Editorial:

It Is Time for a Human Epigenome Project

Frank J. Rauscher, III
Cancer Res 2005 65: 11229. [Full Text] [PDF]  

Reviews:

Anoikis and Survival Connections in the Tumor Microenvironment: Is There a Role in Prostate Cancer Metastasis?

Gabriela Rennebeck, Matthew Martelli, and Natasha Kyprianou
Cancer Res 2005 65: 11230-11235. [Abstract] [Full Text] [PDF]  

Loss of Imprinting of IGF2: A Common Epigenetic Modifier of Intestinal Tumor Risk

Atsushi Kaneda and Andrew P. Feinberg
Cancer Res 2005 65: 11236-11240. [Abstract] [Full Text] [PDF]  

Special Workshop:

A Blueprint for a Human Epigenome Project: The AACR Human Epigenome Workshop

Peter A. Jones and Robert Martienssen
Cancer Res 2005 65: 11241-11246. [Abstract] [Full Text] [PDF]  

Meeting Reports:

Modeling Human Cancer: Report on the Eighth Beatson International Cancer Conference

Michael F. Olson
Cancer Res 2005 65: 11247-11250. [Abstract] [Full Text] [PDF] Supplementary Data  

Seventeenth Annual Pezcoller Symposium: Molecular Understanding of Solid Tumors

Enrico Mihich and William R. Sellers
Cancer Res 2005 65: 11251-11254. [Full Text] [PDF]  

Priority Reports:

Cyclophosphamide Allows for In vivo Dose Reduction of a Potent Oncolytic Virus

Hirokazu Kambara, Yoshinaga Saeki, and E. Antonio Chiocca
Cancer Res 2005 65: 11255-11258. [Abstract] [Full Text] [PDF]  

Identification of GATA3 as a Breast Cancer Prognostic Marker by Global Gene Expression Meta-analysis

Rohit Mehra, Sooryanarayana Varambally, Lei Ding, Ronglai Shen, Michael S. Sabel, Debashis Ghosh, Arul M. Chinnaiyan, and Celina G. Kleer
Cancer Res 2005 65: 11259-11264. [Abstract] [Full Text] [PDF] Supplementary Data  

TRAIL Receptor-Selective Mutants Signal to Apoptosis via TRAIL-R1 in Primary Lymphoid Malignancies

Marion MacFarlane, Susan L. Kohlhaas, Michael J. Sutcliffe, Martin J.S. Dyer, and Gerald M. Cohen
Cancer Res 2005 65: 11265-11270. [Abstract] [Full Text] [PDF]  

Organ-Specific Increase in Mutation Accumulation and Apoptosis Rate in CuZn-Superoxide Dismutase–Deficient Mice

Rita A. Busuttil, Ana Maria Garcia, Carlos Cabrera, Armando Rodriguez, Yousin Suh, Woo Ho Kim, Ting-Ting Huang, and Jan Vijg
Cancer Res 2005 65: 11271-11275. [Abstract] [Full Text] [PDF]  

Loss of Phosphatase and Tensin Homologue Increases Transforming Growth Factor ß–Mediated Invasion with Enhanced SMAD3 Transcriptional Activity

Anita B. Hjelmeland, Mark D. Hjelmeland, Qing Shi, Janet L. Hart, Darell D. Bigner, Xiao-Fan Wang, Christopher D. Kontos, and Jeremy N. Rich
Cancer Res 2005 65: 11276-11281. [Abstract] [Full Text] [PDF] Supplementary Data  

Akt Phosphorylates and Regulates Pdcd4 Tumor Suppressor Protein

Alexey Palamarchuk, Alexey Efanov, Vadim Maximov, Rami I. Aqeilan, Carlo M. Croce, and Yuri Pekarsky
Cancer Res 2005 65: 11282-11286. [Abstract] [Full Text] [PDF]  

Aromatase Inhibitors in Human Lung Cancer Therapy

Olga K. Weinberg, Diana C. Marquez-Garban, Michael C. Fishbein, Lee Goodglick, Hermes J. Garban, Steven M. Dubinett, and Richard J. Pietras
Cancer Res 2005 65: 11287-11291. [Abstract] [Full Text] [PDF]  

Checkpoint Abrogation in G₂ Compromises Repair of Chromosomal Breaks in Ataxia Telangiectasia Cells

Georgia I. Terzoudi, Kaliopi N. Manola, Gabriel E. Pantelias, and George Iliakis
Cancer Res 2005 65: 11292-11296. [Abstract] [Full Text] [PDF]  

Molecular Biology, Pathobiology and Genetics:

Mutation of Lkb1 and p53 Genes Exert a Cooperative Effect on Tumorigenesis

Chongjuan Wei, Christopher I. Amos, L. Clifton Stephens, Imelda Campos, Jian Min Deng, Richard R. Behringer, Asif Rashid, and Marsha L. Frazier
Cancer Res 2005 65: 11297-11303. [Abstract] [Full Text] [PDF]  

FBXO31 Is the Chromosome 16q24.3 Senescence Gene, a Candidate Breast Tumor Suppressor, and a Component of an SCF Complex

Raman Kumar, Paul M. Neilsen, Joanne Crawford, Ross McKirdy, Jaclyn Lee, Jason A. Powell, Zarqa Saif, Julie M. Martin, Marc Lombaerts, Cees J. Cornelisse, Anne-Marie Cleton-Jansen, and David F. Callen
Cancer Res 2005 65: 11304-11313. [Abstract] [Full Text] [PDF]  

ANLN Plays a Critical Role in Human Lung Carcinogenesis through the Activation of RHOA and by Involvement in the Phosphoinositide 3-Kinase/AKT Pathway

Chie Suzuki, Yataro Daigo, Nobuhisa Ishikawa, Tatsuya Kato, Satoshi Hayama, Tomoo Ito, Eiju Tsuchiya, and Yusuke Nakamura
Cancer Res 2005 65: 11314-11325. [Abstract] [Full Text] [PDF]  

A Putative Role for Psoriasin in Breast Tumor Progression

Ian Krop, Annette März, Hanna Carlsson, Xiaochun Li, Noga Bloushtain-Qimron, Min Hu, Rebecca Gelman, Michael S. Sabel, Stuart Schnitt, Sridhar Ramaswamy, Celina G. Kleer, Charlotta Enerbäck, and Kornelia Polyak
Cancer Res 2005 65: 11326-11334. [Abstract] [Full Text] [PDF]  

Gene Expression Profiles Associated with Treatment Response in Oligodendrogliomas

Pim J. French, Sigrid M.A. Swagemakers, Jord H.A. Nagel, Mathilde C.M. Kouwenhoven, Eric Brouwer, Peter van der Spek, Theo M. Luider, Johan M. Kros, Martin J. van den Bent, and Peter A. Sillevis Smitt
Cancer Res 2005 65: 11335-11344. [Abstract] [Full Text] [PDF] Supplementary DataSupplementary DataSupplementary Data  

Mutually Exclusive Cyclin-Dependent Kinase 4/Cyclin D1 and Cyclin-Dependent Kinase 6/Cyclin D2 Pairing Inactivates Retinoblastoma Protein and Promotes Cell Cycle Dysregulation in Multiple Myeloma

Scott Ely, Maurizio Di Liberto, Ruben Niesvizky, Linda B. Baughn, Hearn J. Cho, Eunice N. Hatada, Daniel M. Knowles, Joseph Lane, and Selina Chen-Kiang
Cancer Res 2005 65: 11345-11353. [Abstract] [Full Text] [PDF]  

Negative Regulation of TSC1-TSC2 by Mammalian D-Type Cyclins

Sima J. Zacharek, Yue Xiong, and Stuart D. Shumway
Cancer Res 2005 65: 11354-11360. [Abstract] [Full Text] [PDF]  

CDC4 Mutations Occur in a Subset of Colorectal Cancers but Are Not Predicted to Cause Loss of Function and Are Not Associated with Chromosomal Instability

Zoe Kemp, Andrew Rowan, William Chambers, Noel Wortham, Sarah Halford, Oliver Sieber, Neil Mortensen, Axel von Herbay, Thomas Gunther, Mohammad Ilyas, and Ian Tomlinson
Cancer Res 2005 65: 11361-11366. [Abstract] [Full Text] [PDF]  

Leukemogenic MLL Fusion Proteins Bind across a Broad Region of the Hox a9 Locus, Promoting Transcription and Multiple Histone Modifications

Thomas A. Milne, Mary Ellen Martin, Hugh W. Brock, Robert K. Slany, and Jay L. Hess
Cancer Res 2005 65: 11367-11374. [Abstract] [Full Text] [PDF] Supplementary Data  

Inducible IB Kinase/IB Kinase Expression Is Induced by CK2 and Promotes Aberrant Nuclear Factor-B Activation in Breast Cancer Cells

Sean F. Eddy, Shangqin Guo, Elizabeth G. Demicco, Raphaëlle Romieu-Mourez, Esther Landesman-Bollag, David C. Seldin, and Gail E. Sonenshein
Cancer Res 2005 65: 11375-11383. [Abstract] [Full Text] [PDF]  

BRCA1 Regulates RAD51 Function in Response to DNA Damage and Suppresses Spontaneous Sister Chromatid Replication Slippage: Implications for Sister Chromatid Cohesion, Genome Stability, and Carcinogenesis

Isabelle Cousineau, Christine Abaji, and Abdellah Belmaaza
Cancer Res 2005 65: 11384-11391. [Abstract] [Full Text] [PDF]  

Cell and Tumor Biology:

Widespread CXCR4 Activation in Astrocytomas Revealed by Phospho-CXCR4-Specific Antibodies

B. Mark Woerner, Nicole M. Warrington, Andrew L. Kung, Arie Perry, and Joshua B. Rubin
Cancer Res 2005 65: 11392-11399. [Abstract] [Full Text] [PDF] Supplemental Data  

Methyl CpG–Binding Domain Protein 3 Mediates Cancer-Selective Cytotoxicity by Histone Deacetylase Inhibitors via Differential Transcriptional Reprogramming in Lung Cancer Cells

Eun Joo Noh, Eun Ryoung Jang, Gajin Jeong, You Mie Lee, Churl Ki Min, and Jong-Soo Lee
Cancer Res 2005 65: 11400-11410. [Abstract] [Full Text] [PDF]  

Stepwise Neoplastic Transformation of a Telomerase Immortalized Fibroblast Cell Line

Samantha Zongaro, Elisa de Stanchina, Tina Colombo, Maurizio D'Incalci, Elena Giulotto, and Chiara Mondello
Cancer Res 2005 65: 11411-11418. [Abstract] [Full Text] [PDF] Supplementary Data  

ABCC Drug Efflux Pumps and Organic Anion Uptake Transporters in Human Gliomas and the Blood-Tumor Barrier

Holger Bronger, Jörg König, Kathrin Kopplow, Hans-Herbert Steiner, Rezvan Ahmadi, Christel Herold-Mende, Dietrich Keppler, and Anne T. Nies
Cancer Res 2005 65: 11419-11428. [Abstract] [Full Text] [PDF]  

Lysyl Oxidase Regulates Breast Cancer Cell Migration and Adhesion through a Hydrogen Peroxide–Mediated Mechanism

Stacey L. Payne, Ben Fogelgren, Angela R. Hess, Elisabeth A. Seftor, Elizabeth L. Wiley, Sheri F.T. Fong, Katalin Csiszar, Mary J.C. Hendrix, and Dawn A. Kirschmann
Cancer Res 2005 65: 11429-11436. [Abstract] [Full Text] [PDF]  

-Aminobutyric Acid Inhibits Cholangiocarcinoma Growth by Cyclic AMP–Dependent Regulation of the Protein Kinase A/Extracellular Signal-Regulated Kinase 1/2 Pathway

Giammarco Fava, Luca Marucci, Shannon Glaser, Heather Francis, Sharon De Morrow, Antonio Benedetti, Domenico Alvaro, Julie Venter, Cynthia Meininger, Tushar Patel, Silvia Taffetani, Marco Marzioni, Ryun Summers, Ramona Reichenbach, and Gianfranco Alpini
Cancer Res 2005 65: 11437-11446. [Abstract] [Full Text] [PDF]  

Cyclooxygenase-2 Inhibition Sensitizes Human Colon Carcinoma Cells to TRAIL-Induced Apoptosis through Clustering of DR5 and Concentrating Death-Inducing Signaling Complex Components into Ceramide-Enriched Caveolae

Sophie Martin, Darren C. Phillips, Kinga Szekely-Szucs, Lynda Elghazi, Fabienne Desmots, and Janet A. Houghton
Cancer Res 2005 65: 11447-11458. [Abstract] [Full Text] [PDF]  

Development of Ewing's Sarcoma from Primary Bone Marrow–Derived Mesenchymal Progenitor Cells

Nicolò Riggi, Luisa Cironi, Paolo Provero, Mario-Luca Suvà, Konstantinos Kaloulis, Carlos Garcia-Echeverria, Francesco Hoffmann, Andreas Trumpp, and Ivan Stamenkovic
Cancer Res 2005 65: 11459-11468. [Abstract] [Full Text] [PDF] Supplementary Data  

Inhibition of DNA Methylation Sensitizes Glioblastoma for Tumor Necrosis Factor–Related Apoptosis-Inducing Ligand–Mediated Destruction

Adriana Eramo, Roberto Pallini, Fiorenza Lotti, Giovanni Sette, Mariella Patti, Monica Bartucci, Lucia Ricci-Vitiani, Michele Signore, Giorgio Stassi, Luigi M. Larocca, Lucio Crinò, Cesare Peschle, and Ruggero De Maria
Cancer Res 2005 65: 11469-11477. [Abstract] [Full Text] [PDF]  

High Expression of ErbB Family Members and Their Ligands in Lung Adenocarcinomas That Are Sensitive to Inhibition of Epidermal Growth Factor Receptor

Nobukazu Fujimoto, Marie Wislez, Jie Zhang, Kentaro Iwanaga, Jennifer Dackor, Amy E. Hanna, Shailaja Kalyankrishna, Dianna D. Cody, Roger E. Price, Mitsuo Sato, Jerry W. Shay, John D. Minna, Michael Peyton, Ximing Tang, Erminia Massarelli, Roy Herbst, David W. Threadgill, Ignacio I. Wistuba, and Jonathan M. Kurie
Cancer Res 2005 65: 11478-11485. [Abstract] [Full Text] [PDF] Supplementary DataSupplementary Data  

The Critical Role of 15-Lipoxygenase-1 in Colorectal Epithelial Cell Terminal Differentiation and Tumorigenesis

Imad Shureiqi, Yuanqing Wu, Dongning Chen, Xiu L. Yang, Baoxiang Guan, Jeffrey S. Morris, Peiying Yang, Robert A. Newman, Russell Broaddus, Stanley R. Hamilton, Patrick Lynch, Bernard Levin, Susan M. Fischer, and Scott M. Lippman
Cancer Res 2005 65: 11486-11492. [Abstract] [Full Text] [PDF]  

Expression of Endogenous Oncogenic ^V600EB-raf Induces Proliferation and Developmental Defects in Mice and Transformation of Primary Fibroblasts

Kathryn Mercer, Susan Giblett, Stuart Green, David Lloyd, Silvy DaRocha Dias, Mark Plumb, Richard Marais, and Catrin Pritchard
Cancer Res 2005 65: 11493-11500. [Abstract] [Full Text] [PDF]  

Headpin: A Serpin with Endogenous and Exogenous Suppression of Angiogenesis

Thomas D. Shellenberger, Abhijit Mazumdar, Ying Henderson, Katrina Briggs, Mary Wang, Chandrani Chattopadhyay, Arumugam Jayakumar, Mitchell Frederick, and Gary L. Clayman
Cancer Res 2005 65: 11501-11509. [Abstract] [Full Text] [PDF]  

Bortezomib Inhibits PKR-Like Endoplasmic Reticulum (ER) Kinase and Induces Apoptosis via ER Stress in Human Pancreatic Cancer Cells

Steffan T. Nawrocki, Jennifer S. Carew, Kenneth Dunner, Jr., Lawrence H. Boise, Paul J. Chiao, Peng Huang, James L. Abbruzzese, and David J. McConkey
Cancer Res 2005 65: 11510-11519. [Abstract] [Full Text] [PDF]  

Tumor Cell Plasticity in Ewing Sarcoma, an Alternative Circulatory System Stimulated by Hypoxia

Daisy W.J. van der Schaft, Femke Hillen, Patrick Pauwels, Dawn A. Kirschmann, Karolien Castermans, Mirjam G.A. oude Egbrink, Maxine G.B. Tran, Rafael Sciot, Esther Hauben, Pancras C.W. Hogendoorn, Olivier Delattre, Patrick H. Maxwell, Mary J.C. Hendrix, and Arjan W. Griffioen
Cancer Res 2005 65: 11520-11528. [Abstract] [Full Text] [PDF]  

Apoptotic Cells Initiate Endothelial Cell Sprouting via Electrostatic Signaling

Zhang Weihua, Rachel Tsan, Alan J. Schroit, and Isaiah J. Fidler
Cancer Res 2005 65: 11529-11535. [Abstract] [Full Text] [PDF]  

The G691S RET Polymorphism Increases Glial Cell Line–Derived Neurotrophic Factor–Induced Pancreatic Cancer Cell Invasion by Amplifying Mitogen-Activated Protein Kinase Signaling

Hirozumi Sawai, Yuji Okada, Kevork Kazanjian, Joseph Kim, Sascha Hasan, Oscar J. Hines, Howard A. Reber, Dave S.B. Hoon, and Guido Eibl
Cancer Res 2005 65: 11536-11544. [Abstract] [Full Text] [PDF] Supplementary Data  

Dentin Matrix Protein 1 Enhances Invasion Potential of Colon Cancer Cells by Bridging Matrix Metalloproteinase-9 to Integrins and CD44

Abdullah Karadag, Neal S. Fedarko, and Larry W. Fisher
Cancer Res 2005 65: 11545-11552. [Abstract] [Full Text] [PDF]  

Gold(III) Porphyrin 1a Induced Apoptosis by Mitochondrial Death Pathways Related to Reactive Oxygen Species

Ying Wang, Qing-Yu He, Raymond Wai-Yin Sun, Chi-Ming Che, and Jen-Fu Chiu
Cancer Res 2005 65: 11553-11564. [Abstract] [Full Text] [PDF]  

Context-Dependent Hormone-Refractory Progression Revealed through Characterization of a Novel Murine Prostate Cancer Cell Line

Philip A. Watson, Katharine Ellwood-Yen, Jennifer C. King, John Wongvipat, Michelle M. LeBeau, and Charles L. Sawyers
Cancer Res 2005 65: 11565-11571. [Abstract] [Full Text] [PDF]  

Novel Role for PDEF in Epithelial Cell Migration and Invasion

Ruwanthi N. Gunawardane, Dennis C. Sgroi, Carolyn N. Wrobel, Eugene Koh, George Q. Daley, and Joan S. Brugge
Cancer Res 2005 65: 11572-11580. [Abstract] [Full Text] [PDF]  

Prognostic and Functional Significance of Thromboxane Synthase Gene Overexpression in Invasive Bladder Cancer

Omar Moussa, John S. Yordy, Hassan Abol-Enein, Debajyoti Sinha, Nabil K. Bissada, Perry V. Halushka, Mohamed A. Ghoneim, and Dennis K. Watson
Cancer Res 2005 65: 11581-11587. [Abstract] [Full Text] [PDF]  

Differentiation of Androgen-Independent Prostate Cancer PC-3 Cells Is Associated with Increased Nuclear Factor-B Activity

Daniel Floryk and Eliezer Huberman
Cancer Res 2005 65: 11588-11596. [Abstract] [Full Text] [PDF] Supplementary Data  

Hypoxia-Induced Down-regulation of BRCA1 Expression by E2Fs

Ranjit S. Bindra, Shannon L. Gibson, Alice Meng, Ulrica Westermark, Maria Jasin, Andrew J. Pierce, Robert G. Bristow, Marie K. Classon, and Peter M. Glazer
Cancer Res 2005 65: 11597-11604. [Abstract] [Full Text] [PDF] Supplementary Data  

The Shed Ectodomain of Nr-CAM Stimulates Cell Proliferation and Motility, and Confers Cell Transformation

Maralice Conacci-Sorrell, Anna Kaplan, Shani Raveh, Nancy Gavert, Takeshi Sakurai, and Avri Ben-Ze'ev
Cancer Res 2005 65: 11605-11612. [Abstract] [Full Text] [PDF]  

Papillomavirus E2 Protein Induces Expression of the Matrix Metalloproteinase-9 via the Extracellular Signal-Regulated Kinase/Activator Protein-1 Signaling Pathway

Andreas Behren, Christian Simon, Roxana Michaela Schwab, Ekaterina Loetzsch, Stephan Brodbeck, Evamaria Huber, Frank Stubenrauch, Hans Peter Zenner, and Thomas Iftner
Cancer Res 2005 65: 11613-11621. [Abstract] [Full Text] [PDF]  

Experimental Therapeutics, Molecular Targets, and Chemical Biology:

Hypoxia-Regulated Expression of Attenuated Diphtheria Toxin A Fused with Hypoxia-Inducible Factor-1 Oxygen-Dependent Degradation Domain Preferentially Induces Apoptosis of Hypoxic Cells in Solid Tumor

Nobuko Koshikawa and Keizo Takenaga
Cancer Res 2005 65: 11622-11630. [Abstract] [Full Text] [PDF]  

Epidermal Growth Factor Receptor–Targeted Immunoliposomes Significantly Enhance the Efficacy of Multiple Anticancer Drugs In vivo

Christoph Mamot, Daryl C. Drummond, Charles O. Noble, Verena Kallab, Zexiong Guo, Keelung Hong, Dmitri B. Kirpotin, and John W. Park
Cancer Res 2005 65: 11631-11638. [Abstract] [Full Text] [PDF]  

Cancer Cells Regulate Lymphocyte Recruitment and Leukocyte-Endothelium Interactions in the Tumor-Draining Lymph Node

Virginie Carrière, Renaud Colisson, Carine Jiguet-Jiglaire, Elisabeth Bellard, Gérard Bouche, Talal Al Saati, François Amalric, Jean-Philippe Girard, and Christine M'Rini
Cancer Res 2005 65: 11639-11648. [Abstract] [Full Text] [PDF]  

Endothelin-1 Promotes Epithelial-to-Mesenchymal Transition in Human Ovarian Cancer Cells

Laura Rosanò, Francesca Spinella, Valeriana Di Castro, Maria Rita Nicotra, Shoukat Dedhar, Antonio Garcia de Herreros, Pier Giorgio Natali, and Anna Bagnato
Cancer Res 2005 65: 11649-11657. [Abstract] [Full Text] [PDF] Supplementary Data  

Bortezomib Sensitizes Pancreatic Cancer Cells to Endoplasmic Reticulum Stress-Mediated Apoptosis

Steffan T. Nawrocki, Jennifer S. Carew, Maria S. Pino, Ralph A. Highshaw, Kenneth Dunner, Jr., Peng Huang, James L. Abbruzzese, and David J. McConkey
Cancer Res 2005 65: 11658-11666. [Abstract] [Full Text] [PDF]  

Sphingosine Kinase-1 as a Chemotherapy Sensor in Prostate Adenocarcinoma Cell and Mouse Models

Dimitri Pchejetski, Muriel Golzio, Elisabeth Bonhoure, Cyril Calvet, Nicolas Doumerc, Virginie Garcia, Catherine Mazerolles, Pascal Rischmann, Justin Teissié, Bernard Malavaud, and Olivier Cuvillier
Cancer Res 2005 65: 11667-11675. [Abstract] [Full Text] [PDF]  

Motexafin Gadolinium and Zinc Induce Oxidative Stress Responses and Apoptosis in B-Cell Lymphoma Lines

Philip S. Lecane, Mazen W. Karaman, Mint Sirisawad, Louie Naumovski, Richard A. Miller, Joseph G. Hacia, and Darren Magda
Cancer Res 2005 65: 11676-11688. [Abstract] [Full Text] [PDF]  

Bcl-2/Adenovirus E1B 19 kDa Interacting Protein-3 Knockdown Enables Growth of Breast Cancer Metastases in the Lung, Liver, and Bone

David Manka, Zachary Spicer, and David E. Millhorn
Cancer Res 2005 65: 11689-11693. [Abstract] [Full Text] [PDF]  

Aberrant Transcription from an Unrelated Promoter Can Result in MDR-1 Expression following Drug Selection In vitro and in Relapsed Lymphoma Samples

Lyn Mickley Huff, Zheng Wang, Angel Iglesias, Tito Fojo, and Jong-Seok Lee
Cancer Res 2005 65: 11694-11703. [Abstract] [Full Text] [PDF]  

Multiple Repair Pathways Mediate Tolerance to Chemotherapeutic Cross-linking Agents in Vertebrate Cells

Kuniharu Nojima, Helfrid Hochegger, Alihossein Saberi, Toru Fukushima, Koji Kikuchi, Michio Yoshimura, Brian J. Orelli, Douglas K. Bishop, Seiki Hirano, Mioko Ohzeki, Masamichi Ishiai, Kazuhiko Yamamoto, Minoru Takata, Hiroshi Arakawa, Jean-Marie Buerstedde, Mitsuyoshi Yamazoe, Takuo Kawamoto, Kasumi Araki, Jun A. Takahashi, Nobuo Hashimoto, Shunichi Takeda, and Eiichiro Sonoda
Cancer Res 2005 65: 11704-11711. [Abstract] [Full Text] [PDF] Supplementary Data  

Immunomodulatory Drug Lenalidomide (CC-5013, IMiD3) Augments Anti-CD40 SGN-40–Induced Cytotoxicity in Human Multiple Myeloma: Clinical Implications

Yu-Tzu Tai, Xian-Feng Li, Laurence Catley, Rory Coffey, Iris Breitkreutz, Jooeun Bae, Weihua Song, Klaus Podar, Teru Hideshima, Dharminder Chauhan, Robert Schlossman, Paul Richardson, Steven P. Treon, Iqbal S. Grewal, Nikhil C. Munshi, and Kenneth C. Anderson
Cancer Res 2005 65: 11712-11720. [Abstract] [Full Text] [PDF]  

BGC 945, a Novel Tumor-Selective Thymidylate Synthase Inhibitor Targeted to -Folate Receptor–Overexpressing Tumors

David D. Gibbs, Davinder S. Theti, Nadya Wood, Matthew Green, Florence Raynaud, Melanie Valenti, Martin D. Forster, Fraser Mitchell, Vassilios Bavetsias, Elisa Henderson, and Ann L. Jackman
Cancer Res 2005 65: 11721-11728. [Abstract] [Full Text] [PDF] Supplementary Data  

Para to Ortho Repositioning of the Arsenical Moiety of the Angiogenesis Inhibitor 4-(N-(S-Glutathionylacetyl)Amino)Phenylarsenoxide Results in a Markedly Increased Cellular Accumulation and Antiproliferative Activity

Pierre J. Dilda, Stephanie Decollogne, Michael Rossiter-Thornton, and Philip J. Hogg
Cancer Res 2005 65: 11729-11734. [Abstract] [Full Text] [PDF]  

Glutathione-Related Systems and Modulation of Extracellular Signal–Regulated Kinases Are Involved in the Resistance of AGS Adenocarcinoma Gastric Cells to Diallyl Disulfide–Induced Apoptosis

Giuseppe Filomeni, Katia Aquilano, Giuseppe Rotilio, and Maria R. Ciriolo
Cancer Res 2005 65: 11735-11742. [Abstract] [Full Text] [PDF]  

Immunology:

Interleukin-13–regulated M2 Macrophages in Combination with Myeloid Suppressor Cells Block Immune Surveillance against Metastasis

Pratima Sinha, Virginia K. Clements, and Suzanne Ostrand-Rosenberg
Cancer Res 2005 65: 11743-11751. [Abstract] [Full Text] [PDF]  

Activation of Tumor-Associated Macrophages by the Vascular Disrupting Agent 5,6-Dimethylxanthenone-4-Acetic Acid Induces an Effective CD8⁺ T-Cell–Mediated Antitumor Immune Response in Murine Models of Lung Cancer and Mesothelioma

Arminder S. Jassar, Eiji Suzuki, Veena Kapoor, Jing Sun, Michael B. Silverberg, Lumei Cheung, Marie D. Burdick, Robert M. Strieter, Lai-Ming Ching, Larry R. Kaiser, and Steven M. Albelda
Cancer Res 2005 65: 11752-11761. [Abstract] [Full Text] [PDF]  

Endocrinology:

Coactivation of Liver Receptor Homologue-1 by Peroxisome Proliferator-Activated Receptor Coactivator-1 on Aromatase Promoter II and Its Inhibition by Activated Retinoid X Receptor Suggest a Novel Target for Breast-Specific Antiestrogen Therapy

Rachid Safi, Agnes Kovacic, Stéphanie Gaillard, Yoko Murata, Evan R. Simpson, Donald P. McDonnell, and Colin D. Clyne
Cancer Res 2005 65: 11762-11770. [Abstract] [Full Text] [PDF]  

Epidemiology and Prevention:

Sequence Variants of Toll-Like Receptor 4 and Susceptibility to Prostate Cancer

Yen-Ching Chen, Edward Giovannucci, Ross Lazarus, Peter Kraft, Shamika Ketkar, and David J. Hunter
Cancer Res 2005 65: 11771-11778. [Abstract] [Full Text] [PDF]  

A Prospective Study of Meat and Meat Mutagens and Prostate Cancer Risk

Amanda J. Cross, Ulrike Peters, Victoria A. Kirsh, Gerald L. Andriole, Douglas Reding, Richard B. Hayes, and Rashmi Sinha
Cancer Res 2005 65: 11779-11784. [Abstract] [Full Text] [PDF]  

Correction:

Targeting LPAAT-ß in Gynecologic Cancer

Cancer Res 2005 65: 11785. [Full Text] [PDF]  

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