Reviews:

Germ Line Polymorphism in Metastatic Progression

Kent W. Hunter and Nigel P. Crawford
Cancer Res 2006 66: 1251-1254. [Abstract] [Full Text] [PDF]  

Counting Heads in the War against Cancer: Defining the Role of Annexin A5 Imaging in Cancer Treatment and Surveillance

Maarten F. Corsten, Leonard Hofstra, Jagat Narula, and Chris P.M. Reutelingsperger
Cancer Res 2006 66: 1255-1260. [Abstract] [Full Text] [PDF]  

Priority Reports:

The High-Affinity IgG Receptor, FcRI, Plays a Central Role in Antibody Therapy of Experimental Melanoma

Lisette Bevaart, Marco J.H. Jansen, Martine J. van Vugt, J. Sjef Verbeek, Jan G.J. van de Winkel, and Jeanette H.W. Leusen
Cancer Res 2006 66: 1261-1264. [Abstract] [Full Text] [PDF]  

Bone Marrow–Derived Stromal Cells Express Lineage-Related Messenger RNA Species

Natalie C. Direkze, Rosemary Jeffery, Kairbaan Hodivala-Dilke, Toby Hunt, Raymond J. Playford, George Elia, Richard Poulsom, Nicholas A. Wright, and Malcolm R. Alison
Cancer Res 2006 66: 1265-1269. [Abstract] [Full Text] [PDF] Supplementary Data  

Syrian Hamster as a Permissive Immunocompetent Animal Model for the Study of Oncolytic Adenovirus Vectors

Maria A. Thomas, Jacqueline F. Spencer, Marie C. La Regina, Debanjan Dhar, Ann E. Tollefson, Karoly Toth, and William S.M. Wold
Cancer Res 2006 66: 1270-1276. [Abstract] [Full Text] [PDF]  

Rapid Alteration of MicroRNA Levels by Histone Deacetylase Inhibition

Gary K. Scott, Michael D. Mattie, Crystal E. Berger, Stephen C. Benz, and Christopher C. Benz
Cancer Res 2006 66: 1277-1281. [Abstract] [Full Text] [PDF]  

Adenovirus-Induced Extracellular Signal-Regulated Kinase Phosphorylation during the Late Phase of Infection Enhances Viral Protein Levels and Virus Progeny

Michael Schümann and Matthias Dobbelstein
Cancer Res 2006 66: 1282-1288. [Abstract] [Full Text] [PDF]  

The c-myc Gene Is a Direct Target of Mammalian SWI/SNF–Related Complexes during Differentiation-Associated Cell Cycle Arrest

Norman G. Nagl, Jr., Daniel R. Zweitzig, Bayar Thimmapaya, George R. Beck, Jr., and Elizabeth Moran
Cancer Res 2006 66: 1289-1293. [Abstract] [Full Text] [PDF]  

Molecular Biology, Pathobiology, and Genetics:

Grg1 Acts as a Lung-Specific Oncogene in a Transgenic Mouse Model

Thaddeus Allen, Minke van Tuyl, Pratibha Iyengar, Serge Jothy, Martin Post, Ming-Sound Tsao, and Corrinne G. Lobe
Cancer Res 2006 66: 1294-1301. [Abstract] [Full Text] [PDF]  

PTEN Loss Promotes ras^Ha-Mediated Papillomatogenesis via Dual Up-Regulation of AKT Activity and Cell Cycle Deregulation but Malignant Conversion Proceeds via PTEN-Associated Pathways

Denggao Yao, Claire L. Alexander, Jean A. Quinn, Michael J. Porter, Hong Wu, and David A. Greenhalgh
Cancer Res 2006 66: 1302-1312. [Abstract] [Full Text] [PDF] Supplementary Data  

Characterization of a von Hippel Lindau Pathway Involved in Extracellular Matrix Remodeling, Cell Invasion, and Angiogenesis

Ghada Kurban, Valérie Hudon, Eric Duplan, Michael Ohh, and Arnim Pause
Cancer Res 2006 66: 1313-1319. [Abstract] [Full Text] [PDF]  

Extracellular Signal–Regulated Kinase 1/2 Mitogen-Activated Protein Kinase Pathway Is Involved in Myostatin-Regulated Differentiation Repression

Wei Yang, Yan Chen, Yong Zhang, Xueyan Wang, Ning Yang, and Dahai Zhu
Cancer Res 2006 66: 1320-1326. [Abstract] [Full Text] [PDF]  

Delayed Onset of Igf2-Induced Mammary Tumors in Igf2r Transgenic Mice

Thomas L. Wise and Dimitrina D. Pravtcheva
Cancer Res 2006 66: 1327-1336. [Abstract] [Full Text] [PDF]  

Urogenital Carcinogenesis in Female CD1 Mice Induced by In utero Arsenic Exposure Is Exacerbated by Postnatal Diethylstilbestrol Treatment

Michael P. Waalkes, Jie Liu, Jerrold M. Ward, Douglas A. Powell, and Bhalchandra A. Diwan
Cancer Res 2006 66: 1337-1345. [Abstract] [Full Text] [PDF]  

Cofactor of BRCA1: A Novel Transcription Factor Regulator in Upper Gastrointestinal Adenocarcinomas

Patricia A. McChesney, Sarah E. Aiyar, Ok-Jae Lee, Alexander Zaika, Christopher Moskaluk, Rong Li, and Wa'el El-Rifai
Cancer Res 2006 66: 1346-1353. [Abstract] [Full Text] [PDF]  

Fibroblast Growth Factor 9 Has Oncogenic Activity and Is a Downstream Target of Wnt Signaling in Ovarian Endometrioid Adenocarcinomas

Neali D. Hendrix, Rong Wu, Rork Kuick, Donald R. Schwartz, Eric R. Fearon, and Kathleen R. Cho
Cancer Res 2006 66: 1354-1362. [Abstract] [Full Text] [PDF]  

Transcriptional Repression of Telomerase RNA Gene Expression by c-Jun-NH₂-Kinase and Sp1/Sp3

Alan E. Bilsland, Katrina Stevenson, Stuart Atkinson, Walter Kolch, and W. Nicol Keith
Cancer Res 2006 66: 1363-1370. [Abstract] [Full Text] [PDF]  

Mutational and Epigenetic Evidence for Independent Pathways for Lung Adenocarcinomas Arising in Smokers and Never Smokers

Shinichi Toyooka, Masaki Tokumo, Hisayuki Shigematsu, Keitaro Matsuo, Hiroaki Asano, Kunitoshi Tomii, Shuji Ichihara, Makoto Suzuki, Motoi Aoe, Hiroshi Date, Adi F. Gazdar, and Nobuyoshi Shimizu
Cancer Res 2006 66: 1371-1375. [Abstract] [Full Text] [PDF]  

Protein Chip Discovery of Secreted Proteins Regulated by the Phosphatidylinositol 3-Kinase Pathway in Ovarian Cancer Cell Lines

Michelle Moscova, Deborah J. Marsh, and Robert C. Baxter
Cancer Res 2006 66: 1376-1383. [Abstract] [Full Text] [PDF]  

GATA5 Activation of the Progesterone Receptor Gene Promoter in Breast Cancer Cells Is Influenced by the +331G/A Polymorphism

Gordon S. Huggins, Jason Y.Y. Wong, Susan E. Hankinson, and Immaculata De Vivo
Cancer Res 2006 66: 1384-1390. [Abstract] [Full Text] [PDF]  

Ataxia Telangiectasia Mutated and Checkpoint Kinase 2 Regulate BRCA1 to Promote the Fidelity of DNA End-Joining

Hui-Chun Wang, Wen-Cheng Chou, Sheau-Yann Shieh, and Chen-Yang Shen
Cancer Res 2006 66: 1391-1400. [Abstract] [Full Text] [PDF] Supplementary Data  

Checkpoint Kinase 2–Mediated Phosphorylation of BRCA1 Regulates the Fidelity of Nonhomologous End-Joining

Jing Zhuang, Junran Zhang, Henning Willers, Hong Wang, Jay H. Chung, Dik C. van Gent, Dennis E. Hallahan, Simon N. Powell, and Fen Xia
Cancer Res 2006 66: 1401-1408. [Abstract] [Full Text] [PDF]  

Cell, Tumor, and Stem Cell Biology:

An Essential Role of Alternative Splicing of c-myc Suppressor FUSE-Binding Protein–Interacting Repressor in Carcinogenesis

Kazuyuki Matsushita, Takeshi Tomonaga, Hideaki Shimada, Ayumi Shioya, Morihiro Higashi, Hisahiro Matsubara, Kenichi Harigaya, Fumio Nomura, Daniel Libutti, David Levens, and Takenori Ochiai
Cancer Res 2006 66: 1409-1417. [Abstract] [Full Text] [PDF] Supplementary Data  

ErbB3-Dependent Motility and Intravasation in Breast Cancer Metastasis

Chengsen Xue, Fubo Liang, Radma Mahmood, Magalis Vuolo, Jeffrey Wyckoff, Hong Qian, Kun-Lin Tsai, Mimi Kim, Joseph Locker, Zhong-Yin Zhang, and Jeffrey E. Segall
Cancer Res 2006 66: 1418-1426. [Abstract] [Full Text] [PDF] Supplementary Data  

Arachidonic Acid Activates Phosphatidylinositol 3-Kinase Signaling and Induces Gene Expression in Prostate Cancer

Millie Hughes-Fulford, Chai-Fei Li, Jim Boonyaratanakornkit, and Sina Sayyah
Cancer Res 2006 66: 1427-1433. [Abstract] [Full Text] [PDF]  

Effect of Inhibition of Vascular Endothelial Growth Factor Signaling on Distribution of Extravasated Antibodies in Tumors

Tsutomu Nakahara, Scott M. Norberg, David R. Shalinsky, Dana D. Hu-Lowe, and Donald M. McDonald
Cancer Res 2006 66: 1434-1445. [Abstract] [Full Text] [PDF]  

Vascular Endothelial Growth Factor Receptor-3 and Focal Adhesion Kinase Bind and Suppress Apoptosis in Breast Cancer Cells

Christopher A. Garces, Elena V. Kurenova, Vita M. Golubovskaya, and William G. Cance
Cancer Res 2006 66: 1446-1454. [Abstract] [Full Text] [PDF]  

Heparanase Induces Vascular Endothelial Growth Factor Expression: Correlation with p38 Phosphorylation Levels and Src Activation

Anna Zetser, Yulia Bashenko, Evgeny Edovitsky, Flonia Levy-Adam, Israel Vlodavsky, and Neta Ilan
Cancer Res 2006 66: 1455-1463. [Abstract] [Full Text] [PDF] Supplementary Data  

Isolation of a Natural Inhibitor of Human Malignant Glial Cell Invasion: Inter -Trypsin Inhibitor Heavy Chain 2

Tamra E. Werbowetski-Ogilvie, Nathalie Y.R. Agar, Roberta M. Waldkircher de Oliveira, Damien Faury, Jack P. Antel, Nada Jabado, and Rolando F. Del Maestro
Cancer Res 2006 66: 1464-1472. [Abstract] [Full Text] [PDF]  

Human Lymphoblastoid Proteome Analysis Reveals a Role for the Inhibitor of Acetyltransferases Complex in DNA Double-Strand Break Response

Eef H.C. Dirksen, Jacqueline Cloos, Boudewijn J.M. Braakhuis, Ruud H. Brakenhoff, Albert J.R. Heck, and Monique Slijper
Cancer Res 2006 66: 1473-1480. [Abstract] [Full Text] [PDF] Supplementary Data  

Ectopic Activity of Fibroblast Growth Factor Receptor 1 in Hepatocytes Accelerates Hepatocarcinogenesis by Driving Proliferation and Vascular Endothelial Growth Factor–Induced Angiogenesis

Xinqiang Huang, Chundong Yu, Chengliu Jin, Masashi Kobayashi, Courtney A. Bowles, Fen Wang, and Wallace L. McKeehan
Cancer Res 2006 66: 1481-1490. [Abstract] [Full Text] [PDF]  

Autocrine Production of Interleukin-4 and Interleukin-10 Is Required for Survival and Growth of Thyroid Cancer Cells

Matilde Todaro, Monica Zerilli, Lucia Ricci-Vitiani, Miriam Bini, Mileidys Perez Alea, Ada Maria Florena, Laura Miceli, Gerolama Condorelli, Sebastiano Bonventre, Giuseppe Di Gesù, Ruggero De Maria, and Giorgio Stassi
Cancer Res 2006 66: 1491-1499. [Abstract] [Full Text] [PDF]  

mTOR Inhibition Induces Upstream Receptor Tyrosine Kinase Signaling and Activates Akt

Kathryn E. O'Reilly, Fredi Rojo, Qing-Bai She, David Solit, Gordon B. Mills, Debra Smith, Heidi Lane, Francesco Hofmann, Daniel J. Hicklin, Dale L. Ludwig, Jose Baselga, and Neal Rosen
Cancer Res 2006 66: 1500-1508. [Abstract] [Full Text] [PDF]  

Activation of the Nuclear Factor B Pathway by Astrocyte Elevated Gene-1: Implications for Tumor Progression and Metastasis

Luni Emdad, Devanand Sarkar, Zao-zhong Su, Aaron Randolph, Habib Boukerche, Kristoffer Valerie, and Paul B. Fisher
Cancer Res 2006 66: 1509-1516. [Abstract] [Full Text] [PDF]  

Aberrant Activation of Notch Signaling in Human Breast Cancer

Spyros Stylianou, Rob B. Clarke, and Keith Brennan
Cancer Res 2006 66: 1517-1525. [Abstract] [Full Text] [PDF]  

ß₁ Integrin Inhibitory Antibody Induces Apoptosis of Breast Cancer Cells, Inhibits Growth, and Distinguishes Malignant from Normal Phenotype in Three Dimensional Cultures and In vivo

Catherine C. Park, Hui Zhang, Maria Pallavicini, Joe W. Gray, Frederick Baehner, Chong J. Park, and Mina J. Bissell
Cancer Res 2006 66: 1526-1535. [Abstract] [Full Text] [PDF] Supplementary Data  

L-Selectin Facilitation of Metastasis Involves Temporal Induction of Fut7-Dependent Ligands at Sites of Tumor Cell Arrest

Heinz Läubli, Jennifer L. Stevenson, Ajit Varki, Nissi M. Varki, and Lubor Borsig
Cancer Res 2006 66: 1536-1542. [Abstract] [Full Text] [PDF]  

Src Uses Cas to Suppress Fhl1 in Order to Promote Nonanchored Growth and Migration of Tumor Cells

Yongquan Shen, Zhenyu Jia, Robert G. Nagele, Hitoshi Ichikawa, and Gary S. Goldberg
Cancer Res 2006 66: 1543-1552. [Abstract] [Full Text] [PDF] Supplementary Data  

von Hippel-Lindau Tumor Suppressor Protein Regulates the Assembly of Intercellular Junctions in Renal Cancer Cells through Hypoxia-Inducible Factor–Independent Mechanisms

Maria J. Calzada, Miguel A. Esteban, Monica Feijoo-Cuaresma, Maria C. Castellanos, Salvador Naranjo-Suárez, Elisa Temes, Fernando Méndez, Maria Yánez-Mo, Michael Ohh, and Manuel O. Landázuri
Cancer Res 2006 66: 1553-1560. [Abstract] [Full Text] [PDF]  

Mutations in the PI3K/PTEN/TSC2 Pathway Contribute to Mammalian Target of Rapamycin Activity and Increased Translation under Hypoxic Conditions

Fiona Kaper, Nadja Dornhoefer, and Amato J. Giaccia
Cancer Res 2006 66: 1561-1569. [Abstract] [Full Text] [PDF]  

B7-H4 Is a Novel Membrane-Bound Protein and a Candidate Serum and Tissue Biomarker for Ovarian Cancer

Iris Simon, Shaoqiu Zhuo, Laura Corral, Eleftherios P. Diamandis, Mark J. Sarno, Robert L. Wolfert, and Nam W. Kim
Cancer Res 2006 66: 1570-1575. [Abstract] [Full Text] [PDF]  

Octreotide, a Somatostatin Analogue, Mediates Its Antiproliferative Action in Pituitary Tumor Cells by Altering Phosphatidylinositol 3-Kinase Signaling and Inducing Zac1 Expression

Marily Theodoropoulou, Jing Zhang, Sandra Laupheimer, Marcelo Paez-Pereda, Christophe Erneux, Tullio Florio, Uberto Pagotto, and Günter K. Stalla
Cancer Res 2006 66: 1576-1582. [Abstract] [Full Text] [PDF]  

EFA6A Enhances Glioma Cell Invasion through ADP Ribosylation Factor 6/Extracellular Signal–Regulated Kinase Signaling

Ming Li, Samuel Sai-ming Ng, Jide Wang, Lihui Lai, Suet Yi Leung, Michel Franco, Ying Peng, Ming-liang He, Hsiang-fu Kung, and Marie Chia-mi Lin
Cancer Res 2006 66: 1583-1590. [Abstract] [Full Text] [PDF]  

Growth Properties of Colonic Tumor Cells Are a Function of the Intrinsic Mitochondrial Membrane Potential

Barbara G. Heerdt, Michele A. Houston, and Leonard H. Augenlicht
Cancer Res 2006 66: 1591-1596. [Abstract] [Full Text] [PDF] Supplementary Data  

An Integrated Computational/Experimental Model of Tumor Invasion

Hermann B. Frieboes, Xiaoming Zheng, Chung-Ho Sun, Bruce Tromberg, Robert Gatenby, and Vittorio Cristini
Cancer Res 2006 66: 1597-1604. [Abstract] [Full Text] [PDF]  

Inhibition of Glutamate Cysteine Ligase Activity Sensitizes Human Breast Cancer Cells to the Toxicity of 2-Deoxy-D-Glucose

Kelly K. Andringa, Mitchell C. Coleman, Nukhet Aykin-Burns, Michael J. Hitchler, Susan A. Walsh, Frederick E. Domann, and Douglas R. Spitz
Cancer Res 2006 66: 1605-1610. [Abstract] [Full Text] [PDF]  

Experimental Therapeutics, Molecular Targets, and Chemical Biology:

The Raf Inhibitor BAY 43-9006 (Sorafenib) Induces Caspase-Independent Apoptosis in Melanoma Cells

David J. Panka, Wei Wang, Michael B. Atkins, and James W. Mier
Cancer Res 2006 66: 1611-1619. [Abstract] [Full Text] [PDF]  

Increased Efficacy and Safety in the Treatment of Experimental Liver Cancer with a Novel Adenovirus-Alphavirus Hybrid Vector

Min Guan, Juan R. Rodriguez-Madoz, Pilar Alzuguren, Celia Gomar, M. Gabriela Kramer, Stefan Kochanek, Jesus Prieto, Cristian Smerdou, and Cheng Qian
Cancer Res 2006 66: 1620-1629. [Abstract] [Full Text] [PDF] Supplementary Data  

Activity of the Dual Kinase Inhibitor Lapatinib (GW572016) against HER-2-Overexpressing and Trastuzumab-Treated Breast Cancer Cells

Gottfried E. Konecny, Mark D. Pegram, Natarajan Venkatesan, Richard Finn, Guorong Yang, Martina Rahmeh, Michael Untch, David W. Rusnak, Glenn Spehar, Robert J. Mullin, Barry R. Keith, Tona M. Gilmer, Mark Berger, Karl C. Podratz, and Dennis J. Slamon
Cancer Res 2006 66: 1630-1639. [Abstract] [Full Text] [PDF]  

Regulation of Survivin by ErbB2 Signaling: Therapeutic Implications for ErbB2-Overexpressing Breast Cancers

Wenle Xia, John Bisi, Jay Strum, Leihua Liu, Kevin Carrick, Katherine M. Graham, Amanda L. Treece, Mary Ann Hardwicke, Michael Dush, Qiaoyin Liao, Ron E. Westlund, Sumin Zhao, Sarah Bacus, and Neil L. Spector
Cancer Res 2006 66: 1640-1647. [Abstract] [Full Text] [PDF] Supplementary Data  

Transforming Growth Factor-ß Receptor Inhibition Enhances Adenoviral Infectability of Carcinoma Cells via Up-Regulation of Coxsackie and Adenovirus Receptor in Conjunction with Reversal of Epithelial-Mesenchymal Transition

Markus D. Lacher, Maarit I. Tiirikainen, Elise F. Saunier, Christine Christian, Mario Anders, Martin Oft, Allan Balmain, Rosemary J. Akhurst, and Wolfgang Michael Korn
Cancer Res 2006 66: 1648-1657. [Abstract] [Full Text] [PDF]  

Identification of a Melanoma Marker Derived from Melanoma-Associated Endogenous Retroviruses

Johannes Humer, Andrea Waltenberger, Andreas Grassauer, Martin Kurz, Julia Valencak, Ronald Rapberger, Silvia Hahn, Roswitha Löwer, Klaus Wolff, Michael Bergmann, Thomas Muster, Bernd Mayer, and Hubert Pehamberger
Cancer Res 2006 66: 1658-1663. [Abstract] [Full Text] [PDF]  

Low-Dose Metronomic Daily Cyclophosphamide and Weekly Tirapazamine: A Well-Tolerated Combination Regimen with Enhanced Efficacy That Exploits Tumor Hypoxia

Urban Emmenegger, Gerard C. Morton, Giulio Francia, Yuval Shaked, Marcela Franco, Adina Weinerman, Shan Man, and Robert S. Kerbel
Cancer Res 2006 66: 1664-1674. [Abstract] [Full Text] [PDF]  

The Dispersal of Replication Proteins after Etoposide Treatment Requires the Cooperation of Nbs1 with the Ataxia Telangiectasia Rad3-Related/Chk1 Pathway

Rossella Rossi, Maria Rosa Lidonnici, Samuela Soza, Giuseppe Biamonti, and Alessandra Montecucco
Cancer Res 2006 66: 1675-1683. [Abstract] [Full Text] [PDF] Supplementary Data  

Hypoxia-Inducible Factor-1 Promotes Nonhypoxia-Mediated Proliferation in Colon Cancer Cells and Xenografts

Duyen T. Dang, Fang Chen, Lawrence B. Gardner, Jordan M. Cummins, Carlo Rago, Fred Bunz, Sergey V. Kantsevoy, and Long H. Dang
Cancer Res 2006 66: 1684-1693. [Abstract] [Full Text] [PDF]  

P21-Activated Kinase 1 Regulation of Estrogen Receptor- Activation Involves Serine 305 Activation Linked with Serine 118 Phosphorylation

Suresh K. Rayala, Amjad H. Talukder, Seetharaman Balasenthil, Robbin Tharakan, Christopher J. Barnes, Rui-An Wang, Marcelo Aldaz, Sohaib Khan, and Rakesh Kumar
Cancer Res 2006 66: 1694-1701. [Abstract] [Full Text] [PDF]  

Functional Coupling of p38-Induced Up-regulation of BiP and Activation of RNA-Dependent Protein Kinase–Like Endoplasmic Reticulum Kinase to Drug Resistance of Dormant Carcinoma Cells

Aparna C. Ranganathan, Lin Zhang, Alejandro P. Adam, and Julio A. Aguirre-Ghiso
Cancer Res 2006 66: 1702-1711. [Abstract] [Full Text] [PDF] Supplementary Data  

Increased Levels of the FoxM1 Transcription Factor Accelerate Development and Progression of Prostate Carcinomas in both TRAMP and LADY Transgenic Mice

Tanya V. Kalin, I-Ching Wang, Timothy J. Ackerson, Michael L. Major, Carol J. Detrisac, Vladimir V. Kalinichenko, Alexander Lyubimov, and Robert H. Costa
Cancer Res 2006 66: 1712-1720. [Abstract] [Full Text] [PDF] Supplementary Data  

Fully Human Monoclonal Antibodies to Hepatocyte Growth Factor with Therapeutic Potential against Hepatocyte Growth Factor/c-Met–Dependent Human Tumors

Teresa Burgess, Angela Coxon, Susanne Meyer, Jan Sun, Karen Rex, Trace Tsuruda, Qing Chen, Shu-Yin Ho, Luke Li, Stephen Kaufman, Kevin McDorman, Russell C. Cattley, Jilin Sun, Gary Elliott, Ke Zhang, Xiao Feng, Xiao-Chi Jia, Larry Green, Robert Radinsky, and Richard Kendall
Cancer Res 2006 66: 1721-1729. [Abstract] [Full Text] [PDF]  

Resistance of Cancers to Immunologic Cytotoxicity and Adoptive Immunotherapy via X-Linked Inhibitor of Apoptosis Protein Expression and Coexisting Defects in Mitochondrial Death Signaling

Rajani Ravi, Ephraim J. Fuchs, Ajay Jain, Vui Pham, Kiyoshi Yoshimura, Traci Prouser, Sanju Jalla, Xianzheng Zhou, Elizabeth Garrett-Mayer, Scott H. Kaufmann, Richard D. Schulick, Drew M. Pardoll, and Atul Bedi
Cancer Res 2006 66: 1730-1739. [Abstract] [Full Text] [PDF]  

Sulforaphane Sensitizes Tumor Necrosis Factor–Related Apoptosis-Inducing Ligand (TRAIL)–Resistant Hepatoma Cells to TRAIL-Induced Apoptosis through Reactive Oxygen Species–Mediated Up-regulation of DR5

Heesue Kim, Eun Hee Kim, Young Woo Eom, Wook-Hwan Kim, Taeg Kyu Kwon, Soo Jae Lee, and Kyeong Sook Choi
Cancer Res 2006 66: 1740-1750. [Abstract] [Full Text] [PDF] Supplementary Data  

Identification of Arctigenin as an Antitumor Agent Having the Ability to Eliminate the Tolerance of Cancer Cells to Nutrient Starvation

Suresh Awale, Jie Lu, Surya K. Kalauni, Yukiko Kurashima, Yasuhiro Tezuka, Shigetoshi Kadota, and Hiroyasu Esumi
Cancer Res 2006 66: 1751-1757. [Abstract] [Full Text] [PDF]  

The Cyclin-Dependent Kinase 2 Inhibitor Down-regulates Interleukin-1ß-Mediated Induction of Cyclooxygenase-2 Expression in Human Lung Carcinoma Cells

Partha Mukhopadhyay, M. Aktar Ali, Animesh Nandi, Peter Carreon, Hak Choy, and Debabrata Saha
Cancer Res 2006 66: 1758-1766. [Abstract] [Full Text] [PDF]  

A Novel Small-Molecule Inhibitor of Protein Kinase C Blocks Transformed Growth of Non–Small-Cell Lung Cancer Cells

Melody Stallings-Mann, Lee Jamieson, Roderick P. Regala, Capella Weems, Nicole R. Murray, and Alan P. Fields
Cancer Res 2006 66: 1767-1774. [Abstract] [Full Text] [PDF]  

The Immunomodulatory Benzodiazepine Bz-423 Inhibits B-Cell Proliferation by Targeting c-Myc Protein for Rapid and Specific Degradation

Thomas B. Sundberg, Gina M. Ney, Chitra Subramanian, Anthony W. Opipari, Jr., and Gary D. Glick
Cancer Res 2006 66: 1775-1782. [Abstract] [Full Text] [PDF] Supplementary Data  

Targeting Heat Shock Response to Sensitize Cancer Cells to Proteasome and Hsp90 Inhibitors

Nava Zaarur, Vladimir L. Gabai, John A. Porco, Jr., Stuart Calderwood, and Michael Y. Sherman
Cancer Res 2006 66: 1783-1791. [Abstract] [Full Text] [PDF]  

Immunology:

Application of Bayesian Modeling of Autologous Antibody Responses against Ovarian Tumor-Associated Antigens to Cancer Detection

Al Erkanli, Douglas D. Taylor, Deyrick Dean, Faria Eksir, Daniel Egger, James Geyer, Brad H. Nelson, Brad Stone, Herbert A. Fritsche, and Richard B.S. Roden
Cancer Res 2006 66: 1792-1798. [Abstract] [Full Text] [PDF] Supplementary Data  

The Anti–Human Leukocyte Antigen-DR Monoclonal Antibody 1D09C3 Activates the Mitochondrial Cell Death Pathway and Exerts a Potent Antitumor Activity in Lymphoma-Bearing Nonobese Diabetic/Severe Combined Immunodeficient Mice

Carmelo Carlo-Stella, Massimo Di Nicola, Maria Caterina Turco, Loredana Cleris, Cristiana Lavazza, Paolo Longoni, Marco Milanesi, Michele Magni, Massimo Ammirante, Arturo Leone, Zoltan Nagy, Walter R. Gioffrè, Franca Formelli, and Alessandro M. Gianni
Cancer Res 2006 66: 1799-1808. [Abstract] [Full Text] [PDF]  

An Essential Role of Antigen-Presenting Cell/T-Helper Type 1 Cell-Cell Interactions in Draining Lymph Node during Complete Eradication of Class II–Negative Tumor Tissue by T-Helper Type 1 Cell Therapy

Kenji Chamoto, Daiko Wakita, Yoshinori Narita, Yue Zhang, Daisuke Noguchi, Hideaki Ohnishi, Takeshi Iguchi, Tomoaki Sakai, Hiroaki Ikeda, and Takashi Nishimura
Cancer Res 2006 66: 1809-1817. [Abstract] [Full Text] [PDF]  

Identification and Epitope Enhancement of a PAX-FKHR Fusion Protein Breakpoint Epitope in Alveolar Rhabdomyosarcoma Cells Created by a Tumorigenic Chromosomal Translocation Inducing CTL Capable of Lysing Human Tumors

Leon T. van den Broeke, C. David Pendleton, Crystal Mackall, Lee J. Helman, and Jay A. Berzofsky
Cancer Res 2006 66: 1818-1823. [Abstract] [Full Text] [PDF]  

Endocrinology:

Defining the Role of Prolactin as an Invasion Suppressor Hormone in Breast Cancer Cells

Zaynab Nouhi, Naila Chughtai, Strachan Hartley, Eftihia Cocolakis, Jean-Jacques Lebrun, and Suhad Ali
Cancer Res 2006 66: 1824-1832. [Abstract] [Full Text] [PDF]  

Hepatocellular Neoplasms Induced by Low-Number Pancreatic Islet Transplants in Autoimmune Diabetic BB/Pfd Rats

Frank Dombrowski, Chantal Mathieu, and Matthias Evert
Cancer Res 2006 66: 1833-1843. [Abstract] [Full Text] [PDF]  

Clinical Research:

Discovering Clinical Biomarkers of Ionizing Radiation Exposure with Serum Proteomic Analysis

Cynthia Ménard, Donald Johann, Mark Lowenthal, Thierry Muanza, Mary Sproull, Sally Ross, James Gulley, Emanuel Petricoin, C. Norman Coleman, Gordon Whiteley, Lance Liotta, and Kevin Camphausen
Cancer Res 2006 66: 1844-1850. [Abstract] [Full Text] [PDF]  

Epidemiology and Prevention:

Soy Phytochemicals Prevent Orthotopic Growth and Metastasis of Bladder Cancer in Mice by Alterations of Cancer Cell Proliferation and Apoptosis and Tumor Angiogenesis

Ajita V. Singh, Adrian A. Franke, George L. Blackburn, and Jin-Rong Zhou
Cancer Res 2006 66: 1851-1858. [Abstract] [Full Text] [PDF]  

Red Meat Enhances the Colonic Formation of the DNA Adduct O⁶-Carboxymethyl Guanine: Implications for Colorectal Cancer Risk

Michelle H. Lewin, Nina Bailey, Tanya Bandaletova, Richard Bowman, Amanda J. Cross, Jim Pollock, David E.G. Shuker, and Sheila A. Bingham
Cancer Res 2006 66: 1859-1865. [Abstract] [Full Text] [PDF]  

Mammographic Density and Breast Cancer Risk in BRCA1 and BRCA2 Mutation Carriers

Gillian Mitchell, Antonis C. Antoniou, Ruth Warren, Susan Peock, Judith Brown, Russell Davies, Jenny Mattison, Margaret Cook, Iqbal Warsi, D. Gareth Evans, Diana Eccles, Fiona Douglas, Joan Paterson, Shirley Hodgson, Louise Izatt, Trevor Cole, Lucy Burgess, EMBRACE collaborators, Ros Eeles, and Douglas F. Easton
Cancer Res 2006 66: 1866-1872. [Abstract] [Full Text] [PDF]  

Thiazolidinediones Inhibit Insulin-Like Growth Factor-I–Induced Activation of p70S6 Kinase and Suppress Insulin-Like Growth Factor-I Tumor-Promoting Activity

Guobin He, You Me Sung, John DiGiovanni, and Susan M. Fischer
Cancer Res 2006 66: 1873-1878. [Abstract] [Full Text] [PDF] Supplementary Data  

Letter to the Editor:

Mitochondrial DNA G10398A Polymorphism and Invasive Breast Cancer in African-American Women

Martha P. Mims, Teresa G. Hayes, Shiyan Zheng, Suzanne M. Leal, Anna Frolov, Michael M. Ittmann, Thomas M. Wheeler, Josef T. Prchal, Jeffrey A. Canter, Asha R. Kallianpur, Fritz F. Parl, and Robert C. Millikan
Cancer Res 2006 66: 1880-1881. [Full Text] [PDF]  

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