Reviews:

Nuclear Factor-B, an Unappreciated Tumor Suppressor

Fei Chen and Vince Castranova
Cancer Res 2007 67: 11093-11098. doi: 10.1158/0008-5472.CAN-07-1576 [Abstract] [Full Text] [PDF] Supplementary Data  

The Guardian's Little Helper: MicroRNAs in the p53 Tumor Suppressor Network

Xingyue He, Lin He, and Gregory J. Hannon
Cancer Res 2007 67: 11099-11101. doi: 10.1158/0008-5472.CAN-07-2672 [Abstract] [Full Text] [PDF]  

Meeting Report:

Nineteenth Annual Pezcoller Symposium: Hypothesis-Driven Clinical Investigation in Cancer

William G. Kaelin, Charles L. Sawyers, and Enrico Mihich
Cancer Res 2007 67: 11102-11105. Published Online First November 28, 2007. doi: 10.1158/0008-5472.CAN-07-3230 [Abstract] [Full Text] [PDF]  

Priority Reports:

Polo-like Kinase 1 Is Involved in Invasion through Extracellular Matrix

Aylin Rizki, Joni D. Mott, and Mina J. Bissell
Cancer Res 2007 67: 11106-11110. doi: 10.1158/0008-5472.CAN-07-2348 [Abstract] [Full Text] [PDF]  

MicroRNAs as Potential Agents to Alter Resistance to Cytotoxic Anticancer Therapy

Joanne B. Weidhaas, Imran Babar, Sunitha M. Nallur, Phong Trang, Sarah Roush, Michelle Boehm, Erin Gillespie, and Frank J. Slack
Cancer Res 2007 67: 11111-11116. doi: 10.1158/0008-5472.CAN-07-2858 [Abstract] [Full Text] [PDF] Supplementary Data  

Cells Deficient in the FANC/BRCA Pathway Are Hypersensitive to Plasma Levels of Formaldehyde

John R. Ridpath, Ayumi Nakamura, Keizo Tano, April M. Luke, Eiichiro Sonoda, Hiroshi Arakawa, Jean-Marie Buerstedde, David A.F. Gillespie, Julian E. Sale, Mitsuyoshi Yamazoe, Douglas K. Bishop, Minoru Takata, Shunichi Takeda, Masami Watanabe, James A. Swenberg, and Jun Nakamura
Cancer Res 2007 67: 11117-11122. doi: 10.1158/0008-5472.CAN-07-3028 [Abstract] [Full Text] [PDF] Supplementary Data  

Plasma Cysteinylglycine Levels and Breast Cancer Risk in Women

Jennifer Lin, JoAnn E. Manson, Jacob Selhub, Julie E. Buring, and Shumin M. Zhang
Cancer Res 2007 67: 11123-11127. doi: 10.1158/0008-5472.CAN-07-3061 [Abstract] [Full Text] [PDF]  

Variants on 9p24 and 8q24 Are Associated with Risk of Colorectal Cancer: Results from the Colon Cancer Family Registry

Jenny N. Poynter, Jane C. Figueiredo, David V. Conti, Kathleen Kennedy, Steven Gallinger, Kimberly D. Siegmund, Graham Casey, Stephen N. Thibodeau, Mark A. Jenkins, John L. Hopper, Graham B. Byrnes, John A. Baron, Ellen L. Goode, Maarit Tiirikainen, Noralane Lindor, John Grove, Polly Newcomb, Jeremy Jass, Joanne Young, John D. Potter, Robert W. Haile, David J. Duggan, Loic Le Marchand for the Colon CFR
Cancer Res 2007 67: 11128-11132. doi: 10.1158/0008-5472.CAN-07-3239 [Abstract] [Full Text] [PDF]  

Molecular Biology, Pathobiology, and Genetics:

Direct Transcriptional Activation of Promyelocytic Leukemia Protein by IFN Regulatory Factor 3 Induces the p53-Dependent Growth Inhibition of Cancer Cells

Tae-Kyung Kim, Joong-Seob Lee, Se-Yeong Oh, Xun Jin, Yun-Jaie Choi, Tae-Hoon Lee, Eun ho Lee, Young-Ki Choi, Seungkwon You, Yong Gu Chung, Jang-Bo Lee, Ronald A. DePinho, Lynda Chin, and Hyunggee Kim
Cancer Res 2007 67: 11133-11140. doi: 10.1158/0008-5472.CAN-07-1342 [Abstract] [Full Text] [PDF] Supplementary Data  

Role of CYP2E1 in Diethylnitrosamine-Induced Hepatocarcinogenesis In vivo

Jin Seok Kang, Hideki Wanibuchi, Keiichirou Morimura, Frank J. Gonzalez, and Shoji Fukushima
Cancer Res 2007 67: 11141-11146. doi: 10.1158/0008-5472.CAN-07-1369 [Abstract] [Full Text] [PDF]  

Epithelial to Mesenchymal Transition in Human Breast Epithelial Cells Transformed by 17β-Estradiol

Yong Huang, Sandra V. Fernandez, Shirlean Goodwin, Patricia A. Russo, Irma H. Russo, Thomas R. Sutter, and Jose Russo
Cancer Res 2007 67: 11147-11157. doi: 10.1158/0008-5472.CAN-07-1371 [Abstract] [Full Text] [PDF] Supplementary Data  

Novel NBS1 Heterozygous Germ Line Mutation Causing MRE11-Binding Domain Loss Predisposes to Common Types of Cancer

Hiromichi Ebi, Keitaro Matsuo, Nobuyoshi Sugito, Motoshi Suzuki, Hirotaka Osada, Kazuo Tajima, Ryuzo Ueda, and Takashi Takahashi
Cancer Res 2007 67: 11158-11165. doi: 10.1158/0008-5472.CAN-07-1749 [Abstract] [Full Text] [PDF]  

Sigma-1 Receptors Bind Cholesterol and Remodel Lipid Rafts in Breast Cancer Cell Lines

Christopher P. Palmer, Robert Mahen, Eva Schnell, Mustafa B.A. Djamgoz, and Ebru Aydar
Cancer Res 2007 67: 11166-11175. doi: 10.1158/0008-5472.CAN-07-1771 [Abstract] [Full Text] [PDF] Supplementary Data  

Adaptor Protein LAPF Recruits Phosphorylated p53 to Lysosomes and Triggers Lysosomal Destabilization in Apoptosis

Nan Li, Yuanyuan Zheng, Wei Chen, Chunmei Wang, Xingguang Liu, Weigang He, Hongmei Xu, and Xuetao Cao
Cancer Res 2007 67: 11176-11185. doi: 10.1158/0008-5472.CAN-07-2333 [Abstract] [Full Text] [PDF] Supplementary Data  

Aurora-A Kinase Regulates Breast Cancer–Associated Gene 1 Inhibition of Centrosome-Dependent Microtubule Nucleation

Satish Sankaran, Donna E. Crone, Robert E. Palazzo, and Jeffrey D. Parvin
Cancer Res 2007 67: 11186-11194. doi: 10.1158/0008-5472.CAN-07-2578 [Abstract] [Full Text] [PDF] Supplementary Data  

Differing Phenotypes between Intraepithelial and Stromal Lymphocytes in Early-Stage Tongue Cancer

Fuminori Katou, Haruo Ohtani, Yoshiko Watanabe, Takashi Nakayama, Osamu Yoshie, and Kenji Hashimoto
Cancer Res 2007 67: 11195-11201. doi: 10.1158/0008-5472.CAN-07-2637 [Abstract] [Full Text] [PDF] Supplementary Data  

CD83 Gene Polymorphisms Increase Susceptibility to Human Invasive Cervical Cancer

Zhengyan Zhang, Ingrid Borecki, Loan Nguyen, Duanduan Ma, Kimberly Smith, Phyllis C. Huettner, David G. Mutch, Thomas J. Herzog, Randall K. Gibb, Matthew A. Powell, Perry W. Grigsby, L. Stewart Massad, Enrique Hernandez, Patricia L. Judson, Elizabeth M. Swisher, Sara Crowder, Jianduan Li, Daniela S. Gerhard, and Janet S. Rader
Cancer Res 2007 67: 11202-11208. doi: 10.1158/0008-5472.CAN-07-2677 [Abstract] [Full Text] [PDF]  

c-myc Repression of TSC2 Contributes to Control of Translation Initiation and Myc-Induced Transformation

Michael J. Ravitz, Li Chen, Mary Lynch, and Emmett V. Schmidt
Cancer Res 2007 67: 11209-11217. doi: 10.1158/0008-5472.CAN-06-4351 [Abstract] [Full Text] [PDF] Supplementary Data  

Traf1 Induction and Protection from Tumor Necrosis Factor by Nuclear Factor-B p65 Is Independent of Serine 536 Phosphorylation

Carl Y. Sasaki, Colin F. Slemenda, Paritosh Ghosh, Theresa J. Barberi, and Dan L. Longo
Cancer Res 2007 67: 11218-11225. doi: 10.1158/0008-5472.CAN-07-0922 [Abstract] [Full Text] [PDF] Supplementary Data  

Identification of Novel Modifier Loci of Apc^Min Affecting Mammary Tumor Development

Hua Wang, Douglas Teske, Alyssa Tess, Rebecca Kohlhepp, YounJeong Choi, Christina Kendziorski, and Amy Rapaich Moser
Cancer Res 2007 67: 11226-11233. doi: 10.1158/0008-5472.CAN-07-2487 [Abstract] [Full Text] [PDF]  

Cell, Tumor, and Stem Cell Biology:

Neuroblastoma Cells Isolated from Bone Marrow Metastases Contain a Naturally Enriched Tumor-Initiating Cell

Loen M. Hansford, Amy E. McKee, Libo Zhang, Rani E. George, J. Ted Gerstle, Paul S. Thorner, Kristen M. Smith, A. Thomas Look, Herman Yeger, Freda D. Miller, Meredith S. Irwin, Carol J. Thiele, and David R. Kaplan
Cancer Res 2007 67: 11234-11243. doi: 10.1158/0008-5472.CAN-07-0718 [Abstract] [Full Text] [PDF] Supplementary Data  

Delta-like 4 Notch Ligand Regulates Tumor Angiogenesis, Improves Tumor Vascular Function, and Promotes Tumor Growth In vivo

Ji-Liang Li, Richard C.A. Sainson, Wen Shi, Russell Leek, Laura S. Harrington, Matthias Preusser, Swethajit Biswas, Helen Turley, Emily Heikamp, Johannes A. Hainfellner, and Adrian L. Harris
Cancer Res 2007 67: 11244-11253. doi: 10.1158/0008-5472.CAN-07-0969 [Abstract] [Full Text] [PDF] Supplementary Data  

Epithelial-Mesenchymal Transition Events during Human Embryonic Stem Cell Differentiation

Angela M. Eastham, Helen Spencer, Francesca Soncin, Sarah Ritson, Catherine L.R. Merry, Peter L. Stern, and Christopher M. Ward
Cancer Res 2007 67: 11254-11262. doi: 10.1158/0008-5472.CAN-07-2253 [Abstract] [Full Text] [PDF]  

Runx2 Disruption Promotes Immortalization and Confers Resistance to Oncogene-Induced Senescence in Primary Murine Fibroblasts

Anna Kilbey, Karen Blyth, Sandy Wotton, Anne Terry, Alma Jenkins, Margaret Bell, Linda Hanlon, Ewan R. Cameron, and James C. Neil
Cancer Res 2007 67: 11263-11271. doi: 10.1158/0008-5472.CAN-07-3016 [Abstract] [Full Text] [PDF]  

Differential Regulation of Elafin in Normal and Tumor-Derived Mammary Epithelial Cells Is Mediated by CCAAT/Enhancer Binding Protein β

Tomoya Yokota, Tuyen Bui, Yanna Liu, Min Yi, Kelly K. Hunt, and Khandan Keyomarsi
Cancer Res 2007 67: 11272-11283. doi: 10.1158/0008-5472.CAN-07-2322 [Abstract] [Full Text] [PDF]  

Choline Kinase Down-regulation Increases the Effect of 5-Fluorouracil in Breast Cancer Cells

Noriko Mori, Kristine Glunde, Tomoyo Takagi, Venu Raman, and Zaver M. Bhujwalla
Cancer Res 2007 67: 11284-11290. doi: 10.1158/0008-5472.CAN-07-2728 [Abstract] [Full Text] [PDF]  

Experimental Therapeutics, Molecular Targets, and Chemical Biology:

WP1066 Disrupts Janus Kinase-2 and Induces Caspase-Dependent Apoptosis in Acute Myelogenous Leukemia Cells

Alessandra Ferrajoli, Stefan Faderl, Quin Van, Patricia Koch, David Harris, Zhiming Liu, Inbal Hazan-Halevy, Yongtao Wang, Hagop M. Kantarjian, Waldemar Priebe, and Zeev Estrov
Cancer Res 2007 67: 11291-11299. doi: 10.1158/0008-5472.CAN-07-0593 [Abstract] [Full Text] [PDF]  

Targeting Protein Translation in Human Non–Small Cell Lung Cancer via Combined MEK and Mammalian Target of Rapamycin Suppression

Marie-Emmanuelle Legrier, Chia-Ping Huang Yang, Han-Guang Yan, Lluis Lopez-Barcons, Steven M. Keller, Roman Pérez-Soler, Susan Band Horwitz, and Hayley M. McDaid
Cancer Res 2007 67: 11300-11308. doi: 10.1158/0008-5472.CAN-07-0702 [Abstract] [Full Text] [PDF] Supplementary Data  

An Oncolytic Adenovirus Redirected with a Tumor-Specific T-Cell Receptor

Zsolt Sebestyen, Jeroen de Vrij, Maria Magnusson, Reno Debets, and Ralph Willemsen
Cancer Res 2007 67: 11309-11316. doi: 10.1158/0008-5472.CAN-07-0739 [Abstract] [Full Text] [PDF]  

Ribosomal Protein S27-like, a p53-Inducible Modulator of Cell Fate in Response to Genotoxic Stress

Jingsong Li, Jing Tan, Li Zhuang, Birendranath Banerjee, Xiaojing Yang, Jenny Fung Ling Chau, Puay Leng Lee, Manoor Prakash Hande, Baojie Li, and Qiang Yu
Cancer Res 2007 67: 11317-11326. doi: 10.1158/0008-5472.CAN-07-1088 [Abstract] [Full Text] [PDF] Supplementary Data  

Histone Deacetylase Inhibitors Promote the Tumoricidal Effect of HAMLET

Patrick Brest, Mattias Gustafsson, Ann-Kristin Mossberg, Lotta Gustafsson, Caroline Duringer, Ali Hamiche, and Catharina Svanborg
Cancer Res 2007 67: 11327-11334. doi: 10.1158/0008-5472.CAN-07-1153 [Abstract] [Full Text] [PDF]  

Drug Sensitivity Prediction by CpG Island Methylation Profile in the NCI-60 Cancer Cell Line Panel

Lanlan Shen, Yutaka Kondo, Saira Ahmed, Yanis Boumber, Kazuo Konishi, Yi Guo, Xinli Chen, Jill N. Vilaythong, and Jean-Pierre J. Issa
Cancer Res 2007 67: 11335-11343. doi: 10.1158/0008-5472.CAN-07-1502 [Abstract] [Full Text] [PDF] Supplementary Data  

Novel Quinazoline-Based Compounds Impair Prostate Tumorigenesis by Targeting Tumor Vascularity

Jason B. Garrison, Yeng-Jeng Shaw, Ching-Shih Chen, and Natasha Kyprianou
Cancer Res 2007 67: 11344-11352. doi: 10.1158/0008-5472.CAN-07-1662 [Abstract] [Full Text] [PDF] Supplementary Data  

Gpx2 Is an Overexpressed Gene in Rat Breast Cancers Induced by Three Different Chemical Carcinogens

Aya Naiki-Ito, Makoto Asamoto, Naomi Hokaiwado, Satoru Takahashi, Hiroko Yamashita, Hiroyuki Tsuda, Kumiko Ogawa, and Tomoyuki Shirai
Cancer Res 2007 67: 11353-11358. doi: 10.1158/0008-5472.CAN-07-2226 [Abstract] [Full Text] [PDF]  

The Novel Combination of Chlorpromazine and Pentamidine Exerts Synergistic Antiproliferative Effects through Dual Mitotic Action

Margaret S. Lee, Lisa Johansen, Yanzhen Zhang, Amy Wilson, Mitchell Keegan, William Avery, Peter Elliott, Alexis A. Borisy, and Curtis T. Keith
Cancer Res 2007 67: 11359-11367. doi: 10.1158/0008-5472.CAN-07-2235 [Abstract] [Full Text] [PDF]  

Genetic Alterations in the Tyrosine Kinase Transcriptome of Human Cancer Cell Lines

Jens E. Ruhe, Sylvia Streit, Stefan Hart, Chee-Hong Wong, Katja Specht, Pjotr Knyazev, Tatjana Knyazeva, Liang Seah Tay, Hooi Linn Loo, Priscilla Foo, Winnie Wong, Sharon Pok, Shu Jing Lim, Huimin Ong, Ming Luo, Han Kiat Ho, Kaitian Peng, Tze Chuen Lee, Martin Bezler, Christian Mann, Silvia Gaertner, Heinz Hoefler, Stefano Iacobelli, Stephan Peter, Alice Tay, Sydney Brenner, Byrappa Venkatesh, and Axel Ullrich
Cancer Res 2007 67: 11368-11376. doi: 10.1158/0008-5472.CAN-07-2703 [Abstract] [Full Text] [PDF] Supplementary Data  

Down-regulation of Platelet-Derived Growth Factor-D Inhibits Cell Growth and Angiogenesis through Inactivation of Notch-1 and Nuclear Factor-B Signaling

Zhiwei Wang, Dejuan Kong, Sanjeev Banerjee, Yiwei Li, N. Volkan Adsay, James Abbruzzese, and Fazlul H. Sarkar
Cancer Res 2007 67: 11377-11385. doi: 10.1158/0008-5472.CAN-07-2803 [Abstract] [Full Text] [PDF]  

Automated, Quantitative Screening Assay for Antiangiogenic Compounds Using Transgenic Zebrafish

T. Cameron Tran, Blossom Sneed, Jamil Haider, Delali Blavo, Audrey White, Temitope Aiyejorun, Timothy C. Baranowski, Amy L. Rubinstein, Thanh N. Doan, Raymond Dingledine, and Eric M. Sandberg
Cancer Res 2007 67: 11386-11392. doi: 10.1158/0008-5472.CAN-07-3126 [Abstract] [Full Text] [PDF] Supplementary Data  

Cks1 Regulates cdk1 Expression: A Novel Role during Mitotic Entry in Breast Cancer Cells

Louise Westbrook, Marina Manuvakhova, Francis G. Kern, Norman R. Estes, II, Harish N. Ramanathan, and Jaideep V. Thottassery
Cancer Res 2007 67: 11393-11401. doi: 10.1158/0008-5472.CAN-06-4173 [Abstract] [Full Text] [PDF] Supplementary Data  

The p38 MAPK Pathway Mediates Aryl Propionic Acid–Induced Messenger RNA Stability of p75^NTR in Prostate Cancer Cells

Emily J. Quann, Fatima Khwaja, and Daniel Djakiew
Cancer Res 2007 67: 11402-11410. doi: 10.1158/0008-5472.CAN-07-1792 [Abstract] [Full Text] [PDF] Supplementary Data  

Identification of Genes Required for Protection from Doxorubicin by a Genome-Wide Screen in Saccharomyces cerevisiae

Ling Xia, Lahcen Jaafar, Anil Cashikar, and Hernan Flores-Rozas
Cancer Res 2007 67: 11411-11418. doi: 10.1158/0008-5472.CAN-07-2399 [Abstract] [Full Text] [PDF] Supplementary Data  

Identification and Characterization of a Membrane Receptor for Proteolysis-Inducing Factor on Skeletal Muscle

Penio T. Todorov, Stacey M. Wyke, and Michael J. Tisdale
Cancer Res 2007 67: 11419-11427. doi: 10.1158/0008-5472.CAN-07-2602 [Abstract] [Full Text] [PDF]  

Immunology:

Sustained Antigen-Specific Antitumor Recall Response Mediated by Gene-Modified CD4⁺ T Helper-1 and CD8⁺ T Cells

Maria Moeller, Michael H. Kershaw, Rachel Cameron, Jennifer A. Westwood, Joseph A. Trapani, Mark J. Smyth, and Phillip K. Darcy
Cancer Res 2007 67: 11428-11437. doi: 10.1158/0008-5472.CAN-07-1141 [Abstract] [Full Text] [PDF] Supplementary Data  

Amino-Biphosphonate–Mediated MMP-9 Inhibition Breaks the Tumor-Bone Marrow Axis Responsible for Myeloid-Derived Suppressor Cell Expansion and Macrophage Infiltration in Tumor Stroma

Cecilia Melani, Sabina Sangaletti, Francesca M. Barazzetta, Zena Werb, and Mario P. Colombo
Cancer Res 2007 67: 11438-11446. doi: 10.1158/0008-5472.CAN-07-1882 [Abstract] [Full Text] [PDF] Supplementary Data  

Suppression of Proximal T Cell Receptor Signaling and Lytic Function in CD8⁺ Tumor-Infiltrating T Cells

Ngozi Monu and Alan B. Frey
Cancer Res 2007 67: 11447-11454. doi: 10.1158/0008-5472.CAN-07-1441 [Abstract] [Full Text] [PDF] Supplementary Data  

Epidemiology:

The Cooked Meat Carcinogen 2-Amino-1-Methyl-6-Phenylimidazo[4,5-b]Pyridine Activates the Extracellular Signal–Regulated Kinase Mitogen-Activated Protein Kinase Pathway

Stuart K. Creton, Huijun Zhu, and Nigel J. Gooderham
Cancer Res 2007 67: 11455-11462. doi: 10.1158/0008-5472.CAN-07-2821 [Abstract] [Full Text] [PDF]  

Prevention:

3'-Deoxy-3'-[¹⁸F]Fluorothymidine Positron Emission Tomography Is a Sensitive Method for Imaging the Response of BRAF-Dependent Tumors to MEK Inhibition

David B. Solit, Elmer Santos, Christine A. Pratilas, Jose Lobo, Maxim Moroz, Shangde Cai, Ronald Blasberg, Judith Sebolt-Leopold, Steven Larson, and Neal Rosen
Cancer Res 2007 67: 11463-11469. doi: 10.1158/0008-5472.CAN-07-2976 [Abstract] [Full Text] [PDF]  

Correction:

Correction: Np-1 Interacts with c-Met

Cancer Res 2007 67: 11470 [Full Text] [PDF]  

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