Reviews:

The DNA Damage Response Arouses the Immune System

Stephan Gasser and David H. Raulet
Cancer Res 2006 66: 3959-3962. [Abstract] [Full Text] [PDF]  

Akt Signaling and Cancer: Surviving but not Moving On

Alex Toker and Merav Yoeli-Lerner
Cancer Res 2006 66: 3963-3966. [Abstract] [Full Text] [PDF]  

Meeting Report:

Antiangiogenesis and Drug Delivery to Tumors: Bench to Bedside and Back

Dan G. Duda
Cancer Res 2006 66: 3967-3970. [Abstract] [Full Text] [PDF]  

Priority Reports:

Placenta Growth Factor Overexpression Inhibits Tumor Growth, Angiogenesis, and Metastasis by Depleting Vascular Endothelial Growth Factor Homodimers in Orthotopic Mouse Models

Lei Xu, David M. Cochran, Ricky T. Tong, Frank Winkler, Satoshi Kashiwagi, Rakesh K. Jain, and Dai Fukumura
Cancer Res 2006 66: 3971-3977. [Abstract] [Full Text] [PDF]  

Methylation of the IL-12Rß2 Gene as Novel Tumor Escape Mechanism for Pediatric B-Acute Lymphoblastic Leukemia Cells

Irma Airoldi, Claudia Cocco, Emma Di Carlo, Silvia Disarò, Emanuela Ognio, Giuseppe Basso, and Vito Pistoia
Cancer Res 2006 66: 3978-3980. [Abstract] [Full Text] [PDF]  

Reactivation of Developmentally Expressed p63 Isoforms Predisposes to Tumor Development and Progression

Maranke I. Koster, Shi-Long Lu, Lisa D. White, Xiao-Jing Wang, and Dennis R. Roop
Cancer Res 2006 66: 3981-3986. [Abstract] [Full Text] [PDF]  

A Hypermutation Phenotype and Somatic MSH6 Mutations in Recurrent Human Malignant Gliomas after Alkylator Chemotherapy

Chris Hunter, Raffaella Smith, Daniel P. Cahill, Philip Stephens, Claire Stevens, Jon Teague, Chris Greenman, Sarah Edkins, Graham Bignell, Helen Davies, Sarah O'Meara, Adrian Parker, Tim Avis, Syd Barthorpe, Lisa Brackenbury, Gemma Buck, Adam Butler, Jody Clements, Jennifer Cole, Ed Dicks, Simon Forbes, Matthew Gorton, Kristian Gray, Kelly Halliday, Rachel Harrison, Katy Hills, Jonathon Hinton, Andy Jenkinson, David Jones, Vivienne Kosmidou, Ross Laman, Richard Lugg, Andrew Menzies, Janet Perry, Robert Petty, Keiran Raine, David Richardson, Rebecca Shepherd, Alexandra Small, Helen Solomon, Calli Tofts, Jennifer Varian, Sofie West, Sara Widaa, Andy Yates, Douglas F. Easton, Gregory Riggins, Jennifer E. Roy, Kymberly K. Levine, Wolf Mueller, Tracy T. Batchelor, David N. Louis, Michael R. Stratton, P. Andrew Futreal, and Richard Wooster
Cancer Res 2006 66: 3987-3991. [Abstract] [Full Text] [PDF] Supplementary Data  

KRAS Mutation Status Is Predictive of Response to Cetuximab Therapy in Colorectal Cancer

Astrid Lièvre, Jean-Baptiste Bachet, Delphine Le Corre, Valérie Boige, Bruno Landi, Jean-François Emile, Jean-François Côté, Gorana Tomasic, Christophe Penna, Michel Ducreux, Philippe Rougier, Frédérique Penault-Llorca, and Pierre Laurent-Puig
Cancer Res 2006 66: 3992-3995. [Abstract] [Full Text] [PDF]  

Immunoglobulin Heavy Chain Locus Events and Expression of Activation-Induced Cytidine Deaminase in Epithelial Breast Cancer Cell Lines

Gavin Babbage, Christian H. Ottensmeier, Jeremy Blaydes, Freda K. Stevenson, and Surinder S. Sahota
Cancer Res 2006 66: 3996-4000. [Abstract] [Full Text] [PDF]  

Molecular Biology, Pathobiology, and Genetics:

Multiple Adaptive Mechanisms to Chronic Liver Disease Revealed at Early Stages of Liver Carcinogenesis in the Mdr2-Knockout Mice

Mark Katzenellenbogen, Orit Pappo, Hila Barash, Naama Klopstock, Lina Mizrahi, Devorah Olam, Jasmine Jacob-Hirsch, Ninette Amariglio, Gidi Rechavi, Leslie Ann Mitchell, Ron Kohen, Eytan Domany, Eithan Galun, and Daniel Goldenberg
Cancer Res 2006 66: 4001-4010. [Abstract] [Full Text] [PDF] Supplementary Data  

Sex-Determining Region Y Box 4 Is a Transforming Oncogene in Human Prostate Cancer Cells

Pengbo Liu, Sumathi Ramachandran, Mohamed Ali Seyed, Christopher D. Scharer, Noelani Laycock, W. Brian Dalton, Holly Williams, Suresh Karanam, Milton W. Datta, David L. Jaye, and Carlos S. Moreno
Cancer Res 2006 66: 4011-4019. [Abstract] [Full Text] [PDF] Supplementary Data  

Suppression of Centrosome Amplification after DNA Damage Depends on p27 Accumulation

Eiji Sugihara, Masayuki Kanai, Soichiro Saito, Takayuki Nitta, Hideo Toyoshima, Keiko Nakayama, Keiichi I. Nakayama, Kenji Fukasawa, Manfred Schwab, Hideyuki Saya, and Masanao Miwa
Cancer Res 2006 66: 4020-4029. [Abstract] [Full Text] [PDF]  

Subtractive Transcriptomics: Establishing Polarity Drives In vitro Human Endothelial Morphogenesis

David A. Glesne, Wen Zhang, Suneeta Mandava, Lyann Ursos, Margaret E. Buell, Lee Makowski, and Diane J. Rodi
Cancer Res 2006 66: 4030-4040. [Abstract] [Full Text] [PDF] Supplementary Data  

Chronic Exposure to Lead Chromate Causes Centrosome Abnormalities and Aneuploidy in Human Lung Cells

Amie L. Holmes, Sandra S. Wise, Sarah J. Sandwick, Wilma L. Lingle, Vivian C. Negron, W. Douglas Thompson, and John Pierce Wise, Sr.
Cancer Res 2006 66: 4041-4048. [Abstract] [Full Text] [PDF]  

Cohypermethylation of p16 and FHIT Promoters as a Prognostic Factor of Recurrence in Surgically Resected Stage I Non–Small Cell Lung Cancer

Jin Seuk Kim, Jin Wook Kim, Joungho Han, Young Mog Shim, Joobae Park, and Duk-Hwan Kim
Cancer Res 2006 66: 4049-4054. [Abstract] [Full Text] [PDF]  

Detection of Recurrent Copy Number Loss at Yp11.2 Involving TSPY Gene Cluster in Prostate Cancer Using Array-Based Comparative Genomic Hybridization

Sapna Vijayakumar, Devon C. Hall, Xavier T. Reveles, Dean A. Troyer, Ian M. Thompson, Dawn Garcia, RuiHua Xiang, Robin J. Leach, Teresa L. Johnson-Pais, and Susan L. Naylor
Cancer Res 2006 66: 4055-4064. [Abstract] [Full Text] [PDF]  

Combined cDNA Array Comparative Genomic Hybridization and Serial Analysis of Gene Expression Analysis of Breast Tumor Progression

Jun Yao, Stanislawa Weremowicz, Bin Feng, Robert C. Gentleman, Jeffrey R. Marks, Rebecca Gelman, Cameron Brennan, and Kornelia Polyak
Cancer Res 2006 66: 4065-4078. [Abstract] [Full Text] [PDF] Supplementary Data  

Two-Dimensional Transcriptome Profiling: Identification of Messenger RNA Isoform Signatures in Prostate Cancer from Archived Paraffin-Embedded Cancer Specimens

Hai-Ri Li, Jessica Wang-Rodriguez, T. Murlidharan Nair, Joanne M. Yeakley, Young-Soo Kwon, Marina Bibikova, Christina Zheng, Lixin Zhou, Kui Zhang, Tracy Downs, Xiang-Dong Fu, and Jian-Bing Fan
Cancer Res 2006 66: 4079-4088. [Abstract] [Full Text] [PDF] Supplementary Data  

Targeting Oncogenes to Improve Breast Cancer Chemotherapy

Laura A. Christensen, Rick A. Finch, Adam J. Booker, and Karen M. Vasquez
Cancer Res 2006 66: 4089-4094. [Abstract] [Full Text] [PDF]  

Identification of EZH2 as a Molecular Marker for a Precancerous State in Morphologically Normal Breast Tissues

Lei Ding, Christine Erdmann, Arul M. Chinnaiyan, Sofia D. Merajver, and Celina G. Kleer
Cancer Res 2006 66: 4095-4099. [Abstract] [Full Text] [PDF] Supplementary Data  

Identification of Domains of BRCA1 Critical for the Ubiquitin-Dependent Inhibition of Centrosome Function

Satish Sankaran, Lea M. Starita, Amanda M. Simons, and Jeffrey D. Parvin
Cancer Res 2006 66: 4100-4107. [Abstract] [Full Text] [PDF] Supplementary Data  

Cell, Tumor, and Stem Cell Biology:

Id1 Transcription Inhibitor–Matrix Metalloproteinase 9 Axis Enhances Invasiveness of the Breakpoint Cluster Region/Abelson Tyrosine Kinase–Transformed Leukemia Cells

Margaret Nieborowska-Skorska, Grazyna Hoser, Lori Rink, Maciej Malecki, Plamen Kossev, Mariusz A. Wasik, and Tomasz Skorski
Cancer Res 2006 66: 4108-4116. [Abstract] [Full Text] [PDF]  

Differential Functional Activation of Chemokine Receptor CXCR4 Is Mediated by G Proteins in Breast Cancer Cells

Jane D. Holland, Marina Kochetkova, Chareeporn Akekawatchai, Mara Dottore, Angel Lopez, and Shaun R. McColl
Cancer Res 2006 66: 4117-4124. [Abstract] [Full Text] [PDF]  

Growth-Regulated Oncogene Is Pivotal in Thrombin-Induced Angiogenesis

Maresa Caunt, Liang Hu, Thomas Tang, Peter C. Brooks, Sherif Ibrahim, and Simon Karpatkin
Cancer Res 2006 66: 4125-4132. [Abstract] [Full Text] [PDF]  

High-throughput Loss-of-Heterozygosity Study of Chromosome 3p in Lung Cancer Using Single-Nucleotide Polymorphism Markers

Amy L.S. Tai, William Mak, Phoebe K.M. Ng, Daniel T.T. Chua, Mandy Y.M. Ng, Li Fu, Kevin K.W. Chu, Yan Fang, You Qiang Song, Muhan Chen, Minyue Zhang, Pak C. Sham, and Xin-Yuan Guan
Cancer Res 2006 66: 4133-4138. [Abstract] [Full Text] [PDF] Supplementary Data  

Related to Testes-Specific, Vespid, and Pathogenesis Protein-1 (RTVP-1) Is Overexpressed in Gliomas and Regulates the Growth, Survival, and Invasion of Glioma Cells

Tovit Rosenzweig, Amotz Ziv-Av, Cunli Xiang, Wei Lu, Simona Cazacu, Dvir Taler, Cathie G. Miller, Reuven Reich, Yigal Shoshan, Yair Anikster, Gila Kazimirsky, Ronit Sarid, and Chaya Brodie
Cancer Res 2006 66: 4139-4148. [Abstract] [Full Text] [PDF]  

The Kinase Mirk/Dyrk1B Mediates Cell Survival in Pancreatic Ductal Adenocarcinoma

Xiaobing Deng, Daina Z. Ewton, Sheena Li, Asghar Naqvi, Stephen E. Mercer, Steve Landas, and Eileen Friedman
Cancer Res 2006 66: 4149-4158. [Abstract] [Full Text] [PDF]  

Noninvasive Magnetic Resonance Imaging of Transport and Interstitial Fluid Pressure in Ectopic Human Lung Tumors

Yaron Hassid, Edna Furman-Haran, Raanan Margalit, Raya Eilam, and Hadassa Degani
Cancer Res 2006 66: 4159-4166. [Abstract] [Full Text] [PDF]  

Hemangioblastomas Share Protein Expression with Embryonal Hemangioblast Progenitor Cell

Sven Gläsker, Jie Li, John B. Xia, Hiroaki Okamoto, Weifen Zeng, Russell R. Lonser, Zhengping Zhuang, Edward H. Oldfield, and Alexander O. Vortmeyer
Cancer Res 2006 66: 4167-4172. [Abstract] [Full Text] [PDF]  

Maspin Retards Cell Detachment via a Novel Interaction with the Urokinase-Type Plasminogen Activator/Urokinase-Type Plasminogen Activator Receptor System

Shuping Yin, Jaron Lockett, Yonghong Meng, Hector Biliran, Jr., Grant E. Blouse, Xiaohua Li, Neelima Reddy, Zimin Zhao, Xinli Lin, John Anagli, Michael L. Cher, and Shijie Sheng
Cancer Res 2006 66: 4173-4181. [Abstract] [Full Text] [PDF]  

Notch1 Signaling Promotes Primary Melanoma Progression by Activating Mitogen-Activated Protein Kinase/Phosphatidylinositol 3-Kinase-Akt Pathways and Up-regulating N-Cadherin Expression

Zhao-Jun Liu, Min Xiao, Klara Balint, Keiran S.M. Smalley, Patricia Brafford, Ruihua Qiu, Chelsea C. Pinnix, Xueli Li, and Meenhard Herlyn
Cancer Res 2006 66: 4182-4190. [Abstract] [Full Text] [PDF]  

Heat Shock Protein 70 Neutralization Exerts Potent Antitumor Effects in Animal Models of Colon Cancer and Melanoma

Elise Schmitt, Loic Maingret, Pierre-Emmanuel Puig, Anne-Laure Rerole, François Ghiringhelli, Arlette Hammann, Eric Solary, Guido Kroemer, and Carmen Garrido
Cancer Res 2006 66: 4191-4197. [Abstract] [Full Text] [PDF]  

High Expression of Ligands for Chemokine Receptor CXCR2 in Alveolar Epithelial Neoplasia Induced by Oncogenic Kras

Marie Wislez, Nobukazu Fujimoto, Julie G. Izzo, Amy E. Hanna, Dianna D. Cody, Robert R. Langley, Hongli Tang, Marie D. Burdick, Mitsuo Sato, John D. Minna, Li Mao, Ignacio Wistuba, Robert M. Strieter, and Jonathan M. Kurie
Cancer Res 2006 66: 4198-4207. [Abstract] [Full Text] [PDF] Supplementary Data  

Development of Real-time Subcellular Dynamic Multicolor Imaging of Cancer-Cell Trafficking in Live Mice with a Variable-Magnification Whole-Mouse Imaging System

Kensuke Yamauchi, Meng Yang, Ping Jiang, Mingxu Xu, Norio Yamamoto, Hiroyuki Tsuchiya, Katsuro Tomita, Abdool R. Moossa, Michael Bouvet, and Robert M. Hoffman
Cancer Res 2006 66: 4208-4214. [Abstract] [Full Text] [PDF] Supplementary Data  

Shh Pathway Activity Is Down-Regulated in Cultured Medulloblastoma Cells: Implications for Preclinical Studies

Ken Sasai, Justyna T. Romer, Youngsoo Lee, David Finkelstein, Christine Fuller, Peter J. McKinnon, and Tom Curran
Cancer Res 2006 66: 4215-4222. [Abstract] [Full Text] [PDF] Supplementary Data  

Radiation-Induced Caspase-8 Mediates p53-Independent Apoptosis in Glioma Cells

Golnar Afshar, Nannette Jelluma, Xiaodong Yang, Daniel Basila, Nils D. Arvold, Amelia Karlsson, Garret L. Yount, Tobias B. Dansen, Erich Koller, and Daphne A. Haas-Kogan
Cancer Res 2006 66: 4223-4232. [Abstract] [Full Text] [PDF] Supplementary Data  

Transformation of Late Passage Insulin-Like Growth Factor-I Receptor Null Mouse Embryo Fibroblasts by SV40 T Antigen

Susan L. Spence, Arthur L. Shaffer, Louis M. Staudt, Sewit Amde, Sutana Manney, Cheryl Terry, Keith Weisz, and Peter Nissley
Cancer Res 2006 66: 4233-4239. [Abstract] [Full Text] [PDF]  

Retinoic Acid Induces p27^Kip1 Nuclear Accumulation by Modulating Its Phosphorylation

Adriana Borriello, Valeria Cucciolla, Maria Criscuolo, Stefania Indaco, Adriana Oliva, Alfonso Giovane, Debora Bencivenga, Achille Iolascon, Vincenzo Zappia, and Fulvio Della Ragione
Cancer Res 2006 66: 4240-4248. [Abstract] [Full Text] [PDF] Supplementary Data  

Brain-Derived Neurotrophic Factor Activation of TrkB Induces Vascular Endothelial Growth Factor Expression via Hypoxia-Inducible Factor-1 in Neuroblastoma Cells

Katsuya Nakamura, Kelly C. Martin, Jennifer K. Jackson, Kiichiro Beppu, Chan-Wook Woo, and Carol J. Thiele
Cancer Res 2006 66: 4249-4255. [Abstract] [Full Text] [PDF]  

Repression of Cap-Dependent Translation Attenuates the Transformed Phenotype in Non–Small Cell Lung Cancer Both In vitro and In vivo

Blake A. Jacobson, Michael D. Alter, Marian G. Kratzke, Sandra P. Frizelle, Ying Zhang, Mark S. Peterson, Svetlana Avdulov, Riikka P. Mohorn, Bryan A. Whitson, Peter B. Bitterman, Vitaly A. Polunovsky, and Robert A. Kratzke
Cancer Res 2006 66: 4256-4262. [Abstract] [Full Text] [PDF]  

Altered Expression of c-IAP1, Survivin, and Smac Contributes to Chemotherapy Resistance in Thyroid Cancer Cells

Elena Tirrò, Maria Letizia Consoli, Michele Massimino, Livia Manzella, Francesco Frasca, Laura Sciacca, Luisa Vicari, Giorgio Stassi, Luigi Messina, Angelo Messina, and Paolo Vigneri
Cancer Res 2006 66: 4263-4272. [Abstract] [Full Text] [PDF]  

Caspase-8 Promotes Cell Motility and Calpain Activity under Nonapoptotic Conditions

Brooke Helfer, Bernard C. Boswell, Darren Finlay, Angel Cipres, Kristiina Vuori, Tae Bong Kang, David Wallach, Andrea Dorfleutner, Jill M. Lahti, Daniel C. Flynn, and Steven M. Frisch
Cancer Res 2006 66: 4273-4278. [Abstract] [Full Text] [PDF] Supplementary Data  

Down-regulation of CXCL5 Inhibits Squamous Carcinogenesis

Hiroshi Miyazaki, Vyomesh Patel, Huixin Wang, Ryan K. Edmunds, J. Silvio Gutkind, and W. Andrew Yeudall
Cancer Res 2006 66: 4279-4284. [Abstract] [Full Text] [PDF]  

Bone Morphogenetic Protein 7 Protects Prostate Cancer Cells from Stress-Induced Apoptosis via Both Smad and c-Jun NH₂-Terminal Kinase Pathways

Shangxin Yang, Minyoung Lim, Linda K. Pham, Stephen E. Kendall, A. Hari Reddi, Dario C. Altieri, and Pradip Roy-Burman
Cancer Res 2006 66: 4285-4290. [Abstract] [Full Text] [PDF] Supplementary Data  

Experimental Therapeutics, Molecular Targets, and Chemical Biology:

Complete Elimination of Colorectal Tumor Xenograft by Combined Manganese Superoxide Dismutase with Tumor Necrosis Factor–Related Apoptosis-Inducing Ligand Gene Virotherapy

Yanhong Zhang, Jinfa Gu, Lili Zhao, Lingfeng He, Wenbin Qian, Jinhui Wang, Yigang Wang, Qijun Qian, Cheng Qian, Jian Wu, and Xin Yuan Liu
Cancer Res 2006 66: 4291-4298. [Abstract] [Full Text] [PDF]  

Discovery and Evaluation of Dual CDK1 and CDK2 Inhibitors

Marc Payton, Grace Chung, Peter Yakowec, Andrew Wong, Dave Powers, Ling Xiong, Nancy Zhang, Juan Leal, Tammy L. Bush, Vincent Santora, Ben Askew, Andrew Tasker, Robert Radinsky, Richard Kendall, and Steve Coats
Cancer Res 2006 66: 4299-4308. [Abstract] [Full Text] [PDF]  

Crosstalk between Extrinsic and Intrinsic Cell Death Pathways in Pancreatic Cancer: Synergistic Action of Estrogen Metabolite and Ligands of Death Receptor Family

Aruna Basu, Valerie P. Castle, Mohammed Bouziane, Kapil Bhalla, and Subrata Haldar
Cancer Res 2006 66: 4309-4318. [Abstract] [Full Text] [PDF]  

Adeno-Associated Virus–Mediated Delivery of a Mutant Endostatin in Combination with Carboplatin Treatment Inhibits Orthotopic Growth of Ovarian Cancer and Improves Long-term Survival

Indira V. Subramanian, Tri Minh Bui Nguyen, Alexander M. Truskinovsky, Jakub Tolar, Bruce R. Blazar, and Sundaram Ramakrishnan
Cancer Res 2006 66: 4319-4328. [Abstract] [Full Text] [PDF]  

Phospholipase C-1 Is a Critical Target for Tumor Necrosis Factor Receptor–Mediated Protection against Adriamycin-Induced Cardiac Injury

Yu-Chin Lien, Teresa Noel, Hua Liu, Arnold J. Stromberg, Kuey-Chu Chen, and Daret K. St. Clair
Cancer Res 2006 66: 4329-4338. [Abstract] [Full Text] [PDF] Supplementary Data  

Tumor Imaging Using a Picomolar Affinity HER2 Binding Affibody Molecule

Anna Orlova, Mikaela Magnusson, Tove L.J. Eriksson, Martin Nilsson, Barbro Larsson, Ingmarie Höidén-Guthenberg, Charles Widström, Jörgen Carlsson, Vladimir Tolmachev, Stefan Ståhl, and Fredrik Y. Nilsson
Cancer Res 2006 66: 4339-4348. [Abstract] [Full Text] [PDF]  

Colony-Stimulating Factor-1 Antibody Reverses Chemoresistance in Human MCF-7 Breast Cancer Xenografts

Patrick Paulus, E. Richard Stanley, Romana Schäfer, Dietmar Abraham, and Seyedhossein Aharinejad
Cancer Res 2006 66: 4349-4356. [Abstract] [Full Text] [PDF]  

Inactivation of Human MAD2B in Nasopharyngeal Carcinoma Cells Leads to Chemosensitization to DNA-Damaging Agents

Hiu Wing Cheung, Abel C.S. Chun, Qi Wang, Wen Deng, Liang Hu, Xin-Yuan Guan, John M. Nicholls, Ming-Tat Ling, Yong Chuan Wong, Sai Wah Tsao, Dong-Yan Jin, and Xianghong Wang
Cancer Res 2006 66: 4357-4367. [Abstract] [Full Text] [PDF] Supplementary Data  

Antitumor Activity of a Small-Molecule Inhibitor of Human Silent Information Regulator 2 Enzymes

Birgit Heltweg, Tonibelle Gatbonton, Aaron D. Schuler, Jeff Posakony, Hongzhe Li, Sondra Goehle, Ramya Kollipara, Ronald A. DePinho, Yansong Gu, Julian A. Simon, and Antonio Bedalov
Cancer Res 2006 66: 4368-4377. [Abstract] [Full Text] [PDF] Supplementary Data  

Inhibition of Cyclooxygenase-2 Disrupts Tumor Vascular Mural Cell Recruitment and Survival Signaling

Alice Lee, Jason Frischer, Anna Serur, Jianzhong Huang, Jae-O Bae, Zev Noah Kornfield, Lucy Eljuga, Carrie J. Shawber, Nikki Feirt, Mahesh Mansukhani, Diana Stempak, Sylvain Baruchel, Julia Glade Bender, Jessica J. Kandel, and Darrell J. Yamashiro
Cancer Res 2006 66: 4378-4384. [Abstract] [Full Text] [PDF]  

1-Methoxy-Canthin-6-One Induces c-Jun NH₂-Terminal Kinase–Dependent Apoptosis and Synergizes with Tumor Necrosis Factor–Related Apoptosis-Inducing Ligand Activity in Human Neoplastic Cells of Hematopoietic or Endodermal Origin

Massimo Ammirante, Rita Di Giacomo, Laura De Martino, Alessandra Rosati, Michela Festa, Antonio Gentilella, Maria Carmela Pascale, Maria Antonietta Belisario, Arturo Leone, Maria Caterina Turco, and Vincenzo De Feo
Cancer Res 2006 66: 4385-4393. [Abstract] [Full Text] [PDF]  

Ligand Activation of Peroxisome Proliferator–Activated Receptor ß Inhibits Colon Carcinogenesis

Holly E. Marin, Marjorie A. Peraza, Andrew N. Billin, Timothy M. Willson, Jerrold M. Ward, Mary J. Kennett, Frank J. Gonzalez, and Jeffrey M. Peters
Cancer Res 2006 66: 4394-4401. [Abstract] [Full Text] [PDF]  

The Requirement for and Changing Composition of the Activating Protein-1 Transcription Factor during Differentiation of Human Leukemia HL60 Cells Induced by 1,25-Dihydroxyvitamin D₃

Xuening Wang and George P. Studzinski
Cancer Res 2006 66: 4402-4409. [Abstract] [Full Text] [PDF]  

Inhibition of Mammalian Thioredoxin Reductase by Some Flavonoids: Implications for Myricetin and Quercetin Anticancer Activity

Jun Lu, Laura V. Papp, Jianguo Fang, Salvador Rodriguez-Nieto, Boris Zhivotovsky, and Arne Holmgren
Cancer Res 2006 66: 4410-4418. [Abstract] [Full Text] [PDF]  

Insulin-like Growth Factor I Secreted from Prostate Stromal Cells Mediates Tumor-Stromal Cell Interactions of Prostate Cancer

Manabu Kawada, Hiroyuki Inoue, Tohru Masuda, and Daishiro Ikeda
Cancer Res 2006 66: 4419-4425. [Abstract] [Full Text] [PDF]  

Antibody-Maytansinoid Conjugates Are Activated in Targeted Cancer Cells by Lysosomal Degradation and Linker-Dependent Intracellular Processing

Hans K. Erickson, Peter U. Park, Wayne C. Widdison, Yelena V. Kovtun, Lisa M. Garrett, Karen Hoffman, Robert J. Lutz, Victor S. Goldmacher, and Walter A. Blättler
Cancer Res 2006 66: 4426-4433. [Abstract] [Full Text] [PDF] Supplementary Data  

Immunology:

Characterization of a Novel Human Tumor Antigen Interleukin-13 Receptor 2 Chain

Koji Kawakami, Masaki Terabe, Mariko Kawakami, Jay A. Berzofsky, and Raj K. Puri
Cancer Res 2006 66: 4434-4442. [Abstract] [Full Text] [PDF]  

A New Melanoma Antigen Fatty Acid–Binding Protein 7, Involved in Proliferation and Invasion, Is a Potential Target for Immunotherapy and Molecular Target Therapy

Yasufumi Goto, Yuriko Matsuzaki, Sachiko Kurihara, Ayako Shimizu, Tsutomu Okada, Kazuhiko Yamamoto, Hiroshi Murata, Minoru Takata, Hiroyuki Aburatani, Dave S.B. Hoon, Toshiaki Saida, and Yutaka Kawakami
Cancer Res 2006 66: 4443-4449. [Abstract] [Full Text] [PDF] Supplementary Data  

Soluble Human LAG-3 Molecule Amplifies the In vitro Generation of Type 1 Tumor-Specific Immunity

Chiara Casati, Chiara Camisaschi, Francesca Rini, Flavio Arienti, Licia Rivoltini, Frédéric Triebel, Giorgio Parmiani, and Chiara Castelli
Cancer Res 2006 66: 4450-4460. [Abstract] [Full Text] [PDF] Supplementary Data  

Stat1 Deficiency in the Host Enhances Interleukin-12–Mediated Tumor Regression

Marina N. Torrero, Xueqing Xia, Williams Henk, Shry Yu, and Shulin Li
Cancer Res 2006 66: 4461-4467. [Abstract] [Full Text] [PDF]  

Characterization of the Mouse IFN- Ligand-Receptor System: IFN-s Exhibit Antitumor Activity against B16 Melanoma

Ahmed Lasfar, Anita Lewis-Antes, Sergey V. Smirnov, Shubha Anantha, Walid Abushahba, Bin Tian, Kenneth Reuhl, Harold Dickensheets, Faruk Sheikh, Raymond P. Donnelly, Elizabeth Raveche, and Sergei V. Kotenko
Cancer Res 2006 66: 4468-4477. [Abstract] [Full Text] [PDF]  

Adoptive Transfer of Type 1 CTL Mediates Effective Anti–Central Nervous System Tumor Response: Critical Roles of IFN-Inducible Protein-10

Fumihiko Nishimura, Jill E. Dusak, Junichi Eguchi, Xinmei Zhu, Andrea Gambotto, Walter J. Storkus, and Hideho Okada
Cancer Res 2006 66: 4478-4487. [Abstract] [Full Text] [PDF]  

Tumor-Induced Expansion of Regulatory T Cells by Conversion of CD4⁺CD25^– Lymphocytes Is Thymus and Proliferation Independent

Barbara Valzasina, Silvia Piconese, Cristiana Guiducci, and Mario P. Colombo
Cancer Res 2006 66: 4488-4495. [Abstract] [Full Text] [PDF]  

Phase I Trial of a Novel Intradermal Idiotype Vaccine in Patients with Advanced B-Cell Lymphoma: Specific Immune Responses Despite Profound Immunosuppression

Cristina Bertinetti, Katja Zirlik, Kristina Heining-Mikesch, Gabriele Ihorst, Heide Dierbach, Cornelius F. Waller, and Hendrik Veelken
Cancer Res 2006 66: 4496-4502. [Abstract] [Full Text] [PDF]  

Epidemiology and Prevention:

Nitric Oxide–Donating Aspirin Prevents Pancreatic Cancer in a Hamster Tumor Model

Nengtai Ouyang, Jennie L. Williams, George J. Tsioulias, Jianjun Gao, Michael J. Iatropoulos, Levy Kopelovich, Khosrow Kashfi, and Basil Rigas
Cancer Res 2006 66: 4503-4511. [Abstract] [Full Text] [PDF]  

Duration but not Intensity of Alcohol and Tobacco Exposure Predicts p16^INK4A Homozygous Deletion in Head and Neck Squamous Cell Carcinoma

Kim S. Kraunz, Michael D. McClean, Heather H. Nelson, Edward Peters, Henry Calderon, and Karl T. Kelsey
Cancer Res 2006 66: 4512-4515. [Abstract] [Full Text] [PDF]  

Inhibition of p38 by Vitamin D Reduces Interleukin-6 Production in Normal Prostate Cells via Mitogen-Activated Protein Kinase Phosphatase 5: Implications for Prostate Cancer Prevention by Vitamin D

Larisa Nonn, Lihong Peng, David Feldman, and Donna M. Peehl
Cancer Res 2006 66: 4516-4524. [Abstract] [Full Text] [PDF]  

Genetic Polymorphisms of Interleukin-1B (IL-1B), IL-6, IL-8, and IL-10 and Risk of Prostate Cancer

Dominique S. Michaud, Sarah E. Daugherty, Sonja I. Berndt, Elizabeth A. Platz, Meredith Yeager, E. David Crawford, Ann Hsing, Wen-Yi Huang, and Richard B. Hayes
Cancer Res 2006 66: 4525-4530. [Abstract] [Full Text] [PDF]  

Serum IgE, Tumor Epidermal Growth Factor Receptor Expression, and Inherited Polymorphisms Associated with Glioma Survival

Margaret Wrensch, John K. Wiencke, Joe Wiemels, Rei Miike, Joe Patoka, Michelle Moghadassi, Alex McMillan, Karl T. Kelsey, Kenneth Aldape, Kathleen R. Lamborn, Andrew T. Parsa, Jennette D. Sison, and Michael D. Prados
Cancer Res 2006 66: 4531-4541. [Abstract] [Full Text] [PDF]  

Prevention of Azoxymethane-Induced Colon Cancer by Combination of Low Doses of Atorvastatin, Aspirin, and Celecoxib in F 344 Rats

Bandaru S. Reddy, Chung Xiou Wang, Ah-Ng Kong, Tin Oo Khor, Xi Zheng, Vernon E. Steele, Levy Kopelovich, and Chinthalapally V. Rao
Cancer Res 2006 66: 4542-4546. [Abstract] [Full Text] [PDF]  

Correction:

EGFR Enhances Motility and Intravasation In vivo

Cancer Res 2006 66: 4547. [Full Text] [PDF]  

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