Advances in Brief:

Swati Biswas, Anna Chytil, Kay Washington, Judith Romero-Gallo, Agnieszka E. Gorska, Pamela S. Wirth, Shiva Gautam, Harold L. Moses, and William M. Grady

Transforming Growth Factor ß Receptor Type II Inactivation Promotes the Establishment and Progression of Colon Cancer
Cancer Res 2004 64: 4687-4692. [Abstract] [Full Text] [PDF] Supplementary Data  

Shannon A. Shulby, Nathan G. Dolloff, Mark E. Stearns, Olimpia Meucci, and Alessandro Fatatis

CX3CR1-Fractalkine Expression Regulates Cellular Mechanisms Involved in Adhesion, Migration, and Survival of Human Prostate Cancer Cells
Cancer Res 2004 64: 4693-4698. [Abstract] [Full Text] [PDF]  

Zhongjun Zhou, Jianming Wang, Renhai Cao, Hiroyuki Morita, Raija Soininen, Kui Ming Chan, Baohua Liu, Yihai Cao, and Karl Tryggvason

Impaired Angiogenesis, Delayed Wound Healing and Retarded Tumor Growth in Perlecan Heparan Sulfate-Deficient Mice
Cancer Res 2004 64: 4699-4702. [Abstract] [Full Text] [PDF]  

Jong Ho Chun, Hark Kyun Kim, Eugene Kim, In-Hoo Kim, Ju Han Kim, Hee Jin Chang, Il Ju Choi, Hyeong-Seok Lim, Il-Jin Kim, Hio Chung Kang, Jae-Hyun Park, Jae-Moon Bae, and Jae-Gahb Park

Increased Expression of Metallothionein Is Associated with Irinotecan Resistance in Gastric Cancer
Cancer Res 2004 64: 4703-4706. [Abstract] [Full Text] [PDF]  

Oliver Moennikes, Sandra Loeppen, Albrecht Buchmann, Patrik Andersson, Carina Ittrich, Lorenz Poellinger, and Michael Schwarz

A Constitutively Active Dioxin/Aryl Hydrocarbon Receptor Promotes Hepatocarcinogenesis in Mice
Cancer Res 2004 64: 4707-4710. [Abstract] [Full Text] [PDF]  

Jun Chung, Sangoh Yoon, Kaustubh Datta, Robin E. Bachelder, and Arthur M. Mercurio

Hypoxia-Induced Vascular Endothelial Growth Factor Transcription and Protection from Apoptosis Are Dependent on 6ß1 Integrin in Breast Carcinoma Cells
Cancer Res 2004 64: 4711-4716. [Abstract] [Full Text] [PDF]  

Julien Mazieres, Biao He, Liang You, Zhidong Xu, Amie Y. Lee, Iwao Mikami, Noemi Reguart, Rafael Rosell, Frank McCormick, and David M. Jablons

Wnt Inhibitory Factor-1 Is Silenced by Promoter Hypermethylation in Human Lung Cancer
Cancer Res 2004 64: 4717-4720. [Abstract] [Full Text] [PDF]  

Molecular Biology, Pathobiology, and Genetics:

Hidewaki Nakagawa, Janet C. Lockman, Wendy L. Frankel, Heather Hampel, Kelle Steenblock, Lawrence J. Burgart, Stephen N. Thibodeau, and Albert de la Chapelle

Mismatch Repair Gene PMS2: Disease-Causing Germline Mutations Are Frequent in Patients Whose Tumors Stain Negative for PMS2 Protein, but Paralogous Genes Obscure Mutation Detection and Interpretation
Cancer Res 2004 64: 4721-4727. [Abstract] [Full Text] [PDF]  

Bernard Kwabi-Addo, Jianghua Wang, Halime Erdem, Ajula Vaid, Patricia Castro, Gustavo Ayala, and Michael Ittmann

The Expression of Sprouty1, an Inhibitor of Fibroblast Growth Factor Signal Transduction, Is Decreased in Human Prostate Cancer
Cancer Res 2004 64: 4728-4735. [Abstract] [Full Text] [PDF]  

Kristian Almstrup, Christina E. Hoei-Hansen, Ute Wirkner, Jonathon Blake, Christian Schwager, Wilhelm Ansorge, John E. Nielsen, Niels E. Skakkebæk, Ewa Rajpert-De Meyts, and Henrik Leffers

Embryonic Stem Cell-Like Features of Testicular Carcinoma in Situ Revealed by Genome-Wide Gene Expression Profiling
Cancer Res 2004 64: 4736-4743. [Abstract] [Full Text] [PDF] Supplementary Data  

Cameron Brennan, Yunyu Zhang, Christopher Leo, Bin Feng, Craig Cauwels, Andrew J. Aguirre, Minjung Kim, Alexei Protopopov, and Lynda Chin

High-Resolution Global Profiling of Genomic Alterations with Long Oligonucleotide Microarray
Cancer Res 2004 64: 4744-4748. [Abstract] [Full Text] [PDF] Supplementary Data  

Damian B. S. Yap, Jung-Kuang Hsieh, Shan Zhong, Vicky Heath, Barry Gusterson, Tim Crook, and Xin Lu

Ser³⁹² Phosphorylation Regulates the Oncogenic Function of Mutant p53
Cancer Res 2004 64: 4749-4754. [Abstract] [Full Text] [PDF]  

Caroline E. Ford, Margaret Faedo, Roger Crouch, James S. Lawson, and William D. Rawlinson

Progression from Normal Breast Pathology to Breast Cancer Is Associated with Increasing Prevalence of Mouse Mammary Tumor Virus-Like Sequences in Men and Women
Cancer Res 2004 64: 4755-4759. [Abstract] [Full Text] [PDF]  

Hai-Ri Li, Elena I. Shagisultanova, Kentaro Yamashita, Zhe Piao, Manuel Perucho, and Sergei R. Malkhosyan

Hypersensitivity of Tumor Cell Lines with Microsatellite Instability to DNA Double Strand Break Producing Chemotherapeutic Agent Bleomycin
Cancer Res 2004 64: 4760-4767. [Abstract] [Full Text] [PDF]  

Cell and Tumor Biology:

Live Eikenes, Øyvind S. Bruland, Christian Brekken, and Catharina de Lange Davies

Collagenase Increases the Transcapillary Pressure Gradient and Improves the Uptake and Distribution of Monoclonal Antibodies in Human Osteosarcoma Xenografts
Cancer Res 2004 64: 4768-4773. [Abstract] [Full Text] [PDF]  

Hongzhen Li, Tommi J. Ahonen, Kalle Alanen, Jianwu Xie, Matthew J. LeBaron, Thomas G. Pretlow, Erica L. Ealley, Ying Zhang, Martti Nurmi, Baljit Singh, Paula M. Martikainen, and Marja T. Nevalainen

Activation of Signal Transducer and Activator of Transcription 5 in Human Prostate Cancer Is Associated with High Histological Grade
Cancer Res 2004 64: 4774-4782. [Abstract] [Full Text] [PDF]  

Alan H. Shih, Chengkai Dai, Xiaoyi Hu, Marc K. Rosenblum, Jason A. Koutcher, and Eric C. Holland

Dose-Dependent Effects of Platelet-Derived Growth Factor-B on Glial Tumorigenesis
Cancer Res 2004 64: 4783-4789. [Abstract] [Full Text] [PDF]  

Michelle R. Staudt, Yogita Kanan, Joseph H. Jeong, James F. Papin, Rebecca Hines-Boykin, and Dirk P. Dittmer

The Tumor Microenvironment Controls Primary Effusion Lymphoma Growth in Vivo
Cancer Res 2004 64: 4790-4799. [Abstract] [Full Text] [PDF]  

Kenji Kawamura, Hideki Izumi, Zhiyong Ma, Ryosuke Ikeda, Manabu Moriyama, Tatsuro Tanaka, Takayuki Nojima, Linda S. Levin, Kohzaburo Fujikawa-Yamamoto, Koji Suzuki, and Kenji Fukasawa

Induction of Centrosome Amplification and Chromosome Instability in Human Bladder Cancer Cells by p53 Mutation and Cyclin E Overexpression
Cancer Res 2004 64: 4800-4809. [Abstract] [Full Text] [PDF] Supplementary Data  

Suguru Hibino, Masahiko Shibuya, Jean A. Engbring, Mayumi Mochizuki, Motoyoshi Nomizu, and Hynda K. Kleinman

Identification of an Active Site on the Laminin 5 Chain Globular Domain That Binds to CD44 and Inhibits Malignancy
Cancer Res 2004 64: 4810-4816. [Abstract] [Full Text] [PDF]  

Eleanor J. Douglas, Heike Fiegler, Andrew Rowan, Sarah Halford, David C. Bicknell, Walter Bodmer, Ian P. M. Tomlinson, and Nigel P. Carter

Array Comparative Genomic Hybridization Analysis of Colorectal Cancer Cell Lines and Primary Carcinomas
Cancer Res 2004 64: 4817-4825. [Abstract] [Full Text] [PDF]  

Taku Nakagawa, Yoji Hayashita, Ken Maeno, Akira Masuda, Nobuyoshi Sugito, Hirotaka Osada, Kiyoshi Yanagisawa, Hiromichi Ebi, Kaoru Shimokata, and Takashi Takahashi

Identification of Decatenation G₂ Checkpoint Impairment Independently of DNA Damage G₂ Checkpoint in Human Lung Cancer Cell Lines
Cancer Res 2004 64: 4826-4832. [Abstract] [Full Text] [PDF]  

Shang Li, Jonathan E. Rosenberg, Annemarie A. Donjacour, Inna L. Botchkina, Yun Kit Hom, Gerald R. Cunha, and Elizabeth H. Blackburn

Rapid Inhibition of Cancer Cell Growth Induced by Lentiviral Delivery and Expression of Mutant-Template Telomerase RNA and Anti-telomerase Short-Interfering RNA
Cancer Res 2004 64: 4833-4840. [Abstract] [Full Text] [PDF] Supplementary Data  

Loïc Lemonnier, Yaroslav Shuba, Alexandre Crepin, Morad Roudbaraki, Christian Slomianny, Brigitte Mauroy, Bernd Nilius, Natalia Prevarskaya, and Roman Skryma

Bcl-2-Dependent Modulation of Swelling-Activated Cl^– Current and ClC-3 Expression in Human Prostate Cancer Epithelial Cells
Cancer Res 2004 64: 4841-4848. [Abstract] [Full Text] [PDF]  

Cha-Kyung Youn, Mi-Hwa Kim, Hyun-Ju Cho, Hong-Beum Kim, In-Youb Chang, Myung-Hee Chung, and Ho Jin You

Oncogenic H-Ras Up-Regulates Expression of ERCC1 to Protect Cells from Platinum-Based Anticancer Agents
Cancer Res 2004 64: 4849-4857. [Abstract] [Full Text] [PDF]  

Ekaterina V. Bobrovnikova-Marjon, Philip L. Marjon, Olena Barbash, David L. Vander Jagt, and Steve F. Abcouwer

Expression of Angiogenic Factors Vascular Endothelial Growth Factor and Interleukin-8/CXCL8 Is Highly Responsive to Ambient Glutamine Availability: Role of Nuclear Factor-B and Activating Protein-1
Cancer Res 2004 64: 4858-4869. [Abstract] [Full Text] [PDF]  

Experimental Therapeutics, Molecular Targets, and Chemical Biology:

Claudia De Lorenzo, Angela Arciello, Rosanna Cozzolino, Donald B. Palmer, Paolo Laccetti, Renata Piccoli, and Giuseppe D’Alessio

A Fully Human Antitumor ImmunoRNase Selective for ErbB-2-Positive Carcinomas
Cancer Res 2004 64: 4870-4874. [Abstract] [Full Text] [PDF]  

Barbara A. Spruce, Lorna A. Campbell, Niall McTavish, Michelle A. Cooper, M. Virginia L. Appleyard, Mary O’Neill, Jacqueline Howie, Jayne Samson, Stephen Watt, Karen Murray, Doris McLean, Nick R. Leslie, Stephen T. Safrany, Michelle J. Ferguson, John A. Peters, Alan R. Prescott, Gary Box, Angela Hayes, Bernard Nutley, Florence Raynaud, C. Peter Downes, Jeremy J. Lambert, Alastair M. Thompson, and Suzanne Eccles

Small Molecule Antagonists of the -1 Receptor Cause Selective Release of the Death Program in Tumor and Self-Reliant Cells and Inhibit Tumor Growth in Vitro and in Vivo
Cancer Res 2004 64: 4875-4886. [Abstract] [Full Text] [PDF]  

Arend van Zon, Marieke H. Mossink, Martijn Schoester, Rik J. Scheper, Pieter Sonneveld, and Erik A. C. Wiemer

Efflux Kinetics and Intracellular Distribution of Daunorubicin Are Not Affected by Major Vault Protein/Lung Resistance-Related Protein (Vault) Expression
Cancer Res 2004 64: 4887-4892. [Abstract] [Full Text] [PDF]  

Ling Geng, Jiahuai Tan, Eric Himmelfarb, Aaron Schueneman, Ken Niermann, Allie Fu, Kyle Cuneo, Edward A. Kesicki, Jennifer Treiberg, Joel S. Hayflick, and Dennis E. Hallahan

A Specific Antagonist of the p110 Catalytic Component of Phosphatidylinositol 3'-Kinase, IC486068, Enhances Radiation-Induced Tumor Vascular Destruction
Cancer Res 2004 64: 4893-4899. [Abstract] [Full Text] [PDF]  

Hongkui Jin, Renhui Yang, Sharon Fong, Klara Totpal, David Lawrence, Zhong Zheng, Jed Ross, Hartmut Koeppen, Ralph Schwall, and Avi Ashkenazi

Apo2 Ligand/Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand Cooperates with Chemotherapy to Inhibit Orthotopic Lung Tumor Growth and Improve Survival
Cancer Res 2004 64: 4900-4905. [Abstract] [Full Text] [PDF]  

Thomas Groot-Wassink, Eric O. Aboagye, Yaohe Wang, Nicholas R. Lemoine, W. Nicol Keith, and Georges Vassaux

Noninvasive Imaging of the Transcriptional Activities of Human Telomerase Promoter Fragments in Mice
Cancer Res 2004 64: 4906-4911. [Abstract] [Full Text] [PDF]  

Katayoun I. Amiri, Linda W. Horton, Bonnie J. LaFleur, Jeffrey A. Sosman, and Ann Richmond

Augmenting Chemosensitivity of Malignant Melanoma Tumors via Proteasome Inhibition: Implication for Bortezomib (VELCADE, PS-341) as a Therapeutic Agent for Malignant Melanoma
Cancer Res 2004 64: 4912-4918. [Abstract] [Full Text] [PDF]  

Bambi D. Anderson, Takafumi Nakamura, Stephen J. Russell, and Kah-Whye Peng

High CD46 Receptor Density Determines Preferential Killing of Tumor Cells by Oncolytic Measles Virus
Cancer Res 2004 64: 4919-4926. [Abstract] [Full Text] [PDF]  

Elizabeth Hopper-Borge, Zhe-Sheng Chen, Irina Shchaveleva, Martin G. Belinsky, and Gary D. Kruh

Analysis of the Drug Resistance Profile of Multidrug Resistance Protein 7 (ABCC10): Resistance to Docetaxel
Cancer Res 2004 64: 4927-4930. [Abstract] [Full Text] [PDF]  

Peter Traxler, Peter R. Allegrini, Ralf Brandt, Josef Brueggen, Robert Cozens, Doriano Fabbro, Konstantina Grosios, Heidi A. Lane, Paul McSheehy, Jürgen Mestan, Thomas Meyer, Careen Tang, Markus Wartmann, Jeanette Wood, and Giorgio Caravatti

AEE788: A Dual Family Epidermal Growth Factor Receptor/ErbB2 and Vascular Endothelial Growth Factor Receptor Tyrosine Kinase Inhibitor with Antitumor and Antiangiogenic Activity
Cancer Res 2004 64: 4931-4941. [Abstract] [Full Text] [PDF]  

Danièle Demarquay, Marion Huchet, Helène Coulomb, Laurence Lesueur-Ginot, Olivier Lavergne, José Camara, Philip G. Kasprzyk, Grégoire Prévost, and Dennis C. H. Bigg

BN80927: A Novel Homocamptothecin That Inhibits Proliferation of Human Tumor Cells in Vitro and in Vivo
Cancer Res 2004 64: 4942-4949. [Abstract] [Full Text] [PDF]  

Doriane Trompier, Xiu-Bao Chang, Régis Barattin, Amaury du Moulinet d’Hardemare, Attilio Di Pietro, and Hélène Baubichon-Cortay

Verapamil and Its Derivative Trigger Apoptosis through Glutathione Extrusion by Multidrug Resistance Protein MRP1
Cancer Res 2004 64: 4950-4956. [Abstract] [Full Text] [PDF]  

Stéphane Honore, Kathy Kamath, Diane Braguer, Susan Band Horwitz, Leslie Wilson, Claudette Briand, and Mary Ann Jordan

Synergistic Suppression of Microtubule Dynamics by Discodermolide and Paclitaxel in Non-Small Cell Lung Carcinoma Cells
Cancer Res 2004 64: 4957-4964. [Abstract] [Full Text] [PDF] Supplementary Data  

Immunology:

Suresh Radhakrishnan, Loc Tan Nguyen, Bogoljub Ciric, Dallas Flies, Virginia P. Van Keulen, Koji Tamada, Lieping Chen, Moses Rodriguez, and Larry R. Pease

Immunotherapeutic Potential of B7-DC (PD-L2) Cross-Linking Antibody In Conferring Antitumor Immunity
Cancer Res 2004 64: 4965-4972. [Abstract] [Full Text] [PDF]  

John S. Yu, Gentao Liu, Han Ying, William H. Yong, Keith L. Black, and Christopher J. Wheeler

Vaccination with Tumor Lysate-Pulsed Dendritic Cells Elicits Antigen-Specific, Cytotoxic T-Cells in Patients with Malignant Glioma
Cancer Res 2004 64: 4973-4979. [Abstract] [Full Text] [PDF]  

Gentao Liu, Han Ying, Gang Zeng, Christopher J. Wheeler, Keith L. Black, and John S. Yu

HER-2, gp100, and MAGE-1 Are Expressed in Human Glioblastoma and Recognized by Cytotoxic T Cells
Cancer Res 2004 64: 4980-4986. [Abstract] [Full Text] [PDF]  

Richard Lo-Man, Sophie Vichier-Guerre, Ronald Perraut, Edith Dériaud, Valérie Huteau, Lbachir BenMohamed, Ousmane M. Diop, Philip O. Livingston, Sylvie Bay, and Claude Leclerc

A Fully Synthetic Therapeutic Vaccine Candidate Targeting Carcinoma-Associated Tn Carbohydrate Antigen Induces Tumor-Specific Antibodies in Nonhuman Primates
Cancer Res 2004 64: 4987-4994. [Abstract] [Full Text] [PDF]  

Asim Saha, Sunil K. Chatterjee, Kenneth A. Foon, F. James Primus, Sunil Sreedharan, Kartik Mohanty, and Malaya Bhattacharya-Chatterjee

Dendritic Cells Pulsed with an Anti-Idiotype Antibody Mimicking Carcinoembryonic Antigen (CEA) Can Reverse Immunological Tolerance to CEA and Induce Antitumor Immunity in CEA Transgenic Mice
Cancer Res 2004 64: 4995-5003. [Abstract] [Full Text] [PDF]  

Epidemiology and Prevention:

Shishir Shishodia and Bharat B. Aggarwal

Cyclooxygenase (COX)-2 Inhibitor Celecoxib Abrogates Activation of Cigarette Smoke-Induced Nuclear Factor (NF)-B by Suppressing Activation of I-B Kinase in Human Non-Small Cell Lung Carcinoma: Correlation with Suppression of Cyclin D1, COX-2, and Matrix Metalloproteinase-9
Cancer Res 2004 64: 5004-5012. [Abstract] [Full Text] [PDF]  

Da-Tian Bau, Yi-Ping Fu, Shou-Tung Chen, Ting-Chih Cheng, Jyh-Cherng Yu, Pei-Ei Wu, and Chen-Yang Shen

Breast Cancer Risk and the DNA Double-Strand Break End-Joining Capacity of Nonhomologous End-Joining Genes Are Affected by BRCA1
Cancer Res 2004 64: 5013-5019. [Abstract] [Full Text] [PDF]  

Yao-Ping Lu, You-Rong Lou, Qing-Yun Peng, Jian-Guo Xie, and Allan H. Conney

Stimulatory Effect of Topical Application of Caffeine on UVB-Induced Apoptosis in the Epidermis of p53 and Bax Knockout Mice
Cancer Res 2004 64: 5020-5027. [Abstract] [Full Text] [PDF]  

Corrections:

Corrections
Cancer Res 2004 64: 5028. [Full Text] [PDF]  

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