Advances in Brief:

Mario F. Fraga, Michel Herranz, Jesús Espada, Esteban Ballestar, Maria F. Paz, Santiago Ropero, Emel Erkek, Onder Bozdogan, Héctor Peinado, Alain Niveleau, Jian-Hua Mao, Alan Balmain, Amparo Cano, and Manel Esteller

A Mouse Skin Multistage Carcinogenesis Model Reflects the Aberrant DNA Methylation Patterns of Human Tumors
Cancer Res 2004 64: 5527-5534. [Abstract] [Full Text] [PDF] Supplementary Data  

Tyler J. Curiel, Pui Cheng, Peter Mottram, Xavier Alvarez, Lieve Moons, Melina Evdemon-Hogan, Shuang Wei, Linhua Zou, Ilona Kryczek, Gary Hoyle, Andrew Lackner, Peter Carmeliet, and Weiping Zou

Dendritic Cell Subsets Differentially Regulate Angiogenesis in Human Ovarian Cancer
Cancer Res 2004 64: 5535-5538. [Abstract] [Full Text] [PDF]  

Marco Wachtel, Marcel Dettling, Eva Koscielniak, Sabine Stegmaier, Jörn Treuner, Katja Simon-Klingenstein, Peter Bühlmann, Felix K. Niggli, and Beat W. Schäfer

Gene Expression Signatures Identify Rhabdomyosarcoma Subtypes and Detect a Novel t(2;2)(q35;p23) Translocation Fusing PAX3 to NCOA1
Cancer Res 2004 64: 5539-5545. [Abstract] [Full Text] [PDF] Supplementary Data  

Martine E. D. Chamuleau, Yuri Souwer, S. Marieke van Ham, Adri Zevenbergen, Theresia M. Westers, Johannes Berkhof, Chris J. L. M. Meijer, Arjan A. van de Loosdrecht, and Gert J. Ossenkoppele

Class II-Associated Invariant Chain Peptide Expression on Myeloid Leukemic Blasts Predicts Poor Clinical Outcome
Cancer Res 2004 64: 5546-5550. [Abstract] [Full Text] [PDF]  

Sujit Basu, Chandrani Sarkar, Debanjan Chakroborty, Janice Nagy, Rita Basu Mitra, Partha Sarathi Dasgupta, and Debabrata Mukhopadhyay

Ablation of Peripheral Dopaminergic Nerves Stimulates Malignant Tumor Growth by Inducing Vascular Permeability Factor/Vascular Endothelial Growth Factor-Mediated Angiogenesis
Cancer Res 2004 64: 5551-5555. [Abstract] [Full Text] [PDF]  

Dimitra Tsavachidou, Mathew L. Coleman, Galene Athanasiadis, Shuixing Li, Jonathan D. Licht, Michael F. Olson, and Barbara L. Weber

SPRY2 Is an Inhibitor of the Ras/Extracellular Signal-Regulated Kinase Pathway in Melanocytes and Melanoma Cells with Wild-Type BRAF but Not with the V599E Mutant
Cancer Res 2004 64: 5556-5559. [Abstract] [Full Text] [PDF]  

Li-E Wang, Melissa L. Bondy, Hongbing Shen, Randa El-Zein, Kenneth Aldape, Yumei Cao, Vinay Pudavalli, Victor A. Levin, W. K. Alfred Yung, and Qingyi Wei

Polymorphisms of DNA Repair Genes and Risk of Glioma
Cancer Res 2004 64: 5560-5563. [Abstract] [Full Text] [PDF]  

Sven Diederichs, Etmar Bulk, Björn Steffen, Ping Ji, Lara Tickenbrock, Kerstin Lang, Kurt S. Zänker, Ralf Metzger, Paul M. Schneider, Volker Gerke, Michael Thomas, Wolfgang E. Berdel, Hubert Serve, and Carsten Müller-Tidow

S100 Family Members and Trypsinogens Are Predictors of Distant Metastasis and Survival in Early-Stage Non-Small Cell Lung Cancer
Cancer Res 2004 64: 5564-5569. [Abstract] [Full Text] [PDF] Supplementary Data  

Molecular Biology, Pathobiology and Genetics:

Steven D. P. Moore, Steven R. Herrick, Tan A. Ince, Michael S. Kleinman, Paola Dal Cin, Cynthia C. Morton, and Bradley J. Quade

Uterine Leiomyomata with t(10;17) Disrupt the Histone Acetyltransferase MORF
Cancer Res 2004 64: 5570-5577. [Abstract] [Full Text] [PDF]  

Remco van Doorn, Remco Dijkman, Maarten H. Vermeer, Jacoba J. Out-Luiting, Elisabeth M. H. van der Raaij-Helmer, Rein Willemze, and Cornelis P. Tensen

Aberrant Expression of the Tyrosine Kinase Receptor EphA4 and the Transcription Factor Twist in Sézary Syndrome Identified by Gene Expression Analysis
Cancer Res 2004 64: 5578-5586. [Abstract] [Full Text] [PDF]  

Alice P. Pentland, Glynis Scott, JoAnne VanBuskirk, Carol Tanck, Gina LaRossa, and Sabine Brouxhon

Cyclooxygenase-1 Deletion Enhances Apoptosis but Does Not Protect Against Ultraviolet Light-Induced Tumors
Cancer Res 2004 64: 5587-5591. [Abstract] [Full Text] [PDF]  

Xin Wang, R. Chase Southard, and Michael W. Kilgore

The Increased Expression of Peroxisome Proliferator-Activated Receptor-1 in Human Breast Cancer Is Mediated by Selective Promoter Usage
Cancer Res 2004 64: 5592-5596. [Abstract] [Full Text] [PDF]  

Jin Yang, Zhiwen Chen, Yang Liu, Robert J. Hickey, and Linda H. Malkas

Altered DNA Polymerase Expression in Breast Cancer Cells Leads to a Reduction in DNA Replication Fidelity and a Higher Rate of Mutagenesis
Cancer Res 2004 64: 5597-5607. [Abstract] [Full Text] [PDF]  

Cell and Tumor Biology:

Debananda Pati, Bassem R. Haddad, Albert Haegele, Henry Thompson, Frances S. Kittrell, Anne Shepard, Cristina Montagna, Nenggang Zhang, Gouqing Ge, Subhendu Kumar Otta, Maureen McCarthy, Robert L. Ullrich, and Daniel Medina

Hormone-Induced Chromosomal Instability in p53-Null Mammary Epithelium
Cancer Res 2004 64: 5608-5616. [Abstract] [Full Text] [PDF]  

Cristina Blázquez, Luis González-Feria, Luis Álvarez, Amador Haro, M. Llanos Casanova, and Manuel Guzmán

Cannabinoids Inhibit the Vascular Endothelial Growth Factor Pathway in Gliomas
Cancer Res 2004 64: 5617-5623. [Abstract] [Full Text] [PDF]  

Joseph C. Harris, Andrew D. Gilliam, Andrew J. McKenzie, Sean A. Evans, Anna M. Grabowska, Philip A. Clarke, Daniel F. McWilliams, and Sue A. Watson

The Biological and Therapeutic Importance of Gastrin Gene Expression in Pancreatic Adenocarcinomas
Cancer Res 2004 64: 5624-5631. [Abstract] [Full Text] [PDF]  

Marta Garcia, Nuria Isabel Fernandez-Garcia, Veronica Rivas, Marta Carretero, Maria J. Escamez, Alicia Gonzalez-Martin, Estela E. Medrano, Olga Volpert, Jose L. Jorcano, Benilde Jimenez, Fernando Larcher, and Marcela Del Rio

Inhibition of Xenografted Human Melanoma Growth and Prevention of Metastasis Development by Dual Antiangiogenic/Antitumor Activities of Pigment Epithelium-Derived Factor
Cancer Res 2004 64: 5632-5642. [Abstract] [Full Text] [PDF]  

Henry J. Thompson, John N. McGinley, Nicole S. Spoelstra, Weiqin Jiang, Zongjian Zhu, and Pamela Wolfe

Effect of Dietary Energy Restriction on Vascular Density during Mammary Carcinogenesis
Cancer Res 2004 64: 5643-5650. [Abstract] [Full Text] [PDF]  

Chunhua Cui, Thomas Elsam, Qinjie Tian, John T. Seykora, Marina Grachtchouk, Andrzej Dlugosz, and Hung Tseng

Gli Proteins Up-Regulate the Expression of Basonuclin in Basal Cell Carcinoma
Cancer Res 2004 64: 5651-5658. [Abstract] [Full Text] [PDF]  

Cristina Agbunag and Dafna Bar-Sagi

Oncogenic K-ras Drives Cell Cycle Progression and Phenotypic Conversion of Primary Pancreatic Duct Epithelial Cells
Cancer Res 2004 64: 5659-5663. [Abstract] [Full Text] [PDF]  

Sofia Halin, Pernilla Wikström, Stina Häggström Rudolfsson, Pär Stattin, Jennifer A. Doll, Susan E. Crawford, and Anders Bergh

Decreased Pigment Epithelium-Derived Factor Is Associated with Metastatic Phenotype in Human and Rat Prostate Tumors
Cancer Res 2004 64: 5664-5671. [Abstract] [Full Text] [PDF]  

Shugo Ueda, Ichiro Kuwabara, and Fu-Tong Liu

Suppression of Tumor Growth by Galectin-7 Gene Transfer
Cancer Res 2004 64: 5672-5676. [Abstract] [Full Text] [PDF]  

Jianping Meng, Chon-Hwa Tsai-Morris, and Maria L. Dufau

Human Prolactin Receptor Variants in Breast Cancer: Low Ratio of Short Forms to the Long-Form Human Prolactin Receptor Associated with Mammary Carcinoma
Cancer Res 2004 64: 5677-5682. [Abstract] [Full Text] [PDF]  

Nils Cordes

Overexpression of Hyperactive Integrin-Linked Kinase Leads to Increased Cellular Radiosensitivity
Cancer Res 2004 64: 5683-5692. [Abstract] [Full Text] [PDF]  

Jussi Koivunen, Vesa Aaltonen, Sanna Koskela, Petri Lehenkari, Matti Laato, and Juha Peltonen

Protein Kinase C /ß Inhibitor Go6976 Promotes Formation of Cell Junctions and Inhibits Invasion of Urinary Bladder Carcinoma Cells
Cancer Res 2004 64: 5693-5701. [Abstract] [Full Text] [PDF]  

Jayne E. Draffin, Suzanne McFarlane, Ashleigh Hill, Patrick G. Johnston, and David J. J. Waugh

CD44 Potentiates the Adherence of Metastatic Prostate and Breast Cancer Cells to Bone Marrow Endothelial Cells
Cancer Res 2004 64: 5702-5711. [Abstract] [Full Text] [PDF]  

Bruce M. Fenton, Scott F. Paoni, and Ivan Ding

Pathophysiological Effects of Vascular Endothelial Growth Factor Receptor-2-Blocking Antibody plus Fractionated Radiotherapy on Murine Mammary Tumors
Cancer Res 2004 64: 5712-5719. [Abstract] [Full Text] [PDF]  

Shingo Miyamoto, Michinari Hirata, Ayano Yamazaki, Takuya Kageyama, Hidetoshi Hasuwa, Hiroto Mizushima, Yoshihiro Tanaka, Hiroshi Yagi, Kenzo Sonoda, Masahiro Kai, Hideo Kanoh, Hitoo Nakano, and Eisuke Mekada

Heparin-Binding EGF-Like Growth Factor Is a Promising Target for Ovarian Cancer Therapy
Cancer Res 2004 64: 5720-5727. [Abstract] [Full Text] [PDF] Supplementary Data  

Josefina Martinez Hoyos, Monica Fedele, Sabrina Battista, Francesca Pentimalli, Mogens Kruhoffer, Claudio Arra, Torben F. Orntoft, Carlo Maria Croce, and Alfredo Fusco

Identification of the Genes Up- and Down-Regulated by the High Mobility Group A1 (HMGA1) Proteins: Tissue Specificity of the HMGA1-Dependent Gene Regulation
Cancer Res 2004 64: 5728-5735. [Abstract] [Full Text] [PDF] Supplementary Data  

Sarah Kraus, Gal Levy, Tamar Hanoch, Zvi Naor, and Rony Seger

Gonadotropin-Releasing Hormone Induces Apoptosis of Prostate Cancer Cells: Role of c-Jun NH₂-Terminal Kinase, Protein Kinase B, and Extracellular Signal-Regulated Kinase Pathways
Cancer Res 2004 64: 5736-5744. [Abstract] [Full Text] [PDF]  

Experimental Therapeutics, Molecular Targets, and Chemical Biology:

Masahiko Nishizaki, Ji-ichiro Sasaki, Bingliang Fang, Edward. N. Atkinson, John D. Minna, Jack A. Roth, and Lin Ji

Synergistic Tumor Suppression by Coexpression of FHIT and p53 Coincides with FHIT-Mediated MDM2 Inactivation and p53 Stabilization in Human Non-Small Cell Lung Cancer Cells
Cancer Res 2004 64: 5745-5752. [Abstract] [Full Text] [PDF]  

Birgit Geoerger, Gilles Vassal, Paule Opolon, Clemens M. F. Dirven, Jackie Morizet, Lysiane Laudani, Jacques Grill, Giuseppe Giaccone, W. Peter Vandertop, Winald R. Gerritsen, and Victor W. van Beusechem

Oncolytic Activity of p53-Expressing Conditionally Replicative Adenovirus Ad24-p53 against Human Malignant Glioma
Cancer Res 2004 64: 5753-5759. [Abstract] [Full Text] [PDF]  

Galina Kuznetsov, Murray J. Towle, Hongsheng Cheng, Takanori Kawamura, Karen TenDyke, Diana Liu, Yoshito Kishi, Melvin J. Yu, and Bruce A. Littlefield

Induction of Morphological and Biochemical Apoptosis following Prolonged Mitotic Blockage by Halichondrin B Macrocyclic Ketone Analog E7389
Cancer Res 2004 64: 5760-5766. [Abstract] [Full Text] [PDF]  

Melinda C. Myzak, P. Andrew Karplus, Fung-Lung Chung, and Roderick H. Dashwood

A Novel Mechanism of Chemoprotection by Sulforaphane: Inhibition of Histone Deacetylase
Cancer Res 2004 64: 5767-5774. [Abstract] [Full Text] [PDF]  

Zhijian Yang, Xinghua Sun, Shukuan Li, Yuying Tan, Xiaoen Wang, Nan Zhang, Shigeo Yagi, Tomoaki Takakura, Yoshinao Kobayashi, Akio Takimoto, Takayuki Yoshioka, Akinori Suginaka, Eugene P. Frenkel, and Robert M. Hoffman

Circulating Half-Life of PEGylated Recombinant Methioninase Holoenzyme Is Highly Dose Dependent on Cofactor Pyridoxal-5'-Phosphate
Cancer Res 2004 64: 5775-5778. [Abstract] [Full Text] [PDF]  

Niv Papo, Amir Braunstein, Zelig Eshhar, and Yechiel Shai

Suppression of Human Prostate Tumor Growth in Mice by a Cytolytic D-, L-Amino Acid Peptide: Membrane Lysis, Increased Necrosis, and Inhibition of Prostate-Specific Antigen Secretion
Cancer Res 2004 64: 5779-5786. [Abstract] [Full Text] [PDF]  

Xiao-Hua Jiang, Shui-Ping Tu, Jian-Tao Cui, Marie C. M. Lin, Harry H. X. Xia, Wai Man Wong, Annie On-On Chan, Man Fung Yuen, Shi-Hu Jiang, Shiu-Kum Lam, Hsiang-Fu Kung, Jae Won Soh, I. Bernard Weinstein, and Benjamin Chun-Yu Wong

Antisense Targeting Protein Kinase C and ß₁ Inhibits Gastric Carcinogenesis
Cancer Res 2004 64: 5787-5794. [Abstract] [Full Text] [PDF]  

Yuan Kong, Raymond Poon, Puviindran Nadesan, Tamara Di Muccio, Riccardo Fodde, Rama Khokha, and Benjamin A. Alman

Matrix Metalloproteinase Activity Modulates Tumor Size, Cell Motility, and Cell Invasiveness in Murine Aggressive Fibromatosis
Cancer Res 2004 64: 5795-5803. [Abstract] [Full Text] [PDF]  

Pauline Breedveld, Noam Zelcer, Dick Pluim, Özgür Sönmezer, Matthijs M. Tibben, Jos H. Beijnen, Alfred H. Schinkel, Olaf van Tellingen, Piet Borst, and Jan H. M. Schellens

Mechanism of the Pharmacokinetic Interaction between Methotrexate and Benzimidazoles: Potential Role for Breast Cancer Resistance Protein in Clinical Drug-Drug Interactions
Cancer Res 2004 64: 5804-5811. [Abstract] [Full Text] [PDF]  

Fernando Doñate, Jose C. Juarez, Xiaojun Guan, Natalya V. Shipulina, Marian L. Plunkett, Ziva Tel-Tsur, David E. Shaw, William T. Morgan, and Andrew P. Mazar

Peptides Derived from the Histidine-Proline Domain of the Histidine-Proline-Rich Glycoprotein Bind to Tropomyosin and Have Antiangiogenic and Antitumor Activities
Cancer Res 2004 64: 5812-5817. [Abstract] [Full Text] [PDF]  

Walid A. Osta, Yian Chen, Kaidi Mikhitarian, Michael Mitas, Mohamed Salem, Yusuf A. Hannun, David J. Cole, and William E. Gillanders

EpCAM Is Overexpressed in Breast Cancer and Is a Potential Target for Breast Cancer Gene Therapy
Cancer Res 2004 64: 5818-5824. [Abstract] [Full Text] [PDF]  

Meili Zhang, Zhuo Zhang, Kayhan Garmestani, Carolyn K. Goldman, Jeffrey V. Ravetch, Martin W. Brechbiel, Jorge A. Carrasquillo, and Thomas A. Waldmann

Activating Fc Receptors Are Required for Antitumor Efficacy of the Antibodies Directed toward CD25 in a Murine Model of Adult T-Cell Leukemia
Cancer Res 2004 64: 5825-5829. [Abstract] [Full Text] [PDF]  

Immunology:

Hideho Okada, Takahiko Tsugawa, Hidemitsu Sato, Naruo Kuwashima, Andrea Gambotto, Kaori Okada, Jill E. Dusak, Wendy K. Fellows-Mayle, Glenn D. Papworth, Simon C. Watkins, William H. Chambers, Douglas M. Potter, Walter J. Storkus, and Ian F. Pollack

Delivery of Interferon- Transfected Dendritic Cells into Central Nervous System Tumors Enhances the Antitumor Efficacy of Peripheral Peptide-Based Vaccines
Cancer Res 2004 64: 5830-5838. [Abstract] [Full Text] [PDF]  

Paulo C. Rodriguez, David G. Quiceno, Jovanny Zabaleta, Blair Ortiz, Arnold H. Zea, Maria B. Piazuelo, Alberto Delgado, Pelayo Correa, Jason Brayer, Eduardo M. Sotomayor, Scott Antonia, Juan B. Ochoa, and Augusto C. Ochoa

Arginase I Production in the Tumor Microenvironment by Mature Myeloid Cells Inhibits T-Cell Receptor Expression and Antigen-Specific T-Cell Responses
Cancer Res 2004 64: 5839-5849. [Abstract] [Full Text] [PDF]  

Mark M. Whitmore, Michael J. DeVeer, Andrea Edling, Rhonda K. Oates, Brenna Simons, Daniel Lindner, and Bryan R. G. Williams

Synergistic Activation of Innate Immunity by Double-Stranded RNA and CpG DNA Promotes Enhanced Antitumor Activity
Cancer Res 2004 64: 5850-5860. [Abstract] [Full Text] [PDF]  

Endocrinology:

Aurélie Bardin, Pascale Hoffmann, Nathalie Boulle, Dionyssios Katsaros, Françoise Vignon, Pascal Pujol, and Gwendal Lazennec

Involvement of Estrogen Receptor ß in Ovarian Carcinogenesis
Cancer Res 2004 64: 5861-5869. [Abstract] [Full Text] [PDF]  

Na Yin, Dan Wang, Hua Zhang, Xia Yi, Xiaojing Sun, Bin Shi, Huijian Wu, Ge Wu, Xinjuan Wang, and Yongfeng Shang

Molecular Mechanisms Involved in the Growth Stimulation of Breast Cancer Cells by Leptin
Cancer Res 2004 64: 5870-5875. [Abstract] [Full Text] [PDF]  

Clinical Research:

Arnulf Mayer, Alexander Wree, Michael Höckel, Cornelia Leo, Henryk Pilch, and Peter Vaupel

Lack of Correlation between Expression of HIF-1 Protein and Oxygenation Status in Identical Tissue Areas of Squamous Cell Carcinomas of the Uterine Cervix
Cancer Res 2004 64: 5876-5881. [Abstract] [Full Text] [PDF]  

Zhen Zhang, Robert C. Bast, Jr., Yinhua Yu, Jinong Li, Lori J. Sokoll, Alex J. Rai, Jason M. Rosenzweig, Bonnie Cameron, Young Y. Wang, Xiao-Ying Meng, Andrew Berchuck, Carolien van Haaften-Day, Neville F. Hacker, Henk W. A. de Bruijn, Ate G. J. van der Zee, Ian J. Jacobs, Eric T. Fung, and Daniel W. Chan

Three Biomarkers Identified from Serum Proteomic Analysis for the Detection of Early Stage Ovarian Cancer
Cancer Res 2004 64: 5882-5890. [Abstract] [Full Text] [PDF]  

Epidemiology and Prevention:

Vasundara Venkateswaran, Neil E. Fleshner, Linda M. Sugar, and Laurence H. Klotz

Antioxidants Block Prostate Cancer in Lady Transgenic Mice
Cancer Res 2004 64: 5891-5896. [Abstract] [Full Text] [PDF]  

Robert L. Keith, York E. Miller, Tyler M. Hudish, Carlos E. Girod, Sylk Sotto-Santiago, Wilbur A. Franklin, Raphael A. Nemenoff, Thomas H. March, S. Patrick Nana-Sinkam, and Mark W. Geraci

Pulmonary Prostacyclin Synthase Overexpression Chemoprevents Tobacco Smoke Lung Carcinogenesis in Mice
Cancer Res 2004 64: 5897-5904. [Abstract] [Full Text] [PDF]  

Yolanda Bayon, Maria A. Ortiz, Francisco J. Lopez-Hernandez, Philip H. Howe, and F. Javier Piedrafita

The Retinoid Antagonist MX781 Induces Clusterin Expression in Prostate Cancer Cells via Heat Shock Factor-1 and Activator Protein-1 Transcription Factors
Cancer Res 2004 64: 5905-5912. [Abstract] [Full Text] [PDF]  

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