Reviews:

Type I Insulin-like Growth Factor Receptor as a Therapeutic Target in Cancer

Bradley S. Miller and Douglas Yee
Cancer Res 2005 65: 10123-10127. doi: 10.1158/0008-5472.CAN-05-2752 [Abstract] [Full Text] [PDF]  

Is mda-7/IL-24 a "Magic Bullet" for Cancer?

Paul B. Fisher
Cancer Res 2005 65: 10128-10138. doi: 10.1158/0008-5472.CAN-05-3127 [Abstract] [Full Text] [PDF]  

Perspectives in Cancer Research:

HLA-G Proteins in Cancer: Do They Provide Tumor Cells with an Escape Mechanism?

Nathalie Rouas-Freiss, Philippe Moreau, Soldano Ferrone, and Edgardo D. Carosella
Cancer Res 2005 65: 10139-10144. doi: 10.1158/0008-5472.CAN-05-0097 [Abstract] [Full Text] [PDF]  

Priority Reports:

Efficient Deletion of Normal Brca2-Deficient Intestinal Epithelium by Poly(ADP-Ribose) Polymerase Inhibition Models Potential Prophylactic Therapy

Trevor Hay, Helen Jenkins, Owen J. Sansom, Niall M.B. Martin, Graeme C.M. Smith, and Alan R. Clarke
Cancer Res 2005 65: 10145-10148. doi: 10.1158/0008-5472.CAN-05-1186 [Abstract] [Full Text] [PDF]  

Noninvasive In vivo Detection of Glutathione Metabolism in Tumors

Peter E. Thelwall, Avner Y. Yemin, Theresa L. Gillian, Nicholas E. Simpson, Mohit S. Kasibhatla, Zahid N. Rabbani, Jeffrey M. Macdonald, Stephen J. Blackband, and Michael P. Gamcsik
Cancer Res 2005 65: 10149-10153. doi: 10.1158/0008-5472.CAN-05-1781 [Abstract] [Full Text] [PDF]  

Noninvasive Visualization of Adenovirus Replication with a Fluorescent Reporter in the E3 Region

Hidetaka A. Ono, Long P. Le, Julia G. Davydova, Tatyana Gavrikova, and Masato Yamamoto
Cancer Res 2005 65: 10154-10158. doi: 10.1158/0008-5472.CAN-05-1871 [Abstract] [Full Text] [PDF]  

Extremely Low Dose Ionizing Radiation Up-regulates CXC Chemokines in Normal Human Fibroblasts

Akira Fujimori, Ryuichi Okayasu, Hiroshi Ishihara, Satoshi Yoshida, Kiyomi Eguchi-Kasai, Kumie Nojima, Satoru Ebisawa, and Sentaro Takahashi
Cancer Res 2005 65: 10159-10163. doi: 10.1158/0008-5472.CAN-05-2015 [Abstract] [Full Text] [PDF]  

Epigenetic Transdifferentiation of Normal Melanocytes by a Metastatic Melanoma Microenvironment

Elisabeth A. Seftor, Kevin M. Brown, Lynda Chin, Dawn A. Kirschmann, William W. Wheaton, Alexei Protopopov, Bin Feng, Yoganand Balagurunathan, Jeffrey M. Trent, Brian J. Nickoloff, Richard E.B. Seftor, and Mary J.C. Hendrix
Cancer Res 2005 65: 10164-10169. doi: 10.1158/0008-5472.CAN-05-2497 [Abstract] [Full Text] [PDF]  

Mechanisms of Inactivation of the Receptor Tyrosine Kinase EPHB2 in Colorectal Tumors

Hafid Alazzouzi, Veronica Davalos, Antti Kokko, Enric Domingo, Stefan M. Woerner, Andrew J. Wilson, Lars Konrad, Päivi Laiho, Eloi Espín, Manel Armengol, Kohzoh Imai, Hiroyuki Yamamoto, John M. Mariadason, Johannes F. Gebert, Lauri A. Aaltonen, Simo Schwartz, Jr., and Diego Arango
Cancer Res 2005 65: 10170-10173. doi: 10.1158/0008-5472.CAN-05-2580 [Abstract] [Full Text] [PDF] Supplementary Data  

Cyclin-Dependent Kinase 4 Expression Is Essential for Neu-Induced Breast Tumorigenesis

Haritha K.D.L. Reddy, Richard V. Mettus, Sushil G. Rane, Xavier Graña, Judith Litvin, and E. Premkumar Reddy
Cancer Res 2005 65: 10174-10178. doi: 10.1158/0008-5472.CAN-05-2639 [Abstract] [Full Text] [PDF]  

Induction of Renal Tumorigenesis with Elevated Levels of Somatic Loss of Heterozygosity in Tsc1^+/- Mice on a Blm-Deficient Background

Catherine Wilson, Shelley Idziaszczyk, James Colley, Vikki Humphreys, Carol Guy, Julie Maynard, Julian R. Sampson, and Jeremy P. Cheadle
Cancer Res 2005 65: 10179-10182. doi: 10.1158/0008-5472.CAN-05-2688 [Abstract] [Full Text] [PDF]  

Control of Multidrug Resistance Gene mdr1 and Cancer Resistance to Chemotherapy by the Longevity Gene sirt1

Fei Chu, Pauline M. Chou, Xin Zheng, Bernard L. Mirkin, and Abdelhadi Rebbaa
Cancer Res 2005 65: 10183-10187. doi: 10.1158/0008-5472.CAN-05-2002 [Abstract] [Full Text] [PDF]  

Reliable High-Throughput Genotyping and Loss-of-Heterozygosity Detection in Formalin-Fixed, Paraffin-Embedded Tumors Using Single Nucleotide Polymorphism Arrays

Esther H. Lips, Jan Willem F. Dierssen, Ronald van Eijk, Jan Oosting, Paul H.C. Eilers, Rob A.E.M. Tollenaar, Eelco J. de Graaf, Ruben van't Slot, Cisca Wijmenga, Hans Morreau, and Tom van Wezel
Cancer Res 2005 65: 10188-10191. doi: 10.1158/0008-5472.CAN-05-2486 [Abstract] [Full Text] [PDF]  

Molecular Biology, Pathobiology and Genetics:

Loss of the hSNF5 Gene Concomitantly Inactivates p21^CIP/WAF1 and p16^INK4a Activity Associated with Replicative Senescence in A204 Rhabdoid Tumor Cells

Jingjing Chai, Aubri L. Charboneau, Bryan L. Betz, and Bernard E. Weissman
Cancer Res 2005 65: 10192-10198. doi: 10.1158/0008-5472.CAN-05-1896 [Abstract] [Full Text] [PDF] Supplementary Data  

Mutation of the PIK3CA Gene in Anaplastic Thyroid Cancer

Ginesa García-Rostán, Angela M. Costa, Isabel Pereira-Castro, Giuliana Salvatore, Radhames Hernandez, Mario J.A. Hermsem, Agustin Herrero, Alfredo Fusco, Jose Cameselle-Teijeiro, and Massimo Santoro
Cancer Res 2005 65: 10199-10207. doi: 10.1158/0008-5472.CAN-04-4259 [Abstract] [Full Text] [PDF]  

Expression Microarray Analysis and Oligo Array Comparative Genomic Hybridization of Acquired Gemcitabine Resistance in Mouse Colon Reveals Selection for Chromosomal Aberrations

Mark A. van de Wiel, Jose L. Costa, Kees Smid, Cees B.M. Oudejans, Andries M. Bergman, Gerrit A. Meijer, Godefridus J. Peters, and Bauke Ylstra
Cancer Res 2005 65: 10208-10213. doi: 10.1158/0008-5472.CAN-05-0760 [Abstract] [Full Text] [PDF] Supplementary Data  

Novel Molecular Signaling and Classification of Human Clinically Nonfunctional Pituitary Adenomas Identified by Gene Expression Profiling and Proteomic Analyses

Carlos S. Moreno, Chheng-Orn Evans, Xianquan Zhan, Mammerhi Okor, Dominic M. Desiderio, and Nelson M. Oyesiku
Cancer Res 2005 65: 10214-10222. doi: 10.1158/0008-5472.CAN-05-0884 [Abstract] [Full Text] [PDF] Supplementary Data  

Postreplicative Joining of DNA Double-Strand Breaks Causes Genomic Instability in DNA-PKcs–Deficient Mouse Embryonic Fibroblasts

Marta Martín, Anna Genescà, Laura Latre, Isabel Jaco, Guillermo E. Taccioli, Josep Egozcue, María A. Blasco, George Iliakis, and Laura Tusell
Cancer Res 2005 65: 10223-10232. doi: 10.1158/0008-5472.CAN-05-0932 [Abstract] [Full Text] [PDF]  

Methylation-Associated Silencing of the Nuclear Receptor 1I2 Gene in Advanced-Type Neuroblastomas, Identified by Bacterial Artificial Chromosome Array-Based Methylated CpG Island Amplification

Akiko Misawa, Jun Inoue, Yuriko Sugino, Hajime Hosoi, Tohru Sugimoto, Fumie Hosoda, Misao Ohki, Issei Imoto, and Johji Inazawa
Cancer Res 2005 65: 10233-10242. doi: 10.1158/0008-5472.CAN-05-1073 [Abstract] [Full Text] [PDF] Supplementary Data  

Heterogeneous Tumor Evolution Initiated by Loss of pRb Function in a Preclinical Prostate Cancer Model

Reginald Hill, Yurong Song, Robert D. Cardiff, and Terry Van Dyke
Cancer Res 2005 65: 10243-10254. doi: 10.1158/0008-5472.CAN-05-1579 [Abstract] [Full Text] [PDF] Supplementary Data  

The p53 Tumor Suppressor Network Is a Key Responder to Microenvironmental Components of Chronic Inflammatory Stress

Frank Staib, Ana I. Robles, Lyuba Varticovski, Xin W. Wang, Barry R. Zeeberg, Michail Sirotin, Victor B. Zhurkin, Lorne J. Hofseth, S. Perwez Hussain, John N. Weinstein, Peter R. Galle, and Curtis C. Harris
Cancer Res 2005 65: 10255-10264. doi: 10.1158/0008-5472.CAN-05-1714 [Abstract] [Full Text] [PDF] Supplementary Data  

BRCA1 and c-Myc Associate to Transcriptionally Repress Psoriasin, a DNA Damage–Inducible Gene

Richard D. Kennedy, Julia J. Gorski, Jennifer E. Quinn, Gail E. Stewart, Colin R. James, Stephen Moore, Karl Mulligan, Ethan D. Emberley, Tong F. Lioe, Patrick J. Morrison, Paul B. Mullan, George Reid, Patrick G. Johnston, Peter H. Watson, and D. Paul Harkin
Cancer Res 2005 65: 10265-10272. doi: 10.1158/0008-5472.CAN-05-1841 [Abstract] [Full Text] [PDF] Supplementary Data  

Some Oral Poliovirus Vaccines Were Contaminated with Infectious SV40 after 1961

Rochelle Cutrone, John Lednicky, Glynis Dunn, Paola Rizzo, Maurizio Bocchetta, Konstantin Chumakov, Philip Minor, and Michele Carbone
Cancer Res 2005 65: 10273-10279. doi: 10.1158/0008-5472.CAN-05-2028 [Abstract] [Full Text] [PDF]  

The Differential Effects of Mutant p53 Alleles on Advanced Murine Lung Cancer

Erica L. Jackson, Kenneth P. Olive, David A. Tuveson, Roderick Bronson, Denise Crowley, Michael Brown, and Tyler Jacks
Cancer Res 2005 65: 10280-10288. doi: 10.1158/0008-5472.CAN-05-2193 [Abstract] [Full Text] [PDF]  

Transcription Repressor Activity of Spleen Tyrosine Kinase Mediates Breast Tumor Suppression

Lei Wang, Eswaran Devarajan, Jin He, Sekhar P. Reddy, and Jia Le Dai
Cancer Res 2005 65: 10289-10297. doi: 10.1158/0008-5472.CAN-05-2231 [Abstract] [Full Text] [PDF]  

Enhanced DDB2 Expression Protects Mice from Carcinogenic Effects of Chronic UV-B Irradiation

Sergey Alekseev, Hanneke Kool, Heggert Rebel, Maria Fousteri, Jill Moser, Claude Backendorf, Frank R. de Gruijl, Harry Vrieling, and Leon H.F. Mullenders
Cancer Res 2005 65: 10298-10306. doi: 10.1158/0008-5472.CAN-05-2295 [Abstract] [Full Text] [PDF]  

Disruption of Protein Kinase A Regulation Causes Immortalization and Dysregulation of D-Type Cyclins

Kiran S. Nadella and Lawrence S. Kirschner
Cancer Res 2005 65: 10307-10315. doi: 10.1158/0008-5472.CAN-05-3183 [Abstract] [Full Text] [PDF]  

Cell and Tumor Biology:

Magnetic Resonance Imaging Visualization of Hyaluronidase in Ovarian Carcinoma

Liora Shiftan, Tomer Israely, Miriam Cohen, Veronica Frydman, Hagit Dafni, Robert Stern, and Michal Neeman
Cancer Res 2005 65: 10316-10323. doi: 10.1158/0008-5472.CAN-04-3947 [Abstract] [Full Text] [PDF]  

A Direct Test of Potential Roles for ß3 and ß5 Integrins in Growth and Metastasis of Murine Mammary Carcinomas

Daniela Taverna, Denise Crowley, Mary Connolly, Roderick T. Bronson, and Richard O. Hynes
Cancer Res 2005 65: 10324-10329. doi: 10.1158/0008-5472.CAN-04-4098 [Abstract] [Full Text] [PDF] Supplementary Data  

CCAAT/Enhancer Binding Protein Knock-in Mice Exhibit Early Liver Glycogen Storage and Reduced Susceptibility to Hepatocellular Carcinoma

Ee Hong Tan, Shing Chuan Hooi, Mirtha Laban, Esther Wong, Sathivel Ponniah, Aileen Wee, and Nai-dy Wang
Cancer Res 2005 65: 10330-10337. doi: 10.1158/0008-5472.CAN-04-4486 [Abstract] [Full Text] [PDF]  

The Role of Peroxiredoxin II in Radiation-Resistant MCF-7 Breast Cancer Cells

Tieli Wang, Daniel Tamae, Thomas LeBon, John E. Shively, Yun Yen, and Jian Jian Li
Cancer Res 2005 65: 10338-10346. doi: 10.1158/0008-5472.CAN-04-4614 [Abstract] [Full Text] [PDF]  

Interleukin-8 Differentially Regulates Migration of Tumor-Associated and Normal Human Brain Endothelial Cells

Christiana Charalambous, Ligaya B. Pen, Yuzhuang S. Su, Johanna Milan, Thomas C. Chen, and Florence M. Hofman
Cancer Res 2005 65: 10347-10354. doi: 10.1158/0008-5472.CAN-05-0949 [Abstract] [Full Text] [PDF]  

The Inflammatory Cytokine Tumor Necrosis Factor- Regulates Chemokine Receptor Expression on Ovarian Cancer Cells

Hagen Kulbe, Thorsten Hagemann, Piotr W. Szlosarek, Frances R. Balkwill, and Julia L. Wilson
Cancer Res 2005 65: 10355-10362. doi: 10.1158/0008-5472.CAN-05-0957 [Abstract] [Full Text] [PDF]  

Transforming Acidic Coiled Coil 1 Promotes Transformation and Mammary Tumorigenesis

Megan Cully, Jessica Shiu, Roland P. Piekorz, William J. Muller, Susan J. Done, and Tak W. Mak
Cancer Res 2005 65: 10363-10370. doi: 10.1158/0008-5472.CAN-05-1633 [Abstract] [Full Text] [PDF]  

Simultaneous Inhibition of EGFR, VEGFR, and Platelet-Derived Growth Factor Receptor Signaling Combined with Gemcitabine Produces Therapy of Human Pancreatic Carcinoma and Prolongs Survival in an Orthotopic Nude Mouse Model

Kenji Yokoi, Takamitsu Sasaki, Corazon D. Bucana, Dominic Fan, Cheryl H. Baker, Yasuhiko Kitadai, Toshio Kuwai, James L. Abbruzzese, and Isaiah J. Fidler
Cancer Res 2005 65: 10371-10380. doi: 10.1158/0008-5472.CAN-05-1698 [Abstract] [Full Text] [PDF]  

Src Tyrosine Kinase and Multidrug Resistance Protein-1 Inhibitions Act Independently but Cooperatively to Restore Paclitaxel Sensitivity to Paclitaxel-Resistant Ovarian Cancer Cells

Jessica A. George, Ting Chen, and Christopher C. Taylor
Cancer Res 2005 65: 10381-10388. doi: 10.1158/0008-5472.CAN-05-1822 [Abstract] [Full Text] [PDF]  

Orthotopic Growth of Human Glioma Cells Quantitatively and Qualitatively Influences Radiation-Induced Changes in Gene Expression

Kevin Camphausen, Benjamin Purow, Mary Sproull, Tamalee Scott, Tomoko Ozawa, Dennis F. Deen, and Philip J. Tofilon
Cancer Res 2005 65: 10389-10393. doi: 10.1158/0008-5472.CAN-05-1904 [Abstract] [Full Text] [PDF]  

Destabilization of Krüppel-Like Factor 4 Protein in Response to Serum Stimulation Involves the Ubiquitin-Proteasome Pathway

Zhi Yi Chen, Xuesheng Wang, Yunhong Zhou, Gwynneth Offner, and Chi-Chuan Tseng
Cancer Res 2005 65: 10394-10400. doi: 10.1158/0008-5472.CAN-05-2059 [Abstract] [Full Text] [PDF]  

A Novel RING-Type Ubiquitin Ligase Breast Cancer-Associated Gene 2 Correlates with Outcome in Invasive Breast Cancer

Angelika M. Burger, Yuguang Gao, Yutaka Amemiya, Harriette J. Kahn, Richard Kitching, Yili Yang, Ping Sun, Steven A. Narod, Wedad M. Hanna, and Arun K. Seth
Cancer Res 2005 65: 10401-10412. doi: 10.1158/0008-5472.CAN-05-2103 [Abstract] [Full Text] [PDF]  

MUC1 Oncoprotein Blocks Glycogen Synthase Kinase 3ß–Mediated Phosphorylation and Degradation of ß-Catenin

Lei Huang, Dongshu Chen, Derek Liu, Li Yin, Surender Kharbanda, and Donald Kufe
Cancer Res 2005 65: 10413-10422. doi: 10.1158/0008-5472.CAN-05-2474 [Abstract] [Full Text] [PDF] Supplementary Data  

Identification of SFRP1 as a Candidate Mediator of Stromal-to-Epithelial Signaling in Prostate Cancer

Margaret S. Joesting, Steve Perrin, Brian Elenbaas, Stephen E. Fawell, Jeffrey S. Rubin, Omar E. Franco, Simon W. Hayward, Gerald R. Cunha, and Paul C. Marker
Cancer Res 2005 65: 10423-10430. doi: 10.1158/0008-5472.CAN-05-0824 [Abstract] [Full Text] [PDF] Supplementary Data  

Transforming Growth Factor-ß Activation of Phosphatidylinositol 3-Kinase Is Independent of Smad2 and Smad3 and Regulates Fibroblast Responses via p21-Activated Kinase-2

Mark C. Wilkes, Hugh Mitchell, Sumedha Gulati Penheiter, Jules J. Doré, Kaori Suzuki, Maryanne Edens, Deepak K. Sharma, Richard E. Pagano, and Edward B. Leof
Cancer Res 2005 65: 10431-10440. doi: 10.1158/0008-5472.CAN-05-1522 [Abstract] [Full Text] [PDF]  

Alternative Splicing of Fibroblast Growth Factor Receptor 3 Produces a Secreted Isoform That Inhibits Fibroblast Growth Factor–Induced Proliferation and Is Repressed in Urothelial Carcinoma Cell Lines

Darren C. Tomlinson, Corine G. L'Hôte, Wendy Kennedy, Eva Pitt, and Margaret A. Knowles
Cancer Res 2005 65: 10441-10449. doi: 10.1158/0008-5472.CAN-05-1718 [Abstract] [Full Text] [PDF]  

Kisspeptin-10-Induced Signaling of GPR54 Negatively Regulates Chemotactic Responses Mediated by CXCR4: a Potential Mechanism for the Metastasis Suppressor Activity of Kisspeptins

Jean-Marc Navenot, Zixuan Wang, Michael Chopin, Nobutaka Fujii, and Stephen C. Peiper
Cancer Res 2005 65: 10450-10456. doi: 10.1158/0008-5472.CAN-05-1757 [Abstract] [Full Text] [PDF]  

Cancer-Specific Functions of SIRT1 Enable Human Epithelial Cancer Cell Growth and Survival

Jack Ford, Ming Jiang, and Jo Milner
Cancer Res 2005 65: 10457-10463. doi: 10.1158/0008-5472.CAN-05-1923 [Abstract] [Full Text] [PDF]  

Experimental Therapeutics, Molecular Targets, and Chemical Biology:

Suppression of Urokinase Receptor Expression by Thalidomide Is Associated with Inhibition of Nuclear Factor B Activation and Subsequently Suppressed Ovarian Cancer Dissemination

Hiroshi Kobayashi, Tatsuo Yagyu, Toshiharu Kondo, Noriyuki Kurita, Kiyokazu Inagaki, Shoji Haruta, Ryuji Kawaguchi, Takashi Kitanaka, Yoshiharu Sakamoto, Yoshihiko Yamada, Naohiro Kanayama, and Toshihiko Terao
Cancer Res 2005 65: 10464-10471. doi: 10.1158/0008-5472.CAN-04-3789 [Abstract] [Full Text] [PDF]  

Sensitization of Human Carcinoma Cells to Alkylating Agents by Small Interfering RNA Suppression of 3-Alkyladenine-DNA Glycosylase

Johanna Paik, Tod Duncan, Tomas Lindahl, and Barbara Sedgwick
Cancer Res 2005 65: 10472-10477. doi: 10.1158/0008-5472.CAN-05-1495 [Abstract] [Full Text] [PDF] Supplementary Data  

Identification of an Inactivating Cysteine Switch in Protein Kinase C, a Rational Target for the Design of Protein Kinase C–Inhibitory Cancer Therapeutics

Feng Chu, John M. Koomen, Ryuji Kobayashi, and Catherine A. O'Brian
Cancer Res 2005 65: 10478-10485. doi: 10.1158/0008-5472.CAN-05-1989 [Abstract] [Full Text] [PDF]  

A Comparative Study on the Protection Profile of Lidocaine, Amifostine, and Pilocarpin on the Parotid Gland during Radiotherapy

Samer G. Hakim, Hartwig Kosmehl, Isabel Lauer, Roger Nadrowitz, Thilo Wedel, and Peter Sieg
Cancer Res 2005 65: 10486-10493. doi: 10.1158/0008-5472.CAN-05-0023 [Abstract] [Full Text] [PDF]  

Laminin 5 Chain Metastasis- and Angiogenesis-Inhibiting Peptide Blocks Fibroblast Growth Factor 2 Activity by Binding to the Heparan Sulfate Chains of CD44

Suguru Hibino, Masahiko Shibuya, Matthew P. Hoffman, Jean A. Engbring, Rydhwana Hossain, Mayumi Mochizuki, Shoji Kudoh, Motoyoshi Nomizu, and Hynda K. Kleinman
Cancer Res 2005 65: 10494-10501. doi: 10.1158/0008-5472.CAN-05-0314 [Abstract] [Full Text] [PDF]  

Sensitization for -Irradiation–Induced Apoptosis by Second Mitochondria-Derived Activator of Caspase

Stavros Giagkousiklidis, Meike Vogler, Mike-Andrew Westhoff, Hubert Kasperczyk, Klaus-Michael Debatin, and Simone Fulda
Cancer Res 2005 65: 10502-10513. doi: 10.1158/0008-5472.CAN-05-0866 [Abstract] [Full Text] [PDF] Supplementary Data  

Activated Tyrosine Kinase Ack1 Promotes Prostate Tumorigenesis: Role of Ack1 in Polyubiquitination of Tumor Suppressor Wwox

Nupam P. Mahajan, Young E. Whang, James L. Mohler, and H. Shelton Earp
Cancer Res 2005 65: 10514-10523. doi: 10.1158/0008-5472.CAN-05-1127 [Abstract] [Full Text] [PDF] Supplementary Data  

Uncoupling between Epidermal Growth Factor Receptor and Downstream Signals Defines Resistance to the Antiproliferative Effect of Gefitinib in Bladder Cancer Cells

Wassim Kassouf, Colin P.N. Dinney, Gordon Brown, David J. McConkey, Alan J. Diehl, Menashe Bar-Eli, and Liana Adam
Cancer Res 2005 65: 10524-10535. doi: 10.1158/0008-5472.CAN-05-1536 [Abstract] [Full Text] [PDF] Supplementary Data  

Abrogation of Heat Shock Protein 70 Induction as a Strategy to Increase Antileukemia Activity of Heat Shock Protein 90 Inhibitor 17-Allylamino-Demethoxy Geldanamycin

Fei Guo, Kathy Rocha, Purva Bali, Michael Pranpat, Warren Fiskus, Sandhya Boyapalle, Sandhya Kumaraswamy, Maria Balasis, Benjamin Greedy, E. Simon M. Armitage, Nicholas Lawrence, and Kapil Bhalla
Cancer Res 2005 65: 10536-10544. doi: 10.1158/0008-5472.CAN-05-1799 [Abstract] [Full Text] [PDF]  

Activation of Glycogen Synthase Kinase 3ß Disrupts the Binding of Hexokinase II to Mitochondria by Phosphorylating Voltage-Dependent Anion Channel and Potentiates Chemotherapy-Induced Cytotoxicity

John G. Pastorino, Jan B. Hoek, and Nataly Shulga
Cancer Res 2005 65: 10545-10554. doi: 10.1158/0008-5472.CAN-05-1925 [Abstract] [Full Text] [PDF]  

Immunology:

Effective Treatment of Preexisting Melanoma with Whole Cell Vaccines Expressing (1,3)-Galactosyl Epitopes

Gabriela R. Rossi, Mario R. Mautino, Robert C. Unfer, Tatiana M. Seregina, Nicholas Vahanian, and Charles J. Link
Cancer Res 2005 65: 10555-10561. doi: 10.1158/0008-5472.CAN-05-0627 [Abstract] [Full Text] [PDF]  

Complement-Mediated Mechanisms in Anti-GD2 Monoclonal Antibody Therapy of Murine Metastatic Cancer

Masaki Imai, Charles Landen, Rieko Ohta, Nai-Kong V. Cheung, and Stephen Tomlinson
Cancer Res 2005 65: 10562-10568. doi: 10.1158/0008-5472.CAN-05-1894 [Abstract] [Full Text] [PDF]  

Interleukin-7-Dependent Expansion and Persistence of Melanoma-Specific T Cells in Lymphodepleted Mice Lead to Tumor Regression and Editing

Li-Xin Wang, Rui Li, Guojun Yang, May Lim, Aisling O'Hara, Yiwei Chu, Bernard A. Fox, Nicholas P. Restifo, Walter J. Urba, and Hong-Ming Hu
Cancer Res 2005 65: 10569-10577. doi: 10.1158/0008-5472.CAN-05-2117 [Abstract] [Full Text] [PDF]  

Diminished Expression of Transcription Factors Nuclear Factor B and CCAAT/Enhancer Binding Protein Underlies a Novel Tumor Evasion Mechanism Affecting Macrophages of Mammary Tumor–Bearing Mice

Marta Torroella-Kouri, Xiaojing Ma, Giselle Perry, Milena Ivanova, Pedro J. Cejas, Jennifer L. Owen, Vijaya Iragavarapu-Charyulu, and Diana M. Lopez
Cancer Res 2005 65: 10578-10584. doi: 10.1158/0008-5472.CAN-05-0365 [Abstract] [Full Text] [PDF]  

Endocrinology:

Steroid Receptor Regulation of Epidermal Growth Factor Signaling through Src in Breast and Prostate Cancer Cells: Steroid Antagonist Action

Antimo Migliaccio, Marina Di Domenico, Gabriella Castoria, Merlin Nanayakkara, Maria Lombardi, Antonietta de Falco, Antonio Bilancio, Lilian Varricchio, Alessandra Ciociola, and Ferdinando Auricchio
Cancer Res 2005 65: 10585-10593. doi: 10.1158/0008-5472.CAN-05-0912 [Abstract] [Full Text] [PDF]  

Negative Regulation of Estrogen Receptor Transactivation Functions by LIM Domain Only 4 Protein

Rajesh R. Singh, Christopher J. Barnes, Amjad H. Talukder, Suzanne A.W. Fuqua, and Rakesh Kumar
Cancer Res 2005 65: 10594-10601. doi: 10.1158/0008-5472.CAN-05-2268 [Abstract] [Full Text] [PDF]  

Clinical Research:

Expression Profiling of Serous Low Malignant Potential, Low-Grade, and High-Grade Tumors of the Ovary

Tomas Bonome, Ji-Young Lee, Dong-Choon Park, Mike Radonovich, Cindy Pise-Masison, John Brady, Ginger J. Gardner, Ke Hao, Wing H. Wong, J. Carl Barrett, Karen H. Lu, Anil K. Sood, David M. Gershenson, Samuel C. Mok, and Michael J. Birrer
Cancer Res 2005 65: 10602-10612. doi: 10.1158/0008-5472.CAN-05-2240 [Abstract] [Full Text] [PDF] Supplementary Data  

Possible Detection of Pancreatic Cancer by Plasma Protein Profiling

Kazufumi Honda, Yasuharu Hayashida, Tomoko Umaki, Takuji Okusaka, Tomoo Kosuge, Satoru Kikuchi, Mitsufumi Endo, Akihiko Tsuchida, Tatsuya Aoki, Takao Itoi, Fuminori Moriyasu, Setsuo Hirohashi, and Tesshi Yamada
Cancer Res 2005 65: 10613-10622. doi: 10.1158/0008-5472.CAN-05-1851 [Abstract] [Full Text] [PDF]  

Epidemiology and Prevention:

Inhibition of Intestinal Tumorigenesis in Apc^min/+ Mice by (–)-Epigallocatechin-3-Gallate, the Major Catechin in Green Tea

Jihyeung Ju, Jungil Hong, Jian-nian Zhou, Zui Pan, Mousumi Bose, Jie Liao, Guang-yu Yang, Ying Ying Liu, Zhe Hou, Yong Lin, Jianjie Ma, Weichung Joe Shih, Adelaide M. Carothers, and Chung S. Yang
Cancer Res 2005 65: 10623-10631. doi: 10.1158/0008-5472.CAN-05-1949 [Abstract] [Full Text] [PDF]  

Letters to the Editor:

DNA Double Strand Breaks Do Not Play a Role in Heat-Induced Cell Killing

Harm H. Kampinga, Andrei Laszlo, Akihisa Takahashi, Eiichiro Mori, and Takeo Ohnishi
Cancer Res 2005 65: 10632-10633. doi: 10.1158/0008-5472.CAN-05-0006 [Full Text] [PDF]  

Minimal Region of Deletion on Chromosomal Arm 3p25.1-p25.2 in Uveal Melanoma

Dietmar R. Lohmann, Thomas Häusler, Bernhard Horsthemke, Michael Zeschnigk, Paola Parrella, and Shannath L. Merbs
Cancer Res 2005 65: 10634 [Full Text] [PDF]  

Corrections:

Apoptosis of Prostate Cancer Cells by CKIs

Cancer Res 2005 65: 10635 [Full Text] [PDF]  

Cover Caption

Cancer Res 2005 65: 10635 [Full Text]  

Measurement of the Human Mutation Rate

Cancer Res 2005 65: 10635 [Full Text]  

Inactivation of Rb and p300/CBP to Bypass Senescence

Cancer Res 2005 65: 10635 [Full Text]  

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