Reviews:

Reassessing Epithelial to Mesenchymal Transition as a Prerequisite for Carcinoma Invasion and Metastasis

Jason J. Christiansen and Ayyappan K. Rajasekaran
Cancer Res 2006 66: 8319-8326. [Abstract] [Full Text] [PDF]  

Breast Cancer in African-American Women: Differences in Tumor Biology from European-American Women

Kandace Amend, David Hicks, and Christine B. Ambrosone
Cancer Res 2006 66: 8327-8330. [Abstract] [Full Text] [PDF]  

Priority Reports:

ARID3B Induces Malignant Transformation of Mouse Embryonic Fibroblasts and Is Strongly Associated with Malignant Neuroblastoma

Kenichiro Kobayashi, Takumi Era, Atsushi Takebe, Lars Martin Jakt, and Shin-Ichi Nishikawa
Cancer Res 2006 66: 8331-8336. [Abstract] [Full Text] [PDF]  

TMPRSS2:ERG Fusion-Associated Deletions Provide Insight into the Heterogeneity of Prostate Cancer

Sven Perner, Francesca Demichelis, Rameen Beroukhim, Folke H. Schmidt, Juan-Miguel Mosquera, Sunita Setlur, Joelle Tchinda, Scott A. Tomlins, Matthias D. Hofer, Kenneth G. Pienta, Rainer Kuefer, Robert Vessella, Xiao-Wei Sun, Matthew Meyerson, Charles Lee, William R. Sellers, Arul M. Chinnaiyan, and Mark A. Rubin
Cancer Res 2006 66: 8337-8341. [Abstract] [Full Text] [PDF] Supplementary Data  

A Profile of Methyl-CpG Binding Domain Protein Occupancy of Hypermethylated Promoter CpG Islands of Tumor Suppressor Genes in Human Cancer

Lidia Lopez-Serra, Esteban Ballestar, Mario F. Fraga, Miguel Alaminos, Fernando Setien, and Manel Esteller
Cancer Res 2006 66: 8342-8346. [Abstract] [Full Text] [PDF] Supplementary Data  

Expression of Variant TMPRSS2/ERG Fusion Messenger RNAs Is Associated with Aggressive Prostate Cancer

Jianghua Wang, Yi Cai, Chengxi Ren, and Michael Ittmann
Cancer Res 2006 66: 8347-8351. [Abstract] [Full Text] [PDF]  

Tumor Cell Radiosensitivity Is a Major Determinant of Tumor Response to Radiation

Leo E. Gerweck, Shashirekha Vijayappa, Akihiro Kurimasa, Kazuhiko Ogawa, and David J. Chen
Cancer Res 2006 66: 8352-8355. [Abstract] [Full Text] [PDF]  

p53 Is Preferentially Recruited to the Promoters of Growth Arrest Genes p21 and GADD45 during Replicative Senescence of Normal Human Fibroblasts

James G. Jackson and Olivia M. Pereira-Smith
Cancer Res 2006 66: 8356-8360. [Abstract] [Full Text] [PDF] Supplementary Data  

Expression of DNMT3B Variants and Its Association with Promoter Methylation of p16 and RASSF1A in Primary Non–Small Cell Lung Cancer

Jie Wang, Garret Walsh, Diane D. Liu, J. Jack Lee, and Li Mao
Cancer Res 2006 66: 8361-8366. [Abstract] [Full Text] [PDF]  

Molecular Biology, Pathobiology, and Genetics:

Interaction of Deleted in Liver Cancer 1 with Tensin2 in Caveolae and Implications in Tumor Suppression

Judy Wai Ping Yam, Frankie Chi Fat Ko, Chung-Yiu Chan, Dong-Yan Jin, and Irene Oi-Lin Ng
Cancer Res 2006 66: 8367-8372. [Abstract] [Full Text] [PDF] Supplementary Data  

AKT Regulation of Estrogen Receptor ß Transcriptional Activity in Breast Cancer

Bich N. Duong, Steven Elliott, Daniel E. Frigo, Lilia I. Melnik, Lyndsay Vanhoy, Suzanne Tomchuck, Helena P. Lebeau, Odile David, Barbara S. Beckman, Jawed Alam, Melyssa R. Bratton, John A. McLachlan, and Matthew E. Burow
Cancer Res 2006 66: 8373-8381. [Abstract] [Full Text] [PDF]  

Prognostic Significance of Nuclear Factor-B p105/p50 in Human Melanoma and Its Role in Cell Migration

Kai Gao, Derek L. Dai, Magdalena Martinka, and Gang Li
Cancer Res 2006 66: 8382-8388. [Abstract] [Full Text] [PDF] Supplementary Data  

Hyperplasia and Carcinomas in Pten-Deficient Mice and Reduced PTEN Protein in Human Bladder Cancer Patients

Hiroshi Tsuruta, Hiroyuki Kishimoto, Takehiko Sasaki, Yasuo Horie, Miyuki Natsui, Yoshiko Shibata, Koichi Hamada, Nobuyuki Yajima, Koichi Kawahara, Masato Sasaki, Norihiko Tsuchiya, Katsuhiko Enomoto, Tak Wah Mak, Toru Nakano, Tomonori Habuchi, and Akira Suzuki
Cancer Res 2006 66: 8389-8396. [Abstract] [Full Text] [PDF] Supplementary Data  

Multiple Endocrine Neoplasia Type 1 Interacts with Forkhead Transcription Factor CHES1 in DNA Damage Response

Valeria Busygina, Molly C. Kottemann, Kenneth L. Scott, Sharon E. Plon, and Allen E. Bale
Cancer Res 2006 66: 8397-8403. [Abstract] [Full Text] [PDF]  

Expression Profiling Identifies Altered Expression of Genes That Contribute to the Inhibition of Transforming Growth Factor-ß Signaling in Ovarian Cancer

Jan S. Sunde, Howard Donninger, Kongming Wu, Michael E. Johnson, Richard G. Pestell, G. Scott Rose, Samuel C. Mok, John Brady, Tomas Bonome, and Michael J. Birrer
Cancer Res 2006 66: 8404-8412. [Abstract] [Full Text] [PDF]  

Silencing of the Metastasis Suppressor RECK by RAS Oncogene Is Mediated by DNA Methyltransferase 3b–Induced Promoter Methylation

Hui-Chiu Chang, Chun-Yu Cho, and Wen-Chun Hung
Cancer Res 2006 66: 8413-8420. [Abstract] [Full Text] [PDF]  

Low and High Dose UVB Regulation of Transcription Factor NF-E2-Related Factor 2

Sankaranarayanan Kannan and Anil K. Jaiswal
Cancer Res 2006 66: 8421-8429. [Abstract] [Full Text] [PDF]  

Smad3 Deficiency Promotes Tumorigenesis in the Distal Colon of Apc^Min/+ Mice

Nicole M. Sodir, Xuan Chen, Ryan Park, Andrea E. Nickel, Peter S. Conti, Rex Moats, James R. Bading, Darryl Shibata, and Peter W. Laird
Cancer Res 2006 66: 8430-8438. [Abstract] [Full Text] [PDF] Supplementary Data  

Male Germ Cell–Associated Kinase, a Male-Specific Kinase Regulated by Androgen, Is a Coactivator of Androgen Receptor in Prostate Cancer Cells

Ai-Hong Ma, Liang Xia, Sonal J. Desai, David L. Boucher, Yi Guan, Hsiu-Ming Shih, Xu-Bao Shi, Ralph W. deVere White, Hong-Wu Chen, Cliff G. Tepper, and Hsing-Jien Kung
Cancer Res 2006 66: 8439-8447. [Abstract] [Full Text] [PDF]  

Gadd45a Suppresses Ras-Driven Mammary Tumorigenesis by Activation of c-Jun NH₂-Terminal Kinase and p38 Stress Signaling Resulting in Apoptosis and Senescence

Jennifer S. Tront, Barbara Hoffman, and Dan A. Liebermann
Cancer Res 2006 66: 8448-8454. [Abstract] [Full Text] [PDF]  

Analysis of Genetic Alterations and Clonal Proliferation in Children Treated for Acute Lymphocytic Leukemia

Heather E. Kendall, Pamela M. Vacek, Jami L. Rivers, Sederick C. Rice, Terri L. Messier, and Barry A. Finette
Cancer Res 2006 66: 8455-8461. [Abstract] [Full Text] [PDF] Supplementary Data  

Chromosomal Instability Correlates with Genome-wide DNA Demethylation in Human Primary Colorectal Cancers

Jairo Rodriguez, Jordi Frigola, Elisenda Vendrell, Rosa-Ana Risques, Mario F. Fraga, Cristina Morales, Victor Moreno, Manel Esteller, Gabriel Capellà, Maria Ribas, and Miguel A. Peinado
Cancer Res 2006 66: 8462-9468. [Abstract] [Full Text] [PDF] Supplementary Data  

Genome-wide Hypomethylation in Human Glioblastomas Associated with Specific Copy Number Alteration, Methylenetetrahydrofolate Reductase Allele Status, and Increased Proliferation

Benoît Cadieux, Tsui-Ting Ching, Scott R. VandenBerg, and Joseph F. Costello
Cancer Res 2006 66: 8469-8476. [Abstract] [Full Text] [PDF] Supplementary Data  

Degradation of Tob1 Mediated by SCF^Skp2-Dependent Ubiquitination

Yoshihiro Hiramatsu, Kyoko Kitagawa, Toru Suzuki, Chiharu Uchida, Takayuki Hattori, Hirotoshi Kikuchi, Toshiaki Oda, Shigetsugu Hatakeyama, Keiichi I. Nakayama, Tadashi Yamamoto, Hiroyuki Konno, and Masatoshi Kitagawa
Cancer Res 2006 66: 8477-8483. [Abstract] [Full Text] [PDF] Supplementary Data  

Cell, Tumor, and Stem Cell Biology:

Silencing of p29 Affects DNA Damage Responses with UV Irradiation

Po-Chen Chu, Yuh-Cheng Yang, Yen-Ta Lu, Hsiang-Ting Chen, Lung-Chih Yu, and Mau-Sun Chang
Cancer Res 2006 66: 8484-8491. [Abstract] [Full Text] [PDF]  

Ephrin-B3 Ligand Promotes Glioma Invasion through Activation of Rac1

Mitsutoshi Nakada, Kelsey L. Drake, Satoko Nakada, Jared A. Niska, and Michael E. Berens
Cancer Res 2006 66: 8492-8500. [Abstract] [Full Text] [PDF] Supplementary Data  

The Role of the Vascular Endothelial Growth Factor–Delta-like 4 Ligand/Notch4-Ephrin B2 Cascade in Tumor Vessel Remodeling and Endothelial Cell Functions

Patricia Hainaud, Jean-Olivier Contrerès, Aude Villemain, Lang-Xia Liu, Jean Plouët, Gérard Tobelem, and Evelyne Dupuy
Cancer Res 2006 66: 8501-8510. [Abstract] [Full Text] [PDF]  

Ionizing Radiation Enhances Matrix Metalloproteinase-2 Secretion and Invasion of Glioma Cells through Src/Epidermal Growth Factor Receptor–Mediated p38/Akt and Phosphatidylinositol 3-Kinase/Akt Signaling Pathways

Chang-Min Park, Myung-Jin Park, Hee-Jin Kwak, Hyung-Chahn Lee, Mi-Suk Kim, Seung-Hoon Lee, In-Chul Park, Chang Hun Rhee, and Seok-Il Hong
Cancer Res 2006 66: 8511-8519. [Abstract] [Full Text] [PDF]  

Inducible Resistance of Tumor Cells to Tumor Necrosis Factor–Related Apoptosis-Inducing Ligand Receptor 2–Mediated Apoptosis by Generation of a Blockade at the Death Domain Function

Yang Li, Hong Wang, Zheng Wang, Sharmila Makhija, Donald Buchsbaum, Albert LoBuglio, Robert Kimberly, and Tong Zhou
Cancer Res 2006 66: 8520-8528. [Abstract] [Full Text] [PDF]  

p27^Kip1 Repression of ErbB2-Induced Mammary Tumor Growth in Transgenic Mice Involves Skp2 and Wnt/ß-Catenin Signaling

James Hulit, Richard J. Lee, Zhiping Li, Chenguang Wang, Sanjay Katiyar, Jianguo Yang, Andrew A. Quong, Kongming Wu, Chris Albanese, Robert Russell, Dolores Di Vizio, Andrew Koff, Saiinder Thummala, Hui Zhang, Jennifer Harrell, Hong Sun, William J. Muller, Giorgio Inghirami, Michael P. Lisanti, and Richard G. Pestell
Cancer Res 2006 66: 8529-8541. [Abstract] [Full Text] [PDF]  

Human ß-Defensin-1, a Potential Chromosome 8p Tumor Suppressor: Control of Transcription and Induction of Apoptosis in Renal Cell Carcinoma

Carrie Q. Sun, Rebecca Arnold, Carina Fernandez-Golarz, Amanda B. Parrish, Tara Almekinder, Ju He, Shuk-mei Ho, Pavel Svoboda, Jan Pohl, Fray F. Marshall, and John A. Petros
Cancer Res 2006 66: 8542-8549. [Abstract] [Full Text] [PDF]  

A₁ Adenosine Receptors in Microglia Control Glioblastoma-Host Interaction

Michael Synowitz, Rainer Glass, Katrin Färber, Darko Markovic, Golo Kronenberg, Ken Herrmann, Juergen Schnermann, Christiane Nolte, Nico van Rooijen, Juergen Kiwit, and Helmut Kettenmann
Cancer Res 2006 66: 8550-8557. [Abstract] [Full Text] [PDF] Supplementary Data  

Redistribution of Nucleoside Transporters to the Cell Membrane Provides a Novel Approach for Imaging Thymidylate Synthase Inhibition by Positron Emission Tomography

Meg Perumal, Radhakrishna G. Pillai, Henryk Barthel, Julius Leyton, John R. Latigo, Martin Forster, Fraser Mitchell, Ann L. Jackman, and Eric O. Aboagye
Cancer Res 2006 66: 8558-8564. [Abstract] [Full Text] [PDF]  

Differential Antiproliferative Effects of Calcitriol on Tumor-Derived and Matrigel-Derived Endothelial Cells

Ivy Chung, Michael K. Wong, Geraldine Flynn, Wei-dong Yu, Candace S. Johnson, and Donald L. Trump
Cancer Res 2006 66: 8565-8573. [Abstract] [Full Text] [PDF]  

Functional Analysis of Alternative Isoforms of the Transcription Factor PAX3 in Melanocytes In vitro

Qiuyu Wang, Shant Kumar, Mark Slevin, and Patricia Kumar
Cancer Res 2006 66: 8574-8580. [Abstract] [Full Text] [PDF]  

Potential Role of Jun Activation Domain–Binding Protein 1 as a Negative Regulator of p27^kip1 in Pancreatic Adenocarcinoma

Maria A. Kouvaraki, Anita L. Korapati, George Z. Rassidakis, Ling Tian, Qingxiu Zhang, Paul Chiao, Linus Ho, Douglas B. Evans, and François X. Claret
Cancer Res 2006 66: 8581-8589. [Abstract] [Full Text] [PDF] Supplementary Data  

DNA Damage Binding Protein Component DDB1 Participates in Nucleotide Excision Repair through DDB2 DNA-binding and Cullin 4A Ubiquitin Ligase Activity

Jinyou Li, Qi-En Wang, Qianzheng Zhu, Mohamed A. El-Mahdy, Gulzar Wani, Mette Prætorius-Ibba, and Altaf A. Wani
Cancer Res 2006 66: 8590-8597. [Abstract] [Full Text] [PDF]  

Low-Calcium Serum-Free Defined Medium Selects for Growth of Normal Prostatic Epithelial Stem Cells

Ivan V. Litvinov, Donald J. Vander Griend, Yi Xu, Lizamma Antony, Susan L. Dalrymple, and John T. Isaacs
Cancer Res 2006 66: 8598-8607. [Abstract] [Full Text] [PDF] Supplementary Data  

The Generation and Regulation of Functional Diversity of Malignant Plasma Cells

Liat Nadav, Ben-Zion Katz, Shoshana Baron, Nir Cohen, Elizabeth Naparstek, and Benjamin Geiger
Cancer Res 2006 66: 8608-8616. [Abstract] [Full Text] [PDF]  

Regulation of Transforming Growth Factor-ß1–Induced Apoptosis and Epithelial-to-Mesenchymal Transition by Protein Kinase A and Signal Transducers and Activators of Transcription 3

Yanan Yang, Xinchao Pan, Weiwei Lei, Jun Wang, Jian Shi, Fuqiang Li, and Jianguo Song
Cancer Res 2006 66: 8617-8624. [Abstract] [Full Text] [PDF]  

The Isopeptidase USP2a Protects Human Prostate Cancer from Apoptosis

Carmen Priolo, Dan Tang, Mohan Brahamandan, Barbara Benassi, Ewa Sicinska, Shuji Ogino, Antonella Farsetti, Alessandro Porrello, Stephen Finn, Johann Zimmermann, Phillip Febbo, and Massimo Loda
Cancer Res 2006 66: 8625-8632. [Abstract] [Full Text] [PDF] Supplementary Data  

Antiangiogenic and Antitumor Effects of Src Inhibition in Ovarian Carcinoma

Liz Y. Han, Charles N. Landen, Jose G. Trevino, Jyotsnabaran Halder, Yvonne G. Lin, Aparna A. Kamat, Tae-Jin Kim, William M. Merritt, Robert L. Coleman, David M. Gershenson, William C. Shakespeare, Yihan Wang, Raji Sundaramoorth, Chester A. Metcalf, III, David C. Dalgarno, Tomi K. Sawyer, Gary E. Gallick, and Anil K. Sood
Cancer Res 2006 66: 8633-8639. [Abstract] [Full Text] [PDF]  

Prohibitin and Cofilin Are Intracellular Effectors of Transforming Growth Factor ß Signaling in Human Prostate Cancer Cells

Beibei Zhu, Kei Fukada, Haining Zhu, and Natasha Kyprianou
Cancer Res 2006 66: 8640-8647. [Abstract] [Full Text] [PDF] Supplementary Data  

Type I Collagen Receptor (₂ß₁) Signaling Promotes the Growth of Human Prostate Cancer Cells within the Bone

Christopher L. Hall, JinLu Dai, Kenneth L. van Golen, Evan T. Keller, and Michael W. Long
Cancer Res 2006 66: 8648-8654. [Abstract] [Full Text] [PDF]  

N-myc Is an Essential Downstream Effector of Shh Signaling during both Normal and Neoplastic Cerebellar Growth

Beryl A. Hatton, Paul S. Knoepfler, Anna Marie Kenney, David H. Rowitch, Ignacio Moreno de Alborán, James M. Olson, and Robert N. Eisenman
Cancer Res 2006 66: 8655-8661. [Abstract] [Full Text] [PDF]  

Calreticulin, a Molecular Chaperone in the Endoplasmic Reticulum, Modulates Radiosensitivity of Human Glioblastoma U251MG Cells

Tomohiro Okunaga, Yoshishige Urata, Shinji Goto, Takayuki Matsuo, Shingo Mizota, Keisuke Tsutsumi, Izumi Nagata, Takahito Kondo, and Yoshito Ihara
Cancer Res 2006 66: 8662-8671. [Abstract] [Full Text] [PDF]  

Chk1- and Claspin-Dependent but ATR/ATM– and Rad17-Independent DNA Replication Checkpoint Response in HeLa Cells

Verónica Rodríguez-Bravo, Sandra Guaita-Esteruelas, Roger Florensa, Oriol Bachs, and Neus Agell
Cancer Res 2006 66: 8672-8679. [Abstract] [Full Text] [PDF]  

E6AP Mediates Regulated Proteasomal Degradation of the Nuclear Receptor Coactivator Amplified in Breast Cancer 1 in Immortalized Cells

Aparna Mani, Annabell S. Oh, Emma T. Bowden, Tyler Lahusen, Kevin L. Lorick, Allan M. Weissman, Richard Schlegel, Anton Wellstein, and Anna T. Riegel
Cancer Res 2006 66: 8680-8686. [Abstract] [Full Text] [PDF]  

Experimental Therapeutics, Molecular Targets, and Chemical Biology:

Mimp, a Mitochondrial Carrier Homologue, Inhibits Met-HGF/SF-Induced Scattering and Tumorigenicity by Altering Met-HGF/SF Signaling Pathways

Raya Leibowitz-Amit, Galia Tsarfaty, Yamit Abargil, Gil M. Yerushalmi, Judith Horev, and Ilan Tsarfaty
Cancer Res 2006 66: 8687-8697. [Abstract] [Full Text] [PDF]  

Antiangiogenic Effect of TW37, a Small-Molecule Inhibitor of Bcl-2

Benjamin D. Zeitlin, Esther Joo, Zhihong Dong, Kristy Warner, Guoping Wang, Zaneta Nikolovska-Coleska, Shaomeng Wang, and Jacques E. Nör
Cancer Res 2006 66: 8698-8706. [Abstract] [Full Text] [PDF]  

Breast Cancer Growth Prevention by Statins

Michael J. Campbell, Laura J. Esserman, Yamei Zhou, Mark Shoemaker, Margaret Lobo, Elizabeth Borman, Frederick Baehner, Anjali S. Kumar, Kelly Adduci, Corina Marx, Emanuel F. Petricoin, Lance A. Liotta, Mary Winters, Stephen Benz, and Christopher C. Benz
Cancer Res 2006 66: 8707-8714. [Abstract] [Full Text] [PDF]  

AMG 706, an Oral, Multikinase Inhibitor that Selectively Targets Vascular Endothelial Growth Factor, Platelet-Derived Growth Factor, and Kit Receptors, Potently Inhibits Angiogenesis and Induces Regression in Tumor Xenografts

Anthony Polverino, Angela Coxon, Charlie Starnes, Zobedia Diaz, Thomas DeMelfi, Ling Wang, James Bready, Juan Estrada, Russell Cattley, Stephen Kaufman, Danlin Chen, Yongmei Gan, Gondi Kumar, James Meyer, Sesha Neervannan, Gonzalo Alva, Jane Talvenheimo, Silvia Montestruque, Andrew Tasker, Vinod Patel, Robert Radinsky, and Richard Kendall
Cancer Res 2006 66: 8715-8721. [Abstract] [Full Text] [PDF]  

AAL881, a Novel Small Molecule Inhibitor of RAF and Vascular Endothelial Growth Factor Receptor Activities, Blocks the Growth of Malignant Glioma

Sith Sathornsumetee, Anita B. Hjelmeland, Stephen T. Keir, Roger E. McLendon, David Batt, Timothy Ramsey, Naeem Yusuff, B.K. Ahmed Rasheed, Mark W. Kieran, Andrea Laforme, Darell D. Bigner, Henry S. Friedman, and Jeremy N. Rich
Cancer Res 2006 66: 8722-8730. [Abstract] [Full Text] [PDF]  

A Small-Molecule Inhibitor of Bcl-X_L Potentiates the Activity of Cytotoxic Drugs In vitro and In vivo

Alex R. Shoemaker, Anatol Oleksijew, Joy Bauch, Barbara A. Belli, Tony Borre, Milan Bruncko, Thomas Deckwirth, David J. Frost, Ken Jarvis, Mary K. Joseph, Kennan Marsh, William McClellan, Hugh Nellans, ShiChung Ng, Paul Nimmer, Jacqueline M. O'Connor, Tilman Oltersdorf, Weiguo Qing, Wang Shen, Jason Stavropoulos, Stephen K. Tahir, Baole Wang, Robert Warner, Haichao Zhang, Stephen W. Fesik, Saul H. Rosenberg, and Steven W. Elmore
Cancer Res 2006 66: 8731-8739. [Abstract] [Full Text] [PDF] Supplementary Data  

A Carbohydrate Recognition–Based Drug Delivery and Controlled Release System using Intraperitoneal Macrophages as a Cellular Vehicle

Yuzuru Ikehara, Toru Niwa, Le Biao, Sanae Kabata Ikehara, Norifumi Ohashi, Takeshi Kobayashi, Yoshitaka Shimizu, Naoya Kojima, and Hayao Nakanishi
Cancer Res 2006 66: 8740-8748. [Abstract] [Full Text] [PDF]  

Agonist and Antagonist of Retinoic Acid Receptors Cause Similar Changes in Gene Expression and Induce Senescence-like Growth Arrest in MCF-7 Breast Carcinoma Cells

Yuhong Chen, Milos Dokmanovic, Wilfred D. Stein, Robert J. Ardecky, and Igor B. Roninson
Cancer Res 2006 66: 8749-8761. [Abstract] [Full Text] [PDF]  

Valproic Acid Enhances the Efficacy of Chemotherapy in EBV-Positive Tumors by Increasing Lytic Viral Gene Expression

Wen-hai Feng and Shannon C. Kenney
Cancer Res 2006 66: 8762-8769. [Abstract] [Full Text] [PDF]  

Vascular Endothelial Growth Factor Overexpression by Soft Tissue Sarcoma Cells: Implications for Tumor Growth, Metastasis, and Chemoresistance

Lianglin Zhang, Jonathan A.F. Hannay, Juehui Liu, Parimal Das, Maocheng Zhan, Theresa Nguyen, Daniel J. Hicklin, Dihua Yu, Raphael E. Pollock, and Dina Lev
Cancer Res 2006 66: 8770-8778. [Abstract] [Full Text] [PDF]  

Oligomannurarate Sulfate, a Novel Heparanase Inhibitor Simultaneously Targeting Basic Fibroblast Growth Factor, Combats Tumor Angiogenesis and Metastasis

Huajun Zhao, Haiying Liu, Yi Chen, Xianliang Xin, Jing Li, Yongtai Hou, Zhonghua Zhang, Xiongwen Zhang, Chengying Xie, Meiyu Geng, and Jian Ding
Cancer Res 2006 66: 8779-8787. [Abstract] [Full Text] [PDF] Supplementary Data  

Overexpression of Tissue Transglutaminase Leads to Constitutive Activation of Nuclear Factor-B in Cancer Cells: Delineation of a Novel Pathway

Aman P. Mann, Amit Verma, Gautam Sethi, Bramanandam Manavathi, Huamin Wang, Jansina Y. Fok, Ajaikumar B. Kunnumakkara, Rakesh Kumar, Bharat B. Aggarwal, and Kapil Mehta
Cancer Res 2006 66: 8788-8795. [Abstract] [Full Text] [PDF]  

Pituitary Adenylate Cyclase-Activating Polypeptide Is a Potent Inhibitor of the Growth of Light Chain-Secreting Human Multiple Myeloma Cells

Min Li, Shirley Cortez, Tomoya Nakamachi, Vecihi Batuman, and Akira Arimura
Cancer Res 2006 66: 8796-8803. [Abstract] [Full Text] [PDF]  

Mechanism of Action of Sulforaphane: Inhibition of p38 Mitogen-Activated Protein Kinase Isoforms Contributing to the Induction of Antioxidant Response Element–Mediated Heme Oxygenase-1 in Human Hepatoma HepG2 Cells

Young-Sam Keum, Siwang Yu, Peter Pil-Jae Chang, Xiaoling Yuan, Jung-Hwan Kim, Changjiang Xu, Jiahuai Han, Anupam Agarwal, and Ah-Ng Tony Kong
Cancer Res 2006 66: 8804-8813. [Abstract] [Full Text] [PDF]  

Class II Histone Deacetylases Are Associated with VHL-Independent Regulation of Hypoxia-Inducible Factor 1

David Z. Qian, Sushant K. Kachhap, Spencer J. Collis, Henk M.W. Verheul, Michael A. Carducci, Peter Atadja, and Roberto Pili
Cancer Res 2006 66: 8814-8821. [Abstract] [Full Text] [PDF]  

Mechanism of Increased Coxsackie and Adenovirus Receptor Gene Expression and Adenovirus Uptake by Phytoestrogen and Histone Deacetylase Inhibitor in Human Bladder Cancer Cells and the Potential Clinical Application

Rey-Chen Pong, Ryan Roark, Jiun-Yih Ou, Jianhai Fan, Jennifer Stanfield, Eugene Frenkel, Arthur Sagalowsky, and Jer-Tsong Hsieh
Cancer Res 2006 66: 8822-8828. [Abstract] [Full Text] [PDF] Supplementary Data  

Fluorodeoxyuridine Modulates Cellular Expression of the DNA Base Excision Repair Enzyme Uracil-DNA Glycosylase

Jennifer A. Fischer, Susan Muller-Weeks, and Salvatore J. Caradonna
Cancer Res 2006 66: 8829-8837. [Abstract] [Full Text] [PDF]  

Farnesyltransferase Inhibitors Reverse Taxane Resistance

Adam I. Marcus, Aurora M. O'Brate, Ruben M. Buey, Jun Zhou, Shala Thomas, Fadlo R. Khuri, Jose Manuel Andreu, Fernando Díaz, and Paraskevi Giannakakou
Cancer Res 2006 66: 8838-8846. [Abstract] [Full Text] [PDF]  

Organic Cation Transporters Are Determinants of Oxaliplatin Cytotoxicity

Shuzhong Zhang, Katherine S. Lovejoy, James E. Shima, Leah L. Lagpacan, Yan Shu, Anna Lapuk, Ying Chen, Takafumi Komori, Joe W. Gray, Xin Chen, Stephen J. Lippard, and Kathleen M. Giacomini
Cancer Res 2006 66: 8847-8857. [Abstract] [Full Text] [PDF] Supplementary Data  

Flavopiridol Induces Cellular FLICE-Inhibitory Protein Degradation by the Proteasome and Promotes TRAIL–Induced Early Signaling and Apoptosis in Breast Tumor Cells

Carmen Palacios, Rosario Yerbes, and Abelardo López-Rivas
Cancer Res 2006 66: 8858-8869. [Abstract] [Full Text] [PDF]  

Mitogen-Activated Protein Kinase Phosphatase-1 Is Required for Cisplatin Resistance

Zhaoqing Wang, Jing Xu, Jun-Ying Zhou, Yusen Liu, and Gen Sheng Wu
Cancer Res 2006 66: 8870-8877. [Abstract] [Full Text] [PDF]  

Enhanced Antitumor Activity of Murine-Human Hybrid T-Cell Receptor (TCR) in Human Lymphocytes Is Associated with Improved Pairing and TCR/CD3 Stability

Cyrille J. Cohen, Yangbing Zhao, Zhili Zheng, Steven A. Rosenberg, and Richard A. Morgan
Cancer Res 2006 66: 8878-8886. [Abstract] [Full Text] [PDF]  

Immunology:

Induction of Potent Antitumor Immunity by Intratumoral Injection of Interleukin 23–Transduced Dendritic Cells

Jinwei Hu, Xiangpeng Yuan, Maria L. Belladonna, John M. Ong, Sebastian Wachsmann-Hogiu, Daniel L. Farkas, Keith L. Black, and John S. Yu
Cancer Res 2006 66: 8887-8896. [Abstract] [Full Text] [PDF]  

Endocrinology:

Susceptibility to Induced and Spontaneous Carcinogenesis Is Increased in Fatless A-ZIP/F-1 but not in Obese ob/ob Mice

Vitaly Ablamunits, Yehuda Cohen, Irina B. Brazee, Harold P. Gaetz, Charles Vinson, and Simon Klebanov
Cancer Res 2006 66: 8897-8902. [Abstract] [Full Text] [PDF]  

Clinical Research:

Sequential Valproic Acid/All-trans Retinoic Acid Treatment Reprograms Differentiation in Refractory and High-Risk Acute Myeloid Leukemia

Giuseppe Cimino, Francesco Lo-Coco, Susanna Fenu, Lorena Travaglini, Erica Finolezzi, Marco Mancini, Mauro Nanni, Angela Careddu, Francesco Fazi, Fabrizio Padula, Roberto Fiorini, Maria Antonietta Aloe Spiriti, Maria Concetta Petti, Adriano Venditti, Sergio Amadori, Franco Mandelli, Pier Giuseppe Pelicci, and Clara Nervi
Cancer Res 2006 66: 8903-8911. [Abstract] [Full Text] [PDF] Supplementary Data  

The Extent and Severity of Vascular Leakage as Evidence of Tumor Aggressiveness in High-Grade Gliomas

Yue Cao, Vijaya Nagesh, Daniel Hamstra, Christina I. Tsien, Brian D. Ross, Thomas L. Chenevert, Larry Junck, and Theodore S. Lawrence
Cancer Res 2006 66: 8912-8917. [Abstract] [Full Text] [PDF]  

Telomere Maintenance Mechanisms in Liposarcomas: Association with Histologic Subtypes and Disease Progression

Aurora Costa, Maria Grazia Daidone, Laura Daprai, Raffaella Villa, Sabrina Cantù, Silvana Pilotti, Luigi Mariani, Alessandro Gronchi, Jeremy D. Henson, Roger R. Reddel, and Nadia Zaffaroni
Cancer Res 2006 66: 8918-8924. [Abstract] [Full Text] [PDF]  

Corrections:

IL-23–Expressing Neural Stem Cell Antiglioma

Cancer Res 2006 66: 8925. [Full Text] [PDF]  

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Brca1 Deficiency and IGF-1 Signaling Pathway

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