Reviews:

Cancer's Molecular Sweet Tooth and the Warburg Effect

Jung-whan Kim and Chi V. Dang
Cancer Res 2006 66: 8927-8930. [Abstract] [Full Text] [PDF]  

Interplay between Notch Signaling and Epigenetic Silencers in Cancer

Maria Dominguez
Cancer Res 2006 66: 8931-8934. [Abstract] [Full Text] [PDF]  

Perspectives in Cancer Research:

Small Molecules, Big Players: the National Cancer Institute's Initiative for Chemical Genetics

Nicola Tolliday, Paul A. Clemons, Paul Ferraiolo, Angela N. Koehler, Timothy A. Lewis, Xiaohua Li, Stuart L. Schreiber, Daniela S. Gerhard, and Scott Eliasof
Cancer Res 2006 66: 8935-8942. [Abstract] [Full Text] [PDF]  

Priority Reports:

EPHB4 and Survival of Colorectal Cancer Patients

Veronica Davalos, Higinio Dopeso, Julio Castaño, Andrew J. Wilson, Felip Vilardell, Jordi Romero-Gimenez, Eloy Espín, Manel Armengol, Gabriel Capella, John M. Mariadason, Lauri A. Aaltonen, Simo Schwartz, Jr., and Diego Arango
Cancer Res 2006 66: 8943-8948. [Abstract] [Full Text] [PDF] Supplementary Data  

A Mouse Model for the Molecular Characterization of Brca1-Associated Ovarian Carcinoma

Deyin Xing and Sandra Orsulic
Cancer Res 2006 66: 8949-8953. [Abstract] [Full Text] [PDF] Supplementary Data  

Inhibition of Mitogen-Elicited Signal Transduction and Growth in Prostate Cancer with a Small Peptide Derived from the Functional Domain of DOC-2/DAB2 Delivered by a Unique Vehicle

Jian Zhou, Jinhai Fan, and Jer-Tsong Hsieh
Cancer Res 2006 66: 8954-8958. [Abstract] [Full Text] [PDF] Supplementary Data  

Asynchronous Growth of Prostate Cancer Is Reflected by Circulating Tumor Cells Delivered from Distinct, Even Small Foci, Harboring Loss of Heterozygosity of the PTEN Gene

Hartmut Schmidt, Gabriela DeAngelis, Elke Eltze, Iris Gockel, Axel Semjonow, and Burkhard Brandt
Cancer Res 2006 66: 8959-8965. [Abstract] [Full Text] [PDF]  

Rare Germ Line CHEK2 Variants Identified in Breast Cancer Families Encode Proteins That Show Impaired Activation

Nayanta Sodha, Tine S. Mantoni, Sean V. Tavtigian, Rosalind Eeles, and Michelle D. Garrett
Cancer Res 2006 66: 8966-8970. [Abstract] [Full Text] [PDF]  

Autoantibody Cancer Biomarker: Extracellular Protein Kinase A

Maria V. Nesterova, Natalie Johnson, Christopher Cheadle, Susan E. Bates, Sridhar Mani, Constantine A. Stratakis, Islam Kahn, Rishab K. Gupta, and Yoon S. Cho-Chung
Cancer Res 2006 66: 8971-8974. [Abstract] [Full Text] [PDF]  

Role of Apoptotic Nuclease Caspase-Activated DNase in Etoposide-Induced Treatment-Related Acute Myelogenous Leukemia

Eszter S. Hars, Yi Lisa Lyu, Chao-Po Lin, and Leroy F. Liu
Cancer Res 2006 66: 8975-8979. [Abstract] [Full Text] [PDF]  

Implications of Gene-Environment Interaction in Studies of Gene Variants in Breast Cancer: An Example of Dietary Isoflavones and the D356N Polymorphism in the Sex Hormone-Binding Globulin Gene

Yen-Ling Low, Alison M. Dunning, Mitch Dowsett, Robert N. Luben, Kay-Tee Khaw, Nick J. Wareham, and Sheila A. Bingham
Cancer Res 2006 66: 8980-8983. [Abstract] [Full Text] [PDF]  

Molecular Biology, Pathobiology, and Genetics:

Array Comparative Genomic Hybridization Reveals Distinct DNA Copy Number Differences between Gastrointestinal Stromal Tumors and Leiomyosarcomas

Leonardo A. Meza-Zepeda, Stine H. Kresse, Ana H. Barragan-Polania, Bodil Bjerkehagen, Hege O. Ohnstad, Heidi M. Namløs, Junbai Wang, Bjørn E. Kristiansen, and Ola Myklebost
Cancer Res 2006 66: 8984-8993. [Abstract] [Full Text] [PDF] Supplementary Data  

MCT-1 Protein Interacts with the Cap Complex and Modulates Messenger RNA Translational Profiles

Line S. Reinert, Bo Shi, Suvobroto Nandi, Krystyna Mazan-Mamczarz, Michele Vitolo, Kurtis E. Bachman, Huili He, and Ronald B. Gartenhaus
Cancer Res 2006 66: 8994-9001. [Abstract] [Full Text] [PDF] Supplementary Data  

The Expression of CD30 in Anaplastic Large Cell Lymphoma Is Regulated by Nucleophosmin-Anaplastic Lymphoma Kinase–Mediated JunB Level in a Cell Type–Specific Manner

Faye Yuan-Yi Hsu, Patrick B. Johnston, Kathleen A. Burke, and Yi Zhao
Cancer Res 2006 66: 9002-9008. [Abstract] [Full Text] [PDF]  

Hypoxic Stress Induces Dimethylated Histone H3 Lysine 9 through Histone Methyltransferase G9a in Mammalian Cells

Haobin Chen, Yan Yan, Todd L. Davidson, Yoichi Shinkai, and Max Costa
Cancer Res 2006 66: 9009-9016. [Abstract] [Full Text] [PDF]  

Cytogenetic Instability in Ovarian Epithelial Cells from Women at Risk of Ovarian Cancer

Tanja Pejovic, Jane E. Yates, Hong Y. Liu, Laura E. Hays, Yassmine Akkari, Yumi Torimaru, Winifred Keeble, R. Keaney Rathbun, William H. Rodgers, Allen E. Bale, Najim Ameziane, C. Michael Zwaan, Abdellatif Errami, Philippe Thuillier, Fabio Cappuccini, Susan B. Olson, Joanna M. Cain, and Grover C. Bagby, Jr.
Cancer Res 2006 66: 9017-9025. [Abstract] [Full Text] [PDF] Supplementary Data  

Daxx Represses Expression of a Subset of Antiapoptotic Genes Regulated by Nuclear Factor-B

Rhonda Croxton, Lorena A. Puto, Ian de Belle, Michael Thomas, Seiji Torii, Farid Hanaii, Michael Cuddy, and John C. Reed
Cancer Res 2006 66: 9026-9035. [Abstract] [Full Text] [PDF]  

A Human Cell-Based Assay to Evaluate the Effects of Alterations in the MLH1 Mismatch Repair Gene

Monica Francesca Blasi, Ilenia Ventura, Gabriele Aquilina, Paolo Degan, Lucio Bertario, Chiara Bassi, Paolo Radice, and Margherita Bignami
Cancer Res 2006 66: 9036-9044. [Abstract] [Full Text] [PDF]  

Cell, Tumor, and Stem Cell Biology:

Aberrant Expression of a Disintegrin and Metalloproteinase 17/Tumor Necrosis Factor- Converting Enzyme Increases the Malignant Potential in Human Pancreatic Ductal Adenocarcinoma

Jörg Ringel, Ralf Jesnowski, Nicolas Moniaux, Jutta Lüttges, Jens Ringel, Amit Choudhury, Surinder K. Batra, Günter Klöppel, and Matthias Löhr
Cancer Res 2006 66: 9045-9053. [Abstract] [Full Text] [PDF]  

Tumor Stromal-Derived Factor-1 Recruits Vascular Progenitors to Mitotic Neovasculature, where Microenvironment Influences Their Differentiated Phenotypes

Manish Aghi, Kenneth S. Cohen, Rachael J. Klein, David T. Scadden, and E. Antonio Chiocca
Cancer Res 2006 66: 9054-9064. [Abstract] [Full Text] [PDF]  

Extracellular Calcium as a Candidate Mediator of Prostate Cancer Skeletal Metastasis

Jinhui Liao, Abraham Schneider, Nabanita S. Datta, and Laurie K. McCauley
Cancer Res 2006 66: 9065-9073. [Abstract] [Full Text] [PDF]  

IQGAP1 Protein Specifies Amplifying Cancer Cells in Glioblastoma Multiforme

Laurent Balenci, Ian D. Clarke, Peter B. Dirks, Nicole Assard, François Ducray, Anne Jouvet, Marie-Françoise Belin, Jerôme Honnorat, and Jacques Baudier
Cancer Res 2006 66: 9074-9082. [Abstract] [Full Text] [PDF] Supplementary Data  

Inhibition of the Janus Kinase Family Increases Extracellular Signal-Regulated Kinase 1/2 Phosphorylation and Causes Endoreduplication

Gudrun Reiterer and Andrew Yen
Cancer Res 2006 66: 9083-9089. [Abstract] [Full Text] [PDF]  

MicroRNA Regulates the Expression of Human Cytochrome P450 1B1

Yuki Tsuchiya, Miki Nakajima, Shingo Takagi, Takao Taniya, and Tsuyoshi Yokoi
Cancer Res 2006 66: 9090-9098. [Abstract] [Full Text] [PDF]  

HBXIP, Cellular Target of Hepatitis B Virus Oncoprotein, Is a Regulator of Centrosome Dynamics and Cytokinesis

Ryoji Fujii, Changjun Zhu, Yunfei Wen, Hiroyuki Marusawa, Beatrice Bailly-Maitre, Shu-ichi Matsuzawa, Hong Zhang, Youngsoo Kim, C. Frank Bennett, Wei Jiang, and John C. Reed
Cancer Res 2006 66: 9099-9107. [Abstract] [Full Text] [PDF]  

ß2-Microglobulin Is a Signaling and Growth-Promoting Factor for Human Prostate Cancer Bone Metastasis

Wen-Chin Huang, Daqing Wu, Zhihui Xie, Haiyen E. Zhau, Takeo Nomura, Majd Zayzafoon, Jan Pohl, Chia-Ling Hsieh, M. Neale Weitzmann, Mary C. Farach-Carson, and Leland W.K. Chung
Cancer Res 2006 66: 9108-9116. [Abstract] [Full Text] [PDF]  

Death Receptor-3, a New E-Selectin Counter-Receptor that Confers Migration and Survival Advantages to Colon Carcinoma Cells by Triggering p38 and ERK MAPK Activation

Stéphanie Gout, Chantale Morin, François Houle, and Jacques Huot
Cancer Res 2006 66: 9117-9124. [Abstract] [Full Text] [PDF]  

Epigenetic Silencing of Occludin Promotes Tumorigenic and Metastatic Properties of Cancer Cells via Modulations of Unique Sets of Apoptosis-Associated Genes

Makoto Osanai, Masaki Murata, Nami Nishikiori, Hideki Chiba, Takashi Kojima, and Norimasa Sawada
Cancer Res 2006 66: 9125-9133. [Abstract] [Full Text] [PDF]  

Experimental Therapeutics, Molecular Targets, and Chemical Biology:

KRN951, a Highly Potent Inhibitor of Vascular Endothelial Growth Factor Receptor Tyrosine Kinases, Has Antitumor Activities and Affects Functional Vascular Properties

Kazuhide Nakamura, Eri Taguchi, Toru Miura, Atsushi Yamamoto, Kazumi Takahashi, Francis Bichat, Nicolas Guilbaud, Kazumasa Hasegawa, Kazuo Kubo, Yasunari Fujiwara, Rika Suzuki, Kinya Kubo, Masabumi Shibuya, and Toshiyuki Isae
Cancer Res 2006 66: 9134-9142. [Abstract] [Full Text] [PDF] Supplementary Data  

Chemosensitization by Knockdown of Adenine Nucleotide Translocase-2

Morgane Le Bras, Annie Borgne-Sanchez, Zahia Touat, Ossama Sharaf El Dein, Aurélien Deniaud, Evelyne Maillier, Gael Lecellier, Dominique Rebouillat, Christophe Lemaire, Guido Kroemer, Etienne Jacotot, and Catherine Brenner
Cancer Res 2006 66: 9143-9152. [Abstract] [Full Text] [PDF] Supplementary Data  

Heat Shock Protein 90 Inhibition in Imatinib-Resistant Gastrointestinal Stromal Tumor

Sebastian Bauer, Lynn K. Yu, George D. Demetri, and Jonathan A. Fletcher
Cancer Res 2006 66: 9153-9161. [Abstract] [Full Text] [PDF]  

Therapeutic Implications of a Human Neutralizing Antibody to the Macrophage-Stimulating Protein Receptor Tyrosine Kinase (RON), a c-MET Family Member

Jennifer M. O'Toole, Karen E. Rabenau, Kerri Burns, Dan Lu, Venkat Mangalampalli, Paul Balderes, Nicole Covino, Rajiv Bassi, Marie Prewett, Kimberly J. Gottfredsen, Megan N. Thobe, Yuan Cheng, Yiwen Li, Daniel J. Hicklin, Zhenping Zhu, Susan E. Waltz, Michael J. Hayman, Dale L. Ludwig, and Daniel S. Pereira
Cancer Res 2006 66: 9162-9170. [Abstract] [Full Text] [PDF] Supplementary Data  

A Dimeric Peptide That Binds Selectively to Prostate-Specific Membrane Antigen and Inhibits its Enzymatic Activity

Saurabh Aggarwal, Pratap Singh, Ozlem Topaloglu, John T. Isaacs, and Samuel R. Denmeade
Cancer Res 2006 66: 9171-9177. [Abstract] [Full Text] [PDF]  

Quantifying the Activity of Adenoviral E1A CR2 Deletion Mutants Using Renilla Luciferase Bioluminescence and 3'-Deoxy-3'-[¹⁸F]Fluorothymidine Positron Emission Tomography Imaging

Julius Leyton, Michelle Lockley, Joeri L. Aerts, Sarah K. Baird, Eric O. Aboagye, Nicholas R. Lemoine, and Iain A. McNeish
Cancer Res 2006 66: 9178-9185. [Abstract] [Full Text] [PDF] Supplementary Data  

PDZ-Binding Kinase/T-LAK Cell-Originated Protein Kinase, a Putative Cancer/Testis Antigen with an Oncogenic Activity in Breast Cancer

Jae-Hyun Park, Meng-Lay Lin, Toshihiko Nishidate, Yusuke Nakamura, and Toyomasa Katagiri
Cancer Res 2006 66: 9186-9195. [Abstract] [Full Text] [PDF]  

Magnetic Resonance Visualization of Tumor Angiogenesis by Targeting Neural Cell Adhesion Molecules with the Highly Sensitive Gadolinium-Loaded Apoferritin Probe

Simonetta Geninatti Crich, Benedetta Bussolati, Lorenzo Tei, Cristina Grange, Giovanna Esposito, Stefania Lanzardo, Giovanni Camussi, and Silvio Aime
Cancer Res 2006 66: 9196-9201. [Abstract] [Full Text] [PDF]  

Alteration of the Methylation Status of Tumor-Promoting Genes Decreases Prostate Cancer Cell Invasiveness and Tumorigenesis In vitro and In vivo

Nicholas Shukeir, Pouya Pakneshan, Gaoping Chen, Moshe Szyf, and Shafaat A. Rabbani
Cancer Res 2006 66: 9202-9210. [Abstract] [Full Text] [PDF]  

Inhibition of Hsp90 Compromises the DNA Damage Response to Radiation

Hideaki Dote, William E. Burgan, Kevin Camphausen, and Philip J. Tofilon
Cancer Res 2006 66: 9211-9220. [Abstract] [Full Text] [PDF]  

Role of p53 Up-regulated Modulator of Apoptosis and Phosphorylated Akt in Melanoma Cell Growth, Apoptosis, and Patient Survival

Alison M. Karst, Derek L. Dai, Jin Q. Cheng, and Gang Li
Cancer Res 2006 66: 9221-9226. [Abstract] [Full Text] [PDF]  

Anticancer Activity of BIM-46174, a New Inhibitor of the Heterotrimeric G/Gß Protein Complex

Grégoire P. Prévost, Marie O. Lonchampt, Susan Holbeck, Samir Attoub, Daniel Zaharevitz, Mike Alley, John Wright, Marie C. Brezak, Hélène Coulomb, Ann Savola, Marion Huchet, Sophie Chaumeron, Quang-Dé Nguyen, Patricia Forgez, Erik Bruyneel, Mark Bracke, Eric Ferrandis, Pierre Roubert, Danièle Demarquay, Christian Gespach, and Philip G. Kasprzyk
Cancer Res 2006 66: 9227-9234. [Abstract] [Full Text] [PDF]  

Identification of New Compounds That Trigger Apoptosome-Independent Caspase Activation and Apoptosis

Emanuela Aleo, Clare J. Henderson, Alessandra Fontanini, Barbara Solazzo, and Claudio Brancolini
Cancer Res 2006 66: 9235-9244. [Abstract] [Full Text] [PDF]  

Adenomatous Polyposis Coli Determines Sensitivity to Histone Deacetylase Inhibitor–Induced Apoptosis in Colon Cancer Cells

Xiangwei Huang and Bin Guo
Cancer Res 2006 66: 9245-9251. [Abstract] [Full Text] [PDF]  

Nelfinavir Down-regulates Hypoxia-Inducible Factor 1 and VEGF Expression and Increases Tumor Oxygenation: Implications for Radiotherapy

Nabendu Pore, Anjali K. Gupta, George J. Cerniglia, Zibin Jiang, Eric J. Bernhard, Sydney M. Evans, Cameron J. Koch, Stephen M. Hahn, and Amit Maity
Cancer Res 2006 66: 9252-9259. [Abstract] [Full Text] [PDF] Supplementary Data  

(–)–Epigallocatechin Gallate Overcomes Resistance to Etoposide-Induced Cell Death by Targeting the Molecular Chaperone Glucose-Regulated Protein 78

Svetlana P. Ermakova, Bong Seok Kang, Bu Young Choi, Hong Seok Choi, Todd F. Schuster, Wei-Ya Ma, Ann M. Bode, and Zigang Dong
Cancer Res 2006 66: 9260-9269. [Abstract] [Full Text] [PDF]  

Combined Depletion of Cell Cycle and Transcriptional Cyclin-Dependent Kinase Activities Induces Apoptosis in Cancer Cells

Dongpo Cai, Vaughan M. Latham, Jr., Xinxin Zhang, and Geoffrey I. Shapiro
Cancer Res 2006 66: 9270-9280. [Abstract] [Full Text] [PDF] Supplementary Data  

Immunology:

HLA Class I Antigen Down-regulation in Primary Laryngeal Squamous Cell Carcinoma Lesions as a Poor Prognostic Marker

Takeshi Ogino, Hiroshi Shigyo, Hideyuki Ishii, Akihiro Katayama, Naoyuki Miyokawa, Yasuaki Harabuchi, and Soldano Ferrone
Cancer Res 2006 66: 9281-9289. [Abstract] [Full Text] [PDF]  

Human Tumor-Released Microvesicles Promote the Differentiation of Myeloid Cells with Transforming Growth Factor-ß–Mediated Suppressive Activity on T Lymphocytes

Roberta Valenti, Veronica Huber, Paola Filipazzi, Lorenzo Pilla, Gloria Sovena, Antonello Villa, Alessandro Corbelli, Stefano Fais, Giorgio Parmiani, and Licia Rivoltini
Cancer Res 2006 66: 9290-9298. [Abstract] [Full Text] [PDF]  

All-trans-Retinoic Acid Improves Differentiation of Myeloid Cells and Immune Response in Cancer Patients

Noweeda Mirza, Mayer Fishman, Ingo Fricke, Mary Dunn, Anthony M. Neuger, Timothy J. Frost, Richard M. Lush, Scott Antonia, and Dmitry I. Gabrilovich
Cancer Res 2006 66: 9299-9307. [Abstract] [Full Text] [PDF]  

Endocrinology:

Estrogen Receptor Positive Breast Cancer Metastasis: Altered Hormonal Sensitivity and Tumor Aggressiveness in Lymphatic Vessels and Lymph Nodes

Joshua Chuck Harrell, Wendy W. Dye, D. Craig Allred, Paul Jedlicka, Nicole S. Spoelstra, Carol A. Sartorius, and Kathryn B. Horwitz
Cancer Res 2006 66: 9308-9315. [Abstract] [Full Text] [PDF]  

The Corepressor Silencing Mediator for Retinoid and Thyroid Hormone Receptor Facilitates Cellular Recovery from DNA Double-Strand Breaks

Jiujiu Yu, Christine Palmer, Theresa Alenghat, Yun Li, Gary Kao, and Mitchell A. Lazar
Cancer Res 2006 66: 9316-9322. [Abstract] [Full Text] [PDF]  

Epidemiology and Prevention:

Endogenous Inhibition of Histone Deacetylase 1 by Tumor-Suppressive Maspin

Xiaohua Li, Shuping Yin, Yonghong Meng, Wael Sakr, and Shijie Sheng
Cancer Res 2006 66: 9323-9329. [Abstract] [Full Text] [PDF]  

Population-Based Study of Natural Variation in the Melanocortin-1 Receptor Gene and Melanoma

Peter A. Kanetsky, Timothy R. Rebbeck, Amanda J. Hummer, Saarene Panossian, Bruce K. Armstrong, Anne Kricker, Loraine D. Marrett, Robert C. Millikan, Stephen B. Gruber, Hoda Anton Culver, Roberto Zanetti, Richard P. Gallagher, Terence Dwyer, Klaus Busam, Lynn From, Urvi Mujumdar, Homer Wilcox, Colin B. Begg, Marianne Berwick for the Genes Environment and Melanoma Study Group
Cancer Res 2006 66: 9330-9337. [Abstract] [Full Text] [PDF]  

Correction:

hEcd, a p53 Regulator

Cancer Res 2006 66: 9338. [Full Text] [PDF]  

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