Reviews:

Shark Cartilage, Cancer and the Growing Threat of Pseudoscience

Gary K. Ostrander, Keith C. Cheng, Jeffrey C. Wolf, and Marilyn J. Wolfe
Cancer Res 2004 64: 8485-8491. doi: 10.1158/0008-5472.CAN-04-2260 [Abstract] [Full Text] [PDF]  

Advances in Brief:

Bone Marrow Contribution to Tumor-Associated Myofibroblasts and Fibroblasts

Natalie C. Direkze, Kairbaan Hodivala-Dilke, Rosemary Jeffery, Toby Hunt, Richard Poulsom, Dahmane Oukrif, Malcolm R. Alison, and Nicholas A. Wright
Cancer Res 2004 64: 8492-8495. doi: 10.1158/0008-5472.CAN-04-1708 [Abstract] [Full Text] [PDF]  

Role of a BCL9-Related ß-Catenin-Binding Protein, B9L, in Tumorigenesis Induced by Aberrant Activation of Wnt Signaling

Shungo Adachi, Takafumi Jigami, Toshio Yasui, Tetsuhiro Nakano, Susumu Ohwada, Yoshihiro Omori, Sumio Sugano, Bisei Ohkawara, Hiroshi Shibuya, Tsutomu Nakamura, and Tetsu Akiyama
Cancer Res 2004 64: 8496-8501. doi: 10.1158/0008-5472.CAN-04-2254 [Abstract] [Full Text] [PDF]  

TRAIL Inhibits Tumor Growth but Is Nontoxic to Human Hepatocytes in Chimeric Mice

Chunhai Hao, Jin H. Song, Belinda Hsi, Jamie Lewis, Doyoun K. Song, Kenneth C. Petruk, David L. J. Tyrrell, and Norman M. Kneteman
Cancer Res 2004 64: 8502-8506. doi: 10.1158/0008-5472.CAN-04-2599 [Abstract] [Full Text] [PDF]  

Identification of a Binding Partner for the Endothelial Cell Surface Proteins TEM7 and TEM7R

Akash Nanda, Phillip Buckhaults, Steven Seaman, Nishant Agrawal, Paula Boutin, Srinivas Shankara, Mariana Nacht, Beverly Teicher, Jason Stampfl, Sujay Singh, Bert Vogelstein, Kenneth W. Kinzler, and Brad St. Croix
Cancer Res 2004 64: 8507-8511. doi: 10.1158/0008-5472.CAN-04-2716 [Abstract] [Full Text] [PDF]  

2-(8-Hydroxy-6-methoxy-1-oxo-1H-2-benzopyran-3-yl)propionic Acid, a Small Molecule Isocoumarin, Potentiates Dexamethasone-Induced Apoptosis of Human Multiple Myeloma Cells

Naoki Agata, Hiroko Nogi, Michael Milhollen, Surender Kharbanda, and Donald Kufe
Cancer Res 2004 64: 8512-8516. doi: 10.1158/0008-5472.CAN-04-2626 [Abstract] [Full Text] [PDF]  

Analysis of Diepoxide-Specific Cyclic N-Terminal Globin Adducts in Mice and Rats after Inhalation Exposure to 1,3-Butadiene

Gunnar Boysen, Nadia I. Georgieva, Patricia B. Upton, Karupiah Jayaraj, Yutai Li, Vernon E. Walker, and James A. Swenberg
Cancer Res 2004 64: 8517-8520. doi: 10.1158/0008-5472.CAN-04-3184 [Abstract] [Full Text] [PDF] Supplementary Data  

Spermine Oxidation Induced by Helicobacter pylori Results in Apoptosis and DNA Damage: Implications for Gastric Carcinogenesis

Hangxiu Xu, Rupesh Chaturvedi, Yulan Cheng, Francoise I. Bussiere, Mohammad Asim, Micheal D. Yao, Darryn Potosky, Stephen J. Meltzer, Juong G. Rhee, Sung S. Kim, Steven F. Moss, Amy Hacker, Yanlin Wang, Robert A. Casero, Jr., and Keith T. Wilson
Cancer Res 2004 64: 8521-8525. doi: 10.1158/0008-5472.CAN-04-3511 [Abstract] [Full Text] [PDF]  

Molecular Biology, Pathobiology and Genetics:

Defective DNA Strand Break Repair after DNA Damage in Prostate Cancer Cells: Implications for Genetic Instability and Prostate Cancer Progression

Rong Fan, Tirukalikundram S. Kumaravel, Farid Jalali, Paula Marrano, Jeremy A. Squire, and Robert G. Bristow
Cancer Res 2004 64: 8526-8533. doi: 10.1158/0008-5472.CAN-04-1601 [Abstract] [Full Text] [PDF]  

Prognostic Relevance of Gene Amplifications and Coamplifications in Breast Cancer

Khawla Al-Kuraya, Peter Schraml, Joachim Torhorst, Coya Tapia, Boriana Zaharieva, Hedvika Novotny, Hanspeter Spichtin, Robert Maurer, Martina Mirlacher, Ossi Köchli, Markus Zuber, Holger Dieterich, Friedrich Mross, Kim Wilber, Ronald Simon, and Guido Sauter
Cancer Res 2004 64: 8534-8540. doi: 10.1158/0008-5472.CAN-04-1945 [Abstract] [Full Text] [PDF]  

Array Comparative Genomic Hybridization Analysis of Genomic Alterations in Breast Cancer Subtypes

Lenora W. M. Loo, Douglas I. Grove, Eleanor M. Williams, Cassandra L. Neal, Laura A. Cousens, Elizabeth L. Schubert, Ilona N. Holcomb, Hillary F. Massa, Jeri Glogovac, Christopher I. Li, Kathleen E. Malone, Janet R. Daling, Jeffrey J. Delrow, Barbara J. Trask, Li Hsu, and Peggy L. Porter
Cancer Res 2004 64: 8541-8549. doi: 10.1158/0008-5472.CAN-04-1992 [Abstract] [Full Text] [PDF] Supplementary Data  

Analysis of Gene Expression Patterns and Chromosomal Changes Associated with Aging

Jochen B. Geigl, Sabine Langer, Simone Barwisch, Katrin Pfleghaar, Gaby Lederer, and Michael R. Speicher
Cancer Res 2004 64: 8550-8557. doi: 10.1158/0008-5472.CAN-04-2151 [Abstract] [Full Text] [PDF] Supplementary Data  

Gene Expression Profiling for Molecular Characterization of Inflammatory Breast Cancer and Prediction of Response to Chemotherapy

François Bertucci, Pascal Finetti, Jacques Rougemont, Emmanuelle Charafe-Jauffret, Valéry Nasser, Béatrice Loriod, Jacques Camerlo, Rebecca Tagett, Carole Tarpin, Gilles Houvenaeghel, Catherine Nguyen, Dominique Maraninchi, Jocelyne Jacquemier, Rémi Houlgatte, Daniel Birnbaum, and Patrice Viens
Cancer Res 2004 64: 8558-8565. doi: 10.1158/0008-5472.CAN-04-2696 [Abstract] [Full Text] [PDF] Supplementary Data  

Gene Expression in the Lung of p53 Mutant Mice Exposed to Cigarette Smoke

Alberto Izzotti, Cristina Cartiglia, Mariagrazia Longobardi, Maria Bagnasco, Andrea Merello, Ming You, Ronald A. Lubet, and Silvio De Flora
Cancer Res 2004 64: 8566-8572. doi: 10.1158/0008-5472.CAN-04-1420 [Abstract] [Full Text] [PDF]  

Cell and Tumor Biology:

Overexpression of Activating Transcription Factor-2 Is Required for Tumor Growth and Progression in Mouse Skin Tumors

Paraskevi Papassava, Vassilis G. Gorgoulis, Dimitra Papaevangeliou, Spiros Vlahopoulos, Hans van Dam, and Vassilis Zoumpourlis
Cancer Res 2004 64: 8573-8584. doi: 10.1158/0008-5472.CAN-03-0955 [Abstract] [Full Text] [PDF]  

Identification and Testing of a Gene Expression Signature of Invasive Carcinoma Cells within Primary Mammary Tumors

Weigang Wang, Sumanta Goswami, Kyle Lapidus, Amber L. Wells, Jeffrey B. Wyckoff, Erik Sahai, Robert H. Singer, Jeffrey E. Segall, and John S. Condeelis
Cancer Res 2004 64: 8585-8594. doi: 10.1158/0008-5472.CAN-04-1136 [Abstract] [Full Text] [PDF] Supplementary Data  

In vitro and In vivo Models Analyzing von Hippel-Lindau Disease-Specific Mutations

W. Kimryn Rathmell, Michele M. Hickey, Natalie A. Bezman, Christie A. Chmielecki, Natalie C. Carraway, and M. Celeste Simon
Cancer Res 2004 64: 8595-8603. doi: 10.1158/0008-5472.CAN-04-1430 [Abstract] [Full Text] [PDF]  

CXCR4 Regulates Growth of Both Primary and Metastatic Breast Cancer

Matthew C. P. Smith, Kathryn E. Luker, Joel R. Garbow, Julie L. Prior, Erin Jackson, David Piwnica-Worms, and Gary D. Luker
Cancer Res 2004 64: 8604-8612. doi: 10.1158/0008-5472.CAN-04-1844 [Abstract] [Full Text] [PDF]  

Coagulation Facilitates Tumor Cell Spreading in the Pulmonary Vasculature during Early Metastatic Colony Formation

Jae Hong Im, Weili Fu, Hui Wang, Sujata K. Bhatia, Daniel A. Hammer, M. Anna Kowalska, and Ruth J. Muschel
Cancer Res 2004 64: 8613-8619. doi: 10.1158/0008-5472.CAN-04-2078 [Abstract] [Full Text] [PDF]  

Increased Insulin-Like Growth Factor I Receptor Expression and Signaling Are Components of Androgen-Independent Progression in a Lineage-Derived Prostate Cancer Progression Model

Sandra L. Krueckl, Robert A. Sikes, N. Magnus Edlund, Robert H. Bell, Antonio Hurtado-Coll, Ladan Fazli, Martin E. Gleave, and Michael E. Cox
Cancer Res 2004 64: 8620-8629. doi: 10.1158/0008-5472.CAN-04-2446 [Abstract] [Full Text] [PDF]  

Loss of Neural Cell Adhesion Molecule Induces Tumor Metastasis by Up-regulating Lymphangiogenesis

Ivana Crnic, Karin Strittmatter, Ugo Cavallaro, Lucie Kopfstein, Lotta Jussila, Kari Alitalo, and Gerhard Christofori
Cancer Res 2004 64: 8630-8638. doi: 10.1158/0008-5472.CAN-04-2523 [Abstract] [Full Text] [PDF] Supplementary Data  

Phosphorylation of the Eukaryotic Translation Initiation Factor eIF4E Contributes to Its Transformation and mRNA Transport Activities

Ivan Topisirovic, Melisa Ruiz-Gutierrez, and Katherine L. B. Borden
Cancer Res 2004 64: 8639-8642. doi: 10.1158/0008-5472.CAN-04-2677 [Abstract] [Full Text] [PDF]  

Elevated Flk1 (Vascular Endothelial Growth Factor Receptor 2) Signaling Mediates Enhanced Angiogenesis in ß₃-Integrin–Deficient Mice

Andrew R. Reynolds, Louise E. Reynolds, Tobi E. Nagel, Julie C. Lively, Stephen D. Robinson, Daniel J. Hicklin, Sarah C. Bodary, and Kairbaan M. Hodivala-Dilke
Cancer Res 2004 64: 8643-8650. doi: 10.1158/0008-5472.CAN-04-2760 [Abstract] [Full Text] [PDF]  

Transgenic Nude Mouse with Ubiquitous Green Fluorescent Protein Expression as a Host for Human Tumors

Meng Yang, Jose Reynoso, Ping Jiang, Lingna Li, Abdool R. Moossa, and Robert M. Hoffman
Cancer Res 2004 64: 8651-8656. doi: 10.1158/0008-5472.CAN-04-3118 [Abstract] [Full Text] [PDF]  

Matrix Metalloproteinase-26 Is Associated with Estrogen-Dependent Malignancies and Targets 1-Antitrypsin Serpin

Wei Li, Alexei Y. Savinov, Dmitri V. Rozanov, Vladislav S. Golubkov, Hirad Hedayat, Tatiana I. Postnova, Natalia V. Golubkova, Yu Linli, Stanislaw Krajewski, and Alex Y. Strongin
Cancer Res 2004 64: 8657-8665. doi: 10.1158/0008-5472.CAN-04-3019 [Abstract] [Full Text] [PDF]  

Transcriptional Abnormality of the hsMAD2 Mitotic Checkpoint Gene Is a Potential Link to Hepatocellular Carcinogenesis

Sook-Jung Jeong, Hyun-Jin Shin, So-Jung Kim, Geun-Hyoung Ha, Bok-Im Cho, Kwan-Hyuck Baek, Chang-Min Kim, and Chang-Woo Lee
Cancer Res 2004 64: 8666-8673. doi: 10.1158/0008-5472.CAN-03-3455 [Abstract] [Full Text] [PDF]  

Integrin Fibronectin Receptors in Matrix Metalloproteinase-1–Dependent Invasion by Breast Cancer and Mammary Epithelial Cells

Yifeng Jia, Zhao-Zhu Zeng, Sonja M. Markwart, Korrene F. Rockwood, Kathleen M. Woods Ignatoski, Stephen P. Ethier, and Donna L. Livant
Cancer Res 2004 64: 8674-8681. doi: 10.1158/0008-5472.CAN-04-0069 [Abstract] [Full Text] [PDF]  

Membrane-Associated and Secreted Genes in Breast Cancer

Nathan O. Stitziel, Brenton G. Mar, Jie Liang, and Carol A. Westbrook
Cancer Res 2004 64: 8682-8687. doi: 10.1158/0008-5472.CAN-04-1729 [Abstract] [Full Text] [PDF]  

RASSF4/AD037 Is a Potential Ras Effector/Tumor Suppressor of the RASSF Family

Kristin Eckfeld, Luke Hesson, Michele D. Vos, Ivan Bieche, Farida Latif, and Geoffrey J. Clark
Cancer Res 2004 64: 8688-8693. doi: 10.1158/0008-5472.CAN-04-2065 [Abstract] [Full Text] [PDF]  

Functional Analysis of the Contribution of RhoA and RhoC GTPases to Invasive Breast Carcinoma

Kaylene J. Simpson, Aisling S. Dugan, and Arthur M. Mercurio
Cancer Res 2004 64: 8694-8701. doi: 10.1158/0008-5472.CAN-04-2247 [Abstract] [Full Text] [PDF]  

Loss of Heterozygosity of Chromosome 3p21 Is Associated with Mutant TP53 and Better Patient Survival in Non–Small-Cell Lung Cancer

Carmen J. Marsit, Masayuki Hasegawa, Tomoko Hirao, Duk-Hwan Kim, Kenneth Aldape, Philip W. Hinds, John K. Wiencke, Heather H. Nelson, and Karl T. Kelsey
Cancer Res 2004 64: 8702-8707. doi: 10.1158/0008-5472.CAN-04-2558 [Abstract] [Full Text] [PDF]  

Experimental Therapeutics, Molecular Targets, and Chemical Biology:

Survivin Deregulation in ß-Tubulin Mutant Ovarian Cancer Cells Underlies Their Compromised Mitotic Response to Taxol

Jun Zhou, Aurora O’Brate, Amelia Zelnak, and Paraskevi Giannakakou
Cancer Res 2004 64: 8708-8714. doi: 10.1158/0008-5472.CAN-04-2538 [Abstract] [Full Text] [PDF]  

Oral Consumption of Green Tea Polyphenols Inhibits Insulin-Like Growth Factor-I–Induced Signaling in an Autochthonous Mouse Model of Prostate Cancer

Vaqar Mustafa Adhami, Imtiaz Ahmad Siddiqui, Nihal Ahmad, Sanjay Gupta, and Hasan Mukhtar
Cancer Res 2004 64: 8715-8722. doi: 10.1158/0008-5472.CAN-04-2840 [Abstract] [Full Text] [PDF]  

Inhibition of Akt/Protein Kinase B Signaling by Naltrindole in Small Cell Lung Cancer Cells

Yulong L. Chen, P. Y. Law, and Horace H. Loh
Cancer Res 2004 64: 8723-8730. doi: 10.1158/0008-5472.CAN-03-3091 [Abstract] [Full Text] [PDF]  

Mechanism of the Attenuation of Proteolysis-Inducing Factor Stimulated Protein Degradation in Muscle by ß-Hydroxy-ß-Methylbutyrate

Helen J. Smith, Stacey M. Wyke, and Michael J. Tisdale
Cancer Res 2004 64: 8731-8735. doi: 10.1158/0008-5472.CAN-04-1760 [Abstract] [Full Text] [PDF]  

The Prosurvival Activity of p53 Protects Cells from UV-Induced Apoptosis by Inhibiting c-Jun NH₂-terminal Kinase Activity and Mitochondrial Death Signaling

Pang-Kuo Lo, Sheng-Zhu Huang, Hsiang-Chin Chen, and Fung-Fang Wang
Cancer Res 2004 64: 8736-8745. doi: 10.1158/0008-5472.CAN-04-2584 [Abstract] [Full Text] [PDF] Supplementary Data  

Proteasomal Degradation of Topoisomerase I Is Preceded by c-Jun NH₂-Terminal Kinase Activation, Fas Up-Regulation, and Poly(ADP-Ribose) Polymerase Cleavage in SN38-Mediated Cytotoxicity against Multiple Myeloma

Laurence Catley, Yu-Tzu Tai, Reshma Shringarpure, Renate Burger, Moni Thi Son, Klaus Podar, Pierfrancesco Tassone, Dharminder Chauhan, Teru Hideshima, Louis Denis, Paul Richardson, Nikhil C. Munshi, and Kenneth C. Anderson
Cancer Res 2004 64: 8746-8753. doi: 10.1158/0008-5472.CAN-04-2894 [Abstract] [Full Text] [PDF]  

Immunology:

Liposome-Encapsulated CpG Oligodeoxynucleotides as a Potent Adjuvant for Inducing Type 1 Innate Immunity

Yoshinori Suzuki, Daiko Wakita, Kenji Chamoto, Yoshinori Narita, Takemasa Tsuji, Tsuguhide Takeshima, Hiroshi Gyobu, You Kawarada, Satoshi Kondo, Shizuo Akira, Hiroyuki Katoh, Hiroaki Ikeda, and Takashi Nishimura
Cancer Res 2004 64: 8754-8760. doi: 10.1158/0008-5472.CAN-04-1691 [Abstract] [Full Text] [PDF]  

Spontaneous Regression of Grade 3 Vulvar Intraepithelial Neoplasia Associated with Human Papillomavirus-16–Specific CD4⁺ and CD8⁺ T-Cell Responses

Isabelle Bourgault Villada, Micheline Moyal Barracco, Marianne Ziol, Aude Chaboissier, Nathalie Barget, Sophie Berville, Bernard Paniel, Eric Jullian, Thierry Clerici, Bernard Maillère, and Jean Gérard Guillet
Cancer Res 2004 64: 8761-8766. doi: 10.1158/0008-5472.CAN-04-2455 [Abstract] [Full Text] [PDF]  

Clinical Research:

Automated Quantitative Analysis of HDM2 Expression in Malignant Melanoma Shows Association with Early-Stage Disease and Improved Outcome

Aaron J. Berger, Robert L. Camp, Kyle A. DiVito, Harriet M. Kluger, Ruth Halaban, and David L. Rimm
Cancer Res 2004 64: 8767-8772. doi: 10.1158/0008-5472.CAN-04-1384 [Abstract] [Full Text] [PDF]  

Automated Quantitative Analysis of Tissue Microarrays Reveals an Association between High Bcl-2 Expression and Improved Outcome in Melanoma

Kyle A. DiVito, Aaron J. Berger, Robert L. Camp, Marisa Dolled-Filhart, David L. Rimm, and Harriet M. Kluger
Cancer Res 2004 64: 8773-8777. doi: 10.1158/0008-5472.CAN-04-1387 [Abstract] [Full Text] [PDF]  

Epidemiology and Prevention:

The Histone Deacetylase Inhibitor Suberoylanilide Hydroxamic Acid Induces Apoptosis via Induction of 15-Lipoxygenase-1 in Colorectal Cancer Cells

Linda C. Hsi, Xiaopei Xi, Reuben Lotan, Imad Shureiqi, and Scott M. Lippman
Cancer Res 2004 64: 8778-8781. doi: 10.1158/0008-5472.CAN-04-1867 [Abstract] [Full Text] [PDF]  

Respective Roles of Serological Status and Blood Specific Antihuman Herpesvirus 8 Antibody Levels in Human Herpesvirus 8 Intrafamilial Transmission in a Highly Endemic Area

Sabine Plancoulaine, Laurent Abel, David Trégouët, Renan Duprez, Monique van Beveren, Patricia Tortevoye, Alain Froment, and Antoine Gessain
Cancer Res 2004 64: 8782-8787. doi: 10.1158/0008-5472.CAN-04-2000 [Abstract] [Full Text] [PDF]  

Folate Is Associated with the Natural History of High-Risk Human Papillomaviruses

Chandrika J. Piyathilake, Olga L. Henao, Maurizio Macaluso, Phillip E. Cornwell, Sreelatha Meleth, Douglas C. Heimburger, and Edward E. Partridge
Cancer Res 2004 64: 8788-8793. doi: 10.1158/0008-5472.CAN-04-2402 [Abstract] [Full Text] [PDF]  

Correction:

Correction

Cancer Res 2004 64: 8794. doi: 10.1158/0008-5472.CAN-64-23-COR [Full Text] [PDF]  

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