Reviews:

Exploring a New Twist on Tumor Metastasis

Jing Yang, Sendurai A. Mani, and Robert A. Weinberg
Cancer Res 2006 66: 4549-4552. [Abstract] [Full Text] [PDF]  

Normal Stem Cells and Cancer Stem Cells: The Niche Matters

Linheng Li and William B. Neaves
Cancer Res 2006 66: 4553-4557. [Abstract] [Full Text] [PDF]  

Meeting Report:

Meeting Report: Exploiting the Tumor Microenvironment for Therapeutics

Giovanni Melillo and Gregg L. Semenza
Cancer Res 2006 66: 4558-4560. [Abstract] [Full Text] [PDF]  

Priority Report:

DNA Damage–Induced BARD1 Phosphorylation Is Critical for the Inhibition of Messenger RNA Processing by BRCA1/BARD1 Complex

Ho-Shik Kim, Hongjie Li, Murat Cevher, Alissa Parmelee, Danae Fonseca, Frida Esther Kleiman, and Sean Bong Lee
Cancer Res 2006 66: 4561-4565. [Abstract] [Full Text] [PDF] Supplementary Data  

Molecular Biology, Pathobiology, and Genetics:

Epigenetic Inactivation of Betaig-h3 Gene in Human Cancer Cells

Genze Shao, Jessica Berenguer, Alain C. Borczuk, Charles A. Powell, Tom K. Hei, and Yongliang Zhao
Cancer Res 2006 66: 4566-4573. [Abstract] [Full Text] [PDF]  

Comparative Genome Analysis Identifies the Vitamin D Receptor Gene as a Direct Target of p53-Mediated Transcriptional Activation

Reo Maruyama, Fumio Aoki, Minoru Toyota, Yasushi Sasaki, Hirofumi Akashi, Hiroaki Mita, Hiromu Suzuki, Kimishige Akino, Mutsumi Ohe-Toyota, Yumiko Maruyama, Haruyuki Tatsumi, Kohzoh Imai, Yasuhisa Shinomura, and Takashi Tokino
Cancer Res 2006 66: 4574-4583. [Abstract] [Full Text] [PDF] Supplementary Data  

Trans-Repressive Effect of NUP98-PMX1 on PMX1-Regulated c-FOS Gene through Recruitment of Histone Deacetylase 1 by FG Repeats

Xue-Tao Bai, Bai-Wei Gu, Tong Yin, Chao Niu, Xiao-Dong Xi, Ji Zhang, Zhu Chen, and Sai-Juan Chen
Cancer Res 2006 66: 4584-4590. [Abstract] [Full Text] [PDF]  

Reversible Kinetic Analysis of Myc Targets In vivo Provides Novel Insights into Myc-Mediated Tumorigenesis

Elizabeth R. Lawlor, Laura Soucek, Lamorna Brown-Swigart, Ksenya Shchors, C. Uli Bialucha, and Gerard I. Evan
Cancer Res 2006 66: 4591-4601. [Abstract] [Full Text] [PDF] Supplementary Data  

Functional Gene Expression Analysis Uncovers Phenotypic Switch in Aggressive Uveal Melanomas

Michael D. Onken, Justis P. Ehlers, Lori A. Worley, Jun Makita, Yoshifumi Yokota, and J. William Harbour
Cancer Res 2006 66: 4602-4609. [Abstract] [Full Text] [PDF] Supplementary Data  

Chromatin Modification of the Trefoil Factor 1 Gene in Human Breast Cancer Cells by the Ras/Mitogen-Activated Protein Kinase Pathway

Paula S. Espino, Lin Li, Shihua He, Jenny Yu, and James R. Davie
Cancer Res 2006 66: 4610-4616. [Abstract] [Full Text] [PDF]  

Frequent Silencing of the Candidate Tumor Suppressor PCDH20 by Epigenetic Mechanism in Non–Small-Cell Lung Cancers

Issei Imoto, Hiroyuki Izumi, Sana Yokoi, Hiroshi Hosoda, Tatsuhiro Shibata, Fumie Hosoda, Misao Ohki, Setsuo Hirohashi, and Johji Inazawa
Cancer Res 2006 66: 4617-4626. [Abstract] [Full Text] [PDF]  

Integrative Genomic Analysis of Protein Kinase C (PKC) Family Identifies PKC as a Biomarker and Potential Oncogene in Ovarian Carcinoma

Lin Zhang, Jia Huang, Nuo Yang, Shun Liang, Andrea Barchetti, Antonis Giannakakis, Mark G. Cadungog, Ann O'Brien-Jenkins, Marco Massobrio, Katherine F. Roby, Dionyssios Katsaros, Phyllis Gimotty, Ralf Butzow, Barbara L. Weber, and George Coukos
Cancer Res 2006 66: 4627-4635. [Abstract] [Full Text] [PDF]  

Gene Expression Profiling Shows Medullary Breast Cancer Is a Subgroup of Basal Breast Cancers

François Bertucci, Pascal Finetti, Nathalie Cervera, Emmanuelle Charafe-Jauffret, Emilie Mamessier, José Adélaïde, Stéphane Debono, Gilles Houvenaeghel, Dominique Maraninchi, Patrice Viens, Colette Charpin, Jocelyne Jacquemier, and Daniel Birnbaum
Cancer Res 2006 66: 4636-4644. [Abstract] [Full Text] [PDF] Supplementary Data  

Dysregulated Human Myeloid Nuclear Differentiation Antigen Expression in Myelodysplastic Syndromes: Evidence for a Role in Apoptosis

Robert C. Briggs, Keith E. Shults, Leanne A. Flye, Sara A. McClintock-Treep, Madan H. Jagasia, Stacey A. Goodman, Fouad I. Boulos, James W. Jacobberger, Greg T. Stelzer, and David R. Head
Cancer Res 2006 66: 4645-4651. [Abstract] [Full Text] [PDF] Supplementary Data  

Cell, Tumor, and Stem Cell Biology:

The Protease Complex Consisting of Dipeptidyl Peptidase IV and Seprase Plays a Role in the Migration and Invasion of Human Endothelial Cells in Collagenous Matrices

Giulio Ghersi, Qiang Zhao, Monica Salamone, Yunyun Yeh, Stanley Zucker, and Wen-Tien Chen
Cancer Res 2006 66: 4652-4661. [Abstract] [Full Text] [PDF]  

Collagen Type I Induces Disruption of E-Cadherin–Mediated Cell-Cell Contacts and Promotes Proliferation of Pancreatic Carcinoma Cells

Alexander Koenig, Claudia Mueller, Cornelia Hasel, Guido Adler, and Andre Menke
Cancer Res 2006 66: 4662-4671. [Abstract] [Full Text] [PDF]  

p130Cas as a New Regulator of Mammary Epithelial Cell Proliferation, Survival, and HER2-Neu Oncogene–Dependent Breast Tumorigenesis

Sara Cabodi, Agata Tinnirello, Paola Di Stefano, Brigitte Bisarò, Elena Ambrosino, Isabella Castellano, Anna Sapino, Riccardo Arisio, Federica Cavallo, Guido Forni, Marina Glukhova, Lorenzo Silengo, Fiorella Altruda, Emilia Turco, Guido Tarone, and Paola Defilippi
Cancer Res 2006 66: 4672-4680. [Abstract] [Full Text] [PDF] Supplementary Data  

Platelet-Activating Factor Induces Up-regulation of Antiapoptotic Factors in a Melanoma Cell Line through Nuclear Factor-B Activation

Kook Heon Seo, Hyun-Mi Ko, Han-A Kim, Jung-Hwa Choi, Sung Jun Park, Kyoung-Jin Kim, Hern-Ku Lee, and Suhn-Young Im
Cancer Res 2006 66: 4681-4686. [Abstract] [Full Text] [PDF]  

Dynamic Imaging of Emerging Resistance during Cancer Therapy

Kuei C. Lee, Daniel E. Hall, Benjamin A. Hoff, Bradford A. Moffat, Surabhi Sharma, Thomas L. Chenevert, Charles R. Meyer, Wilbur R. Leopold, Timothy D. Johnson, Richard V. Mazurchuk, Alnawaz Rehemtulla, and Brian D. Ross
Cancer Res 2006 66: 4687-4692. [Abstract] [Full Text] [PDF]  

Melanoma Antigen A4 Is Expressed in Non–Small Cell Lung Cancers and Promotes Apoptosis

Tobias Peikert, Ulrich Specks, Carol Farver, Serpil C. Erzurum, and Suzy A.A. Comhair
Cancer Res 2006 66: 4693-4700. [Abstract] [Full Text] [PDF]  

Noninvasive Bioluminescence Imaging of Normal and Spontaneously Transformed Prostate Tissue in Mice

Scott K. Lyons, Ed Lim, Anne O. Clermont, Joan Dusich, Lingyun Zhu, Kenneth D. Campbell, Richard J. Coffee, David S. Grass, John Hunter, Tony Purchio, and Darlene Jenkins
Cancer Res 2006 66: 4701-4707. [Abstract] [Full Text] [PDF]  

The Interaction Mode of Premalignant Schwann and Immune Effector Cells during Chemically Induced Carcinogenesis in the Rat Peripheral Nervous System Is Strongly Influenced by Genetic Background

Katharina M. Gering, Judith A.M. Marx, Klaus Lennartz, Christine Fischer, Manfred F. Rajewsky, and Andrea Kindler-Röhrborn
Cancer Res 2006 66: 4708-4714. [Abstract] [Full Text] [PDF]  

Survival Signaling by Notch1: Mammalian Target of Rapamycin (mTOR)–Dependent Inhibition of p53

Sathish Kumar Mungamuri, XiaoHe Yang, Ann D. Thor, and Kumaravel Somasundaram
Cancer Res 2006 66: 4715-4724. [Abstract] [Full Text] [PDF] Supplementary Data  

Distinct Roles of Nonmuscle Myosin II Isoforms in the Regulation of MDA-MB-231 Breast Cancer Cell Spreading and Migration

Venkaiah Betapudi, Lucila S. Licate, and Thomas T. Egelhoff
Cancer Res 2006 66: 4725-4733. [Abstract] [Full Text] [PDF]  

ß-Catenin/Wnt Signaling Regulates Expression of the Membrane Type 3 Matrix Metalloproteinase in Gastric Cancer

Andrew M. Lowy, Wilson M. Clements, John Bishop, Ling Kong, Tera Bonney, Karena Sisco, Bruce Aronow, Cecilia Fenoglio-Preiser, and Joanna Groden
Cancer Res 2006 66: 4734-4741. [Abstract] [Full Text] [PDF]  

Validation of Met as a Therapeutic Target in Alveolar and Embryonal Rhabdomyosarcoma

Riccardo Taulli, Claudio Scuoppo, Francesca Bersani, Paolo Accornero, Paolo E. Forni, Silvia Miretti, Alberto Grinza, Paola Allegra, Michel Schmitt-Ney, Tiziana Crepaldi, and Carola Ponzetto
Cancer Res 2006 66: 4742-4749. [Abstract] [Full Text] [PDF] Supplementary Data  

MET Overexpression Turns Human Primary Osteoblasts into Osteosarcomas

Salvatore Patanè, Sofia Avnet, Nadia Coltella, Barbara Costa, Simone Sponza, Martina Olivero, Elisa Vigna, Luigi Naldini, Nicola Baldini, Riccardo Ferracini, Simona Corso, Silvia Giordano, Paolo M. Comoglio, and Maria Flavia Di Renzo
Cancer Res 2006 66: 4750-4757. [Abstract] [Full Text] [PDF] Supplementary Data  

Celastrol, a Triterpene Extracted from the Chinese "Thunder of God Vine," Is a Potent Proteasome Inhibitor and Suppresses Human Prostate Cancer Growth in Nude Mice

Huanjie Yang, Di Chen, Qiuzhi Cindy Cui, Xiao Yuan, and Q. Ping Dou
Cancer Res 2006 66: 4758-4765. [Abstract] [Full Text] [PDF]  

Cooperative Interactions of p53 Mutation, Telomere Dysfunction, and Chronic Liver Damage in Hepatocellular Carcinoma Progression

Paraskevi A. Farazi, Jonathan Glickman, James Horner, and Ronald A. DePinho
Cancer Res 2006 66: 4766-4773. [Abstract] [Full Text] [PDF] Supplementary Data  

Splicing Factor Tra2-ß1 Is Specifically Induced in Breast Cancer and Regulates Alternative Splicing of the CD44 Gene

Dirk O. Watermann, Yesheng Tang, Axel zur Hausen, Markus Jäger, Stefan Stamm, and Elmar Stickeler
Cancer Res 2006 66: 4774-4780. [Abstract] [Full Text] [PDF]  

Inhibition of the Phosphatidylinositol 3'-Kinase Pathway Promotes Autocrine Fas-Induced Death of Phosphatase and Tensin Homologue–Deficient Prostate Cancer Cells

Jerod Bertram, James W. Peacock, Clara Tan, Alice L-F. Mui, Stephen W. Chung, Martin E. Gleave, Shoukat Dedhar, Michael E. Cox, and Christopher J. Ong
Cancer Res 2006 66: 4781-4788. [Abstract] [Full Text] [PDF]  

Estradiol and Tamoxifen Regulate Endostatin Generation via Matrix Metalloproteinase Activity in Breast Cancer In vivo

Ulrika W. Nilsson and Charlotta Dabrosin
Cancer Res 2006 66: 4789-4794. [Abstract] [Full Text] [PDF]  

The Regulation of Exosome Secretion: a Novel Function of the p53 Protein

Xin Yu, Sandra L. Harris, and Arnold J. Levine
Cancer Res 2006 66: 4795-4801. [Abstract] [Full Text] [PDF]  

Experimental Therapeutics, Molecular Targets, and Chemical Biology:

Gefitinib Modulates the Function of Multiple ATP-Binding Cassette Transporters In vivo

Markos Leggas, John C. Panetta, Yanli Zhuang, John D. Schuetz, Brad Johnston, Feng Bai, Brian Sorrentino, Sheng Zhou, Peter J. Houghton, and Clinton F. Stewart
Cancer Res 2006 66: 4802-4807. [Abstract] [Full Text] [PDF]  

Selective Toxicity of NSC73306 in MDR1-Positive Cells as a New Strategy to Circumvent Multidrug Resistance in Cancer

Joseph A. Ludwig, Gergely Szakács, Scott E. Martin, Benjamin F. Chu, Carol Cardarelli, Zuben E. Sauna, Natasha J. Caplen, Henry M. Fales, Suresh V. Ambudkar, John N. Weinstein, and Michael M. Gottesman
Cancer Res 2006 66: 4808-4815. [Abstract] [Full Text] [PDF]  

Antitumor and Antimetastatic Activities of Docetaxel Are Enhanced by Genistein through Regulation of Osteoprotegerin/Receptor Activator of Nuclear Factor-B (RANK)/RANK Ligand/MMP-9 Signaling in Prostate Cancer

Yiwei Li, Omer Kucuk, Maha Hussain, Judith Abrams, Michael L. Cher, and Fazlul H. Sarkar
Cancer Res 2006 66: 4816-4825. [Abstract] [Full Text] [PDF]  

Luteolin Promotes Degradation in Signal Transducer and Activator of Transcription 3 in Human Hepatoma Cells: An Implication for the Antitumor Potential of Flavonoids

Karuppaiyah Selvendiran, Hironori Koga, Takato Ueno, Takafumi Yoshida, Michiko Maeyama, Takuji Torimura, Hirohisa Yano, Masamichi Kojiro, and Michio Sata
Cancer Res 2006 66: 4826-4834. [Abstract] [Full Text] [PDF]  

Combination of a Fusogenic Glycoprotein, Prodrug Activation, and Oncolytic Herpes Simplex Virus for Enhanced Local Tumor Control

Guy R. Simpson, Ziqun Han, Binlei Liu, Yibing Wang, Gregor Campbell, and Robert S. Coffin
Cancer Res 2006 66: 4835-4842. [Abstract] [Full Text] [PDF]  

IMC-EB10, an Anti-FLT3 Monoclonal Antibody, Prolongs Survival and Reduces Nonobese Diabetic/Severe Combined Immunodeficient Engraftment of Some Acute Lymphoblastic Leukemia Cell Lines and Primary Leukemic Samples

Obdulio Piloto, Bao Nguyen, David Huso, Kyu-Tae Kim, Yiwen Li, Larry Witte, Daniel J. Hicklin, Patrick Brown, and Donald Small
Cancer Res 2006 66: 4843-4851. [Abstract] [Full Text] [PDF]  

Attenuation of Mitogen- and Stress-Activated Protein Kinase-1–Driven Nuclear Factor-B Gene Expression by Soy Isoflavones Does Not Require Estrogenic Activity

Wim Vanden Berghe, Nathalie Dijsselbloem, Linda Vermeulen, 'Matladi N. Ndlovu, Elke Boone, and Guy Haegeman
Cancer Res 2006 66: 4852-4862. [Abstract] [Full Text] [PDF] Supplementary Data  

Doxorubicin-DNA Adducts Induce a Non-Topoisomerase II–Mediated Form of Cell Death

Lonnie P. Swift, Ada Rephaeli, Abraham Nudelman, Don R. Phillips, and Suzanne M. Cutts
Cancer Res 2006 66: 4863-4871. [Abstract] [Full Text] [PDF]  

Disruption of the Y-Box Binding Protein-1 Results in Suppression of the Epidermal Growth Factor Receptor and HER-2

Joyce Wu, Cathy Lee, Daniel Yokom, Helen Jiang, Maggie C.U. Cheang, Erika Yorida, Dmitry Turbin, Isabelle M. Berquin, Peter R. Mertens, Thomas Iftner, C. Blake Gilks, and Sandra E. Dunn
Cancer Res 2006 66: 4872-4879. [Abstract] [Full Text] [PDF] Supplementary Data  

3,3'-Diindolylmethane Is a Novel Mitochondrial H⁺-ATP Synthase Inhibitor that Can Induce p21^Cip1/Waf1 Expression by Induction of Oxidative Stress in Human Breast Cancer Cells

Yixuan Gong, Heesook Sohn, Ling Xue, Gary L. Firestone, and Leonard F. Bjeldanes
Cancer Res 2006 66: 4880-4887. [Abstract] [Full Text] [PDF]  

The Role of Mitogen-Activated Protein Kinase Phosphatase-1 in Oxidative Damage–Induced Cell Death

Jun-Ying Zhou, Yusen Liu, and Gen Sheng Wu
Cancer Res 2006 66: 4888-4894. [Abstract] [Full Text] [PDF]  

Immunology:

Combinational FLt3 Ligand and Granulocyte Macrophage Colony-Stimulating Factor Treatment Promotes Enhanced Tumor Infiltration by Dendritic Cells and Antitumor CD8⁺ T-Cell Cross-priming but Is Ineffective as a Therapy

Aklile Berhanu, Jian Huang, Sean M. Alber, Simon C. Watkins, and Walter J. Storkus
Cancer Res 2006 66: 4895-4903. [Abstract] [Full Text] [PDF]  

Agonist Anti-GITR Antibody Enhances Vaccine-Induced CD8⁺ T-Cell Responses and Tumor Immunity

Adam D. Cohen, Adi Diab, Miguel-Angel Perales, Jedd D. Wolchok, Gabrielle Rizzuto, Taha Merghoub, Deonka Huggins, Cailian Liu, Mary Jo Turk, Nicholas P. Restifo, Shimon Sakaguchi, and Alan N. Houghton
Cancer Res 2006 66: 4904-4912. [Abstract] [Full Text] [PDF]  

Ex vivo Culture with Interleukin (IL)-12 Improves CD8⁺ T-Cell Adoptive Immunotherapy for Murine Leukemia Independent of IL-18 or IFN- but Requires Perforin

Jennifer N. MacGregor, Qiao Li, Alfred E. Chang, Thomas M. Braun, Dennis P.M. Hughes, and Kevin T. McDonagh
Cancer Res 2006 66: 4913-4921. [Abstract] [Full Text] [PDF]  

Identification of a New Cancer/Germline Gene, KK-LC-1, Encoding an Antigen Recognized by Autologous CTL Induced on Human Lung Adenocarcinoma

Takashi Fukuyama, Takeshi Hanagiri, Mitsuhiro Takenoyama, Yoshinobu Ichiki, Makiko Mizukami, Tetsuya So, Masakazu Sugaya, Tomoko So, Kenji Sugio, and Kosei Yasumoto
Cancer Res 2006 66: 4922-4928. [Abstract] [Full Text] [PDF]  

Endocrinology:

Menin Links Estrogen Receptor Activation to Histone H3K4 Trimethylation

Koen M.A. Dreijerink, Klaas W. Mulder, G. Sebastiaan Winkler, Jo W.M. Höppener, Cornelis J.M. Lips, and H.Th. Marc Timmers
Cancer Res 2006 66: 4929-4935. [Abstract] [Full Text] [PDF]  

Clinical Research:

Molecular Evidence for Independent Origin of Multifocal Neuroendocrine Tumors of the Enteropancreatic Axis

Terrence M. Katona, Timothy D. Jones, Mingsheng Wang, Fadi W. Abdul-Karim, Oscar W. Cummings, and Liang Cheng
Cancer Res 2006 66: 4936-4942. [Abstract] [Full Text] [PDF]  

Immunization of Stage IV Melanoma Patients with Melan-A/MART-1 and gp100 Peptides plus IFN- Results in the Activation of Specific CD8⁺ T Cells and Monocyte/Dendritic Cell Precursors

Tiziana Di Pucchio, Lorenzo Pilla, Imerio Capone, Maria Ferrantini, Enrica Montefiore, Francesca Urbani, Roberto Patuzzo, Elisabetta Pennacchioli, Mario Santinami, Agata Cova, Gloria Sovena, Flavio Arienti, Claudia Lombardo, Arianna Lombardi, Patrizia Caporaso, Stefania D'Atri, Paolo Marchetti, Enzo Bonmassar, Giorgio Parmiani, Filippo Belardelli, and Licia Rivoltini
Cancer Res 2006 66: 4943-4951. [Abstract] [Full Text] [PDF] Supplementary Data  

Epidemiology and Prevention:

Gene Expression Profiling Revealed Survivin as a Target of 3,3'-Diindolylmethane-Induced Cell Growth Inhibition and Apoptosis in Breast Cancer Cells

KM Wahidur Rahman, Yiwei Li, Zhiwei Wang, Sarah H. Sarkar, and Fazlul H. Sarkar
Cancer Res 2006 66: 4952-4960. [Abstract] [Full Text] [PDF]  

Dose-Response Relationship between Cooking Fumes Exposures and Lung Cancer among Chinese Nonsmoking Women

Ignatius T.S. Yu, Yuk-lan Chiu, Joseph S.K. Au, Tze-wai Wong, and Jin-ling Tang
Cancer Res 2006 66: 4961-4967. [Abstract] [Full Text] [PDF]  

DNA Sequence Context Affects Repair of the Tobacco-Specific Adduct O⁶-[4-Oxo-4-(3-pyridyl)butyl]guanine by Human O⁶-Alkylguanine-DNA Alkyltransferases

Renée S. Mijal, Sreenivas Kanugula, Choua C. Vu, Qingming Fang, Anthony E. Pegg, and Lisa A. Peterson
Cancer Res 2006 66: 4968-4974. [Abstract] [Full Text] [PDF]  

Nonsteroidal Anti-inflammatory Drugs and the Esophageal Inflammation-Metaplasia-Adenocarcinoma Sequence

Lesley A. Anderson, Brian T. Johnston, R.G. Peter Watson, Seamus J. Murphy, Heather R. Ferguson, Harry Comber, Jim McGuigan, John V. Reynolds, and Liam J. Murray
Cancer Res 2006 66: 4975-4982. [Abstract] [Full Text] [PDF]  

To see an article, click its [Full Text] link. To review many abstracts, check the boxes to the left of the titles you want, and click the 'Get All Checked Abstract(s)' button. To see one abstract at a time, click its [Abstract] link.