Reviews:

Masanobu Sugimoto, Hidetoshi Tahara, Toshinori Ide, and Yasuhiro Furuichi

Steps Involved in Immortalization and Tumorigenesis in Human B-Lymphoblastoid Cell Lines Transformed by Epstein-Barr Virus
Cancer Res 2004 64: 3361-3364. [Abstract] [Full Text] [PDF]  

Advances in Brief:

Yoshifumi Takei, Kenji Kadomatsu, Yukio Yuzawa, Seiichi Matsuo, and Takashi Muramatsu

A Small Interfering RNA Targeting Vascular Endothelial Growth Factor as Cancer Therapeutics
Cancer Res 2004 64: 3365-3370. [Abstract] [Full Text] [PDF]  

Yi Xu, Takita Felder Sumter, Raka Bhattacharya, Abeba Tesfaye, Ephraim J. Fuchs, Lisa J. Wood, David L. Huso, and Linda M. S. Resar

The HMG-I Oncogene Causes Highly Penetrant, Aggressive Lymphoid Malignancy in Transgenic Mice and Is Overexpressed in Human Leukemia
Cancer Res 2004 64: 3371-3375. [Abstract] [Full Text] [PDF]  

Tomoharu Fukumori, Yukinori Takenaka, Natsuo Oka, Tadashi Yoshii, Victor Hogan, Hidenori Inohara, Hiro-omi Kanayama, Hyeong-Reh Choi Kim, and Avraham Raz

Endogenous Galectin-3 Determines the Routing of CD95 Apoptotic Signaling Pathways
Cancer Res 2004 64: 3376-3379. [Abstract] [Full Text] [PDF]  

Amir Abbas Samani, Eric Chevet, Lucia Fallavollita, Jacques Galipeau, and Pnina Brodt

Loss of Tumorigenicity and Metastatic Potential in Carcinoma Cells Expressing the Extracellular Domain of the Type 1 Insulin-Like Growth Factor Receptor
Cancer Res 2004 64: 3380-3385. [Abstract] [Full Text] [PDF]  

Aaron T. Ludwig, Jill M. Moore, Yi Luo, Xiaohong Chen, Nicole A. Saltsgaver, Michael A. O’Donnell, and Thomas S. Griffith

Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand: A Novel Mechanism for Bacillus Calmette-Guérin-Induced Antitumor Activity
Cancer Res 2004 64: 3386-3390. [Abstract] [Full Text] [PDF]  

Efterpi Papouli, Petr Cejka, and Josef Jiricny

Dependence of the Cytotoxicity of DNA-Damaging Agents on the Mismatch Repair Status of Human Cells
Cancer Res 2004 64: 3391-3394. [Abstract] [Full Text] [PDF]  

Molecular Biology, Pathobiology, and Genetics:

Karl-Ludwig Schaefer, Kristin Brachwitz, Daniel H. Wai, Yvonne Braun, Raihanatou Diallo, Eberhard Korsching, Martin Eisenacher, Reinhard Voss, Frans van Valen, Claudia Baer, Barbara Selle, Laura Spahn, Shuen-Kuei Liao, Kevin A. W. Lee, Pancras C. W. Hogendoorn, Guido Reifenberger, Helmut E. Gabbert, and Christopher Poremba

Expression Profiling of t(12;22) Positive Clear Cell Sarcoma of Soft Tissue Cell Lines Reveals Characteristic Up-Regulation of Potential New Marker Genes Including ERBB3
Cancer Res 2004 64: 3395-3405. [Abstract] [Full Text] [PDF] Supplemental Data  

Souhila Medjkane, Eugene Novikov, Isabella Versteege, and Olivier Delattre

The Tumor Suppressor hSNF5/INI1 Modulates Cell Growth and Actin Cytoskeleton Organization
Cancer Res 2004 64: 3406-3413. [Abstract] [Full Text] [PDF] Supplementary Data  

Carlo C. Maley, Patricia C. Galipeau, Xiaohong Li, Carissa A. Sanchez, Thomas G. Paulson, and Brian J. Reid

Selectively Advantageous Mutations and Hitchhikers in Neoplasms: p16 Lesions Are Selected in Barrett’s Esophagus
Cancer Res 2004 64: 3414-3427. [Abstract] [Full Text] [PDF]  

Tsuneo Ikenoue, Yohko Hikiba, Fumihiko Kanai, Jun Aragaki, Yasuo Tanaka, Jun Imamura, Takaaki Imamura, Miki Ohta, Hideaki Ijichi, Keisuke Tateishi, Takayuki Kawakami, Masayuki Matsumura, Takao Kawabe, and Masao Omata

Different Effects of Point Mutations within the B-Raf Glycine-Rich Loop in Colorectal Tumors on Mitogen-Activated Protein/Extracellular Signal-Regulated Kinase Kinase/Extracellular Signal-Regulated Kinase and Nuclear Factor B Pathway and Cellular Transformation
Cancer Res 2004 64: 3428-3435. [Abstract] [Full Text] [PDF]  

Nisreen El-Hashemite, Hongbing Zhang, Victoria Walker, Karin M. Hoffmeister, and David J. Kwiatkowski

Perturbed IFN--Jak-Signal Transducers and Activators of Transcription Signaling in Tuberous Sclerosis Mouse Models: Synergistic Effects of Rapamycin-IFN- Treatment
Cancer Res 2004 64: 3436-3443. [Abstract] [Full Text] [PDF]  

Oliver E. Bechter, Ying Zou, William Walker, Woodring E. Wright, and Jerry W. Shay

Telomeric Recombination in Mismatch Repair Deficient Human Colon Cancer Cells after Telomerase Inhibition
Cancer Res 2004 64: 3444-3451. [Abstract] [Full Text] [PDF]  

Yoshitaka Hosokawa, Hiroko Suzuki, Yasuyuki Suzuki, Ryosuke Takahashi, and Masao Seto

Antiapoptotic Function of Apoptosis Inhibitor 2-MALT1 Fusion Protein Involved in t(11;18)(q21;q21) Mucosa-Associated Lymphoid Tissue Lymphoma
Cancer Res 2004 64: 3452-3457. [Abstract] [Full Text] [PDF]  

Remond J. A. Fijneman, Mariska Vos, Johannes Berkhof, Peter Demant, and Georg Kraal

Genetic Analysis of Macrophage Characteristics as a Tool to Identify Tumor Susceptibility Genes: Mapping of Three Macrophage-Associated Risk Inflammatory Factors, Marif1, Marif2, and Marif3
Cancer Res 2004 64: 3458-3464. [Abstract] [Full Text] [PDF]  

Celine Pompeia, David R. Hodge, Christoph Plass, Yue-Zhong Wu, Victor E. Marquez, James A. Kelley, and William L. Farrar

Microarray Analysis of Epigenetic Silencing of Gene Expression in the KAS-6/1 Multiple Myeloma Cell Line
Cancer Res 2004 64: 3465-3473. [Abstract] [Full Text] [PDF]  

Liang You, Biao He, Kazutsugu Uematsu, Zhidong Xu, Julien Mazieres, Amie Lee, Frank McCormick, and David M. Jablons

Inhibition of Wnt-1 Signaling Induces Apoptosis in ß-Catenin-Deficient Mesothelioma Cells
Cancer Res 2004 64: 3474-3478. [Abstract] [Full Text] [PDF]  

Cell and Tumor Biology:

Shankar Sellappan, Rebecca Grijalva, Xiaoyan Zhou, Wentao Yang, Menashe Bar Eli, Gordon B. Mills, and Dihua Yu

Lineage Infidelity of MDA-MB-435 Cells: Expression of Melanocyte Proteins in a Breast Cancer Cell Line
Cancer Res 2004 64: 3479-3485. [Abstract] [Full Text] [PDF]  

Satoshi Tanno, Nobuyuki Yanagawa, Atsuya Habiro, Kazuya Koizumi, Yasuhiro Nakano, Manabu Osanai, Yusuke Mizukami, Toshikatsu Okumura, Joseph R. Testa, and Yutaka Kohgo

Serine/Threonine Kinase AKT Is Frequently Activated in Human Bile Duct Cancer and Is Associated with Increased Radioresistance
Cancer Res 2004 64: 3486-3490. [Abstract] [Full Text] [PDF]  

Li Liu, Xin-Zi Yu, Tie-Shi Li, Lian-Xia Song, Pei-La Chen, Ta-Lin Suo, Ying-Hua Li, Shi-Dong Wang, Yue Chen, Yong-Ming Ren, Shu-Ping Zhang, Zhi-Jie Chang, and Xin-Yuan Fu

A Novel Protein Tyrosine Kinase NOK that Shares Homology with Platelet- Derived Growth Factor/Fibroblast Growth Factor Receptors Induces Tumorigenesis and Metastasis in Nude Mice
Cancer Res 2004 64: 3491-3499. [Abstract] [Full Text] [PDF]  

Andrew M. Arsham, David R. Plas, Craig B. Thompson, and M. Celeste Simon

Akt and Hypoxia-Inducible Factor-1 Independently Enhance Tumor Growth and Angiogenesis
Cancer Res 2004 64: 3500-3507. [Abstract] [Full Text] [PDF]  

Heidemarie Rossiter, Caterina Barresi, Johannes Pammer, Michael Rendl, Jody Haigh, Erwin F. Wagner, and Erwin Tschachler

Loss of Vascular Endothelial Growth Factor A Activity in Murine Epidermal Keratinocytes Delays Wound Healing and Inhibits Tumor Formation
Cancer Res 2004 64: 3508-3516. [Abstract] [Full Text] [PDF]  

Makiko Taniai, Annette Grambihler, Hajime Higuchi, Nate Werneburg, Steve F. Bronk, Daniel J. Farrugia, Scott H. Kaufmann, and Gregory J. Gores

Mcl-1 Mediates Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand Resistance in Human Cholangiocarcinoma Cells
Cancer Res 2004 64: 3517-3524. [Abstract] [Full Text] [PDF]  

Suh-Chin J. Lin, Kuo-Fen Lee, Alexander Yu. Nikitin, Susan G. Hilsenbeck, Robert D. Cardiff, Aihua Li, Keon-Wook Kang, Steven A. Frank, Wen-Hwa Lee, and Eva Y-H. P. Lee

Somatic Mutation of p53 Leads to Estrogen Receptor -Positive and -Negative Mouse Mammary Tumors with High Frequency of Metastasis
Cancer Res 2004 64: 3525-3532. [Abstract] [Full Text] [PDF]  

Hirofumi Uehara, Masaki Miyamoto, Kentaro Kato, Yuma Ebihara, Hiroyuki Kaneko, Hiroyuki Hashimoto, Yoshihiro Murakami, Ryunosuke Hase, Ryo Takahashi, Seiji Mega, Toshiaki Shichinohe, You Kawarada, Tomoo Itoh, Shunichi Okushiba, Satoshi Kondo, and Hiroyuki Katoh

Expression of Pigment Epithelium-Derived Factor Decreases Liver Metastasis and Correlates with Favorable Prognosis for Patients with Ductal Pancreatic Adenocarcinoma
Cancer Res 2004 64: 3533-3537. [Abstract] [Full Text] [PDF]  

Monilola A. Olayioye, Peter Hoffmann, Thomas Pomorski, Jane Armes, Richard J. Simpson, Bruce E. Kemp, Geoffrey J. Lindeman, and Jane E. Visvader

The Phosphoprotein StarD10 Is Overexpressed in Breast Cancer and Cooperates with ErbB Receptors in Cellular Transformation
Cancer Res 2004 64: 3538-3544. [Abstract] [Full Text] [PDF]  

Kosuke Oikawa, Tetsuya Ohbayashi, Tohru Kiyono, Hirotaka Nishi, Keiichi Isaka, Akihiro Umezawa, Masahiko Kuroda, and Kiyoshi Mukai

Expression of a Novel Human Gene, Human Wings Apart-Like (hWAPL), Is Associated with Cervical Carcinogenesis and Tumor Progression
Cancer Res 2004 64: 3545-3549. [Abstract] [Full Text] [PDF]  

Debra L. Silver, Honami Naora, Jinsong Liu, Wenjun Cheng, and Denise J. Montell

Activated Signal Transducer and Activator of Transcription (STAT) 3: Localization in Focal Adhesions and Function in Ovarian Cancer Cell Motility
Cancer Res 2004 64: 3550-3558. [Abstract] [Full Text] [PDF] Supplementary Data  

Sophie Couvé-Privat, Marc Le Bret, Elisabeth Traiffort, Sophie Queille, Josée Coulombe, Bakar Bouadjar, Marie Françoise Avril, Martial Ruat, Alain Sarasin, and Leela Daya-Grosjean

Functional Analysis of Novel Sonic Hedgehog Gene Mutations Identified in Basal Cell Carcinomas from Xeroderma Pigmentosum Patients
Cancer Res 2004 64: 3559-3565. [Abstract] [Full Text] [PDF]  

Mara H. Rendi, Nanjoo Suh, William W. Lamph, Stan Krajewski, John C. Reed, Richard A. Heyman, Andrew Berchuck, Karen Liby, Renee Risingsong, Darlene B. Royce, Charlotte R. Williams, and Michael B. Sporn

The Selective Estrogen Receptor Modulator Arzoxifene and the Rexinoid LG100268 Cooperate to Promote Transforming Growth Factor ß-Dependent Apoptosis in Breast Cancer
Cancer Res 2004 64: 3566-3571. [Abstract] [Full Text] [PDF]  

Vered Givant-Horwitz, Ben Davidson, and Reuven Reich

Laminin-Induced Signaling in Tumor Cells: The Role of the M_r 67,000 Laminin Receptor
Cancer Res 2004 64: 3572-3579. [Abstract] [Full Text] [PDF]  

Junji Mitsushita, J. David Lambeth, and Tohru Kamata

The Superoxide-Generating Oxidase Nox1 Is Functionally Required for Ras Oncogene Transformation
Cancer Res 2004 64: 3580-3585. [Abstract] [Full Text] [PDF]  

Experimental Therapeutics, Molecular Targets, and Chemical Biology:

Jiazhi Sun, Michelle A. Blaskovich, Rishi K. Jain, Frederic Delarue, Daniel Paris, Steven Brem, Marguerite Wotoczek-Obadia, Qing Lin, Domenico Coppola, Kihang Choi, Michael Mullan, Andrew D. Hamilton, and Saïd M. Sebti

Blocking Angiogenesis and Tumorigenesis with GFA-116, a Synthetic Molecule that Inhibits Binding of Vascular Endothelial Growth Factor to its Receptor
Cancer Res 2004 64: 3586-3592. [Abstract] [Full Text] [PDF]  

Sandrine Lacour, Arlette Hammann, Solène Grazide, Dominique Lagadic-Gossmann, Anne Athias, Odile Sergent, Guy Laurent, Philippe Gambert, Eric Solary, and Marie-Thérèse Dimanche-Boitrel

Cisplatin-Induced CD95 Redistribution into Membrane Lipid Rafts of HT29 Human Colon Cancer Cells
Cancer Res 2004 64: 3593-3598. [Abstract] [Full Text] [PDF]  

Nichole Boyer Arnold, Knut Ketterer, Jörg Kleeff, Helmut Friess, Markus W. Büchler, and Murray Korc

Thioredoxin Is Downstream of Smad7 in a Pathway That Promotes Growth and Suppresses Cisplatin-Induced Apoptosis in Pancreatic Cancer
Cancer Res 2004 64: 3599-3606. [Abstract] [Full Text] [PDF]  

Ji-Hui Hao, Ming Yu, Feng-Ting Liu, Adrian C. Newland, and Li Jia

Bcl-2 Inhibitors Sensitize Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand-Induced Apoptosis by Uncoupling of Mitochondrial Respiration in Human Leukemic CEM Cells
Cancer Res 2004 64: 3607-3616. [Abstract] [Full Text] [PDF]  

Shih-Yin Chen, Jane-Ru Vivan Lin, Ramalakshmi Darbha, Pinpin Lin, Tsung-Yun Liu, and Yi-Ming Arthur Chen

Glycine N-Methyltransferase Tumor Susceptibility Gene in the Benzo(a)pyrene-Detoxification Pathway
Cancer Res 2004 64: 3617-3623. [Abstract] [Full Text] [PDF]  

Akihiro Sako, Joji Kitayama, Hiroyuki Koyama, Hikaru Ueno, Hiroaki Uchida, Hirofumi Hamada, and Hirokazu Nagawa

Transduction of Soluble Flt-1 Gene to Peritoneal Mesothelial Cells Can Effectively Suppress Peritoneal Metastasis of Gastric Cancer
Cancer Res 2004 64: 3624-3628. [Abstract] [Full Text] [PDF]  

Maria M. Facchinetti, Adriana De Siervi, Doreen Toskos, and Adrian M. Senderowicz

UCN-01-Induced Cell Cycle Arrest Requires the Transcriptional Induction of p21^waf1/cip1 by Activation of Mitogen-Activated Protein/Extracellular Signal-Regulated Kinase Kinase/Extracellular Signal-Regulated Kinase Pathway
Cancer Res 2004 64: 3629-3637. [Abstract] [Full Text] [PDF]  

Karoly Toth, Hakim Djeha, Baoling Ying, Ann E. Tollefson, Mohan Kuppuswamy, Konstantin Doronin, Peter Krajcsi, Kai Lipinski, Christopher J. Wrighton, and William S. M. Wold

An Oncolytic Adenovirus Vector Combining Enhanced Cell-to-Cell Spreading, Mediated by the ADP Cytolytic Protein, with Selective Replication in Cancer Cells with Deregulated Wnt Signaling
Cancer Res 2004 64: 3638-3644. [Abstract] [Full Text] [PDF]  

Prince George, Purva Bali, Pamela Cohen, Jianguo Tao, Fei Guo, Celia Sigua, Anasuya Vishvanath, Warren Fiskus, Anna Scuto, Srinivas Annavarapu, Lynn Moscinski, and Kapil Bhalla

Cotreatment with 17-Allylamino-Demethoxygeldanamycin and FLT-3 Kinase Inhibitor PKC412 Is Highly Effective against Human Acute Myelogenous Leukemia Cells with Mutant FLT-3
Cancer Res 2004 64: 3645-3652. [Abstract] [Full Text] [PDF]  

Zoya N. Demidenko and Mikhail V. Blagosklonny

Flavopiridol Induces p53 via Initial Inhibition of Mdm2 and p21 and, Independently of p53, Sensitizes Apoptosis-Reluctant Cells to Tumor Necrosis Factor
Cancer Res 2004 64: 3653-3660. [Abstract] [Full Text] [PDF]  

Immunology:

Tong Xu, Chen-Tsen Shu, Elizabeth Purdom, Demi Dang, Diane Ilsley, Yaqian Guo, Jeffrey Weber, Susan P. Holmes, and Peter P. Lee

Microarray Analysis Reveals Differences in Gene Expression of Circulating CD8+ T Cells in Melanoma Patients and Healthy Donors
Cancer Res 2004 64: 3661-3667. [Abstract] [Full Text] [PDF]  

Hasan E. Zeytin, Arti C. Patel, Connie J. Rogers, Daniel Canter, Stephen D. Hursting, Jeffrey Schlom, and John W. Greiner

Combination of a Poxvirus-Based Vaccine with a Cyclooxygenase-2 Inhibitor (Celecoxib) Elicits Antitumor Immunity and Long-Term Survival in CEA.Tg/MIN Mice
Cancer Res 2004 64: 3668-3678. [Abstract] [Full Text] [PDF]  

Endocrinology:

Niina Veitonmäki, Renhai Cao, Lin-Hua Wu, Tammy L. Moser, Bo Li, Salvatore V. Pizzo, Boris Zhivotovsky, and Yihai Cao

Endothelial Cell Surface ATP Synthase-Triggered Caspase-Apoptotic Pathway Is Essential for K1-5-Induced Antiangiogenesis
Cancer Res 2004 64: 3679-3686. [Abstract] [Full Text] [PDF]  

Reidar Fossmark, Tom C. Martinsen, Karin E. Bakkelund, Shiro Kawase, and Helge L. Waldum

ECL-Cell Derived Gastric Cancer in Male Cotton Rats Dosed with the H2-Blocker Loxtidine
Cancer Res 2004 64: 3687-3693. [Abstract] [Full Text] [PDF]  

Clinical Research:

Ling-Chun Chen, Chun-Yi Hao, Yanek S. Y. Chiu, Patrick Wong, Jane S. Melnick, Martin Brotman, John Moretto, Fredrick Mendes, Andrew P. Smith, James L. Bennington, Dan Moore, and Nancy M. Lee

Alteration of Gene Expression in Normal-Appearing Colon Mucosa of APC^min Mice and Human Cancer Patients
Cancer Res 2004 64: 3694-3700. [Abstract] [Full Text] [PDF]  

Epidemiology and Prevention:

Eun Young Park, Il Je Cho, and Sang Geon Kim

Transactivation of the PPAR-Responsive Enhancer Module in Chemopreventive Glutathione S-Transferase Gene by the Peroxisome Proliferator-Activated Receptor- and Retinoid X Receptor Heterodimer
Cancer Res 2004 64: 3701-3713. [Abstract] [Full Text] [PDF]  

Tong Chen, Ronald G. Nines, Sarah M. Peschke, Laura A. Kresty, and Gary D. Stoner

Chemopreventive Effects of a Selective Nitric Oxide Synthase Inhibitor on Carcinogen-Induced Rat Esophageal Tumorigenesis
Cancer Res 2004 64: 3714-3717. [Abstract] [Full Text] [PDF]  

Meeting Report:

Anat O. Stemmer-Rachamimov, David N. Louis, Gunnlaugur P. Nielsen, Cristina R. Antonescu, Alexander D. Borowsky, Roderick T. Bronson, Dennis K. Burns, Pascale Cervera, Margaret E. McLaughlin, Guido Reifenberger, Michael C. Schmale, Mia MacCollin, Richard C. Chao, Karen Cichowski, Michel Kalamarides, Shanta M. Messerli, Andrea I. McClatchey, Michiko Niwa-Kawakita, Nancy Ratner, Karlyne M. Reilly, Yuan Zhu, and Marco Giovannini

Comparative Pathology of Nerve Sheath Tumors in Mouse Models and Humans
Cancer Res 2004 64: 3718-3724. [Abstract] [Full Text] [PDF]  

Corrections:

Corrections
Cancer Res 2004 64: 3725. [Full Text] [PDF]  

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