Advances in Brief:

Nitrosative Stress in Rotated Three-Dimensional Colorectal Carcinoma Cell Cultures Induces Microtubule Depolymerization and Apoptosis

Luciana M. Laguinge, Shuling Lin, Raed N. Samara, Anastasios N. Salesiotis, and J. Milburn Jessup
Cancer Res 2004 64: 2643-2648. [Abstract] [Full Text] [PDF]  

HCMOGT-1 Is a Novel Fusion Partner to PDGFRB in Juvenile Myelomonocytic Leukemia with t(5;17)(q33;p11.2)

Cristina Morerio, Maura Acquila, Cristina Rosanda, Annamaria Rapella, Carlo Dufour, Franco Locatelli, Emanuela Maserati, Francesco Pasquali, and Claudio Panarello
Cancer Res 2004 64: 2649-2651. [Abstract] [Full Text] [PDF]  

Acetylcholinesterase Plays a Pivotal Role in Apoptosome Formation

Sang Eun Park, Nam Deuk Kim, and Young Hyun Yoo
Cancer Res 2004 64: 2652-2655. [Abstract] [Full Text] [PDF]  

Specific Histone Patterns and Acetylase/Deacetylase Activity at the Breakpoint-Cluster Region of the Human MLL Gene

Andriy Khobta, Carmelo Carlo-Stella, and Giovanni Capranico
Cancer Res 2004 64: 2656-2662. [Abstract] [Full Text] [PDF]  

Conditionally Replicating Adenoviruses Expressing Short Hairpin RNAs Silence the Expression of a Target Gene in Cancer Cells

Jan E. Carette, Renée M. Overmeer, Frederik H. E. Schagen, Ramon Alemany, Oleg A. Barski, Winald R. Gerritsen, and Victor W. van Beusechem
Cancer Res 2004 64: 2663-2667. [Abstract] [Full Text] [PDF]  

EGF Gene Polymorphism and the Risk of Incident Primary Melanoma

Kandace L. Amend, James T. Elder, Lynn P. Tomsho, Joseph D. Bonner, Timothy M. Johnson, Jennifer Schwartz, Marianne Berwick, and Stephen B. Gruber
Cancer Res 2004 64: 2668-2672. [Abstract] [Full Text] [PDF]  

NIN, a Gene Encoding a CEP110-Like Centrosomal Protein, Is Fused to PDGFRB in a Patient with a t(5;14)(q33;q24) and an Imatinib-Responsive Myeloproliferative Disorder¹

José L. Vizmanos, Francisco J. Novo, José P. Román, E. Joanna Baxter, Idoya Lahortiga, María J. Larráyoz, María D. Odero, Pilar Giraldo, María J. Calasanz, and Nicholas C. P. Cross
Cancer Res 2004 64: 2673-2676. [Abstract] [Full Text] [PDF]  

A Novel Founder CHEK2 Mutation is Associated with Increased Prostate Cancer Risk

Cezary Cybulski, Tomasz Huzarski, Bohdan Górski, Bartlomiej Masojc, Marek Mierzejewski, Tadeusz Debniak, Bartlomiej Gliniewicz, Joanna Matyjasik, Elzbieta Zlowocka, Grzegorz Kurzawski, Andrzej Sikorski, Michal Posmyk, Marek Szwiec, Ryszard Czajka, Steven A. Narod, and Jan Lubinski
Cancer Res 2004 64: 2677-2679. [Abstract] [Full Text] [PDF]  

Functional STK15 Phe31Ile Polymorphism Is Associated with the Occurrence and Advanced Disease Status of Esophageal Squamous Cell Carcinoma

Xiaoping Miao, Tong Sun, Yonggang Wang, Xuemei Zhang, Wen Tan, and Dongxin Lin
Cancer Res 2004 64: 2680-2683. [Abstract] [Full Text] [PDF]  

Molecular Biology, Pathobiology, and Genetics:

Caspase-8-Dependent HER-2 Cleavage in Response to Tumor Necrosis Factor Stimulation Is Counteracted by Nuclear Factor B through c-FLIP-L Expression

Valérie Benoit, Alain Chariot, Laurence Delacroix, Valérie Deregowski, Nathalie Jacobs, Marie-Paule Merville, and Vincent Bours
Cancer Res 2004 64: 2684-2691. [Abstract] [Full Text] [PDF]  

Promoter Methylation Inhibits APC Gene Expression by Causing Changes in Chromatin Conformation and Interfering with the Binding of Transcription Factor CCAAT-Binding Factor

Guoren Deng, Geun-Am Song, Erik Pong, Marvin Sleisenger, and Young S. Kim
Cancer Res 2004 64: 2692-2698. [Abstract] [Full Text] [PDF]  

Ultraviolet Irradiation Represses PATCHED Gene Transcription in Human Epidermal Keratinocytes through an Activator Protein-1-Dependent Process

Florence Brellier, Claire Marionnet, Odile Chevallier-Lagente, Rune Toftgard, Alain Mauviel, Alain Sarasin, and Thierry Magnaldo
Cancer Res 2004 64: 2699-2704. [Abstract] [Full Text] [PDF]  

Cell and Tumor Biology:

Increased Immunogenicity of Colon Cancer Cells by Selective Depletion of Cytochrome c

Elise Schmitt, Arnaud Parcellier, François Ghiringhelli, Noelia Casares, Sandeep Gurbuxani, Nathalie Droin, Ahmed Hamai, Marie Pequignot, Arlette Hammann, Monique Moutet, Annie Fromentin, Guido Kroemer, Eric Solary, and Carmen Garrido
Cancer Res 2004 64: 2705-2711. [Abstract] [Full Text] [PDF]  

Seprase Promotes Rapid Tumor Growth and Increased Microvessel Density in a Mouse Model of Human Breast Cancer

Yan Huang, Sophie Wang, and Thomas Kelly
Cancer Res 2004 64: 2712-2716. [Abstract] [Full Text] [PDF]  

Activation of the Tumor Suppressor Merlin Modulates Its Interaction with Lipid Rafts

John T. Stickney, W. Clark Bacon, Meghan Rojas, Nancy Ratner, and Wallace Ip
Cancer Res 2004 64: 2717-2724. [Abstract] [Full Text] [PDF]  

Platelet-Derived Growth Factor Production by B16 Melanoma Cells Leads to Increased Pericyte Abundance in Tumors and an Associated Increase in Tumor Growth Rate

Masao Furuhashi, Tobias Sjöblom, Alexandra Abramsson, Jens Ellingsen, Patrick Micke, Hong Li, Erika Bergsten-Folestad, Ulf Eriksson, Rainer Heuchel, Christer Betsholtz, Carl-Henrik Heldin, and Arne Östman
Cancer Res 2004 64: 2725-2733. [Abstract] [Full Text] [PDF]  

Dickkopf 3 Inhibits Invasion and Motility of Saos-2 Osteosarcoma Cells by Modulating the Wnt-ß-Catenin Pathway

Bang H. Hoang, Tadahiko Kubo, John H. Healey, Rui Yang, Saminathan S. Nathan, E. Anders Kolb, BethAnne Mazza, Paul A. Meyers, and Richard Gorlick
Cancer Res 2004 64: 2734-2739. [Abstract] [Full Text] [PDF]  

Detection of Primary Lung Tumors in Rodents by Magnetic Resonance Imaging

Joel R. Garbow, Zhongqiu Zhang, and Ming You
Cancer Res 2004 64: 2740-2742. [Abstract] [Full Text] [PDF]  

Endothelial P-Selectin as a Target of Heparin Action in Experimental Melanoma Lung Metastasis

Ralf J. Ludwig, Beatrice Boehme, Maurizio Podda, Reinhard Henschler, Elke Jager, Christa Tandi, Wolf-Henning Boehncke, Thomas M. Zollner, Roland Kaufmann, and Jens Gille
Cancer Res 2004 64: 2743-2750. [Abstract] [Full Text] [PDF]  

Integrin ß3 Overexpression Suppresses Tumor Growth in a Human Model of Gliomagenesis: Implications for the Role of ß3 Overexpression in Glioblastoma Multiforme

Masayuki Kanamori, Scott R. Vanden Berg, Gabriele Bergers, Mitchel S. Berger, and Russell O. Pieper
Cancer Res 2004 64: 2751-2758. [Abstract] [Full Text] [PDF]  

K-Ras and H-Ras Activation Promote Distinct Consequences on Endometrial Cell Survival

Yumiko Ninomiya, Kiyoko Kato, Akira Takahashi, Yousuke Ueoka, Tetsuya Kamikihara, Takahiro Arima, Takao Matsuda, Hidenori Kato, Jun-ichi Nishida, and Norio Wake
Cancer Res 2004 64: 2759-2765. [Abstract] [Full Text] [PDF]  

TC-1 Is a Novel Tumorigenic and Natively Disordered Protein Associated with Thyroid Cancer

Margaret Sunde, Kristine C. Y. McGrath, Lei Young, Jacqueline M. Matthews, Elizabeth L. Chua, Joel P. Mackay, and Alison K. Death
Cancer Res 2004 64: 2766-2773. [Abstract] [Full Text] [PDF]  

The Kaposi’s Sarcoma-Associated Herpesvirus (KSHV/HHV-8) K1 Protein Induces Expression of Angiogenic and Invasion Factors

Ling Wang, Naohiro Wakisaka, Christine C Tomlinson, Scott M DeWire, Stuart Krall, Joseph S Pagano, and Blossom Damania
Cancer Res 2004 64: 2774-2781. [Abstract] [Full Text] [PDF]  

Experimental Therapeutics, Molecular Targets, and Chemical Biology:

Preferential Inhibition of Akt and Killing of Akt-Dependent Cancer Cells by Rationally Designed Phosphatidylinositol Ether Lipid Analogues

S. Sianna Castillo, John Brognard, Pavel A. Petukhov, Chunyu Zhang, Junji Tsurutani, Courtney A. Granville, Min Li, Michael Jung, Kip A. West, Joell G. Gills, Alan P. Kozikowski, and Phillip A. Dennis
Cancer Res 2004 64: 2782-2792. [Abstract] [Full Text] [PDF]  

Overexpression of a Dominant-Negative Mutant Ubc9 Is Associated with Increased Sensitivity to Anticancer Drugs

Yin-Yuan Mo, Yanni Yu, P. L. Rachel Ee, and William T. Beck
Cancer Res 2004 64: 2793-2798. [Abstract] [Full Text] [PDF]  

Optimization of the Tet-on System To Regulate Interleukin 12 Expression in the Liver for the Treatment of Hepatic Tumors

Maider Zabala, Lin Wang, Ruben Hernandez-Alcoceba, Wolfgang Hillen, Cheng Qian, Jesus Prieto, and M. Gabriela Kramer
Cancer Res 2004 64: 2799-2804. [Abstract] [Full Text] [PDF]  

A Serial Analysis of Gene Expression (SAGE) Database Analysis of Chemosensitivity: Comparing Solid Tumors with Cell Lines and Comparing Solid Tumors from Different Tissue Origins

Wilfred D Stein, Thomas Litman, Tito Fojo, and Susan E Bates
Cancer Res 2004 64: 2805-2816. [Abstract] [Full Text] [PDF] Supplementary Data  

CXCR4 Regulates Migration and Development of Human Acute Myelogenous Leukemia Stem Cells in Transplanted NOD/SCID Mice

Sigal Tavor, Isabelle Petit, Svetlana Porozov, Abraham Avigdor, Ayelet Dar, Leonor Leider-Trejo, Noga Shemtov, Varda Deutsch, Ella Naparstek, Arnon Nagler, and Tsvee Lapidot
Cancer Res 2004 64: 2817-2824. [Abstract] [Full Text] [PDF]  

Cytostatic and Cytotoxic Effects of Topotecan Decoded by a Novel Mathematical Simulation Approach

Monica Lupi, Giada Matera, Davide Branduardi, Maurizio D’Incalci, and Paolo Ubezio
Cancer Res 2004 64: 2825-2832. [Abstract] [Full Text] [PDF]  

Antitumor Activity of 3-Ingenyl Angelate: Plasma Membrane and Mitochondrial Disruption and Necrotic Cell Death

Steven M. Ogbourne, Andreas Suhrbier, Brad Jones, Sarah-Jane Cozzi, Glen M. Boyle, Melanie Morris, Devi McAlpine, Jenny Johns, Tania M. Scott, Kirsty P. Sutherland, Joy M. Gardner, Thuy T. T. Le, Aleksandra Lenarczyk, James H. Aylward, and Peter G. Parsons
Cancer Res 2004 64: 2833-2839. [Abstract] [Full Text] [PDF]  

Survivin As a Therapeutic Target for Radiation Sensitization in Lung Cancer

Bo Lu, Yi Mu, Carolyn Cao, Fenghua Zeng, Sylke Schneider, Jiahui Tan, Jim Price, Jun Chen, Michael Freeman, and Dennis E. Hallahan
Cancer Res 2004 64: 2840-2845. [Abstract] [Full Text] [PDF]  

Mechanisms by which SGN-40, a Humanized Anti-CD40 Antibody, Induces Cytotoxicity in Human Multiple Myeloma Cells: Clinical Implications

Yu-Tzu Tai, Laurence P. Catley, Constantine S. Mitsiades, Renate Burger, Klaus Podar, Reshma Shringpaure, Teru Hideshima, Dharminder Chauhan, Makoto Hamasaki, Kenji Ishitsuka, Paul Richardson, Steven P. Treon, Nikhil C. Munshi, and Kenneth C. Anderson
Cancer Res 2004 64: 2846-2852. [Abstract] [Full Text] [PDF]  

Efficient Cancer Therapy with a Nanobody-Based Conjugate

Virna Cortez-Retamozo, Natalija Backmann, Peter D. Senter, Ullrich Wernery, Patrick De Baetselier, Serge Muyldermans, and Hilde Revets
Cancer Res 2004 64: 2853-2857. [Abstract] [Full Text] [PDF]  

Immunology:

Electroporated DNA Vaccine Clears Away Multifocal Mammary Carcinomas in Her-2/neu Transgenic Mice

Elena Quaglino, Manuela Iezzi, Cristina Mastini, Augusto Amici, Federica Pericle, Emma Di Carlo, Serenella M. Pupa, Carla De Giovanni, Michela Spadaro, Claudia Curcio, Pier Luigi Lollini, Piero Musiani, Guido Forni, and Federica Cavallo
Cancer Res 2004 64: 2858-2864. [Abstract] [Full Text] [PDF]  

Effector Function of Human Tumor-Specific CD8 T Cells in Melanoma Lesions: A State of Local Functional Tolerance

Alfred Zippelius, Pascal Batard, Verena Rubio-Godoy, Gilles Bioley, Danielle Liénard, Ferdy Lejeune, Donata Rimoldi, Philippe Guillaume, Norbert Meidenbauer, Andreas Mackensen, Nathalie Rufer, Norbert Lubenow, Daniel Speiser, Jean-Charles Cerottini, Pedro Romero, and Mikaël J. Pittet
Cancer Res 2004 64: 2865-2873. [Abstract] [Full Text] [PDF]  

Facilitating Role of Preprotachykinin-I Gene in the Integration of Breast Cancer Cells within the Stromal Compartment of the Bone Marrow: A Model of Early Cancer Progression

Gayatri Rao, Prem S. Patel, Suji P. Idler, Paul Maloof, Pedro Gascon, Julius A. Potian, and Pranela Rameshwar
Cancer Res 2004 64: 2874-2881. [Abstract] [Full Text] [PDF]  

Immediate Early Response Gene X-1, a Stress-Inducible Antiapoptotic Gene, Encodes Cytotoxic T-Lymphocyte (CTL) Epitopes Capable of Inducing Human Leukocyte Antigen-A33-Restricted and Tumor-Reactive CTLs in Gastric Cancer Patients

Tetsuro Sasada, Hiroko Takedatsu, Koichi Azuma, Makoto Koga, Yoshiaki Maeda, Shigeki Shichijo, Hiroki Shoumura, Tatsuya Hirai, Arimichi Takabayashi, and Kyogo Itoh
Cancer Res 2004 64: 2882-2888. [Abstract] [Full Text] [PDF]  

Endocrinology:

Interaction of the Aryl Hydrocarbon Receptor Ligand 6-Methyl-1,3,8-trichlorodibenzofuran with Estrogen Receptor

Sandra Timm Pearce, Hong Liu, Ishwar Radhakrishnan, Maen Abdelrahim, Stephen Safe, and V. Craig Jordan
Cancer Res 2004 64: 2889-2897. [Abstract] [Full Text] [PDF]  

Using Gene Expression Profiling to Differentiate Benign versus Malignant Thyroid Tumors

Chiara Mazzanti, Martha A. Zeiger, Nick Costourous, Christopher Umbricht, William H Westra, Danelle Smith, Helina Somervell, Generoso Bevilacqua, H. Richard Alexander, and Steven K. Libutti
Cancer Res 2004 64: 2898-2903. [Abstract] [Full Text] [PDF]  

Epidemiology and Prevention:

Serum Proteomic Profiles Suggest Celecoxib-Modulated Targets and Response Predictors

Zhen Xiao, Brian T. Luke, Grant Izmirlian, Asad Umar, Patrick M. Lynch, Robin K. S. Phillips, Sherri Patterson, Thomas P. Conrads, Timothy D. Veenstra, Peter Greenwald, Ernest T. Hawk, and Iqbal U. Ali
Cancer Res 2004 64: 2904-2909. [Abstract] [Full Text] [PDF]  

Selenium Deficiency Abrogates Inflammation-Dependent Plasma Cell Tumors in Mice

Klaus Felix, Simone Gerstmeier, Antonios Kyriakopoulos, O. M. Zack Howard, Hui-Fang Dong, Michael Eckhaus, Dietrich Behne, Georg W. Bornkamm, and Siegfried Janz
Cancer Res 2004 64: 2910-2917. [Abstract] [Full Text] [PDF] Supplementary Data  

Sequence Variants of Toll-Like Receptor 4 Are Associated with Prostate Cancer Risk: Results from the CAncer Prostate in Sweden Study

S. Lilly Zheng, Katarina Augustsson-Bälter, Baoli Chang, Maria Hedelin, Liwu Li, Hans-Olov Adami, Jeanette Bensen, Ge Li, Jan-Erik Johnasson, Aubrey R. Turner, Tamara S. Adams, Deborah A. Meyers, William B. Isaacs, Jianfeng Xu, and Henrik Grönberg
Cancer Res 2004 64: 2918-2922. [Abstract] [Full Text] [PDF]  

Effect of Exercise on Serum Estrogens in Postmenopausal Women: A 12-Month Randomized Clinical Trial

Anne McTiernan, Shelley S. Tworoger, Cornelia M. Ulrich, Yutaka Yasui, Melinda L. Irwin, Kumar B. Rajan, Bess Sorensen, Rebecca E. Rudolph, Deborah Bowen, Frank Z. Stanczyk, John D. Potter, and Robert S. Schwartz
Cancer Res 2004 64: 2923-2928. [Abstract] [Full Text] [PDF]  

Meeting Report:

Fifteenth Annual Pezcoller Symposium: Molecular in Vivo Visualization of Cancer Cells

Enrico Mihich and William Kaelin
Cancer Res 2004 64: 2929-2933. [Abstract] [Full Text] [PDF]  

Letters to the Editor:

Correspondence Re S. S. Virtanen et al., Alendronate Inhibits Invasion of PC-3 Prostate Cancer Cells by Affecting the Mevalonate Pathway. Cancer Res 2002;62:2708–14. Re K. Sawada et al., Alendronate Inhibits Lysophosphatidic Acid-Induced Migration of Human Ovarian Cancer Cells by Attenuating the Activation of Rho. Cancer Res 2002;62:6015–20.

Valentine B. Andela, Päivi T. Lakkakorpi, H. Kalervo Väänänen, Pirkko L. Härkönen, Kenjiro Sawada, Ken-ichirou Morishige, Masahiro Tahara, Rikako Kawagishi, Yoshihide Ikebuchi, Keiichi Tasaka, and Yuji Murata
Cancer Res 2004 64: 2934-2936. [Full Text] [PDF]  

Correspondence re: M. V. Swamy et al., Inhibition of COX-2 in Colon Cancer Cell Lines by Celecoxib Increases the Nuclear Localization of Active p53. Cancer Res 2003;63:5239–42.

Axel H. Schönthal, Christopher R. Herzog, Malisetty V. Swamy, and Chinthalapally V. Rao
Cancer Res 2004 64: 2937-2938. [Full Text] [PDF]  

Correction:

Correction

Cancer Res 2004 64: 2939. [Full Text] [PDF]  

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