Reviews:

Development of Vaccines for High-Risk Ductal Carcinoma In situ of the Breast

Brian J. Czerniecki, Robert E. Roses, and Gary K. Koski
Cancer Res 2007 67: 6531-6534. doi: 10.1158/0008-5472.CAN-07-0878 [Abstract] [Full Text] [PDF]  

Pten Inactivation and the Emergence of Androgen-Independent Prostate Cancer

Michael M. Shen and Cory Abate-Shen
Cancer Res 2007 67: 6535-6538. doi: 10.1158/0008-5472.CAN-07-1271 [Abstract] [Full Text] [PDF]  

Meeting Report:

Chemistry in Cancer Research: A Vital Partnership

Shana J. Sturla, John J. Irwin, Richard N. Loeppky, Mark J. Mulvihill, and Mark Searcey
Cancer Res 2007 67: 6539-6543. Published Online First July 9, 2007. doi: 10.1158/0008-5472.CAN-07-1619 [Full Text] [PDF]  

Priority Reports:

A Secreted Isoform of ErbB3 Promotes Osteonectin Expression in Bone and Enhances the Invasiveness of Prostate Cancer Cells

Nanyue Chen, Xiang-Cang Ye, Khoi Chu, Nora M. Navone, E. Helene Sage, Li-Yuan Yu-Lee, Christopher J. Logothetis, and Sue-Hwa Lin
Cancer Res 2007 67: 6544-6548. doi: 10.1158/0008-5472.CAN-07-1330 [Abstract] [Full Text] [PDF]  

Prostatic Acid Phosphatase Is Not a Prostate Specific Target

Ileana B. Quintero, César L. Araujo, Anitta E. Pulkka, Riikka S. Wirkkala, Annakaisa M. Herrala, Eeva-Liisa Eskelinen, Eija Jokitalo, Pekka A. Hellström, Hannu J. Tuominen, Pasi P. Hirvikoski, and Pirkko T. Vihko
Cancer Res 2007 67: 6549-6554. doi: 10.1158/0008-5472.CAN-07-1651 [Abstract] [Full Text] [PDF] Supplementary Data  

Molecular Biology, Pathobiology, and Genetics:

Target Sequence Accessibility Limits Activation-Induced Cytidine Deaminase Activity in Primary Mediastinal B-Cell Lymphoma

Sergey W. Popov, Gerhard Moldenhauer, Beate Wotschke, Silke Brüderlein, Thomas F. Barth, Karola Dorsch, Olga Ritz, Peter Möller, and Frank Leithäuser
Cancer Res 2007 67: 6555-6564. doi: 10.1158/0008-5472.CAN-06-2166 [Abstract] [Full Text] [PDF] Supplementary Data  

Proteomics-Based Identification of Proteins Secreted in Apical Surface Fluid of Squamous Metaplastic Human Tracheobronchial Epithelial Cells Cultured by Three-Dimensional Organotypic Air-Liquid Interface Method

Seung-Wook Kim, Kyounga Cheon, Chang-Hoon Kim, Joo-Heon Yoon, David H. Hawke, Ryuji Kobayashi, Ludmila Prudkin, Ignacio I. Wistuba, Reuben Lotan, Waun Ki Hong, and Ja Seok Koo
Cancer Res 2007 67: 6565-6573. doi: 10.1158/0008-5472.CAN-06-2783 [Abstract] [Full Text] [PDF]  

The E2F-Regulated Gene Chk1 Is Highly Expressed in Triple-Negative Estrogen Receptor–/Progesterone Receptor–/HER-2– Breast Carcinomas

Lieve Verlinden, Isabelle Vanden Bempt, Guy Eelen, Maria Drijkoningen, Ilse Verlinden, Kathleen Marchal, Christiane De Wolf-Peeters, Marie-Rose Christiaens, Luc Michiels, Roger Bouillon, and Annemieke Verstuyf
Cancer Res 2007 67: 6574-6581. doi: 10.1158/0008-5472.CAN-06-3545 [Abstract] [Full Text] [PDF] Supplementary Data  

HER4 D-Box Sequences Regulate Mitotic Progression and Degradation of the Nuclear HER4 Cleavage Product s80^HER4

Karen E. Strunk, Carty Husted, Leah C. Miraglia, Melissa Sandahl, William A. Rearick, Debra M. Hunter, H. Shelton Earp, III, and Rebecca S. Muraoka-Cook
Cancer Res 2007 67: 6582-6590. doi: 10.1158/0008-5472.CAN-06-4145 [Abstract] [Full Text] [PDF]  

Transforming Growth Factor –Dependent Cancer Progression Is Modulated by Muc1

Mamata R. Pochampalli, Benjamin G. Bitler, and Joyce A. Schroeder
Cancer Res 2007 67: 6591-6598. doi: 10.1158/0008-5472.CAN-06-4518 [Abstract] [Full Text] [PDF]  

MUTYH-Null Mice Are Susceptible to Spontaneous and Oxidative Stress–Induced Intestinal Tumorigenesis

Katsumi Sakamoto, Yohei Tominaga, Kazumi Yamauchi, Yoshimichi Nakatsu, Kunihiko Sakumi, Kaoru Yoshiyama, Akinori Egashira, Shinobu Kura, Takashi Yao, Masazumi Tsuneyoshi, Hisaji Maki, Yusaku Nakabeppu, and Teruhisa Tsuzuki
Cancer Res 2007 67: 6599-6604. doi: 10.1158/0008-5472.CAN-06-4802 [Abstract] [Full Text] [PDF]  

Hemizygous Disruption of Cdc25A Inhibits Cellular Transformation and Mammary Tumorigenesis in Mice

Dipankar Ray, Yasuhisa Terao, Dipali Nimbalkar, Hiroyuki Hirai, Evan C. Osmundson, Xianghong Zou, Roberta Franks, Konstantin Christov, and Hiroaki Kiyokawa
Cancer Res 2007 67: 6605-6611. doi: 10.1158/0008-5472.CAN-06-4815 [Abstract] [Full Text] [PDF] Supplementary Data  

SIRT1 Is Significantly Elevated in Mouse and Human Prostate Cancer

Derek M. Huffman, William E. Grizzle, Marcas M. Bamman, Jeong-su Kim, Isam A. Eltoum, Ada Elgavish, and Tim R. Nagy
Cancer Res 2007 67: 6612-6618. doi: 10.1158/0008-5472.CAN-07-0085 [Abstract] [Full Text] [PDF]  

Human Polynucleotide Kinase Participates in Repair of DNA Double-Strand Breaks by Nonhomologous End Joining but not Homologous Recombination

Feridoun Karimi-Busheri, Aghdass Rasouli-Nia, Joan Allalunis-Turner, and Michael Weinfeld
Cancer Res 2007 67: 6619-6625. doi: 10.1158/0008-5472.CAN-07-0480 [Abstract] [Full Text] [PDF]  

Gene Expression Profiling of Liposarcoma Identifies Distinct Biological Types/Subtypes and Potential Therapeutic Targets in Well-Differentiated and Dedifferentiated Liposarcoma

Samuel Singer, Nicholas D. Socci, Grazia Ambrosini, Elliot Sambol, Penelope Decarolis, Yuhsin Wu, Rachael O'Connor, Robert Maki, Agnes Viale, Chris Sander, Gary K. Schwartz, and Cristina R. Antonescu
Cancer Res 2007 67: 6626-6636. doi: 10.1158/0008-5472.CAN-07-0584 [Abstract] [Full Text] [PDF] Supplementary Data  

Small Interfering RNA–Directed Reversal of Urokinase Plasminogen Activator Demethylation Inhibits Prostate Tumor Growth and Metastasis

Sai Murali Krishna Pulukuri and Jasti S. Rao
Cancer Res 2007 67: 6637-6646. doi: 10.1158/0008-5472.CAN-07-0751 [Abstract] [Full Text] [PDF] Supplementary Data  

The Ubiquitin-Interacting Motif–Containing Protein RAP80 Interacts with BRCA1 and Functions in DNA Damage Repair Response

Jun Yan, Yong-Sik Kim, Xiao-Ping Yang, Li-Ping Li, Grace Liao, Fen Xia, and Anton M. Jetten
Cancer Res 2007 67: 6647-6656. Published Online First July 9, 2007. doi: 10.1158/0008-5472.CAN-07-0924 [Abstract] [Full Text] [PDF] Supplementary Data  

Cancer Cells and Normal Cells Differ in Their Requirements for Thoc1

Yanping Li, Athena W. Lin, Xiaojing Zhang, Yanqing Wang, Xiaoling Wang, and David W. Goodrich
Cancer Res 2007 67: 6657-6664. doi: 10.1158/0008-5472.CAN-06-3234 [Abstract] [Full Text] [PDF] Supplementary Data  

Cytochrome P450 Epoxygenase Promotes Human Cancer Metastasis

Jian-Gang Jiang, Yao-Gui Ning, Chen Chen, Ding Ma, Zhen-Jun Liu, Shilin Yang, Jianfeng Zhou, Xiao Xiao, Xin A. Zhang, Matthew L. Edin, Jeffrey W. Card, Jianing Wang, Darryl C. Zeldin, and Dao Wen Wang
Cancer Res 2007 67: 6665-6674. doi: 10.1158/0008-5472.CAN-06-3643 [Abstract] [Full Text] [PDF] Supplementary Data  

EWS/FLI1 Regulates Tumor Angiogenesis in Ewing's Sarcoma via Suppression of Thrombospondins

Gary Potikyan, Rupert O.V. Savene, Julie M. Gaulden, Kelly A. France, Zhichao Zhou, Eugenie S. Kleinerman, Stephen L. Lessnick, and Christopher T. Denny
Cancer Res 2007 67: 6675-6684. doi: 10.1158/0008-5472.CAN-06-4140 [Abstract] [Full Text] [PDF] Supplementary Data  

Cyclin-Dependent Kinase 2–Dependent Phosphorylation of ATRIP Regulates the G₂-M Checkpoint Response to DNA Damage

Jeremy S. Myers, Runxiang Zhao, Xin Xu, Amy-Joan L. Ham, and David Cortez
Cancer Res 2007 67: 6685-6690. doi: 10.1158/0008-5472.CAN-07-0495 [Abstract] [Full Text] [PDF]  

Cell, Tumor, and Stem Cell Biology:

The PAX3-FKHR Fusion Gene of Rhabdomyosarcoma Cooperates with Loss of p16^INK4A to Promote Bypass of Cellular Senescence

Corinne M. Linardic, Sarasija Naini, James E. Herndon, II, Chimen Kesserwan, Stephen J. Qualman, and Christopher M. Counter
Cancer Res 2007 67: 6691-6699. doi: 10.1158/0008-5472.CAN-06-3210 [Abstract] [Full Text] [PDF]  

IRE1 Signaling Is Essential for Ischemia-Induced Vascular Endothelial Growth Factor-A Expression and Contributes to Angiogenesis and Tumor Growth In vivo

Benjamin Drogat, Patrick Auguste, Duc Thang Nguyen, Marion Bouchecareilh, Raphael Pineau, Josephine Nalbantoglu, Randal J. Kaufman, Eric Chevet, Andréas Bikfalvi, and Michel Moenner
Cancer Res 2007 67: 6700-6707. doi: 10.1158/0008-5472.CAN-06-3235 [Abstract] [Full Text] [PDF] Supplementary Data  

Subcellular Localization of Sigma-2 Receptors in Breast Cancer Cells Using Two-Photon and Confocal Microscopy

Chenbo Zeng, Suwanna Vangveravong, Jinbin Xu, Katherine C. Chang, Richard S. Hotchkiss, Kenneth T. Wheeler, Duanwen Shen, Zhi-Ping Zhuang, Hank F. Kung, and Robert H. Mach
Cancer Res 2007 67: 6708-6716. doi: 10.1158/0008-5472.CAN-06-3803 [Abstract] [Full Text] [PDF]  

Effect of Dominant Negative Transforming Growth Factor-ß Receptor Type II on Cytotoxic Activity of RAW 264.7, a Murine Macrophage Cell Line

Geun Taek Lee, Jun Hyuk Hong, Cheol Kwak, Jaesung Woo, Victoria Liu, Chung Lee, and Isaac Yi Kim
Cancer Res 2007 67: 6717-6724. doi: 10.1158/0008-5472.CAN-06-4263 [Abstract] [Full Text] [PDF]  

BEX2 Is Overexpressed in a Subset of Primary Breast Cancers and Mediates Nerve Growth Factor/Nuclear Factor-B Inhibition of Apoptosis in Breast Cancer Cell Lines

Ali Naderi, Andrew E. Teschendorff, Juergen Beigel, Massimiliano Cariati, Ian O. Ellis, James D. Brenton, and Carlos Caldas
Cancer Res 2007 67: 6725-6736. doi: 10.1158/0008-5472.CAN-06-4394 [Abstract] [Full Text] [PDF] Supplementary Data  

Dual Specificity Phosphatase 1/CL100 Is a Direct Transcriptional Target of E2F-1 in the Apoptotic Response to Oxidative Stress

Jianli Wang, David P. Yin, Yu-Xin Liu, Richard Baer, and Yuxin Yin
Cancer Res 2007 67: 6737-6744. doi: 10.1158/0008-5472.CAN-06-4402 [Abstract] [Full Text] [PDF] Supplementary Data  

Systemic Treatment with the Antidiabetic Drug Metformin Selectively Impairs p53-Deficient Tumor Cell Growth

Monica Buzzai, Russell G. Jones, Ravi K. Amaravadi, Julian J. Lum, Ralph J. DeBerardinis, Fangping Zhao, Benoit Viollet, and Craig B. Thompson
Cancer Res 2007 67: 6745-6752. doi: 10.1158/0008-5472.CAN-06-4447 [Abstract] [Full Text] [PDF] Supplementary Data  

ERM/ETV5 Up-regulation Plays a Role during Myometrial Infiltration through Matrix Metalloproteinase-2 Activation in Endometrial Cancer

Marta Monge, Eva Colas, Andreas Doll, Marta Gonzalez, Antonio Gil-Moreno, Jesus Planaguma, Maite Quiles, Maria Antonia Arbos, Angel Garcia, Josep Castellvi, Marta Llaurado, Marina Rigau, Hafid Alazzouzi, Jordi Xercavins, Francesc Alameda, Jaume Reventos, and Miguel Abal
Cancer Res 2007 67: 6753-6759. doi: 10.1158/0008-5472.CAN-06-4487 [Abstract] [Full Text] [PDF] Supplementary Data  

Matrix Metalloproteinase 7 Mediates Mammary Epithelial Cell Tumorigenesis through the ErbB4 Receptor

Conor C. Lynch, Tracy Vargo-Gogola, Michelle D. Martin, Barbara Fingleton, Howard C. Crawford, and Lynn M. Matrisian
Cancer Res 2007 67: 6760-6767. doi: 10.1158/0008-5472.CAN-07-0026 [Abstract] [Full Text] [PDF] Supplementary Data  

Genetic Ablation of CCAAT/Enhancer Binding Protein in Epidermis Reveals Its Role in Suppression of Epithelial Tumorigenesis

Kari D. Loomis, Songyun Zhu, Kyungsil Yoon, Peter F. Johnson, and Robert C. Smart
Cancer Res 2007 67: 6768-6776. doi: 10.1158/0008-5472.CAN-07-0139 [Abstract] [Full Text] [PDF]  

MFG-E8/Lactadherin Promotes Tumor Growth in an Angiogenesis-Dependent Transgenic Mouse Model of Multistage Carcinogenesis

Melanie Neutzner, Theresa Lopez, Xu Feng, Elke S. Bergmann-Leitner, Wolfgang W. Leitner, and Mark C. Udey
Cancer Res 2007 67: 6777-6785. doi: 10.1158/0008-5472.CAN-07-0165 [Abstract] [Full Text] [PDF] Supplementary Data  

S100A4 Contributes to the Suppression of BNIP3 Expression, Chemoresistance, and Inhibition of Apoptosis in Pancreatic Cancer

Patrick C. Mahon, Patrick Baril, Vipul Bhakta, Claude Chelala, Krishna Caulee, Tomohiko Harada, and Nicholas R. Lemoine
Cancer Res 2007 67: 6786-6795. doi: 10.1158/0008-5472.CAN-07-0440 [Abstract] [Full Text] [PDF]  

Hierarchical Organization of Prostate Cancer Cells in Xenograft Tumors: The CD44⁺2ß1⁺ Cell Population Is Enriched in Tumor-Initiating Cells

Lubna Patrawala, Tammy Calhoun-Davis, Robin Schneider-Broussard, and Dean G. Tang
Cancer Res 2007 67: 6796-6805. doi: 10.1158/0008-5472.CAN-07-0490 [Abstract] [Full Text] [PDF] Supplementary Data  

The Putative Tumor Suppressor Gene PTPN13/PTPL1 Induces Apoptosis through Insulin Receptor Substrate-1 Dephosphorylation

Mathilde Dromard, Guillaume Bompard, Murielle Glondu-Lassis, Carole Puech, Dany Chalbos, and Gilles Freiss
Cancer Res 2007 67: 6806-6813. doi: 10.1158/0008-5472.CAN-07-0513 [Abstract] [Full Text] [PDF] Supplementary Data  

Eukaryotic Translation Initiation Factor 4E–Induced Progression of Primary Human Mammary Epithelial Cells along the Cancer Pathway Is Associated with Targeted Translational Deregulation of Oncogenic Drivers and Inhibitors

Ola Larsson, Shunan Li, Olga A. Issaenko, Svetlana Avdulov, Mark Peterson, Karen Smith, Peter B. Bitterman, and Vitaly A. Polunovsky
Cancer Res 2007 67: 6814-6824. doi: 10.1158/0008-5472.CAN-07-0752 [Abstract] [Full Text] [PDF] Supplementary Data  

Breast Cancer Expressing the Activated HER2/neu Is Sensitive to Gefitinib In vitro and In vivo and Acquires Resistance through a Novel Point Mutation in the HER2/neu

Marie P. Piechocki, George H. Yoo, Susan K. Dibbley, and Fulvio Lonardo
Cancer Res 2007 67: 6825-6843. doi: 10.1158/0008-5472.CAN-07-0765 [Abstract] [Full Text] [PDF] Supplementary Data  

Fascin, a Novel Target of ß-Catenin-TCF Signaling, Is Expressed at the Invasive Front of Human Colon Cancer

Danijela Vignjevic, Marie Schoumacher, Nancy Gavert, Klaus-Peter Janssen, Gloria Jih, Marick Laé, Daniel Louvard, Avri Ben-Ze'ev, and Sylvie Robine
Cancer Res 2007 67: 6844-6853. doi: 10.1158/0008-5472.CAN-07-0929 [Abstract] [Full Text] [PDF] Supplementary Data  

Interleukin-8 Is a Molecular Determinant of Androgen Independence and Progression in Prostate Cancer

Shinako Araki, Yohei Omori, Dominic Lyn, Rajendra K. Singh, David M. Meinbach, Yekutiel Sandman, Vinata B. Lokeshwar, and Bal L. Lokeshwar
Cancer Res 2007 67: 6854-6862. doi: 10.1158/0008-5472.CAN-07-1162 [Abstract] [Full Text] [PDF] Supplementary Data  

Nongenomic ß Estrogen Receptors Enhance ß1 Adrenergic Signaling Induced by the Nicotine-Derived Carcinogen 4-(Methylnitrosamino)-1-(3-Pyridyl)-1-Butanone in Human Small Airway Epithelial Cells

Mourad Majidi, Hussein A. Al-Wadei, Takashi Takahashi, and Hildegard M. Schuller
Cancer Res 2007 67: 6863-6871. doi: 10.1158/0008-5472.CAN-07-0483 [Abstract] [Full Text] [PDF]  

Experimental Therapeutics, Molecular Targets, and Chemical Biology:

Targeted Cancer Gene Therapy Using a Hypoxia Inducible Factor–Dependent Oncolytic Adenovirus Armed with Interleukin-4

Dawn E. Post, Eric M. Sandberg, Michele M. Kyle, Narra Sarojini Devi, Daniel J. Brat, Zhiheng Xu, Mourad Tighiouart, and Erwin G. Van Meir
Cancer Res 2007 67: 6872-6881. doi: 10.1158/0008-5472.CAN-06-3244 [Abstract] [Full Text] [PDF] Supplementary Data  

Tumor Paint: A Chlorotoxin:Cy5.5 Bioconjugate for Intraoperative Visualization of Cancer Foci

Mandana Veiseh, Patrik Gabikian, S-Bahram Bahrami, Omid Veiseh, Miqin Zhang, Robert C. Hackman, Ali C. Ravanpay, Mark R. Stroud, Yumiko Kusuma, Stacey J. Hansen, Deborah Kwok, Nina M. Munoz, Raymond W. Sze, William M. Grady, Norman M. Greenberg, Richard G. Ellenbogen, and James M. Olson
Cancer Res 2007 67: 6882-6888. doi: 10.1158/0008-5472.CAN-06-3948 [Abstract] [Full Text] [PDF] Supplementary Data  

Inhibition of Nuclear Factor-B Activity by Temozolomide Involves O⁶-Methylguanine–Induced Inhibition of p65 DNA Binding

Bakhtiar Yamini, Xiaohong Yu, M. Eileen Dolan, Michael H. Wu, Donald W. Kufe, and Ralph R. Weichselbaum
Cancer Res 2007 67: 6889-6898. doi: 10.1158/0008-5472.CAN-06-4496 [Abstract] [Full Text] [PDF] Supplementary Data  

Discovery and Validation of Biomarkers that Respond to Treatment with Brivanib Alaninate, a Small-Molecule VEGFR-2/FGFR-1 Antagonist

Mark Ayers, Joseph Fargnoli, Anne Lewin, Qiuyan Wu, and J. Suso Platero
Cancer Res 2007 67: 6899-6906. doi: 10.1158/0008-5472.CAN-06-4555 [Abstract] [Full Text] [PDF]  

A Galactolipid Possesses Novel Cancer Chemopreventive Effects by Suppressing Inflammatory Mediators and Mouse B16 Melanoma

Chia-Chung Hou, Yi-Ping Chen, Jyh-Horng Wu, Chi-Chang Huang, Sheng-Yang Wang, Ning-Sun Yang, and Lie-Fen Shyur
Cancer Res 2007 67: 6907-6915. doi: 10.1158/0008-5472.CAN-07-0158 [Abstract] [Full Text] [PDF]  

Structural Analysis Identifies Imidazo[1,2-b]Pyridazines as PIM Kinase Inhibitors with In vitro Antileukemic Activity

Vanda Pogacic, Alex N. Bullock, Oleg Fedorov, Panagis Filippakopoulos, Christelle Gasser, Andrea Biondi, Sandrine Meyer-Monard, Stefan Knapp, and Juerg Schwaller
Cancer Res 2007 67: 6916-6924. doi: 10.1158/0008-5472.CAN-07-0320 [Abstract] [Full Text] [PDF] Supplementary Data  

Blockade of ß-Catenin Signaling by Plant Flavonoid Apigenin Suppresses Prostate Carcinogenesis in TRAMP Mice

Sanjeev Shukla, Gregory T. MacLennan, Chris A. Flask, Pingfu Fu, Anil Mishra, Martin I. Resnick, and Sanjay Gupta
Cancer Res 2007 67: 6925-6935. doi: 10.1158/0008-5472.CAN-07-0717 [Abstract] [Full Text] [PDF] Supplementary Data  

Nonhomologous End Joining Is Essential for Cellular Resistance to the Novel Antitumor Agent, ß-Lapachone

Melissa S. Bentle, Kathryn E. Reinicke, Ying Dong, Erik A. Bey, and David A. Boothman
Cancer Res 2007 67: 6936-6945. doi: 10.1158/0008-5472.CAN-07-0935 [Abstract] [Full Text] [PDF] Supplementary Data  

Lipid Rafts and Nonrafts Mediate Tumor Necrosis Factor–Related Apoptosis-Inducing Ligand–Induced Apoptotic and Nonapoptotic Signals in Non–Small Cell Lung Carcinoma Cells

Jin H. Song, Margaret C.L. Tse, Anita Bellail, Surasak Phuphanich, Fadlo Khuri, Norman M. Kneteman, and Chunhai Hao
Cancer Res 2007 67: 6946-6955. doi: 10.1158/0008-5472.CAN-06-3896 [Abstract] [Full Text] [PDF]  

The RET Kinase Inhibitor NVP-AST487 Blocks Growth and Calcitonin Gene Expression through Distinct Mechanisms in Medullary Thyroid Cancer Cells

Nagako Akeno-Stuart, Michelle Croyle, Jeffrey A. Knauf, Roberta Malaguarnera, Donata Vitagliano, Massimo Santoro, Christine Stephan, Konstantina Grosios, Markus Wartmann, Robert Cozens, Giorgio Caravatti, Doriano Fabbro, Heidi A. Lane, and James A. Fagin
Cancer Res 2007 67: 6956-6964. doi: 10.1158/0008-5472.CAN-06-4605 [Abstract] [Full Text] [PDF]  

Substrate Overlap between Mrp4 and Abcg2/Bcrp Affects Purine Analogue Drug Cytotoxicity and Tissue Distribution

Kazumasa Takenaka, Jessica A. Morgan, George L. Scheffer, Masashi Adachi, Clinton F. Stewart, Daxi Sun, Markos Leggas, Karin F.K. Ejendal, Christine A. Hrycyna, and John D. Schuetz
Cancer Res 2007 67: 6965-6972. doi: 10.1158/0008-5472.CAN-06-4720 [Abstract] [Full Text] [PDF] Supplementary Data  

Doxorubicin Affects Testicular Lipids with Long-Chain (C₁₈-C₂₂) and Very Long-Chain (C₂₄-C₃₂) Polyunsaturated Fatty Acids

Samanta R. Zanetti, Eduardo N. Maldonado, and Marta I. Aveldaño
Cancer Res 2007 67: 6973-6980. doi: 10.1158/0008-5472.CAN-07-0376 [Abstract] [Full Text] [PDF]  

Induction of Sonic Hedgehog Mediators by Transforming Growth Factor-ß: Smad3-Dependent Activation of Gli2 and Gli1 Expression In vitro and In vivo

Sylviane Dennler, Jocelyne André, Ismini Alexaki, Allen Li, Thierry Magnaldo, Peter ten Dijke, Xiao-Jing Wang, Franck Verrecchia, and Alain Mauviel
Cancer Res 2007 67: 6981-6986. doi: 10.1158/0008-5472.CAN-07-0491 [Abstract] [Full Text] [PDF]  

Histone Deacetylase Inhibitors Enhance Lexatumumab-Induced Apoptosis via a p21^Cip1-Dependent Decrease in Survivin Levels

Steffan T. Nawrocki, Jennifer S. Carew, Leslie Douglas, John L. Cleveland, Robin Humphreys, and Janet A. Houghton
Cancer Res 2007 67: 6987-6994. doi: 10.1158/0008-5472.CAN-07-0812 [Abstract] [Full Text] [PDF] Supplementary Data  

Tamoxifen Forms DNA Adducts in Human Colon after Administration of a Single [¹⁴C]-Labeled Therapeutic Dose

Karen Brown, Elaine M. Tompkins, David J. Boocock, Elizabeth A. Martin, Peter B. Farmer, Kenneth W. Turteltaub, Esther Ubick, David Hemingway, Emma Horner-Glister, and Ian N.H. White
Cancer Res 2007 67: 6995-7002. doi: 10.1158/0008-5472.CAN-07-0913 [Abstract] [Full Text] [PDF]  

Hypoxia Enhances the Phosphorylation and Cytotoxicity of Ganciclovir and Zidovudine in Kaposi's Sarcoma-Associated Herpesvirus–Infected Cells

David A. Davis, Kathleen E. Singer, Irene P. Reynolds, Muzammel Haque, and Robert Yarchoan
Cancer Res 2007 67: 7003-7010. doi: 10.1158/0008-5472.CAN-07-0939 [Abstract] [Full Text] [PDF]  

Immunology:

The Vascular Disrupting Agent, DMXAA, Directly Activates Dendritic Cells through a MyD88-Independent Mechanism and Generates Antitumor Cytotoxic T Lymphocytes

Africa Wallace, David F. LaRosa, Veena Kapoor, Jing Sun, Guanjun Cheng, Arminder Jassar, Aaron Blouin, Lai-Ming Ching, and Steven M. Albelda
Cancer Res 2007 67: 7011-7019. doi: 10.1158/0008-5472.CAN-06-3757 [Abstract] [Full Text] [PDF]  

Control of Her-2 Tumor Immunity and Thyroid Autoimmunity by MHC and Regulatory T Cells

Jennifer B. Jacob, Yi-chi M. Kong, Chady Meroueh, Daniel P. Snower, Chella S. David, Ye-Shih Ho, and Wei-Zen Wei
Cancer Res 2007 67: 7020-7027. doi: 10.1158/0008-5472.CAN-06-4755 [Abstract] [Full Text] [PDF] Supplementary Data  

A Polyepitope DNA Vaccine Targeted to Her-2/ErbB-2 Elicits a Broad Range of Human and Murine CTL Effectors to Protect against Tumor Challenge

Antonio Scardino, Maurizio Alimandi, Pierpaolo Correale, Steven G. Smith, Roberto Bei, Hüseyin Firat, Maria Grazia Cusi, Olivier Faure, Stephanie Graf-Dubois, Giulia Cencioni, Jordan Marrocco, Salem Chouaib, François A. Lemonnier, Andrew Michael Jackson, and Kostas Kosmatopoulos
Cancer Res 2007 67: 7028-7036. doi: 10.1158/0008-5472.CAN-06-3998 [Abstract] [Full Text] [PDF]  

Therapeutic Vaccination against Murine Lymphoma by Intratumoral Injection of Recombinant Fowlpox Virus Encoding CD40 Ligand

Aichun Liu, Alice Guardino, Lek Chinsangaram, Matthew J. Goldstein, Dennis Panicali, and Ronald Levy
Cancer Res 2007 67: 7037-7044. doi: 10.1158/0008-5472.CAN-07-0224 [Abstract] [Full Text] [PDF]  

Clinical Research:

BCR-Tyrosine 177 Plays an Essential Role in Ras and Akt Activation and in Human Hematopoietic Progenitor Transformation in Chronic Myelogenous Leukemia

Su Chu, Liang Li, Harjeet Singh, and Ravi Bhatia
Cancer Res 2007 67: 7045-7053. doi: 10.1158/0008-5472.CAN-06-4312 [Abstract] [Full Text] [PDF]  

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