Successful treatment of malignant glioma, the most deadly adult brain tumor, has not been realized partly because of inadequate delivery of therapeutic agents. Delivery problems have especially limited the application of newer biologically based strategies. In an effort to improve delivery, Nakamizo et al. studied the potential of bone marrowere obtained from human bone marrow, labeled with a fluorescent dye, and injected intravascularly into mice bearing xenografts of human gliomas in the frontal lobes of their brains. Unstained (middle) and H&E-stained (top) sections of a whole mount of the brain revealed the tumor in the right frontal lobe. Fluorescent microscopy (bottom) demonstrated hMSCs exclusively within the tumor. These stem cells appear to target specific growth factors within gliomas. Importantly, systemically injected IFN-bain tumors. For details, see the article by Nakamizo et al. on page 3307 of this issue.

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