Advances in Brief:

Jihua Liu, Jun Chen, Qiang Dai, and Ray M. Lee

Phospholipid Scramblase 3 Is the Mitochondrial Target of Protein Kinase C -induced Apoptosis
Cancer Res 2003 63: 1153-1156. [Abstract] [Full Text] [PDF]  

Aditi Hazra, Robert M. Chamberlain, H. Barton Grossman, Yong Zhu, Margaret R. Spitz, and Xifeng Wu

Death Receptor 4 and Bladder Cancer Risk
Cancer Res 2003 63: 1157-1159. [Abstract] [Full Text] [PDF]  

Pritha Ray, Anna M. Wu, and Sanjiv S. Gambhir

Optical Bioluminescence and Positron Emission Tomography Imaging of a Novel Fusion Reporter Gene in Tumor Xenografts of Living Mice
Cancer Res 2003 63: 1160-1165. [Abstract] [Full Text] [PDF]  

Yucheng Tang, Donglei Zhang, Lucia Fallavollita, and Pnina Brodt

Vascular Endothelial Growth Factor C Expression and Lymph Node Metastasis Are Regulated by the Type I Insulin-like Growth Factor Receptor
Cancer Res 2003 63: 1166-1171. [Abstract] [Full Text] [PDF]  

Nicola Tidow, Almuth Boecker, Hartmut Schmidt, Konstantin Agelopoulos, Werner Boecker, Horst Buerger, and Burkhard Brandt

Distinct Amplification of an Untranslated Regulatory Sequence in the egfr Gene Contributes to Early Steps in Breast Cancer Development
Cancer Res 2003 63: 1172-1178. [Abstract] [Full Text] [PDF]  

Kolja Freier, Stefan Joos, Christa Flechtenmacher, Frauke Devens, Axel Benner, Franz X. Bosch, Peter Lichter, and Christof Hofele

Tissue Microarray Analysis Reveals Site-specific Prevalence of Oncogene Amplifications in Head and Neck Squamous Cell Carcinoma
Cancer Res 2003 63: 1179-1182. [Abstract] [Full Text] [PDF]  

Cinzia Sevignani, George A. Calin, Rossano Cesari, Manuela Sarti, Hideshi Ishii, Sai Yendamuri, Andrea Vecchione, Francesco Trapasso, and Carlo M. Croce

Restoration of Fragile Histidine Triad (FHIT) Expression Induces Apoptosis and Suppresses Tumorigenicity in Breast Cancer Cell Lines
Cancer Res 2003 63: 1183-1187. [Abstract] [Full Text] [PDF]  

Vera Balz, Kathrin Scheckenbach, Karl Götte, Ulrike Bockmühl, Iver Petersen, and Henning Bier

Is the p53 Inactivation Frequency in Squamous Cell Carcinomas of the Head and Neck Underestimated? Analysis of p53 Exons 2–11 and Human Papillomavirus 16/18 E6 Transcripts in 123 Unselected Tumor Specimens
Cancer Res 2003 63: 1188-1191. [Abstract] [Full Text] [PDF]  

Caterina Bianco, Luigi Strizzi, Aasia Rehman, Nicola Normanno, Christian Wechselberger, Youping Sun, Nadia Khan, Morihisa Hirota, Heather Adkins, Kevin Williams, Richard U. Margolis, Michele Sanicola, and David S. Salomon

A Nodal- and ALK4-independent Signaling Pathway Activated by Cripto-1 through Glypican-1 and c-Src
Cancer Res 2003 63: 1192-1197. [Abstract] [Full Text] [PDF]  

Sébastien Soubeyrand, Louise Pope, Benjamin Pakuts, and Robert J. G. Haché

Threonines 2638/2647 in DNA-PK Are Essential for Cellular Resistance to Ionizing Radiation
Cancer Res 2003 63: 1198-1201. [Abstract] [Full Text] [PDF]  

Aikaterini Barbouti, Mattias Höglund, Bertil Johansson, Carin Lassen, Per-Gunnar Nilsson, Anne Hagemeijer, Felix Mitelman, and Thoas Fioretos

A Novel Gene, MSI2, Encoding a Putative RNA-binding Protein Is Recurrently Rearranged at Disease Progression of Chronic Myeloid Leukemia and Forms a Fusion Gene with HOXA9 as a Result of the Cryptic t(7;17)(p15;q23)
Cancer Res 2003 63: 1202-1206. [Abstract] [Full Text] [PDF]  

Laura A. Martello, Pascal Verdier-Pinard, Heng-Jia Shen, Lifeng He, Keila Torres, George A. Orr, and Susan Band Horwitz

Elevated Levels of Microtubule Destabilizing Factors in a Taxol-resistant/dependent A549 Cell Line with an -Tubulin Mutation
Cancer Res 2003 63: 1207-1213. [Abstract] [Full Text] [PDF]  

Biochemistry and Biophysics:

Hamta Madari, Dulal Panda, Leslie Wilson, and Robert S. Jacobs

Dicoumarol: A Unique Microtubule Stabilizing Natural Product that Is Synergistic with Taxol
Cancer Res 2003 63: 1214-1220. [Abstract] [Full Text] [PDF]  

Carcinogenesis:

Kevin D. Houston, John A. Copland, Russell R. Broaddus, Marco M. Gottardis, Susan M. Fischer, and Cheryl Lyn Walker

Inhibition of Proliferation and Estrogen Receptor Signaling by Peroxisome Proliferator-activated Receptor Ligands in Uterine Leiomyoma
Cancer Res 2003 63: 1221-1227. [Abstract] [Full Text] [PDF]  

Weiqin Jiang, Zongjian Zhu, and Henry J. Thompson

Effect of Energy Restriction on Cell Cycle Machinery in 1-Methyl-1-Nitrosourea-induced Mammary Carcinomas in Rats
Cancer Res 2003 63: 1228-1234. [Abstract] [Full Text] [PDF]  

Clinical Investigations:

John Farley, Leia M. Smith, Kathleen M. Darcy, Eugene Sobel, Dennis O’Connor, Benita Henderson, Larry E. Morrison, and Michael J. Birrer

Cyclin E Expression Is a Significant Predictor of Survival in Advanced, Suboptimally Debulked Ovarian Epithelial Cancers: A Gynecologic Oncology Group Study
Cancer Res 2003 63: 1235-1241. [Abstract] [Full Text] [PDF]  

Aaron D. Schimmer, Irene Munk Pedersen, Shinichi Kitada, Emel Eksioglu-Demiralp, Mark D. Minden, Ryan Pinto, Ken Mah, Michael Andreeff, Youngsoo Kim, Won Suk Suh, and John C. Reed

Functional Blocks in Caspase Activation Pathways Are Common in Leukemia and Predict Patient Response to Induction Chemotherapy
Cancer Res 2003 63: 1242-1248. [Abstract] [Full Text] [PDF]  

Epidemiology and Prevention:

Bastiaan T. Heijmans, Jolanda M. A. Boer, H. Eka D. Suchiman, Cees J. Cornelisse, Rudi G. J. Westendorp, Daan Kromhout, Edith J. M. Feskens, and P. Eline Slagboom

A Common Variant of the Methylenetetrahydrofolate Reductase Gene (1p36) Is Associated with an Increased Risk of Cancer
Cancer Res 2003 63: 1249-1253. [Abstract] [Full Text] [PDF]  

G. Darío Díaz, Qingjie Li, and Roderick H. Dashwood

Caspase-8 and Apoptosis-inducing Factor Mediate a Cytochrome c-independent Pathway of Apoptosis in Human Colon Cancer Cells Induced by the Dietary Phytochemical Chlorophyllin
Cancer Res 2003 63: 1254-1261. [Abstract] [Full Text] [PDF]  

Experimental Therapeutics:

Yosuke Kawakami, Hui Li, John T. Lam, Victor Krasnykh, David T. Curiel, and Jerry L. Blackwell

Substitution of the Adenovirus Serotype 5 Knob with a Serotype 3 Knob Enhances Multiple Steps in Virus Replication
Cancer Res 2003 63: 1262-1269. [Abstract] [Full Text] [PDF]  

Michelle A. Blaskovich, Jiazhi Sun, Alan Cantor, James Turkson, Richard Jove, and Saïd M. Sebti

Discovery of JSI-124 (Cucurbitacin I), a Selective Janus Kinase/Signal Transducer and Activator of Transcription 3 Signaling Pathway Inhibitor with Potent Antitumor Activity against Human and Murine Cancer Cells in Mice
Cancer Res 2003 63: 1270-1279. [Abstract] [Full Text] [PDF]  

Maureen A. Chung, Yi Luo, Michael O’Donnell, Claire Rodriguez, Walter Heber, Surendra Sharma, and Helena R. Chang

Development and Preclinical Evaluation of a Bacillus Calmette-Guérin-MUC1-based Novel Breast Cancer Vaccine
Cancer Res 2003 63: 1280-1287. [Abstract] [Full Text] [PDF]  

Christilyn P. Graff and K. Dane Wittrup

Theoretical Analysis of Antibody Targeting of Tumor Spheroids: Importance of Dosage for Penetration, and Affinity for Retention
Cancer Res 2003 63: 1288-1296. [Abstract] [Full Text] [PDF]  

Joseph J. Cullen, Christine Weydert, Marilyn M. Hinkhouse, Justine Ritchie, Frederick E. Domann, Douglas Spitz, and Larry W. Oberley

The Role of Manganese Superoxide Dismutase in the Growth of Pancreatic Adenocarcinoma
Cancer Res 2003 63: 1297-1303. [Abstract] [Full Text] [PDF]  

Colin L. Sweeney, Joel L. Frandsen, Catherine M. Verfaillie, and R. Scott McIvor

Trimetrexate Inhibits Progression of the Murine 32Dp210 Model of Chronic Myeloid Leukemia in Animals Expressing Drug-resistant Dihydrofolate Reductase
Cancer Res 2003 63: 1304-1310. [Abstract] [Full Text] [PDF]  

Muthu Selvakumaran, Debra A. Pisarcik, Rudi Bao, Anthony T. Yeung, and Thomas C. Hamilton

Enhanced Cisplatin Cytotoxicity by Disturbing the Nucleotide Excision Repair Pathway in Ovarian Cancer Cell Lines
Cancer Res 2003 63: 1311-1316. [Abstract] [Full Text] [PDF]  

Lawrence M. Wein, Joseph T. Wu, and David H. Kirn

Validation and Analysis of a Mathematical Model of a Replication-competent Oncolytic Virus for Cancer Treatment: Implications for Virus Design and Delivery
Cancer Res 2003 63: 1317-1324. [Abstract] [Full Text] [PDF]  

Michael Danilenko, Qing Wang, Xuening Wang, Joseph Levy, Yoav Sharoni, and George P. Studzinski

Carnosic Acid Potentiates the Antioxidant and Prodifferentiation Effects of 1,25-Dihydroxyvitamin D₃ in Leukemia Cells but Does Not Promote Elevation of Basal Levels of Intracellular Calcium
Cancer Res 2003 63: 1325-1332. [Abstract] [Full Text] [PDF]  

Meike L. Schipper, Alexander Weber, Martin Béhé, Rüdiger Göke, Werner Joba, Harald Schmidt, Till Bert, Babette Simon, Rudolf Arnold, Armin E. Heufelder, and Thomas M. Behr

Radioiodide Treatment after Sodium Iodide Symporter Gene Transfer Is a Highly Effective Therapy in Neuroendocrine Tumor Cells
Cancer Res 2003 63: 1333-1338. [Abstract] [Full Text] [PDF]  

John D. Allen, Sonja C. van Dort, Marije Buitelaar, Olaf van Tellingen, and Alfred H. Schinkel

Mouse Breast Cancer Resistance Protein (Bcrp1/Abcg2) Mediates Etoposide Resistance and Transport, but Etoposide Oral Availability Is Limited Primarily by P-glycoprotein
Cancer Res 2003 63: 1339-1344. [Abstract] [Full Text] [PDF]  

Immunology:

Weixin Lu, Jindong Su, Lee Su Kim, Corazon D. Bucana, Cherrie Donawho, Junqing He, Isaiah J. Fidler, and Zhongyun Dong

Active Specific Immunotherapy against Occult Brain Metastasis
Cancer Res 2003 63: 1345-1350. [Abstract] [Full Text] [PDF]  

Molecular Biology and Genetics:

Bradley J. Quade, Stanislawa Weremowicz, David M. Neskey, Roberta Vanni, Carll Ladd, Paola Dal Cin, and Cynthia C. Morton

Fusion Transcripts Involving HMGA2 Are not a Common Molecular Mechanism in Uterine Leiomyomata with Rearrangements in 12q15
Cancer Res 2003 63: 1351-1358. [Abstract] [Full Text] [PDF]  

Jennelle C. Hodge, Jeffrey Bub, Sushma Kaul, André Kajdacsy-Balla, and Paul F. Lindholm

Requirement of RhoA Activity for Increased Nuclear Factor B Activity and PC-3 Human Prostate Cancer Cell Invasion
Cancer Res 2003 63: 1359-1364. [Abstract] [Full Text] [PDF]  

Junichi Asakuma, Makoto Sumitomo, Takako Asano, Tomohiko Asano, and Masamichi Hayakawa

Selective Akt Inactivation and Tumor Necrosis Factor-related Apoptosis-inducing Ligand Sensitization of Renal Cancer Cells by Low Concentrations of Paclitaxel
Cancer Res 2003 63: 1365-1370. [Abstract] [Full Text] [PDF]  

Nanjoo Suh, Anita B. Roberts, Stephanie Birkey Reffey, Kohei Miyazono, Susumu Itoh, Peter ten Dijke, Elke H. Heiss, Andrew E. Place, Renee Risingsong, Charlotte R. Williams, Tadashi Honda, Gordon W. Gribble, and Michael B. Sporn

Synthetic Triterpenoids Enhance Transforming Growth Factor ß/Smad Signaling
Cancer Res 2003 63: 1371-1376. [Abstract] [Full Text] [PDF]  

Christopher J. Betti, Michael J. Villalobos, Manuel O. Diaz, and Andrew T. M. Vaughan

Apoptotic Stimuli Initiate MLL-AF9 Translocations that Are Transcribed in Cells Capable of Division
Cancer Res 2003 63: 1377-1381. [Abstract] [Full Text] [PDF]  

Ana I. Jimenez, Paloma Fernandez, Orlando Dominguez, Ana Dopazo, and Montserrat Sanchez-Cespedes

Growth and Molecular Profile of Lung Cancer Cells Expressing Ectopic LKB1: Down-Regulation of the Phosphatidylinositol 3'-Phosphate Kinase/PTEN Pathway
Cancer Res 2003 63: 1382-1388. [Abstract] [Full Text] [PDF]  

Tumor Biology:

Denise C. Connolly, Rudi Bao, Alexander Yu Nikitin, Kasie C. Stephens, Timothy W. Poole, Xiang Hua, Skye S. Harris, Barbara C. Vanderhyden, and Thomas C. Hamilton

Female Mice Chimeric for Expression of the Simian Virus 40 TAg under Control of the MISIIR Promoter Develop Epithelial Ovarian Cancer
Cancer Res 2003 63: 1389-1397. [Abstract] [Full Text] [PDF]  

German A. Pihan, Jan Wallace, Yening Zhou, and Stephen J. Doxsey

Centrosome Abnormalities and Chromosome Instability Occur Together in Pre-invasive Carcinomas
Cancer Res 2003 63: 1398-1404. [Abstract] [Full Text] [PDF]  

Marie Wislez, Nathalie Rabbe, Joëlle Marchal, Bernard Milleron, Bruno Crestani, Charles Mayaud, Martine Antoine, Paul Soler, and Jacques Cadranel

Hepatocyte Growth Factor Production by Neutrophils Infiltrating Bronchioloalveolar Subtype Pulmonary Adenocarcinoma: Role in Tumor Progression and Death
Cancer Res 2003 63: 1405-1412. [Abstract] [Full Text] [PDF]  

Rae Lynn Baldwin, Hang Tran, and Beth Y. Karlan

Loss of c-myc Repression Coincides with Ovarian Cancer Resistance to Transforming Growth Factor ß Growth Arrest Independent of Transforming Growth Factor ß/Smad Signaling
Cancer Res 2003 63: 1413-1419. [Abstract] [Full Text] [PDF]  

Maria von Willebrand, Eldad Zacksenhaus, Elaine Cheng, Peter Glazer, and Ruth Halaban

The Tyrphostin AG1024 Accelerates the Degradation of Phosphorylated Forms of Retinoblastoma Protein (pRb) and Restores pRb Tumor Suppressive Function in Melanoma Cells
Cancer Res 2003 63: 1420-1429. [Abstract] [Full Text] [PDF]  

Virology:

Antonio De Luca, Rosamaria Mangiacasale, Anna Severino, Lorenzo Malquori, Alfonso Baldi, Antonella Palena, Anna Maria Mileo, Patrizia Lavia, and Marco G. Paggi

E1A Deregulates the Centrosome Cycle in a Ran GTPase-dependent Manner
Cancer Res 2003 63: 1430-1437. [Abstract] [Full Text] [PDF]  

Correction:

Cancer Res 2003 63: 1439. [Full Text] [PDF]  

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