Editorial:

Message from the Editor-in-Chief

Frank J. Rauscher, III
Cancer Res 2005 65: 1. [Full Text] [PDF]  

Priority Reports:

A Spliced Isoform of Interleukin 6 mRNA Produced by Renal Cell Carcinoma Encodes for an Interleukin 6 Inhibitor

Laurent Alberti, Thoma Bachelot, Adeline Duc, Catherine Biota, and Jean Yves Blay
Cancer Res 2005 65: 2-5. [Abstract] [Full Text] [PDF]  

Down-regulation of BRCA1-BARD1 Ubiquitin Ligase by CDK2

Ryosuke Hayami, Ko Sato, Wenwen Wu, Toru Nishikawa, Junya Hiroi, Ritsuko Ohtani-Kaneko, Mamoru Fukuda, and Tomohiko Ohta
Cancer Res 2005 65: 6-10. [Abstract] [Full Text] [PDF]  

Molecular Biology, Pathobiology and Genetics:

Decreased Fidelity in Replicating CpG Methylation Patterns in Cancer Cells

Toshikazu Ushijima, Naoko Watanabe, Kimiko Shimizu, Kazuaki Miyamoto, Takashi Sugimura, and Atsushi Kaneda
Cancer Res 2005 65: 11-17. [Abstract] [Full Text] [PDF]  

The Dual ErbB1/ErbB2 Inhibitor, Lapatinib (GW572016), Cooperates with Tamoxifen to Inhibit Both Cell Proliferation- and Estrogen-Dependent Gene Expression in Antiestrogen-Resistant Breast Cancer

Isabel Chu, Kimberly Blackwell, Susie Chen, and Joyce Slingerland
Cancer Res 2005 65: 18-25. [Abstract] [Full Text] [PDF]  

Inactivation of Imprinted Genes Induced by Cellular Stress and Tumorigenesis

Cristina Pantoja, Laura de los Ríos, Ander Matheu, Francisco Antequera, and Manuel Serrano
Cancer Res 2005 65: 26-33. [Abstract] [Full Text] [PDF]  

High-Density Single Nucleotide Polymorphism Array Defines Novel Stage and Location-Dependent Allelic Imbalances in Human Bladder Tumors

Karen Koed, Carsten Wiuf, Lise-Lotte Christensen, Friedrik P. Wikman, Karsten Zieger, Klaus Møller, Hans von der Maase, and Torben F. Ørntoft
Cancer Res 2005 65: 34-45. [Abstract] [Full Text] [PDF] Supplementary Data  

A Functional Common Polymorphism in a Sp1 Recognition Site of the Epidermal Growth Factor Receptor Gene Promoter

Wanqing Liu, Federico Innocenti, Michael H. Wu, Apurva A. Desai, M. Eileen Dolan, Edwin H. Cook, Jr., and Mark J. Ratain
Cancer Res 2005 65: 46-53. [Abstract] [Full Text] [PDF]  

Xenoestrogen Action in Prostate Cancer: Pleiotropic Effects Dependent on Androgen Receptor Status

Yelena B. Wetherill, Nicola L. Fisher, Ann Staubach, Mark Danielsen, Ralph W. de Vere White, and Karen E. Knudsen
Cancer Res 2005 65: 54-65. [Abstract] [Full Text] [PDF]  

Loss of Heterozygosity Analysis and DNA Copy Number Measurement on 8p in Bladder Cancer Reveals Two Mechanisms of Allelic Loss

Jacqui Adams, Sarah V. Williams, Joanne S. Aveyard, and Margaret A. Knowles
Cancer Res 2005 65: 66-75. [Abstract] [Full Text] [PDF]  

Expression Analysis of Juvenile Pilocytic Astrocytomas by Oligonucleotide Microarray Reveals Two Potential Subgroups

Kwong-Kwok Wong, Yi-Mieng Chang, Yvonne T.M. Tsang, Laszlo Perlaky, Jack Su, Adekunle Adesina, Dawna L. Armstrong, Meenakshi Bhattacharjee, Robert Dauser, Susan M. Blaney, Murali Chintagumpala, and Ching C. Lau
Cancer Res 2005 65: 76-84. [Abstract] [Full Text] [PDF] Supplementary Data  

Heterozygosity for p53 (Trp53^+/–) Accelerates Epithelial Tumor Formation in Fanconi Anemia Complementation Group D2 (Fancd2) Knockout Mice

Scott Houghtaling, Laura Granville, Yassmine Akkari, Yumi Torimaru, Susan Olson, Milton Finegold, and Markus Grompe
Cancer Res 2005 65: 85-91. [Abstract] [Full Text] [PDF]  

Tumor Susceptibility of Rassf1a Knockout Mice

Stella Tommasi, Reinhard Dammann, Zhongqiu Zhang, Yian Wang, Limin Liu, Walter M. Tsark, Sharon P. Wilczynski, Jie Li, Ming You, and Gerd P. Pfeifer
Cancer Res 2005 65: 92-98. [Abstract] [Full Text] [PDF]  

Expression-Based Discovery of Variation in the Human Glutathione S-Transferase M3 Promoter and Functional Analysis in a Glioma Cell Line Using Allele-Specific Chromatin Immunoprecipitation

Xuemei Liu, Michelle R. Campbell, Gary S. Pittman, Eric C. Faulkner, Mary A. Watson, and Douglas A. Bell
Cancer Res 2005 65: 99-104. [Abstract] [Full Text] [PDF]  

Down-regulation of RAB6KIFL/KIF20A, a Kinesin Involved with Membrane Trafficking of Discs Large Homologue 5, Can Attenuate Growth of Pancreatic Cancer Cell

Keisuke Taniuchi, Hidewaki Nakagawa, Toru Nakamura, Hidetoshi Eguchi, Hiroaki Ohigashi, Osamu Ishikawa, Toyomasa Katagiri, and Yusuke Nakamura
Cancer Res 2005 65: 105-112. [Abstract] [Full Text] [PDF]  

Cell and Tumor Biology:

Particle Irradiation Suppresses Metastatic Potential of Cancer Cells

Toshiyuki Ogata, Teruki Teshima, Kazufumi Kagawa, Yoshio Hishikawa, Yutaka Takahashi, Atsuko Kawaguchi, Yuko Suzumoto, Kumie Nojima, Yoshiya Furusawa, and Nariaki Matsuura
Cancer Res 2005 65: 113-120. [Abstract] [Full Text] [PDF]  

Flat Dysplastic Aberrant Crypt Foci Are Related to Tumorigenesis in the Colon of Azoxymethane-Treated Rat

Jan Erik Paulsen, Else Marit Løberg, Hege Benedikte Ølstørn, Helle Knutsen, Inger-Lise Steffensen, and Jan Alexander
Cancer Res 2005 65: 121-129. [Abstract] [Full Text] [PDF]  

Matrix Metalloproteinase-2 Contributes to Cancer Cell Migration on Collagen

Xiaoping Xu, Yao Wang, Zhihua Chen, Mark D. Sternlicht, Manuel Hidalgo, and Bjorn Steffensen
Cancer Res 2005 65: 130-136. [Abstract] [Full Text] [PDF]  

Thymosin ß₁₀ Inhibits Angiogenesis and Tumor Growth by Interfering with Ras Function

Seung-Hoon Lee, Myung Jin Son, Sun-Hee Oh, Seung-Bae Rho, Kyungsook Park, Yung-Jin Kim, Mi-Sun Park, and Je-Ho Lee
Cancer Res 2005 65: 137-148. [Abstract] [Full Text] [PDF]  

Anastellin, a Fragment of the First Type III Repeat of Fibronectin, Inhibits Extracellular Signal-Regulated Kinase and Causes G₁ Arrest in Human Microvessel Endothelial Cells

Anthony Ambesi, R. Matthew Klein, Kevin M. Pumiglia, and Paula J. McKeown-Longo
Cancer Res 2005 65: 148-156. [Abstract] [Full Text] [PDF]  

Acceleration of Smad2 and Smad3 Phosphorylation via c-Jun NH₂-Terminal Kinase during Human Colorectal Carcinogenesis

Hideo Yamagata, Koichi Matsuzaki, Shigeo Mori, Katsunori Yoshida, Yoshiya Tahashi, Fukiko Furukawa, Go Sekimoto, Toshihiko Watanabe, Yoshiko Uemura, Noriko Sakaida, Kazuhiko Yoshioka, Yasuo Kamiyama, Toshihito Seki, and Kazuichi Okazaki
Cancer Res 2005 65: 157-165. [Abstract] [Full Text] [PDF]  

Transcriptional Profiles of Intestinal Tumors in Apc^Min Mice are Unique from those of Embryonic Intestine and Identify Novel Gene Targets Dysregulated in Human Colorectal Tumors

Tim Reichling, Kathleen Heppner Goss, Daniel J. Carson, Robert W. Holdcraft, Cathy Ley-Ebert, Dave Witte, Bruce J. Aronow, and Joanna Groden
Cancer Res 2005 65: 166-176. [Abstract] [Full Text] [PDF]  

Glycolytic Enzymes Can Modulate Cellular Life Span

Hiroshi Kondoh, Matilde E. Lleonart, Jesus Gil, Jing Wang, Paolo Degan, Gordon Peters, Dolores Martinez, Amancio Carnero, and David Beach
Cancer Res 2005 65: 177-185. [Abstract] [Full Text] [PDF] Supplementary Data  

Wavelet Transformations of Tumor Expression Profiles Reveals a Pervasive Genome-Wide Imprinting of Aneuploidy on the Cancer Transcriptome

Amit Aggarwal, Siew Hong Leong, Cheryl Lee, Oi Lian Kon, and Patrick Tan
Cancer Res 2005 65: 186-194. [Abstract] [Full Text] [PDF] Supplementary Data  

Implication of STAT3 Signaling in Human Colonic Cancer Cells during Intestinal Trefoil Factor 3 (TFF3) – and Vascular Endothelial Growth Factor–Mediated Cellular Invasion and Tumor Growth

Rivat Christine, Rodrigues Sylvie, Bruyneel Erik, Piétu Geneviève, Robert Amélie, Redeuilh Gérard, Bracke Marc, Gespach Christian, and Attoub Samir
Cancer Res 2005 65: 195-202. [Abstract] [Full Text] [PDF]  

A Mutation in the SDHC Gene of Complex II Increases Oxidative Stress, Resulting in Apoptosis and Tumorigenesis

Takamasa Ishii, Kayo Yasuda, Akira Akatsuka, Okio Hino, Philip S. Hartman, and Naoaki Ishii
Cancer Res 2005 65: 203-209. [Abstract] [Full Text] [PDF]  

cIAP1 Localizes to the Nuclear Compartment and Modulates the Cell Cycle

Temesgen Samuel, Kazuya Okada, Marc Hyer, Kate Welsh, Juan M. Zapata, and John C. Reed
Cancer Res 2005 65: 210-218. [Abstract] [Full Text] [PDF]  

Identification of Brain-Derived Neurotrophic Factor as a Novel Functional Protein in Hepatocellular Carcinoma

Zhen Fan Yang, David W. Ho, Chi Tat Lam, John M. Luk, Ching Tung Lum, Wan Ching Yu, Ronnie T. Poon, and Sheung Tat Fan
Cancer Res 2005 65: 219-225. [Abstract] [Full Text] [PDF]  

Aberrant Epidermal Growth Factor Receptor Signaling and Enhanced Sensitivity to EGFR Inhibitors in Lung Cancer

Joseph Amann, Shailaja Kalyankrishna, Pierre P. Massion, Joyce E. Ohm, Luc Girard, Hisayuki Shigematsu, Michael Peyton, Denise Juroske, Yuhui Huang, J. Stuart Salmon, Young H. Kim, Jonathan R. Pollack, Kiyoshi Yanagisawa, Adi Gazdar, John D. Minna, Jonathan M. Kurie, and David P. Carbone
Cancer Res 2005 65: 226-235. [Abstract] [Full Text] [PDF]  

Glioma Formation in Neurofibromatosis 1 Reflects Preferential Activation of K-RAS in Astrocytes

Biplab Dasgupta, Wen Li, Arie Perry, and David H. Gutmann
Cancer Res 2005 65: 236-245. [Abstract] [Full Text] [PDF] Supplementary Data  

Perinucleolar Compartment Prevalence Has an Independent Prognostic Value for Breast Cancer

Rajesh V. Kamath, Ann D. Thor, Chen Wang, Susan M. Edgerton, Alicja Slusarczyk, D.J. Leary, J. Wang, E.L. Wiley, B. Jovanovic, Q. Wu, R. Nayar, P. Kovarik, F. Shi, and Sui Huang
Cancer Res 2005 65: 246-253. [Abstract] [Full Text] [PDF]  

Experimental Therapeutics and Molecular Targets, and Chemical Biology:

Gene Transfer–Mediated Pre-mRNA Segmental Trans-splicing As a Strategy to Deliver Intracellular Toxins for Cancer Therapy

Katsutoshi Nakayama, Robert G. Pergolizzi, and Ronald G. Crystal
Cancer Res 2005 65: 254-263. [Abstract] [Full Text] [PDF]  

Rituximab (Chimeric Anti-CD20 Monoclonal Antibody) Inhibits the Constitutive Nuclear Factor-B Signaling Pathway in Non-Hodgkin's Lymphoma B-Cell Lines: Role in Sensitization to Chemotherapeutic Drug-induced Apoptosis

Ali R. Jazirehi, Sara Huerta-Yepez, Genhong Cheng, and Benjamin Bonavida
Cancer Res 2005 65: 264-276. [Abstract] [Full Text] [PDF]  

Attenuation of Proteasome-Induced Proteolysis in Skeletal Muscle by ß-Hydroxy-ß-Methylbutyrate in Cancer-Induced Muscle Loss

Helen J. Smith, Pradip Mukerji, and Michael J. Tisdale
Cancer Res 2005 65: 277-283. [Abstract] [Full Text] [PDF]  

Darbepoietin Alfa Potentiates the Efficacy of Radiation Therapy in Mice with Corrected or Uncorrected Anemia

Shoucheng Ning, Cynthia Hartley, Graham Molineux, and Susan J. Knox
Cancer Res 2005 65: 284-290. [Abstract] [Full Text] [PDF]  

A Genome-Wide View of the In vitro Response to L-Asparaginase in Acute Lymphoblastic Leukemia

Bernard M. Fine, Gertjan J.L. Kaspers, Minh Ho, Anne H. Loonen, and Linda M. Boxer
Cancer Res 2005 65: 291-299. [Abstract] [Full Text] [PDF]  

Androgens Repress the Expression of the Angiogenesis Inhibitor Thrombospondin-1 in Normal and Neoplastic Prostate

Marc Colombel, Stéphanie Filleur, Pierick Fournier, Carole Merle, Julien Guglielmi, Aurélie Courtin, Armelle Degeorges, Claire Marie Serre, Raymonde Bouvier, Philippe Clézardin, and Florence Cabon
Cancer Res 2005 65: 300-308. [Abstract] [Full Text] [PDF]  

Immunology:

Modification of Professional Antigen-Presenting Cells with Small Interfering RNA In vivo to Enhance Cancer Vaccine Potency

Tae Woo Kim, Jin-Hyup Lee, Liangmei He, David A.K. Boyd, J. Marie Hardwick, Chien-Fu Hung, and T-C. Wu
Cancer Res 2005 65: 309-316. [Abstract] [Full Text] [PDF]  

Endocrinology:

Oncogenic Transformation of Human Mammary Epithelial Cells by Autocrine Human Growth Hormone

Tao Zhu, B. Starling-Emerald, Xin Zhang, Kok-Onn Lee, Peter D. Gluckman, Hichem C. Mertani, and Peter E. Lobie
Cancer Res 2005 65: 317-324. [Abstract] [Full Text] [PDF]  

Up-Regulation of the Error-Prone DNA Polymerase Promotes Pleiotropic Genetic Alterations and Tumorigenesis

Clarisse Bavoux, Andréia Machado Leopoldino, Valérie Bergoglio, Jiyang O-Wang, Tomoo Ogi, Anne Bieth, Jean-Gabriel Judde, Sérgio Danilo Junho Pena, Marie-France Poupon, Thomas Helleday, Masatoshi Tagawa, CarlosRenato Machado, Jean-Sébastien Hoffmann, and Christophe Cazaux
Cancer Res 2005 65: 325-330. [Abstract] [Full Text] [PDF]  

Clinical Research:

Apolipoprotein E Is Required for Cell Proliferation and Survival in Ovarian Cancer

Yu-Chi Chen, Gudrun Pohl, Tian-Li Wang, Patrice J. Morin, Björn Risberg, Gunnar B. Kristensen, Albert Yu, Ben Davidson, and Ie-Ming Shih
Cancer Res 2005 65: 331-337. [Abstract] [Full Text] [PDF]  

Novel Prognostic Value of Nuclear Epidermal Growth Factor Receptor in Breast Cancer

Hui-Wen Lo, Weiya Xia, Yongkun Wei, Mohamed Ali-Seyed, Shiu-Feng Huang, and Mien-Chie Hung
Cancer Res 2005 65: 338-348. [Abstract] [Full Text] [PDF]  

Epidemiology and Prevention:

Cell Cycle Checkpoints, DNA Damage/Repair, and Lung Cancer Risk

Xifeng Wu, Jack A. Roth, Hua Zhao, Sherry Luo, Yun-Ling Zheng, Silvia Chiang, and Margaret R. Spitz
Cancer Res 2005 65: 349-357. [Abstract] [Full Text] [PDF]  

Association of Fetal Hormone Levels with Stem Cell Potential: Evidence for Early Life Roots of Human Cancer

Inkyung Baik, William J. DeVito, Karen Ballen, Pamela S. Becker, William Okulicz, Qin Liu, Ellen Delpapa, Pagona Lagiou, Susan Sturgeon, Dimitrios Trichopoulos, Peter J. Quesenberry, and Chung-Cheng Hsieh
Cancer Res 2005 65: 358-363. [Abstract] [Full Text] [PDF]  

Inhibition of Nuclear Translocation of Nuclear Factor-B Contributes to 3,3'-Diindolylmethane-Induced Apoptosis in Breast Cancer Cells

KM Wahidur Rahman and Fazlul H. Sarkar
Cancer Res 2005 65: 364-371. [Abstract] [Full Text] [PDF]  

Letters to the Editor:

Glypican-3 as a Serum Marker for Hepatocellular Carcinoma

Mariana Capurro, Jorge Filmus, Yoshitaka Hippo, Hiroyuki Aburatani, and Hirokazu Satoh
Cancer Res 2005 65: 372-373. [Full Text] [PDF]  

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