. Kitchener, and Peter L. Stern
Cancer Res 2003 63: 400-403. [Abstract] [Full Text] [PDF]  

Molecular Biology and Genetics:

An Integrated Physical and Gene Map of the 3.5-Mb Chromosome 3p21.3 (AP20) Region Implicated in Major Human Epithelial Malignancies

Alexei Protopopov, Vladimir Kashuba, Veronika I. Zabarovska, Olga V. Muravenko, Michael I. Lerman, George Klein, and Eugene R. Zabarovsky
Cancer Res 2003 63: 404-412. [Abstract] [Full Text] [PDF]  

Selection Pressures of TP53 Mutation and Microenvironmental Location Influence Epidermal Growth Factor Receptor Gene Amplification in Human Glioblastomas

Yoshifumi Okada, Edward E. Hurwitz, John M. Esposito, Melissa A. Brower, Catherine L. Nutt, and David N. Louis
Cancer Res 2003 63: 413-416. [Abstract] [Full Text] [PDF]  

BRCA1/2 Mutation Status Influences Somatic Genetic Progression in Inherited and Sporadic Epithelial Ovarian Cancer Cases

Susan J. Ramus, Paul D. P. Pharoah, Patricia Harrington, Carole Pye, Bruce Werness, Lynda Bobrow, Ayse Ayhan, Dagan Wells, Ami Fishman, Martin Gore, Richard A. DiCioccio, M. Steven Piver, Alice S. Whittemore, Bruce A. J. Ponder, and Simon A. Gayther
Cancer Res 2003 63: 417-423. [Abstract] [Full Text] [PDF]  

Overexpression of Cyclin D1 Contributes to Malignancy by Up-Regulation of Fibroblast Growth Factor Receptor 1 via the pRB/E2F Pathway

Etsu Tashiro, Hiroko Maruki, Yusuke Minato, Yuichiro Doki, I. Bernard Weinstein, and Masaya Imoto
Cancer Res 2003 63: 424-431. [Abstract] [Full Text] [PDF]  

Melanoma Metastasis Suppression by Chromosome 6: Evidence for a Pathway Regulated by CRSP3 and TXNIP

Steven F. Goldberg, Mary E. Miele, Naohito Hatta, Minoru Takata, Carrie Paquette-Straub, Leonard P. Freedman, and Danny R. Welch
Cancer Res 2003 63: 432-440. [Abstract] [Full Text] [PDF]  

Expression of Differentiation Melanoma-associated Antigen Genes Is Associated with Favorable Disease Outcome in Advanced-Stage Melanomas

Hiroya Takeuchi, Christine Kuo, Donald L. Morton, He-Jing Wang, and Dave S. B. Hoon
Cancer Res 2003 63: 441-448. [Abstract] [Full Text] [PDF]  

The Homeotic Protein Six3 Is a Coactivator of the Nuclear Receptor NOR-1 and a Corepressor of the Fusion Protein EWS/NOR-1 in Human Extraskeletal Myxoid Chondrosarcomas

Cynthia Laflamme, Christine Filion, Julia A. Bridge, Marc Ladanyi, Mary B. Goldring, and Yves Labelle
Cancer Res 2003 63: 449-454. [Abstract] [Full Text] [PDF]  

Deletion of Chromosome 3p14.2-p25 Involving the VHL and FHIT Genes in Conventional Renal Cell Carcinoma

Farkas Sükösd, Naoto Kuroda, Tamas Beothe, Amrit Pal Kaur, and Gyula Kovacs
Cancer Res 2003 63: 455-457. [Abstract] [Full Text] [PDF]  

Tumor Biology:

High Levels of Telomere Dysfunction Bestow a Selective Disadvantage During the Progression of Human Oral Squamous Cell Carcinoma

Katrina E. Gordon, Hazel Ireland, Meryl Roberts, Karen Steeghs, James A. McCaul, D. Gordon MacDonald, and E. Kenneth Parkinson
Cancer Res 2003 63: 458-467. [Abstract] [Full Text] [PDF]  

2-Methoxyestradiol Up-Regulates Death Receptor 5 and Induces Apoptosis through Activation of the Extrinsic Pathway

Theresa M. LaVallee, Xiaoguo H. Zhan, Michelle S. Johnson, Chris J. Herbstritt, Glenn Swartz, Mark S. Williams, Wendy A. Hembrough, Shawn J. Green, and Victor S. Pribluda
Cancer Res 2003 63: 468-475. [Abstract] [Full Text] [PDF]  

Abrogation of the Retinoblastoma Tumor Suppressor Checkpoint During Keratinocyte Immortalization Is Not Sufficient for Induction of Centrosome-mediated Genomic Instability

Siribang-on Piboonniyom, Stefan Duensing, Nathan W. Swilling, Jens Hasskarl, Philip W. Hinds, and Karl Münger
Cancer Res 2003 63: 476-483. [Abstract] [Full Text] [PDF]  

A Nuclear Form of the Heparin-binding Epidermal Growth Factor-like Growth Factor Precursor Is a Feature of Aggressive Transitional Cell Carcinoma

Rosalyn M. Adam, Theodora Danciu, Dawn L. McLellan, Joseph G. Borer, Jianqing Lin, David Zurakowski, Michael H. Weinstein, Paul H. Rajjayabun, J. Kilian Mellon, and Michael R. Freeman
Cancer Res 2003 63: 484-490. [Abstract] [Full Text] [PDF]  

Interleukin-18 Binding Protein Reduces B16 Melanoma Hepatic Metastasis by Neutralizing Adhesiveness and Growth Factors of Sinusoidal Endothelium

Maria Teresa Carrascal, Lorea Mendoza, Maria Valcárcel, Clarisa Salado, Eider Egilegor, Naiara Tellería, Fernando Vidal-Vanaclocha, and Charles A. Dinarello
Cancer Res 2003 63: 491-497. [Abstract] [Full Text] [PDF]  

Methyl-CpG-binding Domain Protein-2 Mediates Transcriptional Repression Associated with Hypermethylated GSTP1 CpG Islands in MCF-7 Breast Cancer Cells

Xiaohui Lin and William G. Nelson
Cancer Res 2003 63: 498-504. [Abstract] [Full Text] [PDF]  

The Aldo-Keto Reductase AKR1C3 Is a Novel Suppressor of Cell Differentiation That Provides a Plausible Target for the Non-Cyclooxygenase-dependent Antineoplastic Actions of Nonsteroidal Anti-Inflammatory Drugs

Julian C. Desmond, Joanne C. Mountford, Mark T. Drayson, Elizabeth A. Walker, Martin Hewison, Jonathan P. Ride, Quang T. Luong, Rachel E. Hayden, Elio F. Vanin, and Christopher M. Bunce
Cancer Res 2003 63: 505-512. [Abstract] [Full Text] [PDF]  

Failure of Activation of Caspase-9 Induces a Higher Threshold for Apoptosis and Cisplatin Resistance in Testicular Cancer

Thomas Mueller, Wieland Voigt, Heike Simon, Angelika Fruehauf, Andrej Bulankin, Axel Grothey, and Hans-Joachim Schmoll
Cancer Res 2003 63: 513-521. [Abstract] [Full Text] [PDF]  

Cyclooxygenase-2 Expression and Prostanoid Biogenesis Reflect Clinical Phenotype in Human Colorectal Fibroblast Strains

Yingting Zhu, Ping Hua, and Peter Lance
Cancer Res 2003 63: 522-526. [Abstract] [Full Text] [PDF]  

Mechanisms by Which Tumor Cells and Monocytes Expressing the Angiogenic Factor Thymidine Phosphorylase Mediate Human Endothelial Cell Migration

Kylie A. Hotchkiss, Anthony W. Ashton, Robert S. Klein, Michelle L. Lenzi, Geng Hui Zhu, and Edward L. Schwartz
Cancer Res 2003 63: 527-533. [Abstract] [Full Text] [PDF]  

Anti-CD20 Therapeutic Antibody Rituximab Modifies the Functional Organization of Rafts/Microdomains of B Lymphoma Cells

Isabelle Semac, Carmen Palomba, Karina Kulangara, Natacha Klages, Gerhild van Echten-Deckert, Bettina Borisch, and Daniel C. Hoessli
Cancer Res 2003 63: 534-540. [Abstract] [Full Text] [PDF]  

Bcl-2 and Bax Modulate Adenine Nucleotide Translocase Activity

Anne-Sophie Belzacq, Helena L. A. Vieira, Florence Verrier, Grégoire Vandecasteele, Isabelle Cohen, Marie-Christine Prévost, Eric Larquet, Fabrizio Pariselli, Patrice X. Petit, Axel Kahn, Rosario Rizzuto, Catherine Brenner, and Guido Kroemer
Cancer Res 2003 63: 541-546. [Abstract] [Full Text] [PDF]  

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