Reviews:

Innate versus Adaptive Immunity: A Paradigm Past Its Prime?

Lisa Borghesi and Christine Milcarek
Cancer Res 2007 67: 3989-3993. doi: 10.1158/0008-5472.CAN-07-0182 [Abstract] [Full Text] [PDF]  

Paradoxes of the EphB4 Receptor in Cancer

Nicole K. Noren and Elena B. Pasquale
Cancer Res 2007 67: 3994-3997. doi: 10.1158/0008-5472.CAN-07-0525 [Abstract] [Full Text] [PDF]  

Priority Reports:

The High-Mobility Group A1 Gene Up-Regulates Cyclooxygenase 2 Expression in Uterine Tumorigenesis

Abeba Tesfaye, Francescopaolo Di Cello, Joelle Hillion, Brigitte M. Ronnett, Ossama Elbahloul, Raheela Ashfaq, Surajit Dhara, Edward Prochownik, Kathryn Tworkoski, Raymond Reeves, Richard Roden, Lora Hedrick Ellenson, David L. Huso, and Linda M. S. Resar
Cancer Res 2007 67: 3998-4004. doi: 10.1158/0008-5472.CAN-05-1684 [Abstract] [Full Text] [PDF] Supplementary Data  

Transgenic E2F1 Expression in the Mouse Brain Induces a Human-Like Bimodal Pattern of Tumors

Melissa V. Olson, David G. Johnson, Hong Jiang, Jing Xu, Marta M. Alonso, Kenneth D. Aldape, Gregory N. Fuller, B. Nebiyou Bekele, W.K. Alfred Yung, Candelaria Gomez-Manzano, and Juan Fueyo
Cancer Res 2007 67: 4005-4009. doi: 10.1158/0008-5472.CAN-06-2973 [Abstract] [Full Text] [PDF] Supplementary Data  

CD133⁺ and CD133^– Glioblastoma-Derived Cancer Stem Cells Show Differential Growth Characteristics and Molecular Profiles

Dagmar Beier, Peter Hau, Martin Proescholdt, Annette Lohmeier, Jörg Wischhusen, Peter J. Oefner, Ludwig Aigner, Alexander Brawanski, Ulrich Bogdahn, and Christoph P. Beier
Cancer Res 2007 67: 4010-4015. doi: 10.1158/0008-5472.CAN-06-4180 [Abstract] [Full Text] [PDF] Supplementary Data  

Influence of Tumor Cell and Stroma Sensitivity on Tumor Response to Radiation

Kazuhiko Ogawa, Yves Boucher, Satoshi Kashiwagi, Dai Fukumura, David Chen, and Leo E. Gerweck
Cancer Res 2007 67: 4016-4021. doi: 10.1158/0008-5472.CAN-06-4498 [Abstract] [Full Text] [PDF]  

The SIL Gene Is Essential for Mitotic Entry and Survival of Cancer Cells

Ayelet Erez, Asher Castiel, Luba Trakhtenbrot, Marina Perelman, Esther Rosenthal, Itamar Goldstein, Noa Stettner, Alon Harmelin, Hagit Eldar-Finkelman, Stefano Campaner, Ilan Kirsch, and Shai Izraeli
Cancer Res 2007 67: 4022-4027. Published Online First April 24, 2007. doi: 10.1158/0008-5472.CAN-07-0064 [Abstract] [Full Text] [PDF]  

Rational Drug Redesign to Overcome Drug Resistance in Cancer Therapy: Imatinib Moving Target

Ariel Fernández, Angela Sanguino, Zhenghong Peng, Alejandro Crespo, Eylem Ozturk, Xi Zhang, Shimei Wang, William Bornmann, and Gabriel Lopez-Berestein
Cancer Res 2007 67: 4028-4033. doi: 10.1158/0008-5472.CAN-07-0345 [Abstract] [Full Text] [PDF] Supplementary Data  

Molecular Biology, Pathobiology, and Genetics:

A Coregulatory Role for the Mediator Complex in Prostate Cancer Cell Proliferation and Gene Expression

Ravi Vijayvargia, Michael S. May, and Joseph D. Fondell
Cancer Res 2007 67: 4034-4041. doi: 10.1158/0008-5472.CAN-06-3039 [Abstract] [Full Text] [PDF] Supplementary Data  

Kaposi's Sarcoma–Associated Herpesvirus-Encoded Interleukin-6 and G-Protein–Coupled Receptor Regulate Angiopoietin-2 Expression in Lymphatic Endothelial Cells

Richard J. Vart, Leonid L. Nikitenko, Dimitrios Lagos, Matthew W.B. Trotter, Mark Cannon, Dimitra Bourboulia, Fiona Gratrix, Yasuhiro Takeuchi, and Chris Boshoff
Cancer Res 2007 67: 4042-4051. doi: 10.1158/0008-5472.CAN-06-3321 [Abstract] [Full Text] [PDF] Supplementary Data  

Carcinogen-Specific Gene Expression Profiles in Short-term Treated Eker and Wild-type Rats Indicative of Pathways Involved in Renal Tumorigenesis

Kerstin Stemmer, Heidrun Ellinger-Ziegelbauer, Hans-Juergen Ahr, and Daniel R. Dietrich
Cancer Res 2007 67: 4052-4068. doi: 10.1158/0008-5472.CAN-06-3587 [Abstract] [Full Text] [PDF] Supplementary Data  

A Transgenic Mouse Model of Plasma Cell Malignancy Shows Phenotypic, Cytogenetic, and Gene Expression Heterogeneity Similar to Human Multiple Myeloma

Kristin L.M. Boylan, Mary A. Gosse, Sarah E. Staggs, Siegfried Janz, Suzanne Grindle, Geoffrey S. Kansas, and Brian G. Van Ness
Cancer Res 2007 67: 4069-4078. doi: 10.1158/0008-5472.CAN-06-3699 [Abstract] [Full Text] [PDF] Supplementary Data  

Development of Gastric Tumors in Apc^Min/+ Mice by the Activation of the ß-Catenin/Tcf Signaling Pathway

Hiroyuki Tomita, Yasuhiro Yamada, Takeru Oyama, Kazuya Hata, Yoshinobu Hirose, Akira Hara, Takahiro Kunisada, Yasuyuki Sugiyama, Yosuke Adachi, Heinz Linhart, and Hideki Mori
Cancer Res 2007 67: 4079-4087. doi: 10.1158/0008-5472.CAN-06-4025 [Abstract] [Full Text] [PDF] Supplementary Data  

Thrombin-Cleaved COOH-Terminal Osteopontin Peptide Binds with Cyclophilin C to CD147 in Murine Breast Cancer Cells

Zhiyong Mi, Tim Oliver, Hongtao Guo, Chengjiang Gao, and Paul C. Kuo
Cancer Res 2007 67: 4088-4097. doi: 10.1158/0008-5472.CAN-06-4066 [Abstract] [Full Text] [PDF]  

Integration of Somatic Deletion Analysis of Prostate Cancers and Germline Linkage Analysis of Prostate Cancer Families Reveals Two Small Consensus Regions for Prostate Cancer Genes at 8p

Bao-li Chang, Wennuan Liu, Jishan Sun, Latchezar Dimitrov, Tao Li, Aubrey R. Turner, Siqun L. Zheng, William B. Isaacs, and Jianfeng Xu
Cancer Res 2007 67: 4098-4103. doi: 10.1158/0008-5472.CAN-06-4570 [Abstract] [Full Text] [PDF]  

Identification of Novel Amplification Gene Targets in Mouse and Human Breast Cancer at a Syntenic Cluster Mapping to Mouse ch8A1 and Human ch13q34

Martin C. Abba, Victoria T. Fabris, Yuhui Hu, Frances S. Kittrell, Wei-Wen Cai, Lawrence A. Donehower, Aysegul Sahin, Daniel Medina, and C. Marcelo Aldaz
Cancer Res 2007 67: 4104-4112. doi: 10.1158/0008-5472.CAN-06-4672 [Abstract] [Full Text] [PDF]  

Phosphorylation and Activation of Cell Division Cycle Associated 8 by Aurora Kinase B Plays a Significant Role in Human Lung Carcinogenesis

Satoshi Hayama, Yataro Daigo, Takumi Yamabuki, Daizaburo Hirata, Tatsuya Kato, Masaki Miyamoto, Tomoo Ito, Eiju Tsuchiya, Satoshi Kondo, and Yusuke Nakamura
Cancer Res 2007 67: 4113-4122. doi: 10.1158/0008-5472.CAN-06-4705 [Abstract] [Full Text] [PDF] Supplementary Data  

LOXL1 and LOXL4 Are Epigenetically Silenced and Can Inhibit Ras/Extracellular Signal-Regulated Kinase Signaling Pathway in Human Bladder Cancer

Guojun Wu, Zhongmin Guo, Xiaofei Chang, Myoung Sook Kim, Jatin K. Nagpal, Junwei Liu, Joni M. Maki, Kari I. Kivirikko, Stephen P. Ethier, Barry Trink, and David Sidransky
Cancer Res 2007 67: 4123-4129. Published Online First April 24, 2007. doi: 10.1158/0008-5472.CAN-07-0012 [Abstract] [Full Text] [PDF] Supplementary Data  

p21 Loss Cooperates with INK4 Inactivation Facilitating Immortalization and Bcl-2–Mediated Anchorage-Independent Growth of Oncogene-Transduced Primary Mouse Fibroblasts

Christopher J. Carbone, Xavier Graña, E. Premkumar Reddy, and Dale S. Haines
Cancer Res 2007 67: 4130-4137. doi: 10.1158/0008-5472.CAN-07-0499 [Abstract] [Full Text] [PDF] Supplementary Data  

Identification of Epigenetically Silenced Genes in Tumor Endothelial Cells

Debby M.E.I. Hellebrekers, Veerle Melotte, Emmanuelle Viré, Elise Langenkamp, Grietje Molema, François Fuks, James G. Herman, Wim Van Criekinge, Arjan W. Griffioen, and Manon van Engeland
Cancer Res 2007 67: 4138-4148. doi: 10.1158/0008-5472.CAN-06-3032 [Abstract] [Full Text] [PDF] Supplementary Data  

Phosphoinositide-3-Kinase Signaling Controls S-Phase Kinase–Associated Protein 2 Transcription via E2F1 in Pancreatic Ductal Adenocarcinoma Cells

Maximilian Reichert, Dieter Saur, Rainer Hamacher, Roland M. Schmid, and Günter Schneider
Cancer Res 2007 67: 4149-4156. doi: 10.1158/0008-5472.CAN-06-4484 [Abstract] [Full Text] [PDF] Supplementary Data  

Cell, Tumor, and Stem Cell Biology:

Hypoxia and Hypoxia-Inducible Factor-1 Expression Enhance Osteolytic Bone Metastases of Breast Cancer

Toru Hiraga, Shinae Kizaka-Kondoh, Kiichi Hirota, Masahiro Hiraoka, and Toshiyuki Yoneda
Cancer Res 2007 67: 4157-4163. doi: 10.1158/0008-5472.CAN-06-2355 [Abstract] [Full Text] [PDF] Supplementary Data  

Modeling Breast Cancer–Associated c-Src and EGFR Overexpression in Human MECs: c-Src and EGFR Cooperatively Promote Aberrant Three-dimensional Acinar Structure and Invasive Behavior

Manjari Dimri, Mayumi Naramura, Lei Duan, Jing Chen, Cesar Ortega-Cava, Gengsheng Chen, Rasna Goswami, Norvin Fernandes, Qingshen Gao, Goberdhan P. Dimri, Vimla Band, and Hamid Band
Cancer Res 2007 67: 4164-4172. doi: 10.1158/0008-5472.CAN-06-2580 [Abstract] [Full Text] [PDF] Supplementary Data  

CD34 Expression by Hair Follicle Stem Cells Is Required for Skin Tumor Development in Mice

Carol S. Trempus, Rebecca J. Morris, Matthew Ehinger, Amy Elmore, Carl D. Bortner, Mayumi Ito, George Cotsarelis, Joanne G.W. Nijhof, John Peckham, Norris Flagler, Grace Kissling, Margaret M. Humble, Leon C. King, Linda D. Adams, Dhimant Desai, Shantu Amin, and Raymond W. Tennant
Cancer Res 2007 67: 4173-4181. doi: 10.1158/0008-5472.CAN-06-3128 [Abstract] [Full Text] [PDF]  

Monocarboxylate Transporter 4 Regulates Maturation and Trafficking of CD147 to the Plasma Membrane in the Metastatic Breast Cancer Cell Line MDA-MB-231

Shannon M. Gallagher, John J. Castorino, Dian Wang, and Nancy J. Philp
Cancer Res 2007 67: 4182-4189. doi: 10.1158/0008-5472.CAN-06-3184 [Abstract] [Full Text] [PDF] Supplementary Data  

Her-2 Overexpression Increases the Metastatic Outgrowth of Breast Cancer Cells in the Brain

Diane Palmieri, Julie L. Bronder, Jeanne M. Herring, Toshiyuki Yoneda, Robert J. Weil, Andreas M. Stark, Raffael Kurek, Eleazar Vega-Valle, Lionel Feigenbaum, Douglas Halverson, Alexander O. Vortmeyer, Seth M. Steinberg, Kenneth Aldape, and Patricia S. Steeg
Cancer Res 2007 67: 4190-4198. doi: 10.1158/0008-5472.CAN-06-3316 [Abstract] [Full Text] [PDF] Supplementary Data  

Breast Tumor Kinase (Protein Tyrosine Kinase 6) Regulates Heregulin-Induced Activation of ERK5 and p38 MAP Kinases in Breast Cancer Cells

Julie Hanson Ostrander, Andrea R. Daniel, Kristopher Lofgren, Celina G. Kleer, and Carol A. Lange
Cancer Res 2007 67: 4199-4209. doi: 10.1158/0008-5472.CAN-06-3409 [Abstract] [Full Text] [PDF]  

The Novel Triterpenoid C-28 Methyl Ester of 2-Cyano-3, 12-Dioxoolen-1, 9-Dien-28-Oic Acid Inhibits Metastatic Murine Breast Tumor Growth through Inactivation of STAT3 Signaling

Xiaoyang Ling, Marina Konopleva, Zhihong Zeng, Vivian Ruvolo, L. Clifton Stephens, Wendy Schober, Teresa McQueen, Martin Dietrich, Timothy L. Madden, and Michael Andreeff
Cancer Res 2007 67: 4210-4218. doi: 10.1158/0008-5472.CAN-06-3629 [Abstract] [Full Text] [PDF]  

Reduced PDEF Expression Increases Invasion and Expression of Mesenchymal Genes in Prostate Cancer Cells

Xuesong Gu, Luiz F. Zerbini, Hasan H. Otu, Manoj Bhasin, Quanli Yang, Marie G. Joseph, Franck Grall, Tomi Onatunde, Ricardo G. Correa, and Towia A. Libermann
Cancer Res 2007 67: 4219-4226. doi: 10.1158/0008-5472.CAN-06-3689 [Abstract] [Full Text] [PDF] Supplementary Data  

Cortactin Is an Essential Regulator of Matrix Metalloproteinase Secretion and Extracellular Matrix Degradation in Invadopodia

Emily S. Clark, Amy S. Whigham, Wendell G. Yarbrough, and Alissa M. Weaver
Cancer Res 2007 67: 4227-4235. doi: 10.1158/0008-5472.CAN-06-3928 [Abstract] [Full Text] [PDF] Supplementary Data  

Down-Regulation of Phosphoglucose Isomerase/Autocrine Motility Factor Results in Mesenchymal-to-Epithelial Transition of Human Lung Fibrosarcoma Cells

Tatsuyoshi Funasaka, Huankai Hu, Takashi Yanagawa, Victor Hogan, and Avraham Raz
Cancer Res 2007 67: 4236-4243. doi: 10.1158/0008-5472.CAN-06-3935 [Abstract] [Full Text] [PDF] Supplementary Data  

Cross-talk between Paracrine-Acting Cytokine and Chemokine Pathways Promotes Malignancy in Benign Human Prostatic Epithelium

Mingfang Ao, Omar E. Franco, Dean Park, Dayanidhi Raman, Karin Williams, and Simon W. Hayward
Cancer Res 2007 67: 4244-4253. doi: 10.1158/0008-5472.CAN-06-3946 [Abstract] [Full Text] [PDF]  

Angiopoietin-2 Stimulates Breast Cancer Metastasis through the ₅ß₁ Integrin-Mediated Pathway

Yorihisha Imanishi, Bo Hu, Michael J. Jarzynka, Ping Guo, Esther Elishaev, Ifat Bar-Joseph, and Shi-Yuan Cheng
Cancer Res 2007 67: 4254-4263. doi: 10.1158/0008-5472.CAN-06-4100 [Abstract] [Full Text] [PDF] Supplementary Data  

A Laminin-Collagen Complex Drives Human Epidermal Carcinogenesis through Phosphoinositol-3-Kinase Activation

Elizabeth A. Waterman, Noriyasu Sakai, Ngon T. Nguyen, Basil A.J. Horst, Dallas P. Veitch, Clara N. Dey, Susana Ortiz-Urda, Paul A. Khavari, and M. Peter Marinkovich
Cancer Res 2007 67: 4264-4270. doi: 10.1158/0008-5472.CAN-06-4141 [Abstract] [Full Text] [PDF] Supplementary Data  

Regulation of Breast Cancer Response to Chemotherapy by Fibulin-1

Serenella M. Pupa, Sarah Giuffré, Fabio Castiglioni, Lorenzo Bertola, Marco Cantú, Italia Bongarzone, Paola Baldassari, Roberta Mortarini, W. Scott Argraves, Andrea Anichini, Sylvie Menard, and Elda Tagliabue
Cancer Res 2007 67: 4271-4277. doi: 10.1158/0008-5472.CAN-06-4162 [Abstract] [Full Text] [PDF] Supplementary Data  

The Tyrosine Phosphatase Shp2 Interacts with NPM-ALK and Regulates Anaplastic Lymphoma Cell Growth and Migration

Claudia Voena, Chiara Conte, Chiara Ambrogio, Elisabetta Boeri Erba, Francesco Boccalatte, Shabaz Mohammed, Ole N. Jensen, Giorgio Palestro, Giorgio Inghirami, and Roberto Chiarle
Cancer Res 2007 67: 4278-4286. doi: 10.1158/0008-5472.CAN-06-4350 [Abstract] [Full Text] [PDF] Supplementary Data  

The Akt/Mammalian Target of Rapamycin Signal Transduction Pathway Is Activated in High-Risk Myelodysplastic Syndromes and Influences Cell Survival and Proliferation

Matilde Y. Follo, Sara Mongiorgi, Costanza Bosi, Alessandra Cappellini, Carlo Finelli, Francesca Chiarini, Veronica Papa, Massimo Libra, Giovanni Martinelli, Lucio Cocco, and Alberto M. Martelli
Cancer Res 2007 67: 4287-4294. doi: 10.1158/0008-5472.CAN-06-4409 [Abstract] [Full Text] [PDF]  

DNA Double-Strand Breaks Form in Bystander Cells after Microbeam Irradiation of Three-dimensional Human Tissue Models

Olga A. Sedelnikova, Asako Nakamura, Olga Kovalchuk, Igor Koturbash, Stephen A. Mitchell, Stephen A. Marino, David J. Brenner, and William M. Bonner
Cancer Res 2007 67: 4295-4302. doi: 10.1158/0008-5472.CAN-06-4442 [Abstract] [Full Text] [PDF]  

A Novel Prodrug of the Green Tea Polyphenol (–)-Epigallocatechin-3-Gallate as a Potential Anticancer Agent

Kristin R. Landis-Piwowar, Congde Huo, Di Chen, Vesna Milacic, Guoqing Shi, Tak Hang Chan, and Q. Ping Dou
Cancer Res 2007 67: 4303-4310. doi: 10.1158/0008-5472.CAN-06-4699 [Abstract] [Full Text] [PDF]  

Stroma-Derived Matrix Metalloproteinase (MMP)-2 Promotes Membrane Type 1-MMP–Dependent Tumor Growth in Mice

Kaori Taniwaki, Hiroshi Fukamachi, Kiyoshi Komori, Yohei Ohtake, Takahiro Nonaka, Takeharu Sakamoto, Takayuki Shiomi, Yasunori Okada, Takeshi Itoh, Shigeyoshi Itohara, Motoharu Seiki, and Ikuo Yana
Cancer Res 2007 67: 4311-4319. doi: 10.1158/0008-5472.CAN-06-4761 [Abstract] [Full Text] [PDF]  

p38 Mitogen-Activated Protein Kinase Pathway Is Involved in Protein Kinase C–Regulated Invasion in Human Hepatocellular Carcinoma Cells

Yi-Hsien Hsieh, Trang-Tiau Wu, Chih-Yang Huang, Yih-Shou Hsieh, Jin-Ming Hwang, and Jer-Yuh Liu
Cancer Res 2007 67: 4320-4327. doi: 10.1158/0008-5472.CAN-06-2486 [Abstract] [Full Text] [PDF]  

15(S)-Hydroxyeicosatetraenoic Acid–Induced Angiogenesis Requires STAT3-Dependent Expression of VEGF

Kalyan Srivastava, Venkatesh Kundumani-Sridharan, Baolin Zhang, Arun K. Bajpai, and Gadiparthi N. Rao
Cancer Res 2007 67: 4328-4336. doi: 10.1158/0008-5472.CAN-06-3594 [Abstract] [Full Text] [PDF]  

Mammalian Target of Rapamycin Activation Impairs Hepatocytic Differentiation and Targets Genes Moderating Lipid Homeostasis and Hepatocellular Growth

Romain Parent, Deepak Kolippakkam, Garrett Booth, and Laura Beretta
Cancer Res 2007 67: 4337-4345. doi: 10.1158/0008-5472.CAN-06-3640 [Abstract] [Full Text] [PDF] Supplementary Data  

Listeria monocytogenes Promotes Tumor Growth via Tumor Cell Toll-Like Receptor 2 Signaling

Bo Huang, Jie Zhao, Shiqian Shen, Hongxing Li, Kai-Li He, Guan-Xin Shen, Lloyd Mayer, Jay Unkeless, Dong Li, Ye Yuan, Gui-Mei Zhang, Huabao Xiong, and Zuo-Hua Feng
Cancer Res 2007 67: 4346-4352. doi: 10.1158/0008-5472.CAN-06-4067 [Abstract] [Full Text] [PDF]  

Experimental Therapeutics, Molecular Targets, and Chemical Biology:

Inhibition of Angiogenesis and Tumor Metastasis by Targeting a Matrix Immobilized Cryptic Extracellular Matrix Epitope in Laminin

Abebe Akalu, Jennifer M. Roth, Maresa Caunt, Desiree Policarpio, Leonard Liebes, and Peter C. Brooks
Cancer Res 2007 67: 4353-4363. doi: 10.1158/0008-5472.CAN-06-0482 [Abstract] [Full Text] [PDF]  

ErbB-2 Induces the Cyclin D1 Gene in Prostate Epithelial Cells In vitro and In vivo

Mathew Casimiro, Olga Rodriguez, Llana Pootrakul, Maral Aventian, Nadia Lushina, Caroline Cromelin, Georgina Ferzli, Kevin Johnson, Stanley Fricke, Fantahun Diba, Bhaskar Kallakury, Chioma Ohanyerenwa, Maxine Chen, Michael Ostrowski, Mien-Chie Hung, Shafaat A. Rabbani, Ram Datar, Richard Cote, Richard Pestell, and Chris Albanese
Cancer Res 2007 67: 4364-4372. doi: 10.1158/0008-5472.CAN-06-1898 [Abstract] [Full Text] [PDF]  

Oligomerization Domain of the Multidrug Resistance–Associated Transporter ABCG2 and Its Dominant Inhibitory Activity

Junkang Xu, Hui Peng, Qun Chen, Yang Liu, Zizheng Dong, and Jian-Ting Zhang
Cancer Res 2007 67: 4373-4381. doi: 10.1158/0008-5472.CAN-06-3169 [Abstract] [Full Text] [PDF]  

Regression of Lung and Colon Cancer Xenografts by Depleting or Inhibiting RLIP76 (Ral-Binding Protein 1)

Sharad S. Singhal, Jyotsana Singhal, Sushma Yadav, Seema Dwivedi, Paul J. Boor, Yogesh C. Awasthi, and Sanjay Awasthi
Cancer Res 2007 67: 4382-4389. doi: 10.1158/0008-5472.CAN-06-4124 [Abstract] [Full Text] [PDF] Supplementary Data  

Identification of Ras-Related Nuclear Protein, Targeting Protein for Xenopus Kinesin-like Protein 2, and Stearoyl-CoA Desaturase 1 as Promising Cancer Targets from an RNAi-Based Screen

Susan E. Morgan-Lappe, Lora A. Tucker, Xiaoli Huang, Qian Zhang, Aparna V. Sarthy, Dorothy Zakula, Lawrence Vernetti, Mark Schurdak, Jieyi Wang, and Stephen W. Fesik
Cancer Res 2007 67: 4390-4398. doi: 10.1158/0008-5472.CAN-06-4132 [Abstract] [Full Text] [PDF]  

Relaxin-Expressing, Fiber Chimeric Oncolytic Adenovirus Prolongs Survival of Tumor-Bearing Mice

Shanthi Ganesh, Melissa Gonzalez Edick, Neeraja Idamakanti, Marina Abramova, Melinda VanRoey, Michael Robinson, Chae-Ok Yun, and Karin Jooss
Cancer Res 2007 67: 4399-4407. doi: 10.1158/0008-5472.CAN-06-4260 [Abstract] [Full Text] [PDF] Supplementary Data  

An Orally Available Small-Molecule Inhibitor of c-Met, PF-2341066, Exhibits Cytoreductive Antitumor Efficacy through Antiproliferative and Antiangiogenic Mechanisms

Helen Y. Zou, Qiuhua Li, Joseph H. Lee, Maria E. Arango, Scott R. McDonnell, Shinji Yamazaki, Tatiana B. Koudriakova, Gordon Alton, Jingrong J. Cui, Pei-Pei Kung, Mitchell D. Nambu, Gerrit Los, Steven L. Bender, Barbara Mroczkowski, and James G. Christensen
Cancer Res 2007 67: 4408-4417. doi: 10.1158/0008-5472.CAN-06-4443 [Abstract] [Full Text] [PDF] Supplementary Data  

Thermal Cycling Enhances the Accumulation of a Temperature-Sensitive Biopolymer in Solid Tumors

Matthew R. Dreher, Wenge Liu, Charles R. Michelich, Mark W. Dewhirst, and Ashutosh Chilkoti
Cancer Res 2007 67: 4418-4424. doi: 10.1158/0008-5472.CAN-06-4444 [Abstract] [Full Text] [PDF] Supplementary Data  

Bexarotene (LGD1069, Targretin), a Selective Retinoid X Receptor Agonist, Prevents and Reverses Gemcitabine Resistance in NSCLC Cells by Modulating Gene Amplification

Patricia Tooker, Wan-Ching Yen, Shi-Chung Ng, Andrès Negro-Vilar, and Thomas W. Hermann
Cancer Res 2007 67: 4425-4433. doi: 10.1158/0008-5472.CAN-06-4495 [Abstract] [Full Text] [PDF] Supplementary Data  

Preclinical Evaluation of EC145, a Folate-Vinca Alkaloid Conjugate

Joseph A. Reddy, Ryan Dorton, Elaine Westrick, Alicia Dawson, Terri Smith, Le-Cun Xu, Marilynn Vetzel, Paul Kleindl, Iontcho R. Vlahov, and Christopher P. Leamon
Cancer Res 2007 67: 4434-4442. doi: 10.1158/0008-5472.CAN-07-0033 [Abstract] [Full Text] [PDF]  

Tumor Necrosis Factor Receptor 2–Mediated Tumor Suppression Is Nitric Oxide Dependent and Involves Angiostasis

Xueqiang Zhao, Mariette Mohaupt, Jing Jiang, Shubai Liu, Bing Li, and Zhihai Qin
Cancer Res 2007 67: 4443-4450. doi: 10.1158/0008-5472.CAN-07-0185 [Abstract] [Full Text] [PDF]  

Thanatop: A Novel 5-Nitrofuran that Is a Highly Active, Cell-Permeable Inhibitor of Topoisomerase II

Maria Polycarpou-Schwarz, Kerstin Müller, Stefanie Denger, Andrew Riddell, Joe Lewis, Frank Gannon, and George Reid
Cancer Res 2007 67: 4451-4458. doi: 10.1158/0008-5472.CAN-07-0393 [Abstract] [Full Text] [PDF]  

Mitogen-Activated Protein Kinase Phosphatase-1 Is a Mediator of Breast Cancer Chemoresistance

George W. Small, Yue Y. Shi, Linda S. Higgins, and Robert Z. Orlowski
Cancer Res 2007 67: 4459-4466. doi: 10.1158/0008-5472.CAN-06-2644 [Abstract] [Full Text] [PDF] Supplementary Data  

Phosphatase and Tensin Homologue Deficiency in Glioblastoma Confers Resistance to Radiation and Temozolomide that Is Reversed by the Protease Inhibitor Nelfinavir

Zibin Jiang, Nabendu Pore, George J. Cerniglia, Rosemarie Mick, Maria-Magdelena Georgescu, Eric J. Bernhard, Stephen M. Hahn, Anjali K. Gupta, and Amit Maity
Cancer Res 2007 67: 4467-4473. doi: 10.1158/0008-5472.CAN-06-3398 [Abstract] [Full Text] [PDF]  

A Gynecologic Oncology Group Study of Platinum-DNA Adducts and Excision Repair Cross-Complementation Group 1 Expression in Optimal, Stage III Epithelial Ovarian Cancer Treated with Platinum-Taxane Chemotherapy

Kathleen M. Darcy, Chunqiao Tian, and Eddie Reed
Cancer Res 2007 67: 4474-4481. doi: 10.1158/0008-5472.CAN-06-4076 [Abstract] [Full Text] [PDF]  

Divergent Mechanisms of Glucocorticoid Resistance in Experimental Models of Pediatric Acute Lymphoblastic Leukemia

Petra S. Bachmann, Rosemary Gorman, Rachael A. Papa, Jane E. Bardell, Jette Ford, Ursula R. Kees, Glenn M. Marshall, and Richard B. Lock
Cancer Res 2007 67: 4482-4490. doi: 10.1158/0008-5472.CAN-06-4244 [Abstract] [Full Text] [PDF] Supplementary Data  

Immunology:

Dormant Tumor Cells Develop Cross-Resistance to Apoptosis Induced by CTLs or Imatinib Mesylate via Methylation of Suppressor of Cytokine Signaling 1

Aurore Saudemont, Abdelbasset Hamrouni, Philippe Marchetti, Jizhong Liu, Nathalie Jouy, Dominique Hetuin, Francesco Colucci, and Bruno Quesnel
Cancer Res 2007 67: 4491-4498. doi: 10.1158/0008-5472.CAN-06-1627 [Abstract] [Full Text] [PDF] Supplementary Data  

MHC Class II–Transduced Tumor Cells Originating in the Immune-Privileged Eye Prime and Boost CD4⁺ T Lymphocytes that Cross-react with Primary and Metastatic Uveal Melanoma Cells

Jacobus J. Bosch, James A. Thompson, Minu K. Srivastava, Uzoma K. Iheagwara, Timothy G. Murray, Michal Lotem, Bruce R. Ksander, and Suzanne Ostrand-Rosenberg
Cancer Res 2007 67: 4499-4506. doi: 10.1158/0008-5472.CAN-06-3770 [Abstract] [Full Text] [PDF]  

Prostaglandin E2 Promotes Tumor Progression by Inducing Myeloid-Derived Suppressor Cells

Pratima Sinha, Virginia K. Clements, Amy M. Fulton, and Suzanne Ostrand-Rosenberg
Cancer Res 2007 67: 4507-4513. doi: 10.1158/0008-5472.CAN-06-4174 [Abstract] [Full Text] [PDF]  

Endocrinology:

The Hinge Region Regulates DNA Binding, Nuclear Translocation, and Transactivation of the Androgen Receptor

Annemie Haelens, Tamzin Tanner, Sarah Denayer, Leen Callewaert, and Frank Claessens
Cancer Res 2007 67: 4514-4523. doi: 10.1158/0008-5472.CAN-06-1701 [Abstract] [Full Text] [PDF]  

Epidemiology and Prevention:

Suppressive Effects of Statins on Acute Promyelocytic Leukemia Cells

Antonella Sassano, Efstratios Katsoulidis, Giovanni Antico, Jessica K. Altman, Amanda J. Redig, Saverio Minucci, Martin S. Tallman, and Leonidas C. Platanias
Cancer Res 2007 67: 4524-4532. doi: 10.1158/0008-5472.CAN-06-3686 [Abstract] [Full Text] [PDF]  

Letters to the Editor:

ARLTS1 Trp149Stop Mutation and the Risk of Ovarian Cancer

Bartlomiej Masojc, Krzysztof Medrek, Tadeusz Debniak, Jan Lubinski, Lucjan S. Wyrwicz, Grzegorz Koczyk, Marcin Hoffmann, and Leszek Rychlewski
Cancer Res 2007 67: 4533 [Full Text] [PDF]  

ARLTS1 Trp149Stop Mutation and the Risk of Ovarian Cancer

Fabio Petrocca, George A. Calin, and Carlo M. Croce
Cancer Res 2007 67: 4534 [Full Text] [PDF]  

Corrections:

Correction: Mechanisms of NRIF3-Mediated Apoptosis in Breast Cancer

Cancer Res 2007 67: 4535 [Full Text] [PDF]  

Correction: Differential Expression of 5'UTR Variants of BCRP mRNA

Cancer Res 2007 67: 4535 [Full Text] [PDF]  

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