Advances in Brief:

Karolina Helczynska, Åsa Kronblad, Annika Jögi, Elise Nilsson, Siv Beckman, Göran Landberg, and Sven Påhlman

Hypoxia Promotes a Dedifferentiated Phenotype in Ductal Breast Carcinoma in Situ
Cancer Res 2003 63: 1441-1444. [Abstract] [Full Text] [PDF]  

Robert L. Camp, Marisa Dolled-Filhart, Bonnie L. King, and David L. Rimm

Quantitative Analysis of Breast Cancer Tissue Microarrays Shows That Both High and Normal Levels of HER2 Expression Are Associated with Poor Outcome
Cancer Res 2003 63: 1445-1448. [Abstract] [Full Text] [PDF]  

Frans B. L. Hogervorst, Petra M. Nederlof, Johan J. P. Gille, Cathal J. McElgunn, Maartje Grippeling, Roelof Pruntel, Rein Regnerus, Tibor van Welsem, Resie van Spaendonk, Fred H. Menko, Irma Kluijt, Charlotte Dommering, Senno Verhoef, Jan P. Schouten, Laura J. van’t Veer, and Gerard Pals

Large Genomic Deletions and Duplications in the BRCA1 Gene Identified by a Novel Quantitative Method
Cancer Res 2003 63: 1449-1453. [Abstract] [Full Text] [PDF]  

Edna T. Kimura, Marina N. Nikiforova, Zhaowen Zhu, Jeffrey A. Knauf, Yuri E. Nikiforov, and James A. Fagin

High Prevalence of BRAF Mutations in Thyroid Cancer: Genetic Evidence for Constitutive Activation of the RET/PTC-RAS-BRAF Signaling Pathway in Papillary Thyroid Carcinoma
Cancer Res 2003 63: 1454-1457. [Abstract] [Full Text] [PDF]  

Biochemistry and Biophysics:

Géraldine Siegfried, Abdel-Majid Khatib, Suzanne Benjannet, Michel Chrétien, and Nabil G. Seidah

The Proteolytic Processing of Pro-Platelet-derived Growth Factor-A at RRKR⁸⁶ by Members of the Proprotein Convertase Family Is Functionally Correlated to Platelet-derived Growth Factor-A-induced Functions and Tumorigenicity
Cancer Res 2003 63: 1458-1463. [Abstract] [Full Text] [PDF]  

Carcinogenesis:

Jostein Dahle and Egil Kvam

Induction of Delayed Mutations and Chromosomal Instability in Fibroblasts after UVA-, UVB-, and X-Radiation
Cancer Res 2003 63: 1464-1469. [Abstract] [Full Text] [PDF]  

Zhengdong Liang, Scott M. Lippman, Atsushi Kawabe, Yutaka Shimada, and Xiao-chun Xu

Identification of Benzo(a)pyrene Diol Epoxide-binding DNA Fragments Using DNA Immunoprecipitation Technique
Cancer Res 2003 63: 1470-1474. [Abstract] [Full Text] [PDF]  

Clinical Investigations:

Rana Kaplan, Karsta Luettich, Adriana Heguy, Neil R. Hackett, Ben-Gary Harvey, and Ronald G. Crystal

Monoallelic Up-Regulation of the Imprinted H19 Gene in Airway Epithelium of Phenotypically Normal Cigarette Smokers
Cancer Res 2003 63: 1475-1482. [Abstract] [Full Text] [PDF]  

Epidemiology and Prevention:

Hirohito Yamaguchi, Kapil Bhalla, and Hong-Gang Wang

Bax Plays a Pivotal Role in Thapsigargin-induced Apoptosis of Human Colon Cancer HCT116 Cells by Controlling Smac/Diablo and Omi/HtrA2 Release from Mitochondria
Cancer Res 2003 63: 1483-1489. [Abstract] [Full Text] [PDF]  

Experimental Therapeutics:

John L. Jakubczak, Patricia Ryan, Mario Gorziglia, Lori Clarke, Lynda K. Hawkins, Carl Hay, Ying Huang, Michele Kaloss, Anthony Marinov, Sandrina Phipps, Anne Pinkstaff, Pamela Shirley, Yelena Skripchenko, David Stewart, Suzanne Forry-Schaudies, and Paul L. Hallenbeck

An Oncolytic Adenovirus Selective for Retinoblastoma Tumor Suppressor Protein Pathway-defective Tumors: Dependence on E1A, the E2F-1 Promoter, and Viral Replication for Selectivity and Efficacy
Cancer Res 2003 63: 1490-1499. [Abstract] [Full Text] [PDF]  

Cristina Roca, Luca Primo, Donatella Valdembri, Anna Cividalli, Paul Declerck, Peter Carmeliet, Pietro Gabriele, and Federico Bussolino

Hyperthermia Inhibits Angiogenesis by a Plasminogen Activator Inhibitor 1-dependent Mechanism
Cancer Res 2003 63: 1500-1507. [Abstract] [Full Text] [PDF]  

Jindrich Cinatl, Jr., Jaroslav Cinatl, Martin Michaelis, Hanka Kabickova, Rouslan Kotchetkov, Jens-Uwe Vogel, Hans Wilhelm Doerr, Thomas Klingebiel, and Pablo Hernáiz Driever

Potent Oncolytic Activity of Multimutated Herpes Simplex Virus G207 in Combination with Vincristine against Human Rhabdomyosarcoma
Cancer Res 2003 63: 1508-1514. [Abstract] [Full Text] [PDF]  

Hao Wu, William N. Hait, and Jin-Ming Yang

Small Interfering RNA-induced Suppression of MDR1 (P-Glycoprotein) Restores Sensitivity to Multidrug-resistant Cancer Cells
Cancer Res 2003 63: 1515-1519. [Abstract] [Full Text] [PDF]  

Bo Yang, Nino Keshelava, Clarke P. Anderson, and C. Patrick Reynolds

Antagonism of Buthionine Sulfoximine Cytotoxicity for Human Neuroblastoma Cell Lines by Hypoxia Is Reversed by the Bioreductive Agent Tirapazamine
Cancer Res 2003 63: 1520-1526. [Abstract] [Full Text] [PDF]  

Yin Li, Anthony J. Raffo, Lisa Drew, Yuehua Mao, Andy Tran, Daniel P. Petrylak, and Robert L. Fine

Fas-Mediated Apoptosis Is Dependent on Wild-Type p53 Status in Human Cancer Cells Expressing a Temperature-Sensitive p53 Mutant Alanine-143
Cancer Res 2003 63: 1527-1533. [Abstract] [Full Text] [PDF]  

Gianluca Micheletti, Maura Poli, Patrizia Borsotti, Michele Martinelli, Barbara Imberti, Giulia Taraboletti, and Raffaella Giavazzi

Vascular-targeting Activity of ZD6126, a Novel Tubulin-binding Agent
Cancer Res 2003 63: 1534-1537. [Abstract] [Full Text] [PDF]  

Tina L. Tinley, Rachel M. Leal, Deborah A. Randall-Hlubek, James W. Cessac, Lynne R. Wilkens, Pemmaraju N. Rao, and Susan L. Mooberry

Novel 2-Methoxyestradiol Analogues with Antitumor Activity
Cancer Res 2003 63: 1538-1549. [Abstract] [Full Text] [PDF]  

Spencer J. Collis, Michael J. Swartz, William G. Nelson, and Theodore L. DeWeese

Enhanced Radiation and Chemotherapy-mediated Cell Killing of Human Cancer Cells by Small Inhibitory RNA Silencing of DNA Repair Factors
Cancer Res 2003 63: 1550-1554. [Abstract] [Full Text] [PDF]  

Immunology:

Yasushi Cho, Masaki Miyamoto, Kentaro Kato, Akira Fukunaga, Toshiaki Shichinohe, You Kawarada, Yasuhiro Hida, Taro Oshikiri, Takanori Kurokawa, Masato Suzuoki, Yoshihiro Nakakubo, Kei Hiraoka, Soichi Murakami, Toshiya Shinohara, Tomoo Itoh, Shunichi Okushiba, Satoshi Kondo, and Hiroyuki Katoh

CD4⁺ and CD8⁺ T Cells Cooperate to Improve Prognosis of Patients with Esophageal Squamous Cell Carcinoma
Cancer Res 2003 63: 1555-1559. [Abstract] [Full Text] [PDF]  

Matteo G. Carrabba, Chiara Castelli, Markus J. Maeurer, Paola Squarcina, Agata Cova, Lorenzo Pilla, Nicolina Renkvist, Giorgio Parmiani, and Licia Rivoltini

Suboptimal Activation of CD8⁺ T Cells by Melanoma-derived Altered Peptide Ligands: Role of Melan-A/MART-1 Optimized Analogues
Cancer Res 2003 63: 1560-1567. [Abstract] [Full Text] [PDF]  

Molecular Biology and Genetics:

Elaine B. Brunschwig, Keith Wilson, David Mack, Dawn Dawson, Earl Lawrence, James K.V. Willson, ShiLong Lu, Arman Nosrati, Ronald M. Rerko, Sandra Swinler, Lydia Beard, James D. Lutterbaugh, Joseph Willis, Petra Platzer, and Sanford Markowitz

PMEPA1, a Transforming Growth Factor-ß-induced Marker of Terminal Colonocyte Differentiation Whose Expression Is Maintained in Primary and Metastatic Colon Cancer
Cancer Res 2003 63: 1568-1575. [Abstract] [Full Text] [PDF]  

Juan A. Recio and Glenn Merlino

Hepatocyte Growth Factor/Scatter Factor Induces Feedback Up-Regulation of CD44v6 in Melanoma Cells through Egr-1
Cancer Res 2003 63: 1576-1582. [Abstract] [Full Text] [PDF]  

Eun-Hee Shim, Linda Johnson, Hye-Lim Noh, Yoon-Jung Kim, Hong Sun, Caroline Zeiss, and Hui Zhang

Expression of the F-Box Protein SKP2 Induces Hyperplasia, Dysplasia, and Low-Grade Carcinoma in the Mouse Prostate
Cancer Res 2003 63: 1583-1588. [Abstract] [Full Text] [PDF]  

William A. Weiss, Michael J. Burns, Christopher Hackett, Ken Aldape, John R. Hill, Hiroko Kuriyama, Nagato Kuriyama, Nadezhda Milshteyn, Tim Roberts, Michael F. Wendland, Ron DePinho, and Mark A. Israel

Genetic Determinants of Malignancy in a Mouse Model for Oligodendroglioma
Cancer Res 2003 63: 1589-1595. [Abstract] [Full Text] [PDF]  

Charles R. Holst, Gerard J. Nuovo, Manel Esteller, Karen Chew, Stephen B. Baylin, James G. Herman, and Thea D. Tlsty

Methylation of p16^INK4a Promoters Occurs in Vivo in Histologically Normal Human Mammary Epithelia
Cancer Res 2003 63: 1596-1601. [Abstract] [Full Text] [PDF]  

Catherine L. Nutt, D. R. Mani, Rebecca A. Betensky, Pablo Tamayo, J. Gregory Cairncross, Christine Ladd, Ute Pohl, Christian Hartmann, Margaret E. McLaughlin, Tracy T. Batchelor, Peter M. Black, Andreas von Deimling, Scott L. Pomeroy, Todd R. Golub, and David N. Louis

Gene Expression-based Classification of Malignant Gliomas Correlates Better with Survival than Histological Classification
Cancer Res 2003 63: 1602-1607. [Abstract] [Full Text] [PDF]  

Ajay Goel, Christian N. Arnold, Donna Niedzwiecki, Dong K. Chang, Luigi Ricciardiello, John M. Carethers, Jeannette M. Dowell, Linda Wasserman, Carolyn Compton, Robert J. Mayer, Monica M. Bertagnolli, and C. Richard Boland

Characterization of Sporadic Colon Cancer by Patterns of Genomic Instability
Cancer Res 2003 63: 1608-1614. [Abstract] [Full Text] [PDF]  

Ignacio Pérez de Castro, Roberto Diaz, Marcos Malumbres, María-Inmaculada Hernández, Jaishree Jagirdar, María Jiménez, Daniel Ahn, and Angel Pellicer

Mice Deficient for N-ras: Impaired Antiviral Immune Response and T-Cell Function
Cancer Res 2003 63: 1615-1622. [Abstract] [Full Text] [PDF]  

You-Wei Zhang, Keiko Nakayama, Kei-Ichi Nakayama, and Ikuo Morita

A Novel Route for Connexin 43 to Inhibit Cell Proliferation: Negative Regulation of S-Phase Kinase-associated Protein (Skp 2)
Cancer Res 2003 63: 1623-1630. [Abstract] [Full Text] [PDF]  

Qun Wang, George Hii, Suzanne Shusterman, Yael Mosse, Cynthia L. Winter, Chun Guo, Huaqing Zhao, Eric Rappaport, Michael D. Hogarty, and John M. Maris

ID2 Expression Is not Associated with MYCN Amplification or Expression in Human Neuroblastomas
Cancer Res 2003 63: 1631-1635. [Abstract] [Full Text] [PDF]  

Evans C. Bailey, Lei Zhou, and Ronald L. Johnson

Several Human PATCHED1 Mutations Block Protein Maturation
Cancer Res 2003 63: 1636-1638. [Abstract] [Full Text] [PDF]  

Mia Spugnardi, Stella Tommasi, Reinhard Dammann, Gerd P. Pfeifer, and Dave S. B. Hoon

Epigenetic Inactivation of RAS Association Domain Family Protein 1 (RASSF1A) in Malignant Cutaneous Melanoma
Cancer Res 2003 63: 1639-1643. [Abstract] [Full Text] [PDF]  

Tumor Biology:

Andreas Bräuninger, Hans-Heinrich Wacker, Klaus Rajewsky, Ralf Küppers, and Martin-Leo Hansmann

Typing the Histogenetic Origin of the Tumor Cells of Lymphocyte-rich Classical Hodgkin’s Lymphoma in Relation to Tumor Cells of Classical and Lymphocyte-predominance Hodgkin’s Lymphoma
Cancer Res 2003 63: 1644-1651. [Abstract] [Full Text] [PDF]  

Michael J. Campa, Michael Z. Wang, Brandon Howard, Michael C. Fitzgerald, and Edward F. Patz, Jr.

Protein Expression Profiling Identifies Macrophage Migration Inhibitory Factor and Cyclophilin A as Potential Molecular Targets in Non-Small Cell Lung Cancer
Cancer Res 2003 63: 1652-1656. [Abstract] [Full Text] [PDF]  

Gal Akiri, Edmond Sabo, Hagit Dafni, Zehava Vadasz, Yelena Kartvelishvily, Noga Gan, Ofra Kessler, Tzafra Cohen, Murray Resnick, Michal Neeman, and Gera Neufeld

Lysyl Oxidase-related Protein-1 Promotes Tumor Fibrosis and Tumor Progression in Vivo
Cancer Res 2003 63: 1657-1666. [Abstract] [Full Text] [PDF]  

Carol Sawyer, Justin Sturge, Dorothy C. Bennett, Michael J. O’Hare, William E. Allen, Jennifer Bain, Gareth E. Jones, and Bart Vanhaesebroeck

Regulation of Breast Cancer Cell Chemotaxis by the Phosphoinositide 3-Kinase p110
Cancer Res 2003 63: 1667-1675. [Abstract] [Full Text] [PDF] Supplementary Data  

Daisuke Kudo, Patricia Rayman, Claudine Horton, Martha K. Cathcart, Ronald M. Bukowski, Mark Thornton, Charles Tannenbaum, and James H. Finke

Gangliosides Expressed by the Renal Cell Carcinoma Cell Line SK-RC-45 Are Involved in Tumor-induced Apoptosis of T Cells
Cancer Res 2003 63: 1676-1683. [Abstract] [Full Text] [PDF]  

Julio A. Aguirre-Ghiso, Yeriel Estrada, David Liu, and Liliana Ossowski

ERK^MAPK Activity as a Determinant of Tumor Growth and Dormancy; Regulation by p38^SAPK
Cancer Res 2003 63: 1684-1695. [Abstract] [Full Text] [PDF]  

Benjamin L. Kagan, Ralf T. Henke, Rafael Cabal-Manzano, Gerald E. Stoica, Quang Nguyen, Anton Wellstein, and Anna Tate Riegel

Complex Regulation of the Fibroblast Growth Factor-binding Protein in MDA- MB-468 Breast Cancer Cells by CCAAT/Enhancer-binding Protein ß
Cancer Res 2003 63: 1696-1705. [Abstract] [Full Text] [PDF]  

Dai Shida, Joji Kitayama, Hironori Yamaguchi, Yurai Okaji, Nelson Hirokazu Tsuno, Toshiaki Watanabe, Yoh Takuwa, and Hirokazu Nagawa

Lysophosphatidic Acid (LPA) Enhances the Metastatic Potential of Human Colon Carcinoma DLD1 Cells through LPA1
Cancer Res 2003 63: 1706-1711. [Abstract] [Full Text] [PDF]  

Karthikeyan Kandasamy, Srinivasa M. Srinivasula, Emad S. Alnemri, Craig B. Thompson, Stanley J. Korsmeyer, Joseph L. Bryant, and Rakesh K. Srivastava

Involvement of Proapoptotic Molecules Bax and Bak in Tumor Necrosis Factor-related Apoptosis-inducing Ligand (TRAIL)-induced Mitochondrial Disruption and Apoptosis: Differential Regulation of Cytochrome c and Smac/DIABLO Release
Cancer Res 2003 63: 1712-1721. [Abstract] [Full Text] [PDF]  

Letters to the Editor:

Sandrine Roulland, Pierre Lebailly, Pascal Gauduchon, Natascha Welzel, Bertrand Nadel, and Ulrich Jaeger

Correspondence re: Welzel et al., Cancer Res., 61: 1629–1636.
Cancer Res 2003 63: 1722-1723. [Full Text] [PDF]  

Obituary:

James E. Trosko and Henry C. Pitot

In Memoriam: Professor Emeritus Van Rensselaer Potter II (1911–2001)
Cancer Res 2003 63: 1724. [Full Text] [PDF]  

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