Reviews:

Using Chemopreventive Agents to Enhance the Efficacy of Cancer Therapy

Fazlul H. Sarkar and Yiwei Li
Cancer Res 2006 66: 3347-3350. [Abstract] [Full Text] [PDF]  

Contributions of Human Tumor Xenografts to Anticancer Drug Development

Edward A. Sausville, Angelika M. Burger, Oren J. Becher, and Eric C. Holland
Cancer Res 2006 66: 3351-3354. [Abstract] [Full Text] [PDF]  

Genetically Engineered Models Have Advantages over Xenografts for Preclinical Studies

Oren J. Becher, Eric C. Holland, Edward A. Sausville, and Angelika M. Burger
Cancer Res 2006 66: 3355-3359. [Abstract] [Full Text] [PDF] Correction  

Priority Reports:

Onset of Abnormal Blood and Lymphatic Vessel Function and Interstitial Hypertension in Early Stages of Carcinogenesis

Jeroen Hagendoorn, Ricky Tong, Dai Fukumura, Qingcong Lin, Jennifer Lobo, Timothy P. Padera, Lei Xu, Raju Kucherlapati, and Rakesh K. Jain
Cancer Res 2006 66: 3360-3364. [Abstract] [Full Text] [PDF]  

N-cadherin Gene Expression in Prostate Carcinoma Is Modulated by Integrin-Dependent Nuclear Translocation of Twist1

Nelson R. Alexander, Nhan L. Tran, Harish Rekapally, Carol E. Summers, Carlotta Glackin, and Ronald L. Heimark
Cancer Res 2006 66: 3365-3369. [Abstract] [Full Text] [PDF]  

Prediction of Sensitivity of Rectal Cancer Cells in Response to Preoperative Radiotherapy by DNA Microarray Analysis of Gene Expression Profiles

Toshiaki Watanabe, Yasuhiro Komuro, Tomomichi Kiyomatsu, Takamitsu Kanazawa, Yoshihiro Kazama, Junichiro Tanaka, Toshiaki Tanaka, Yoko Yamamoto, Masatoshi Shirane, Tetsuichiro Muto, and Hirokazu Nagawa
Cancer Res 2006 66: 3370-3374. [Abstract] [Full Text] [PDF] Supplementary Data  

Akt-Mediated Phosphorylation and Activation of Estrogen Receptor Is Required for Endometrial Neoplastic Transformation in Pten^+/– Mice

Anna Vilgelm, Zenglin Lian, Hong Wang, Stephen L. Beauparlant, Andres Klein-Szanto, Lora Hedrick Ellenson, and Antonio Di Cristofano
Cancer Res 2006 66: 3375-3380. [Abstract] [Full Text] [PDF]  

Tumor B7-H1 Is Associated with Poor Prognosis in Renal Cell Carcinoma Patients with Long-term Follow-up

R. Houston Thompson, Susan M. Kuntz, Bradley C. Leibovich, Haidong Dong, Christine M. Lohse, W. Scott Webster, Shomik Sengupta, Igor Frank, Alexander S. Parker, Horst Zincke, Michael L. Blute, Thomas J. Sebo, John C. Cheville, and Eugene D. Kwon
Cancer Res 2006 66: 3381-3385. [Abstract] [Full Text] [PDF]  

Highly Efficacious Nontoxic Preclinical Treatment for Advanced Metastatic Breast Cancer Using Combination Oral UFT-Cyclophosphamide Metronomic Chemotherapy

Raquel Munoz, Shan Man, Yuval Shaked, Christina R. Lee, John Wong, Giulio Francia, and Robert S. Kerbel
Cancer Res 2006 66: 3386-3391. [Abstract] [Full Text] [PDF]  

Mitosis-Independent Survivin Gene Expression In vivo and Regulation by p53

Fang Xia and Dario C. Altieri
Cancer Res 2006 66: 3392-3395. [Abstract] [Full Text] [PDF]  

TMPRSS2:ETV4 Gene Fusions Define a Third Molecular Subtype of Prostate Cancer

Scott A. Tomlins, Rohit Mehra, Daniel R. Rhodes, Lisa R. Smith, Diane Roulston, Beth E. Helgeson, Xuhong Cao, John T. Wei, Mark A. Rubin, Rajal B. Shah, and Arul M. Chinnaiyan
Cancer Res 2006 66: 3396-3400. [Abstract] [Full Text] [PDF]  

Molecular Biology, Pathobiology, and Genetics:

Two Transforming C-RAF Germ-Line Mutations Identified in Patients with Therapy-Related Acute Myeloid Leukemia

Armin Zebisch, Philipp B. Staber, Ali Delavar, Claudia Bodner, Karin Hiden, Katja Fischereder, Manickam Janakiraman, Werner Linkesch, Holger W. Auner, Werner Emberger, Christian Windpassinger, Michael G. Schimek, Gerald Hoefler, Jakob Troppmair, and Heinz Sill
Cancer Res 2006 66: 3401-3408. [Abstract] [Full Text] [PDF]  

N-Methyl-D-Aspartate Receptor Type 2B Is Epigenetically Inactivated and Exhibits Tumor-Suppressive Activity in Human Esophageal Cancer

Myoung Sook Kim, Keishi Yamashita, Jin Hyen Baek, Hannah Lui Park, Andre Lopes Carvalho, Motonobu Osada, Mohammad Obaidul Hoque, Sunil Upadhyay, Masaki Mori, Chulso Moon, and David Sidransky
Cancer Res 2006 66: 3409-3418. [Abstract] [Full Text] [PDF] Supplementary Data  

3p21.3 Tumor Suppressor Gene H37/Luca15/RBM5 Inhibits Growth of Human Lung Cancer Cells through Cell Cycle Arrest and Apoptosis

Juliana J. Oh, Ali Razfar, Idolina Delgado, Rebecca A. Reed, Anna Malkina, Baher Boctor, and Dennis J. Slamon
Cancer Res 2006 66: 3419-3427. [Abstract] [Full Text] [PDF]  

Abnormal Gene Expression Profiles in Unaffected Parents of Patients with Hereditary-Type Retinoblastoma

Eric Y. Chuang, Xi Chen, Mong-Hsun Tsai, Hailing Yan, Chuan-Yuan Li, James B. Mitchell, Hatsumi Nagasawa, Paul F. Wilson, Yuanlin Peng, Markus M. Fitzek, Joel S. Bedford, and John B. Little
Cancer Res 2006 66: 3428-3433. [Abstract] [Full Text] [PDF]  

SOX4 Expression in Bladder Carcinoma: Clinical Aspects and In vitro Functional Characterization

Mads Aaboe, Karin Birkenkamp-Demtroder, Carsten Wiuf, Flemming Brandt Sørensen, Thomas Thykjaer, Guido Sauter, Klaus Møller-Ernst Jensen, Lars Dyrskjøt, and Torben Ørntoft
Cancer Res 2006 66: 3434-3442. [Abstract] [Full Text] [PDF] Supplementary Data  

A Single Nucleotide Polymorphism Chip-Based Method for Combined Genetic and Epigenetic Profiling: Validation in Decitabine Therapy and Tumor/Normal Comparisons

Eric Yuan, Fatemeh Haghighi, Susan White, Ramiro Costa, Julie McMinn, Kathy Chun, Mark Minden, and Benjamin Tycko
Cancer Res 2006 66: 3443-3451. [Abstract] [Full Text] [PDF] Supplementary Data  

Frequent Met Oncogene Amplification in a Brca1/Trp53 Mouse Model of Mammary Tumorigenesis

Gromoslaw A. Smolen, Beth Muir, Gayatry Mohapatra, Anne Barmettler, Woo J. Kim, Miguel N. Rivera, Sara M. Haserlat, Ross A. Okimoto, Eunice Kwak, Sonika Dahiya, Judy E. Garber, Daphne W. Bell, Dennis C. Sgroi, Lynda Chin, Chu-Xia Deng, and Daniel A. Haber
Cancer Res 2006 66: 3452-3455. [Abstract] [Full Text] [PDF] Supplementary Data  

Targeted Ablation of Par-4 Reveals a Cell Type–Specific Susceptibility to Apoptosis-Inducing Agents

El Bachir Affar, Margaret Po-shan Luke, Frédérique Gay, Dominica Calvo, Guangchao Sui, Robert S. Weiss, En Li, and Yang Shi
Cancer Res 2006 66: 3456-3462. [Abstract] [Full Text] [PDF]  

Mouse Double Minute 2 Associates with Chromatin in the Presence of p53 and Is Released to Facilitate Activation of Transcription

David E. White, Kathryn E. Talbott, Nicoleta C. Arva, and Jill Bargonetti
Cancer Res 2006 66: 3463-3470. [Abstract] [Full Text] [PDF]  

Combined Array-Comparative Genomic Hybridization and Single-Nucleotide Polymorphism-Loss of Heterozygosity Analysis Reveals Complex Changes and Multiple Forms of Chromosomal Instability in Colorectal Cancers

Michelle Gaasenbeek, Kimberley Howarth, Andrew J. Rowan, Patricia A. Gorman, Angela Jones, Tracy Chaplin, Ying Liu, David Bicknell, Eleanor J. Davison, Heike Fiegler, Nigel P. Carter, Rebecca R. Roylance, and Ian P.M. Tomlinson
Cancer Res 2006 66: 3471-3479. [Abstract] [Full Text] [PDF] Supplementary Data  

Carcinogenic Cr(VI) and the Nutritional Supplement Cr(III) Induce DNA Deletions in Yeast and Mice

Zhanna Kirpnick-Sobol, Ramune Reliene, and Robert H. Schiestl
Cancer Res 2006 66: 3480-3484. [Abstract] [Full Text] [PDF]  

The p53 Pathway Promotes Efficient Mitochondrial DNA Base Excision Repair in Colorectal Cancer Cells

Dexi Chen, Zhiyong Yu, Zhiyi Zhu, and Charles D. Lopez
Cancer Res 2006 66: 3485-3494. [Abstract] [Full Text] [PDF]  

Cell, Tumor, and Stem Cell Biology:

Distinct Tumor Stage–Specific Inhibitory Effects of 2-Methoxyestradiol in a Breast Cancer Mouse Model Associated with Id-1 Expression

Jung-Im Huh, Alfonso Calvo, Rhonda Charles, and Jeffrey E. Green
Cancer Res 2006 66: 3495-3503. [Abstract] [Full Text] [PDF]  

Gastrin Enhances the Angiogenic Potential of Endothelial Cells via Modulation of Heparin-Binding Epidermal-Like Growth Factor

Philip A. Clarke, Jacqueline H. Dickson, Joseph C. Harris, Anna Grabowska, and Susan A. Watson
Cancer Res 2006 66: 3504-3512. [Abstract] [Full Text] [PDF]  

Adenoviral Gene Transfer of Stromal Cell–Derived Factor-1 to Murine Tumors Induces the Accumulation of Dendritic Cells and Suppresses Tumor Growth

Toshiaki Fushimi, Timothy P. O'Connor, and Ronald G. Crystal
Cancer Res 2006 66: 3513-3522. [Abstract] [Full Text] [PDF]  

Growth and Motility Inhibition of Breast Cancer Cells by Epidermal Growth Factor Receptor Degradation Is Correlated with Inactivation of Cdc42

Dianne S. Hirsch, Yi Shen, and Wen Jin Wu
Cancer Res 2006 66: 3523-3530. [Abstract] [Full Text] [PDF]  

hTERT-Immortalized Prostate Epithelial and Stromal-Derived Cells: an Authentic In vitro Model for Differentiation and Carcinogenesis

Ira Kogan, Naomi Goldfinger, Michael Milyavsky, Merav Cohen, Igor Shats, Gabriele Dobler, Helmut Klocker, Bohdan Wasylyk, Maureen Voller, Tilly Aalders, Jack A. Schalken, Moshe Oren, and Varda Rotter
Cancer Res 2006 66: 3531-3540. [Abstract] [Full Text] [PDF] Supplementary Data  

Silenced Tumor Suppressor Genes Reactivated by DNA Demethylation Do Not Return to a Fully Euchromatic Chromatin State

Kelly M. McGarvey, Jill A. Fahrner, Eriko Greene, Joost Martens, Thomas Jenuwein, and Stephen B. Baylin
Cancer Res 2006 66: 3541-3549. [Abstract] [Full Text] [PDF]  

Constitutive Activation of Extracellular Signal-Regulated Kinase Predisposes Diffuse Large B-Cell Lymphoma Cell Lines to CD40-Mediated Cell Death

C. Annette Hollmann, Trevor Owens, Josephine Nalbantoglu, Thomas J. Hudson, and Robert Sladek
Cancer Res 2006 66: 3550-3557. [Abstract] [Full Text] [PDF] Supplementary Data  

Chemical Enhancers of Cytokine Signaling that Suppress Microfilament Turnover and Tumor Cell Growth

Hyun-Joo Park, Emily Partridge, Pam Cheung, Judy Pawling, Rob Donovan, Jeffrey L. Wrana, and James W. Dennis
Cancer Res 2006 66: 3558-3566. [Abstract] [Full Text] [PDF]  

Regulation of E-cadherin Expression by VHL and Hypoxia-Inducible Factor

Miguel A. Esteban, Maxine G.B. Tran, Sarah K. Harten, Peter Hill, Maria C. Castellanos, Ashish Chandra, Raju Raval, Tim S. O'Brien, and Patrick H. Maxwell
Cancer Res 2006 66: 3567-3575. [Abstract] [Full Text] [PDF]  

Inactivation of Conditional Rb by Villin-Cre Leads to Aggressive Tumors outside the Gastrointestinal Tract

Melanie H. Kucherlapati, Andrew A. Nguyen, Roderick T. Bronson, and Raju S. Kucherlapati
Cancer Res 2006 66: 3576-3583. [Abstract] [Full Text] [PDF]  

Telomerase- and Alternative Telomere Lengthening–Independent Telomere Stabilization in a Metastasis-Derived Human Non–Small Cell Lung Cancer Cell Line: Effect of Ectopic hTERT

Andreas Brachner, Soleman Sasgary, Christine Pirker, Chantal Rodgarkia, Mario Mikula, Wolfgang Mikulits, Helga Bergmeister, Ulrike Setinek, Matthias Wieser, Suet-Feung Chin, Carlos Caldas, Michael Micksche, Christa Cerni, and Walter Berger
Cancer Res 2006 66: 3584-3592. [Abstract] [Full Text] [PDF]  

FoxM1B Is Overexpressed in Human Glioblastomas and Critically Regulates the Tumorigenicity of Glioma Cells

Mingguang Liu, Bingbing Dai, Shin-Hyuk Kang, Kechen Ban, Feng-Ju Huang, Frederick F. Lang, Kenneth D. Aldape, Tong-xin Xie, Christopher E. Pelloski, Keping Xie, Raymond Sawaya, and Suyun Huang
Cancer Res 2006 66: 3593-3602. [Abstract] [Full Text] [PDF]  

A Novel Endocytic Mechanism of Epidermal Growth Factor Receptor Sequestration and Internalization

James D. Orth, Eugene W. Krueger, Shaun G. Weller, and Mark A. McNiven
Cancer Res 2006 66: 3603-3610. [Abstract] [Full Text] [PDF] Supplementary Data  

Antibodies Neutralizing Hepsin Protease Activity Do Not Impact Cell Growth but Inhibit Invasion of Prostate and Ovarian Tumor Cells in Culture

Jian-Ai Xuan, Doug Schneider, Pam Toy, Rick Lin, Alicia Newton, Ying Zhu, Silke Finster, David Vogel, Bob Mintzer, Harald Dinter, David Light, Renate Parry, Mark Polokoff, Marc Whitlow, Qingyu Wu, and Gordon Parry
Cancer Res 2006 66: 3611-3619. [Abstract] [Full Text] [PDF]  

Osteoprotegerin Overexpression by Breast Cancer Cells Enhances Orthotopic and Osseous Tumor Growth and Contrasts with That Delivered Therapeutically

Jane L. Fisher, Rachel J. Thomas-Mudge, Jan Elliott, Daphne K. Hards, Natalie A. Sims, John Slavin, T. John Martin, and Matthew T. Gillespie
Cancer Res 2006 66: 3620-3628. [Abstract] [Full Text] [PDF]  

Cannibalism of Live Lymphocytes by Human Metastatic but Not Primary Melanoma Cells

Luana Lugini, Paola Matarrese, Antonella Tinari, Francesco Lozupone, Cristina Federici, Elisabetta Iessi, Massimo Gentile, Francesca Luciani, Giorgio Parmiani, Licia Rivoltini, Walter Malorni, and Stefano Fais
Cancer Res 2006 66: 3629-3638. [Abstract] [Full Text] [PDF] Supplementary Data  

Targeted Anti–Vascular Endothelial Growth Factor Receptor-2 Therapy Leads to Short-term and Long-term Impairment of Vascular Function and Increase in Tumor Hypoxia

Marcela Franco, Shan Man, Limor Chen, Urban Emmenegger, Yuval Shaked, Alison M. Cheung, Allison S. Brown, Daniel J. Hicklin, F. Stuart Foster, and Robert S. Kerbel
Cancer Res 2006 66: 3639-3648. [Abstract] [Full Text] [PDF] Supplementary Data  

Signal Transducer and Activator of Transcription 1 Activation in Endothelial Cells Is a Negative Regulator of Angiogenesis

Traci E. Battle, Rebecca A. Lynch, and David A. Frank
Cancer Res 2006 66: 3649-3657. [Abstract] [Full Text] [PDF]  

Immortalization of Primary Endothelial Cells by the K1 Protein of Kaposi's Sarcoma–Associated Herpesvirus

Ling Wang, Dirk P. Dittmer, Christine C. Tomlinson, Farnaz D. Fakhari, and Blossom Damania
Cancer Res 2006 66: 3658-3666. [Abstract] [Full Text] [PDF]  

Estrogen Induces Lung Metastasis through a Host Compartment–Specific Response

Carole L. Banka, Caren V. Lund, Mai T.N. Nguyen, Andrew J. Pakchoian, Barbara M. Mueller, and Brian P. Eliceiri
Cancer Res 2006 66: 3667-3672. [Abstract] [Full Text] [PDF]  

High-Resolution Analysis of Chromosomal Breakpoints and Genomic Instability Identifies PTPRD as a Candidate Tumor Suppressor Gene in Neuroblastoma

Raymond L. Stallings, Prakash Nair, John M. Maris, Daniel Catchpoole, Michael McDermott, Anne O'Meara, and Fin Breatnach
Cancer Res 2006 66: 3673-3680. [Abstract] [Full Text] [PDF] Supplementary Data  

-Secretase-Dependent Proteolysis of CD44 Promotes Neoplastic Transformation of Rat Fibroblastic Cells

Ludivine Pelletier, Patricia Guillaumot, Barbara Frêche, Céline Luquain, Dale Christiansen, Sabine Brugière, Jérome Garin, and Serge N. Manié
Cancer Res 2006 66: 3681-3687. [Abstract] [Full Text] [PDF]  

The Oxygen Sensor Factor-Inhibiting Hypoxia-Inducible Factor-1 Controls Expression of Distinct Genes through the Bifunctional Transcriptional Character of Hypoxia-Inducible Factor-1

Frédéric Dayan, Danièle Roux, M. Christiane Brahimi-Horn, Jacques Pouyssegur, and Nathalie M. Mazure
Cancer Res 2006 66: 3688-3698. [Abstract] [Full Text] [PDF]  

Inactivation of von Hippel-Lindau Gene Induces Constitutive Phosphorylation of MET Protein in Clear Cell Renal Carcinoma

Noboru Nakaigawa, Masahiro Yao, Masaya Baba, Shingo Kato, Takeshi Kishida, Keiko Hattori, Yoji Nagashima, and Yoshinobu Kubota
Cancer Res 2006 66: 3699-3705. [Abstract] [Full Text] [PDF]  

Estrogen Up-regulates Neuropeptide Y Y1 Receptor Expression in a Human Breast Cancer Cell Line

Hassane Amlal, Somia Faroqui, Ambikaipakan Balasubramaniam, and Sulaiman Sheriff
Cancer Res 2006 66: 3706-3714. [Abstract] [Full Text] [PDF]  

ERBB2-Mediated Transcriptional Up-regulation of the 5ß1 Integrin Fibronectin Receptor Promotes Tumor Cell Survival Under Adverse Conditions

Christian Spangenberg, Ekkehart U. Lausch, Tatjana M. Trost, Dirk Prawitt, Andreas May, Romy Keppler, Stephan A. Fees, Dirk Reutzel, Carolin Bell, Steffen Schmitt, Ilka B. Schiffer, Achim Weber, Walburgis Brenner, Matthias Hermes, Ugur Sahin, Özlem Türeci, Heinz Koelbl, Jan G. Hengstler, and Bernhard U. Zabel
Cancer Res 2006 66: 3715-3725. [Abstract] [Full Text] [PDF]  

Cyclooxygenase 2 Rescues LNCaP Prostate Cancer Cells from Sanguinarine-Induced Apoptosis by a Mechanism Involving Inhibition of Nitric Oxide Synthase Activity

Jacob Huh, Andrejs Liepins, Jacek Zielonka, Christopher Andrekopoulos, Balaraman Kalyanaraman, and Andrey Sorokin
Cancer Res 2006 66: 3726-3736. [Abstract] [Full Text] [PDF] Supplementary Data  

Experimental Therapeutics, Molecular Targets, and Chemical Biology:

Simultaneous Inhibition of PDK1/AKT and Fms-Like Tyrosine Kinase 3 Signaling by a Small-Molecule KP372-1 Induces Mitochondrial Dysfunction and Apoptosis in Acute Myelogenous Leukemia

Zhihong Zeng, Ismael J. Samudio, Weiguo Zhang, Zeev Estrov, Hélène Pelicano, David Harris, Olga Frolova, Numsen Hail, Jr., Wenjing Chen, Steven M. Kornblau, Peng Huang, Yiling Lu, Gordon B. Mills, Michael Andreeff, and Marina Konopleva
Cancer Res 2006 66: 3737-3746. [Abstract] [Full Text] [PDF]  

Improvement of the Tumor-Suppressive Effect of Boron Neutron Capture Therapy for Amelanotic Melanoma by Intratumoral Injection of the Tyrosinase Gene

Norimasa Morita, Junichi Hiratsuka, Hirohumi Kondoh, Masako Uno, Tomoyuki Asano, Yoko Niki, Yoshinori Sakurai, Koji Ono, Tamotsu Harada, and Yoshinari Imajo
Cancer Res 2006 66: 3747-3753. [Abstract] [Full Text] [PDF]  

Ubiquitin-Proteasome System Stress Sensitizes Ovarian Cancer to Proteasome Inhibitor–Induced Apoptosis

Martina Bazzaro, Michael K. Lee, Alessia Zoso, Wanda L.H. Stirling, Antonio Santillan, Ie-Ming Shih, and Richard B.S. Roden
Cancer Res 2006 66: 3754-3763. [Abstract] [Full Text] [PDF] Supplementary Data  

Selective Inhibition of ErbB2-Overexpressing Breast Cancer In vivo by a Novel TAT-Based ErbB2-Targeting Signal Transducers and Activators of Transcription 3–Blocking Peptide

Ming Tan, Keng-Hsueh Lan, Jun Yao, Chien-Hsing Lu, Menghong Sun, Christopher L. Neal, Jing Lu, and Dihua Yu
Cancer Res 2006 66: 3764-3772. [Abstract] [Full Text] [PDF] Supplementary Data  

Aggresome Disruption: A Novel Strategy to Enhance Bortezomib-Induced Apoptosis in Pancreatic Cancer Cells

Steffan T. Nawrocki, Jennifer S. Carew, Maria S. Pino, Ralph A. Highshaw, Robert H.I. Andtbacka, Kenneth Dunner, Jr., Ashutosh Pal, William G. Bornmann, Paul J. Chiao, Peng Huang, Henry Xiong, James L. Abbruzzese, and David J. McConkey
Cancer Res 2006 66: 3773-3781. [Abstract] [Full Text] [PDF]  

Rational Design of the Microtubule-Targeting Anti–Breast Cancer Drug EM015

Ritu Aneja, Manu Lopus, Jun Zhou, Surya N. Vangapandu, Amr Ghaleb, Joyce Yao, James H. Nettles, Binfei Zhou, Meenakshi Gupta, Dulal Panda, Ramesh Chandra, and Harish C. Joshi
Cancer Res 2006 66: 3782-3791. [Abstract] [Full Text] [PDF]  

The Influence of a Human Embryonic Stem Cell–Derived Microenvironment on Targeting of Human Solid Tumor Xenografts

Maty Tzukerman, Tzur Rosenberg, Irena Reiter, Shoshana Ben-Eliezer, Galit Denkberg, Raymond Coleman, Yoram Reiter, and Karl Skorecki
Cancer Res 2006 66: 3792-3801. [Abstract] [Full Text] [PDF] Supplementary Data  

Transforming Growth Factor Expression Drives Constitutive Epidermal Growth Factor Receptor Pathway Activation and Sensitivity to Gefitinib (Iressa) in Human Pancreatic Cancer Cell Lines

Maria S. Pino, Marissa Shrader, Cheryl H. Baker, Francesco Cognetti, Henry Q. Xiong, James L. Abbruzzese, and David J. McConkey
Cancer Res 2006 66: 3802-3812. [Abstract] [Full Text] [PDF]  

Testicular Xenografts: A Novel Approach to Study Cytotoxic Damage in Juvenile Primate Testis

Kirsi Jahnukainen, Jens Ehmcke, and Stefan Schlatt
Cancer Res 2006 66: 3813-3818. [Abstract] [Full Text] [PDF]  

Targeting the RNA Splicing Machinery as a Novel Treatment Strategy for Pancreatic Carcinoma

Gregory M. Hayes, Patricia E. Carrigan, Alison M. Beck, and Laurence J. Miller
Cancer Res 2006 66: 3819-3827. [Abstract] [Full Text] [PDF]  

Targeting PIM Kinases Impairs Survival of Hematopoietic Cells Transformed by Kinase Inhibitor–Sensitive and Kinase Inhibitor–Resistant Forms of Fms-Like Tyrosine Kinase 3 and BCR/ABL

Myriam Adam, Vanda Pogacic, Marina Bendit, Richard Chappuis, Martijn C. Nawijn, Justus Duyster, Casey J. Fox, Craig B. Thompson, Jan Cools, and Juerg Schwaller
Cancer Res 2006 66: 3828-3835. [Abstract] [Full Text] [PDF]  

5-Amino-4-Imidazolecarboxamide Riboside Potentiates Both Transport of Reduced Folates and Antifolates by the Human Reduced Folate Carrier and Their Subsequent Metabolism

John J. McGuire, William H. Haile, and Chen-Chen Yeh
Cancer Res 2006 66: 3836-3844. [Abstract] [Full Text] [PDF]  

Hydroxyurea Induces Bystander Cytotoxicity in Cocultures of Herpes Simplex Virus Thymidine Kinase–Expressing and Nonexpressing HeLa Cells Incubated with Ganciclovir

Brian G. Gentry, Paul D. Boucher, and Donna S. Shewach
Cancer Res 2006 66: 3845-3851. [Abstract] [Full Text] [PDF]  

Immunology:

Regeneration and Tolerance Factor: A Novel Mediator of Glioblastoma-Associated Immunosuppression

Patrick Roth, Steffen Aulwurm, Isabella Gekel, Dagmar Beier, Roxanne G. Sperry, Michel Mittelbronn, Richard Meyermann, Kenneth D. Beaman, Michael Weller, and Jörg Wischhusen
Cancer Res 2006 66: 3852-3858. [Abstract] [Full Text] [PDF]  

TLR-4 Signaling Promotes Tumor Growth and Paclitaxel Chemoresistance in Ovarian Cancer

Michael G. Kelly, Ayesha B. Alvero, Rui Chen, Dan-Arin Silasi, Vikki M. Abrahams, Serena Chan, Irene Visintin, Thomas Rutherford, and Gil Mor
Cancer Res 2006 66: 3859-3868. [Abstract] [Full Text] [PDF]  

CD1d-Restricted Natural Killer T Cells Can Down-regulate Tumor Immunosurveillance Independent of Interleukin-4 Receptor-Signal Transducer and Activator of Transcription 6 or Transforming Growth Factor-ß

Masaki Terabe, Chand Khanna, Seuli Bose, Fraia Melchionda, Arnulfo Mendoza, Crystal L. Mackall, Lee J. Helman, and Jay A. Berzofsky
Cancer Res 2006 66: 3869-3875. [Abstract] [Full Text] [PDF]  

Complement Activated by Chimeric Anti–Folate Receptor Antibodies Is an Efficient Effector System to Control Ovarian Carcinoma

Paolo Macor, Delia Mezzanzanica, Chiara Cossetti, Paola Alberti, Mariangela Figini, Silvana Canevari, and Francesco Tedesco
Cancer Res 2006 66: 3876-3883. [Abstract] [Full Text] [PDF]  

A Genetically Engineered Anti-CD45 Single-Chain Antibody-Streptavidin Fusion Protein for Pretargeted Radioimmunotherapy of Hematologic Malignancies

Yukang Lin, John M. Pagel, Donald Axworthy, Anastasia Pantelias, Nathan Hedin, and Oliver W. Press
Cancer Res 2006 66: 3884-3892. [Abstract] [Full Text] [PDF]  

Endocrinology:

The Transcription Factor ZEB1 Is Aberrantly Expressed in Aggressive Uterine Cancers

Nicole S. Spoelstra, Nicole G. Manning, Yujiro Higashi, Douglas Darling, Meenakshi Singh, Kenneth R. Shroyer, Russell R. Broaddus, Kathryn B. Horwitz, and Jennifer K. Richer
Cancer Res 2006 66: 3893-3902. [Abstract] [Full Text] [PDF]  

Activation of Mitogen-Activated Protein Kinase in Estrogen Receptor –Positive Breast Cancer Cells In vitro Induces an In vivo Molecular Phenotype of Estrogen Receptor –Negative Human Breast Tumors

Chad J. Creighton, Amy M. Hilger, Shalini Murthy, James M. Rae, Arul M. Chinnaiyan, and Dorraya El-Ashry
Cancer Res 2006 66: 3903-3911. [Abstract] [Full Text] [PDF]  

Gonadotropins Activate Proteolysis and Increase Invasion through Protein Kinase A and Phosphatidylinositol 3-Kinase Pathways in Human Epithelial Ovarian Cancer Cells

Jung-Hye Choi, Kyung-Chul Choi, Nelly Auersperg, and Peter C.K. Leung
Cancer Res 2006 66: 3912-3920. [Abstract] [Full Text] [PDF]  

Clinical Research:

PGP9.5 Methylation in Diffuse-Type Gastric Cancer

Keishi Yamashita, Hannah Lui Park, Myoung Sook Kim, Motonobu Osada, Yutaka Tokumaru, Hiroshi Inoue, Masaki Mori, and David Sidransky
Cancer Res 2006 66: 3921-3927. [Abstract] [Full Text] [PDF] Supplementary Data  

Transcription Analysis of Human Equilibrative Nucleoside Transporter-1 Predicts Survival in Pancreas Cancer Patients Treated with Gemcitabine

Elisa Giovannetti, Mario Del Tacca, Valentina Mey, Niccola Funel, Sara Nannizzi, Sergio Ricci, Cinzia Orlandini, Ugo Boggi, Daniela Campani, Marco Del Chiaro, Mauro Iannopollo, Generoso Bevilacqua, Franco Mosca, and Romano Danesi
Cancer Res 2006 66: 3928-3935. [Abstract] [Full Text] [PDF]  

Epidemiology and Prevention:

Early Loss of Fhit in the Respiratory Tract of Rodents Exposed to Environmental Cigarette Smoke

Francesco D'Agostini, Alberto Izzotti, Roumen Balansky, Nicola Zanesi, Carlo M. Croce, and Silvio De Flora
Cancer Res 2006 66: 3936-3941. [Abstract] [Full Text] [PDF]  

Fruit and Vegetable Consumption and Colorectal Adenomas in the Nurses' Health Study

Karin B. Michels, Edward Giovannucci, Andrew T. Chan, Rohit Singhania, Charles S. Fuchs, and Walter C. Willett
Cancer Res 2006 66: 3942-3953. [Abstract] [Full Text] [PDF]  

Letters to the Editor:

Sleep Duration, Melatonin, and Breast Cancer: Compliment and Complement

Thomas C. Erren, Pia K. Verkasalo, Kirsi Lillberg, Richard G. Stevens, Christer Hublin, Markku Partinen, Markku Koskenvuo, and Jaakko Kaprio
Cancer Res 2006 66: 3954. [Full Text] [PDF]  

It's Erren's Brainchild, Folks!

Alexander Lerchl
Cancer Res 2006 66: 3954-3955. [Full Text] [PDF]  

Genomic Analysis of Tumors by Array Comparative Genomic Hybridization: More Is Better

Donna G. Albertson, Antoine M. Snijders, Jane Fridlyand, Richard Jordan, Daniel Pinkel, Brian L. Schmidt, Corisande Baldwin, Cathie Garnis, Lewei Zhang, Miriam Rosin, and Wan L. Lam
Cancer Res 2006 66: 3955-3956. [Full Text] [PDF]  

Correction:

CXCR4 in Peritoneal Carcinomatosis of Gastric Carcinoma

Cancer Res 2006 66: 3957. [Full Text] [PDF]  

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