The subjectivity of cervical cytology could be reduced by molecular markers that establish the presence and severity of dysplastic cells. cDNA and tissue microarrays were used to identify and evaluate 62 genes that are up-regulated in premalignant cervical lesions and invasive cancers. The cover features an in situ hybridization detecting claudin 1 mRNA in epithelial cells of a squamous cell carcinoma of the cervix. This gene is expressed at high levels in 90% of the carcinomas examined. For details, see the article by Y. Chen et al. on page 1927 of this issue.