Advances in Brief:

Topical Tazarotene Chemoprevention Reduces Basal Cell Carcinoma Number and Size in Ptch1+/– Mice Exposed to Ultraviolet or Ionizing Radiation

Po-Lin So, Kenneth Lee, Jennifer Hebert, Patricia Walker, Ying Lu, Jimmy Hwang, Levy Kopelovich, Mohammed Athar, David Bickers, Michelle Aszterbaum, and Ervin H. Epstein, Jr.
Cancer Res 2004 64: 4385-4389. [Abstract] [Full Text] [PDF]  

Genotoxic Stress Induces Expression of E2F4, Leading to Its Association with p130 in Prostate Carcinoma Cells

Erica L. DuPree, Suparna Mazumder, and Alexandru Almasan
Cancer Res 2004 64: 4390-4393. [Abstract] [Full Text] [PDF]  

Akt/Protein Kinase B Signaling Inhibitor-2, a Selective Small Molecule Inhibitor of Akt Signaling with Antitumor Activity in Cancer Cells Overexpressing Akt

Lin Yang, Han C. Dan, Mei Sun, Qiyuan Liu, Xia-meng Sun, Richard I. Feldman, Andrew D. Hamilton, Mark Polokoff, Santo V. Nicosia, Meenhard Herlyn, Said M. Sebti, and Jin Q. Cheng
Cancer Res 2004 64: 4394-4399. [Abstract] [Full Text] [PDF]  

Peritumor Lymphatics Induced by Vascular Endothelial Growth Factor-C Exhibit Abnormal Function

Naohide Isaka, Timothy P. Padera, Jeroen Hagendoorn, Dai Fukumura, and Rakesh K. Jain
Cancer Res 2004 64: 4400-4404. [Abstract] [Full Text] [PDF]  

Overexpression of Transforming Growth Factor ß1 in Head and Neck Epithelia Results in Inflammation, Angiogenesis, and Epithelial Hyperproliferation

Shi-Long Lu, Douglas Reh, Allen G. Li, Jennifer Woods, Christopher L. Corless, Molly Kulesz-Martin, and Xiao-Jing Wang
Cancer Res 2004 64: 4405-4410. [Abstract] [Full Text] [PDF]  

Accumulation of the Oxidative Base Lesion 8-Hydroxyguanine in DNA of Tumor-Prone Mice Defective in Both the Myh and Ogg1 DNA Glycosylases

Maria Teresa Russo, Gabriele De Luca, Paolo Degan, Eleonora Parlanti, Eugenia Dogliotti, Deborah E. Barnes, Tomas Lindahl, Hanjing Yang, Jeffrey H. Miller, and Margherita Bignami
Cancer Res 2004 64: 4411-4414. [Abstract] [Full Text] [PDF]  

Loss of Nuclear Factor-B Is Tumor Promoting but Does Not Substitute for Loss of p53

Kevin M. Ryan, Jim O’Prey, and Karen H. Vousden
Cancer Res 2004 64: 4415-4418. [Abstract] [Full Text] [PDF]  

Molecular Biology, Pathobiology, and Genetics:

High-Throughput Retroviral Tagging for Identification of Genes Involved in Initiation and Progression of Mouse Splenic Marginal Zone Lymphomas

Min Sun Shin, Torgny N. Fredrickson, Janet W. Hartley, Takeshi Suzuki, Keiko Agaki, and Herbert C. Morse, III
Cancer Res 2004 64: 4419-4427. [Abstract] [Full Text] [PDF] Supplementary Data  

Genomic DNA-Chip Hybridization Reveals a Higher Incidence of Genomic Amplifications in Pancreatic Cancer than Conventional Comparative Genomic Hybridization and Leads to the Identification of Novel Candidate Genes

Karlheinz Holzmann, Holger Kohlhammer, Carsten Schwaenen, Swen Wessendorf, Hans A. Kestler, Alexandra Schwoerer, Bettina Rau, Bernd Radlwimmer, Hartmut Döhner, Peter Lichter, Thomas Gress, and Martin Bentz
Cancer Res 2004 64: 4428-4433. [Abstract] [Full Text] [PDF]  

Microarray and Serial Analysis of Gene Expression Analyses Identify Known and Novel Transcripts Overexpressed in Hematopoietic Stem Cells

Robert W. Georgantas, III, Vivek Tanadve, Matthew Malehorn, Shelly Heimfeld, Chen Chen, Laura Carr, Francisco Martinez-Murillo, Greg Riggins, Jeanne Kowalski, and Curt I. Civin
Cancer Res 2004 64: 4434-4441. [Abstract] [Full Text] [PDF] Supplementary Data  

Quantitative Multiplex Methylation-Specific PCR Assay for the Detection of Promoter Hypermethylation in Multiple Genes in Breast Cancer

Mary Jo Fackler, Megan McVeigh, Jyoti Mehrotra, Marissa A. Blum, Julie Lange, Amanda Lapides, Elizabeth Garrett, Pedram Argani, and Saraswati Sukumar
Cancer Res 2004 64: 4442-4452. [Abstract] [Full Text] [PDF]  

The RET Receptor Is Linked to Stress Response Pathways

Shirley M. Myers and Lois M. Mulligan
Cancer Res 2004 64: 4453-4463. [Abstract] [Full Text] [PDF]  

Genotoxicity of Therapeutic Intervention in Children with Acute Lymphocytic Leukemia

Sederick C. Rice, Pamela Vacek, Alan H. Homans, Terri Messier, Jami Rivers, Heather Kendall, and Barry A. Finette
Cancer Res 2004 64: 4464-4471. [Abstract] [Full Text] [PDF]  

DNA Hypomethylation and Ovarian Cancer Biology

Martin Widschwendter, Guanchao Jiang, Christian Woods, Hannes M. Müller, Heidi Fiegl, Georg Goebel, Christian Marth, Elisabeth Müller-Holzner, Alain G. Zeimet, Peter W. Laird, and Melanie Ehrlich
Cancer Res 2004 64: 4472-4480. [Abstract] [Full Text] [PDF] Supplementary Data  

Cell and Tumor Biology:

Modulation of Tumor-host Interactions, Angiogenesis, and Tumor Growth by Tissue Inhibitor of Metalloproteinase 2 via a Novel Mechanism

Andrew L. Feldman, William G. Stetler-Stevenson, Nick G. Costouros, Vladimir Knezevic, Galina Baibakov, H. Richard Alexander, Jr., Dominique Lorang, Stephen M. Hewitt, Dong-Wan Seo, Marshall S. Miller, Sarah O’Connor, and Steven K. Libutti
Cancer Res 2004 64: 4481-4486. [Abstract] [Full Text] [PDF]  

Increased Susceptibility of Poly(ADP-Ribose) Polymerase-1 Knockout Cells to Antitumor Triazoloacridone C-1305 Is Associated with Permanent G₂ Cell Cycle Arrest

Józefa Wesierska-Gadek, Daniela Schloffer, Marieta Gueorguieva, Maria Uhl, and Andrzej Skladanowski
Cancer Res 2004 64: 4487-4497. [Abstract] [Full Text] [PDF]  

Loss of Disialyl Lewis^a, the Ligand for Lymphocyte Inhibitory Receptor Sialic Acid-Binding Immunoglobulin-Like Lectin-7 (Siglec-7) Associated with Increased Sialyl Lewis^a Expression on Human Colon Cancers

Keiko Miyazaki, Katsuyuki Ohmori, Mineko Izawa, Tetsufumi Koike, Kensuke Kumamoto, Koichi Furukawa, Takayuki Ando, Makoto Kiso, Toshiyuki Yamaji, Yasuhiro Hashimoto, Akemi Suzuki, Aruto Yoshida, Makoto Takeuchi, and Reiji Kannagi
Cancer Res 2004 64: 4498-4505. [Abstract] [Full Text] [PDF]  

Fidelity of Runx2 Activity in Breast Cancer Cells Is Required for the Generation of Metastases-Associated Osteolytic Disease

George L. Barnes, Kerri E. Hebert, Mohammad Kamal, Amjad Javed, Thomas A. Einhorn, Jane B. Lian, Gary S. Stein, and Louis C. Gerstenfeld
Cancer Res 2004 64: 4506-4513. [Abstract] [Full Text] [PDF]  

Integrin 5ß1 Promotes Survival of Growth-Arrested Breast Cancer Cells: An in Vitro Paradigm for Breast Cancer Dormancy in Bone Marrow

Reju Korah, Monika Boots, and Robert Wieder
Cancer Res 2004 64: 4514-4522. [Abstract] [Full Text] [PDF]  

Smad-Binding Defective Mutant of Transforming Growth Factor ß Type I Receptor Enhances Tumorigenesis but Suppresses Metastasis of Breast Cancer Cell Lines

Fang Tian, Stacey DaCosta Byfield, W. Tony Parks, Christina H. Stuelten, Deepa Nemani, Ying E. Zhang, and Anita B. Roberts
Cancer Res 2004 64: 4523-4530. [Abstract] [Full Text] [PDF]  

Methylation-Associated Silencing of the Heat Shock Protein 47 Gene in Human Neuroblastoma

Qiwei Yang, Shuqing Liu, Yufeng Tian, Chiler Hasan, Donna Kersey, Helen R. Salwen, Alexandre Chlenski, Elizabeth J. Perlman, and Susan L. Cohn
Cancer Res 2004 64: 4531-4538. [Abstract] [Full Text] [PDF]  

Synuclein, a Novel Heat-Shock Protein-Associated Chaperone, Stimulates Ligand-Dependent Estrogen Receptor Signaling and Mammary Tumorigenesis

Yangfu Jiang, Yiliang Ellie Liu, Itzhak D. Goldberg, and Y. Eric Shi
Cancer Res 2004 64: 4539-4546. [Abstract] [Full Text] [PDF]  

AML1-ETO Decreases ETO-2 (MTG16) Interactions with Nuclear Receptor Corepressor, an Effect That Impairs Granulocyte Differentiation

Vinzon Ibañez, Arun Sharma, Silvia Buonamici, Amit Verma, Sudhakar Kalakonda, Jianxiang Wang, ShriHari Kadkol, and Yogen Saunthararajah
Cancer Res 2004 64: 4547-4554. [Abstract] [Full Text] [PDF]  

Directionally Specific Paracrine Communication Mediated by Epithelial FGF9 to Stromal FGFR3 in Two-Compartment Premalignant Prostate Tumors

Chengliu Jin, Fen Wang, Xiaochong Wu, Chundong Yu, Yongde Luo, and Wallace L. McKeehan
Cancer Res 2004 64: 4555-4562. [Abstract] [Full Text] [PDF]  

Urokinase-Type Plasminogen Activator System in Breast Cancer: Association with Tamoxifen Therapy in Recurrent Disease

Marion E. Meijer-van Gelder, Maxime P. Look, Harry A. Peters, Manfred Schmitt, Nils Brünner, Nadia Harbeck, Jan G. M. Klijn, and John A. Foekens
Cancer Res 2004 64: 4563-4568. [Abstract] [Full Text] [PDF]  

Hyaluronan Facilitates Invasion of Colon Carcinoma Cells in Vitro via Interaction with CD44

Hyeong-Rok Kim, Marie A. Wheeler, Christopher M. Wilson, Joji Iida, David Eng, Melanie A. Simpson, James B. McCarthy, and Kelli M. Bullard
Cancer Res 2004 64: 4569-4576. [Abstract] [Full Text] [PDF]  

Activation of Antioxidant Pathways in Ras-Mediated Oncogenic Transformation of Human Surface Ovarian Epithelial Cells Revealed by Functional Proteomics and Mass Spectrometry

Travis W. Young, Fang C. Mei, Gong Yang, Jennifer A. Thompson-Lanza, Jinsong Liu, and Xiaodong Cheng
Cancer Res 2004 64: 4577-4584. [Abstract] [Full Text] [PDF]  

Involvement of Ras Activation in Human Breast Cancer Cell Signaling, Invasion, and Anoikis

Lynn B. Eckert, Gretchen A. Repasky, Aylin S. Ülkü, Aidan McFall, Hong Zhou, Carolyn I. Sartor, and Channing J. Der
Cancer Res 2004 64: 4585-4592. [Abstract] [Full Text] [PDF]  

Acquisition of Resistance to Butyrate Enhances Survival after Stress and Induces Malignancy of Human Colon Carcinoma Cells

Isabel López de Silanes, Nieves Olmo, Javier Turnay, Gonzalo González de Buitrago, Pablo Pérez-Ramos, Ana Guzmán-Aránguez, Marta García-Díez, Emilio Lecona, Myriam Gorospe, and M. Antonia Lizarbe
Cancer Res 2004 64: 4593-4600. [Abstract] [Full Text] [PDF]  

Experimental Therapeutics, Molecular Targets, and Chemical Biology:

Regional Effects of an Antivascular Endothelial Growth Factor Receptor Monoclonal Antibody on Receptor Phosphorylation and Apoptosis in Human 253J B-V Bladder Cancer Xenografts

Darren W. Davis, Keiji Inoue, Colin P. N. Dinney, Daniel J. Hicklin, James L. Abbruzzese, and David J. McConkey
Cancer Res 2004 64: 4601-4610. [Abstract] [Full Text] [PDF]  

Gene Therapy with Secretory Leukoprotease Inhibitor Promoter-Controlled Replication-Competent Adenovirus for Non-Small Cell Lung Cancer

Makoto Maemondo, Yasuo Saijo, Ko Narumi, Toshiaki Kikuchi, Kazuhiro Usui, Ryushi Tazawa, Kunio Matsumoto, Toshikazu Nakamura, Katsunori Sasaki, Minoru Takahashi, Yoshiro Niitsu, and Toshihiro Nukiwa
Cancer Res 2004 64: 4611-4620. [Abstract] [Full Text] [PDF]  

BPR0L075, a Novel Synthetic Indole Compound with Antimitotic Activity in Human Cancer Cells, Exerts Effective Antitumoral Activity in Vivo

Ching-Chuan Kuo, Hsing-Pang Hsieh, Wen-Yu Pan, Ching-Ping Chen, Jing-Ping Liou, Shiow-Ju Lee, Yi-Ling Chang, Li-Tzong Chen, Chiung-Tong Chen, and Jang-Yang Chang
Cancer Res 2004 64: 4621-4628. [Abstract] [Full Text] [PDF]  

In Vitro and in Vivo Activity of the Maytansinoid Immunoconjugate huN901-N^2'-Deacetyl-N^2'-(3-Mercapto-1-Oxopropyl)-Maytansine against CD56⁺ Multiple Myeloma Cells

Pierfrancesco Tassone, Antonella Gozzini, Victor Goldmacher, Masood A. Shammas, Kathleen R. Whiteman, Daniel R. Carrasco, Cheng Li, Charles K. Allam, Salvatore Venuta, Kenneth C. Anderson, and Nikhil C. Munshi
Cancer Res 2004 64: 4629-4636. [Abstract] [Full Text] [PDF]  

Prolonged Extracellular Signal-Regulated Kinase 1/2 Activation during Fibroblast Growth Factor 1- or Heregulin ß1-Induced Antiestrogen-Resistant Growth of Breast Cancer Cells Is Resistant to Mitogen-Activated Protein/Extracellular Regulated Kinase Kinase Inhibitors

Jaideep V. Thottassery, Yanjie Sun, Louise Westbrook, Sarah S. Rentz, Marina Manuvakhova, Zhican Qu, Shanti Samuel, Ramanda Upshaw, Amanda Cunningham, and Francis G. Kern
Cancer Res 2004 64: 4637-4647. [Abstract] [Full Text] [PDF]  

Distinct Responses of Xenografted Gliomas to Different Alkylating Agents Are Related to Histology and Genetic Alterations

Pascal Leuraud, Luc Taillandier, Jacques Medioni, Lucinda Aguirre-Cruz, Emmanuelle Crinière, Yannick Marie, Michèle Kujas, Jean-Louis Golmard, Adrien Duprez, Jean-Yves Delattre, Marc Sanson, and Marie-France Poupon
Cancer Res 2004 64: 4648-4653. [Abstract] [Full Text] [PDF]  

Antiangiogenic and Antitumoral Activity of Phenyl-3-(2-Chloroethyl)Ureas: A Class of Soft Alkylating Agents Disrupting Microtubules That Are Unaffected by Cell Adhesion-Mediated Drug Resistance

Éric Petitclerc, Réna G. Deschesnes, Marie-France Côté, Claude Marquis, Richard Janvier, Jacques Lacroix, Élisabeth Miot-Noirault, Jean Legault, Emmanuelle Mounetou, Jean-Claude Madelmont, and René C.-Gaudreault
Cancer Res 2004 64: 4654-4663. [Abstract] [Full Text] [PDF]  

Immunology:

Rituximab-Dependent Cytotoxicity by Natural Killer Cells: Influence of FCGR3A Polymorphism on the Concentration-Effect Relationship

Sébastien Dall’Ozzo, Sophie Tartas, Gilles Paintaud, Guillaume Cartron, Philippe Colombat, Pierre Bardos, Hervé Watier, and Gilles Thibault
Cancer Res 2004 64: 4664-4669. [Abstract] [Full Text] [PDF]  

Endocrinology:

Estrogen-Related Receptor in Human Breast Carcinoma as a Potent Prognostic Factor

Takashi Suzuki, Yasuhiro Miki, Takuya Moriya, Norihiro Shimada, Takanori Ishida, Hisashi Hirakawa, Noriaki Ohuchi, and Hironobu Sasano
Cancer Res 2004 64: 4670-4676. [Abstract] [Full Text] [PDF]  

Decreased Expression of Early Growth Response-1 and Its Role in Uterine Leiomyoma Growth

Makio Shozu, Kouichi Murakami, Tomoya Segawa, Tadayuki Kasai, Hiroshi Ishikawa, Kazunori Shinohara, Masahiko Okada, and Masaki Inoue
Cancer Res 2004 64: 4677-4684. [Abstract] [Full Text] [PDF]  

Letters to the Editor:

True Immunogenicity of Oncofetal Antigen/Immature Laminin Receptor Protein

Joseph H. Coggin, Jr., James W. Rohrer, Adel L. Barsoum, and Johannes Vieweg
Cancer Res 2004 64: 4685. [Full Text] [PDF]  

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