Editorial:

The Year Ahead

Frank J. Rauscher, III
Cancer Res 2008 68: 1 [Full Text] [PDF]  

Reviews:

An Intracellular Signal Pathway That Regulates Cancer Cell Adhesion in Response to Extracellular Forces

Marc D. Basson
Cancer Res 2008 68: 2-4. doi: 10.1158/0008-5472.CAN-07-2992 [Abstract] [Full Text] [PDF]  

Is B-Raf a Good Therapeutic Target for Melanoma and Other Malignancies?

SubbaRao V. Madhunapantula and Gavin P. Robertson
Cancer Res 2008 68: 5-8. doi: 10.1158/0008-5472.CAN-07-2038 [Abstract] [Full Text] [PDF]  

Perspectives in Cancer Research:

Yin-Yang Activities and Vicious Cycles in the Tumor Microenvironment

Isaac P. Witz
Cancer Res 2008 68: 9-13. doi: 10.1158/0008-5472.CAN-07-2917 [Full Text] [PDF]  

Priority Reports:

Allelic Imbalance at rs6983267 Suggests Selection of the Risk Allele in Somatic Colorectal Tumor Evolution

Sari Tuupanen, Iina Niittymäki, Kari Nousiainen, Sakari Vanharanta, Jukka-Pekka Mecklin, Kyösti Nuorva, Heikki Järvinen, Sampsa Hautaniemi, Auli Karhu, and Lauri A. Aaltonen
Cancer Res 2008 68: 14-17. doi: 10.1158/0008-5472.CAN-07-5766 [Abstract] [Full Text] [PDF]  

Circulating Colony Stimulating Factor-1 and Breast Cancer Risk

Rulla M. Tamimi, Joan S. Brugge, Matthew L. Freedman, Alexander Miron, J. Dirk Iglehart, Graham A. Colditz, and Susan E. Hankinson
Cancer Res 2008 68: 18-21. doi: 10.1158/0008-5472.CAN-07-3234 [Abstract] [Full Text] [PDF]  

RASSF1A Polymorphism A133S Is Associated with Early Onset Breast Cancer in BRCA1/2 Mutation Carriers

Boning Gao, Xian-Jin Xie, Chunxian Huang, David S. Shames, Tina T-L. Chen, Cheryl M. Lewis, Aihua Bian, Bifeng Zhang, Olufunmilayo I. Olopade, Judy E. Garber, David M. Euhus, Gail E. Tomlinson, and John D. Minna
Cancer Res 2008 68: 22-25. doi: 10.1158/0008-5472.CAN-07-5183 [Abstract] [Full Text] [PDF] Supplementary Data  

Molecular Biology, Pathobiology, and Genetics:

Distinctive MicroRNA Profiles Relating to Patient Survival in Esophageal Squamous Cell Carcinoma

Yong Guo, Zhaoli Chen, Liang Zhang, Fang Zhou, Susheng Shi, Xiaoli Feng, Baozhong Li, Xin Meng, Xi Ma, Mingyong Luo, Kang Shao, Ning Li, Bin Qiu, Keith Mitchelson, Jing Cheng, and Jie He
Cancer Res 2008 68: 26-33. doi: 10.1158/0008-5472.CAN-06-4418 [Abstract] [Full Text] [PDF] Supplementary Data  

A Macrophage Gene Expression Signature Defines a Field Effect in the Lung Tumor Microenvironment

Robert S. Stearman, Lori Dwyer-Nield, Michael C. Grady, Alvin M. Malkinson, and Mark W. Geraci
Cancer Res 2008 68: 34-43. doi: 10.1158/0008-5472.CAN-07-0988 [Abstract] [Full Text] [PDF] Supplementary Data  

Genome-Wide Transcriptional Response to 5-Aza-2'-Deoxycytidine and Trichostatin A in Multiple Myeloma Cells

Gerwin Heller, Wolfgang M. Schmidt, Barbara Ziegler, Sonja Holzer, Leonhard Müllauer, Martin Bilban, Christoph C. Zielinski, Johannes Drach, and Sabine Zöchbauer-Müller
Cancer Res 2008 68: 44-54. doi: 10.1158/0008-5472.CAN-07-2531 [Abstract] [Full Text] [PDF] Supplementary Data  

LKB1 Deficiency Sensitizes Mice to Carcinogen-Induced Tumorigenesis

Sushma Gurumurthy, Aram F. Hezel, Justin H. Berger, Marcus W. Bosenberg, and Nabeel Bardeesy
Cancer Res 2008 68: 55-63. doi: 10.1158/0008-5472.CAN-07-3225 [Abstract] [Full Text] [PDF]  

Crucial Role of Phospholipase C in Skin Inflammation Induced by Tumor-Promoting Phorbol Ester

Shuzo Ikuta, Hironori Edamatsu, Mingzhen Li, Lizhi Hu, and Tohru Kataoka
Cancer Res 2008 68: 64-72. doi: 10.1158/0008-5472.CAN-07-3245 [Abstract] [Full Text] [PDF] Supplementary Data  

Characterization of TMPRSS2:ETV5 and SLC45A3:ETV5 Gene Fusions in Prostate Cancer

Beth E. Helgeson, Scott A. Tomlins, Nameeta Shah, Bharathi Laxman, Qi Cao, John R. Prensner, Xuhong Cao, Nirmish Singla, James E. Montie, Sooryanarayana Varambally, Rohit Mehra, and Arul M. Chinnaiyan
Cancer Res 2008 68: 73-80. doi: 10.1158/0008-5472.CAN-07-5352 [Abstract] [Full Text] [PDF] Supplementary Data  

Inhibition of MAPK Kinase Signaling Pathways Suppressed Renal Cell Carcinoma Growth and Angiogenesis In vivo

Dan Huang, Yan Ding, Wang-Mei Luo, Stephanie Bender, Chao-Nan Qian, Eric Kort, Zhong-Fa Zhang, Kristin VandenBeldt, Nicholas S. Duesbery, James H. Resau, and Bin Tean Teh
Cancer Res 2008 68: 81-88. doi: 10.1158/0008-5472.CAN-07-5311 [Abstract] [Full Text] [PDF] Supplementary Data  

DNA Protein Kinase–Dependent G₂ Checkpoint Revealed following Knockdown of Ataxia-Telangiectasia Mutated in Human Mammary Epithelial Cells

Sonnet J.H. Arlander, Bryan T. Greene, Cynthia L. Innes, and Richard S. Paules
Cancer Res 2008 68: 89-97. doi: 10.1158/0008-5472.CAN-07-0675 [Abstract] [Full Text] [PDF] Supplementary Data  

Twist Promotes Tumor Cell Growth through YB-1 Expression

Masaki Shiota, Hiroto Izumi, Takamitsu Onitsuka, Naoya Miyamoto, Eiji Kashiwagi, Akihiko Kidani, Akira Yokomizo, Seiji Naito, and Kimitoshi Kohno
Cancer Res 2008 68: 98-105. doi: 10.1158/0008-5472.CAN-07-2981 [Abstract] [Full Text] [PDF]  

Estrogen Induces Repression of the Breast Cancer and Salivary Gland Expression Gene in an Estrogen Receptor –Dependent Manner

Nancy Bretschneider, Heike Brand, Nicola Miller, Aoife J. Lowery, Michael J. Kerin, Frank Gannon, and Stefanie Denger
Cancer Res 2008 68: 106-114. doi: 10.1158/0008-5472.CAN-07-5647 [Abstract] [Full Text] [PDF] Supplementary Data  

Cell, Tumor, and Stem Cell Biology:

Thromboxane A₂ Receptors in Prostate Carcinoma: Expression and Its Role in Regulating Cell Motility via Small GTPase Rho

Daotai Nie, Yande Guo, Dianer Yang, Yong Tang, Yakun Chen, Man-Tzu Wang, Alex Zacharek, Yan Qiao, Mingxin Che, and Kenneth V. Honn
Cancer Res 2008 68: 115-121. doi: 10.1158/0008-5472.CAN-07-1018 [Abstract] [Full Text] [PDF]  

Conservation of Genetic Alterations in Recurrent Melanoma Supports the Melanoma Stem Cell Hypothesis

Marianna Sabatino, Yingdong Zhao, Sonia Voiculescu, Alessandro Monaco, Paul Robbins, Laszlo Karai, Brian J. Nickoloff, Michele Maio, Silvia Selleri, Francesco M. Marincola, and Ena Wang
Cancer Res 2008 68: 122-131. doi: 10.1158/0008-5472.CAN-07-1939 [Abstract] [Full Text] [PDF] Supplementary Data  

Paxillin Is a Target for Somatic Mutations in Lung Cancer: Implications for Cell Growth and Invasion

Ramasamy Jagadeeswaran, Hanna Surawska, Soundararajan Krishnaswamy, Varalakshmi Janamanchi, A. Craig Mackinnon, Tanguy Y. Seiwert, Sivakumar Loganathan, Rajani Kanteti, Trevor Reichman, Vidya Nallasura, Stuart Schwartz, Leonardo Faoro, Yi-Ching Wang, Luc Girard, Maria S. Tretiakova, Salman Ahmed, Osvaldo Zumba, Lioubov Soulii, Vytas P. Bindokas, Livia L. Szeto, Gavin J. Gordon, Raphael Bueno, David Sugarbaker, Mark W. Lingen, Martin Sattler, Thomas Krausz, Wickii Vigneswaran, Viswanathan Natarajan, John Minna, Everett E. Vokes, Mark K. Ferguson, Aliya N. Husain, and Ravi Salgia
Cancer Res 2008 68: 132-142. doi: 10.1158/0008-5472.CAN-07-1998 [Abstract] [Full Text] [PDF] Supplementary Data  

Therapeutic Window of MuS110, a Single-Chain Antibody Construct Bispecific for Murine EpCAM and Murine CD3

Maria Amann, Klaus Brischwein, Petra Lutterbuese, Larissa Parr, Laetitia Petersen, Grit Lorenczewski, Eva Krinner, Sandra Bruckmeier, Sandra Lippold, Roman Kischel, Ralf Lutterbuese, Peter Kufer, Patrick A. Baeuerle, and Bernd Schlereth
Cancer Res 2008 68: 143-151. doi: 10.1158/0008-5472.CAN-07-2182 [Abstract] [Full Text] [PDF]  

Osteopontin Promotes Vascular Endothelial Growth Factor–Dependent Breast Tumor Growth and Angiogenesis via Autocrine and Paracrine Mechanisms

Goutam Chakraborty, Shalini Jain, and Gopal C. Kundu
Cancer Res 2008 68: 152-161. doi: 10.1158/0008-5472.CAN-07-2126 [Abstract] [Full Text] [PDF] Supplementary Data  

Expression of CDK4 or CDK2 in Mouse Oral Cavity Is Retained in Adult Pituitary with Distinct Effects on Tumorigenesis

Everardo Macias, Paula L. Miliani de Marval, Adrian Senderowicz, John Cullen, and Marcelo L. Rodriguez-Puebla
Cancer Res 2008 68: 162-171. doi: 10.1158/0008-5472.CAN-07-2461 [Abstract] [Full Text] [PDF] Supplementary Data  

Hypoxia Regulates Choline Kinase Expression through Hypoxia-Inducible Factor-1 Signaling in a Human Prostate Cancer Model

Kristine Glunde, Tariq Shah, Paul T. Winnard, Jr., Venu Raman, Tomoyo Takagi, Farhad Vesuna, Dmitri Artemov, and Zaver M. Bhujwalla
Cancer Res 2008 68: 172-180. doi: 10.1158/0008-5472.CAN-07-2678 [Abstract] [Full Text] [PDF]  

PAX5/TEL Acts as a Transcriptional Repressor Causing Down-modulation of CD19, Enhances Migration to CXCL12, and Confers Survival Advantage in pre-BI Cells

Grazia Fazio, Chiara Palmi, Antonius Rolink, Andrea Biondi, and Giovanni Cazzaniga
Cancer Res 2008 68: 181-189. doi: 10.1158/0008-5472.CAN-07-2778 [Abstract] [Full Text] [PDF] Supplementary Data  

Clonogenic Multiple Myeloma Progenitors, Stem Cell Properties, and Drug Resistance

William Matsui, Qiuju Wang, James P. Barber, Sarah Brennan, B. Douglas Smith, Ivan Borrello, Ian McNiece, Lan Lin, Richard F. Ambinder, Craig Peacock, D. Neil Watkins, Carol Ann Huff, and Richard J. Jones
Cancer Res 2008 68: 190-197. doi: 10.1158/0008-5472.CAN-07-3096 [Abstract] [Full Text] [PDF]  

A Novel Bone Morphogenetic Protein Signaling in Heterotypic Cell Interactions in Prostate Cancer

Shangxin Yang, Linda K. Pham, Chun-Peng Liao, Baruch Frenkel, A. Hari Reddi, and Pradip Roy-Burman
Cancer Res 2008 68: 198-205. doi: 10.1158/0008-5472.CAN-07-5074 [Abstract] [Full Text] [PDF] Supplementary Data  

Experimental Therapeutics, Molecular Targets, and Chemical Biology:

A Vascular Targeted Pan Phosphoinositide 3-Kinase Inhibitor Prodrug, SF1126, with Antitumor and Antiangiogenic Activity

Joseph R. Garlich, Pradip De, Nandini Dey, Jing Dong Su, Xiaodong Peng, Antoinette Miller, Ravoori Murali, Yiling Lu, Gordon B. Mills, Vikas Kundra, H-K. Shu, Qiong Peng, and Donald L. Durden
Cancer Res 2008 68: 206-215. doi: 10.1158/0008-5472.CAN-07-0669 [Abstract] [Full Text] [PDF] Supplementary Data  

Molecular Imaging of the Efficacy of Heat Shock Protein 90 Inhibitors in Living Subjects

Carmel T. Chan, Ramasamy Paulmurugan, Olivier S. Gheysens, Joungnam Kim, Gabriela Chiosis, and Sanjiv Sam Gambhir
Cancer Res 2008 68: 216-226. doi: 10.1158/0008-5472.CAN-07-2268 [Abstract] [Full Text] [PDF] Supplementary Data  

Capsiate, a Nonpungent Capsaicin-Like Compound, Inhibits Angiogenesis and Vascular Permeability via a Direct Inhibition of Src Kinase Activity

Bo-Jeong Pyun, Sun Choi, Yoonji Lee, Tae-Woong Kim, Jeong-Ki Min, Yonghak Kim, Byung-Dong Kim, Jeong-Han Kim, Tae-Yoon Kim, Young-Myeong Kim, and Young-Guen Kwon
Cancer Res 2008 68: 227-235. doi: 10.1158/0008-5472.CAN-07-2799 [Abstract] [Full Text] [PDF] Supplementary Data  

Transcription Factor Stat5 Synergizes with Androgen Receptor in Prostate Cancer Cells

Shyh-Han Tan, Ayush Dagvadorj, Feng Shen, Lei Gu, Zhiyong Liao, Junaid Abdulghani, Ying Zhang, Edward P. Gelmann, Tobias Zellweger, Zoran Culig, Tapio Visakorpi, Lukas Bubendorf, Robert A. Kirken, James Karras, and Marja T. Nevalainen
Cancer Res 2008 68: 236-248. doi: 10.1158/0008-5472.CAN-07-2972 [Abstract] [Full Text] [PDF] Supplementary Data  

Natriuretic Peptide Receptor A as a Novel Anticancer Target

Xiaoyuan Kong, Xiaoqin Wang, Weidong Xu, Sumita Behera, Gary Hellermann, Arun Kumar, Richard F. Lockey, Subhra Mohapatra, and Shyam S. Mohapatra
Cancer Res 2008 68: 249-256. doi: 10.1158/0008-5472.CAN-07-3086 [Abstract] [Full Text] [PDF]  

Homologous Recombination Is the Principal Pathway for the Repair of DNA Damage Induced by Tirapazamine in Mammalian Cells

James W. Evans, Sophia B. Chernikova, Lisa A. Kachnic, Judit P. Banath, Olivier Sordet, Yvette M. Delahoussaye, Alejandro Treszezamsky, Brian H. Chon, Zhihui Feng, Yongchuan Gu, William R. Wilson, Yves Pommier, Peggy L. Olive, Simon N. Powell, and J. Martin Brown
Cancer Res 2008 68: 257-265. doi: 10.1158/0008-5472.CAN-06-4497 [Abstract] [Full Text] [PDF]  

Arsenic Trioxide Sensitizes Human Glioma Cells, but not Normal Astrocytes, to TRAIL-Induced Apoptosis via CCAAT/Enhancer-Binding Protein Homologous Protein–Dependent DR5 Up-regulation

Eun Hee Kim, Mi Jin Yoon, Seung U. Kim, Taeg Kyu Kwon, Seonghyang Sohn, and Kyeong Sook Choi
Cancer Res 2008 68: 266-275. doi: 10.1158/0008-5472.CAN-07-2444 [Abstract] [Full Text] [PDF] Supplementary Data  

SMAC Mimetics Sensitize Nonsteroidal Anti-inflammatory Drug–Induced Apoptosis by Promoting Caspase-3–Mediated Cytochrome c Release

Alexander Bank, Peng Wang, Chunying Du, Jian Yu, and Lin Zhang
Cancer Res 2008 68: 276-284. doi: 10.1158/0008-5472.CAN-07-5242 [Abstract] [Full Text] [PDF] Supplementary Data  

Differential Involvement of Vascular Endothelial Growth Factor in the Survival of Hypoxic Colon Cancer Cells

Maura Calvani, Daniela Trisciuoglio, Cristina Bergamaschi, Robert H. Shoemaker, and Giovanni Melillo
Cancer Res 2008 68: 285-291. doi: 10.1158/0008-5472.CAN-07-5564 [Abstract] [Full Text] [PDF] Supplementary Data  

Immunology:

Peripheral T-Cell Tolerance Associated with Prostate Cancer Is Independent from CD4⁺CD25⁺ Regulatory T Cells

Elena Degl'Innocenti, Matteo Grioni, Giusy Capuano, Elena Jachetti, Massimo Freschi, Maria T.S. Bertilaccio, Rodrigo Hess-Michelini, Claudio Doglioni, and Matteo Bellone
Cancer Res 2008 68: 292-300. doi: 10.1158/0008-5472.CAN-07-2429 [Abstract] [Full Text] [PDF] Supplementary Data  

Endocrinology:

CARM1 Regulates Estrogen-Stimulated Breast Cancer Growth through Up-regulation of E2F1

Seth Frietze, Mathieu Lupien, Pamela A. Silver, and Myles Brown
Cancer Res 2008 68: 301-306. doi: 10.1158/0008-5472.CAN-07-1983 [Abstract] [Full Text] [PDF] Supplementary Data  

Clinical Research:

Type-Dependent Integration Frequency of Human Papillomavirus Genomes in Cervical Lesions

Svetlana Vinokurova, Nicolas Wentzensen, Irene Kraus, Ruediger Klaes, Corina Driesch, Peter Melsheimer, Fjodor Kisseljov, Mattias Dürst, Achim Schneider, and Magnus von Knebel Doeberitz
Cancer Res 2008 68: 307-313. doi: 10.1158/0008-5472.CAN-07-2754 [Abstract] [Full Text] [PDF]  

Epidemiology:

Specific Genes Expressed in Association with Progesterone Receptors in Meningioma

Elizabeth B. Claus, Peter J. Park, Rona Carroll, Jennifer Chan, and Peter M. Black
Cancer Res 2008 68: 314-322. doi: 10.1158/0008-5472.CAN-07-1796 [Abstract] [Full Text] [PDF]  

Circulating Levels of Inflammatory Cytokines and Risk of Colorectal Adenomas

Sangmi Kim, Temitope O. Keku, Christopher Martin, Joseph Galanko, John T. Woosley, Jane C. Schroeder, Jessie A. Satia, Susan Halabi, and Robert S. Sandler
Cancer Res 2008 68: 323-328. doi: 10.1158/0008-5472.CAN-07-2924 [Abstract] [Full Text] [PDF]  

Insulin, Insulin-like Growth Factor-I, Endogenous Estradiol, and Risk of Colorectal Cancer in Postmenopausal Women

Marc J. Gunter, Donald R. Hoover, Herbert Yu, Sylvia Wassertheil-Smoller, Thomas E. Rohan, JoAnn E. Manson, Barbara V. Howard, Judith Wylie-Rosett, Garnet L. Anderson, Gloria Y.F. Ho, Robert C. Kaplan, Jixin Li, Xiaonan Xue, Tiffany G. Harris, Robert D. Burk, and Howard D. Strickler
Cancer Res 2008 68: 329-337. doi: 10.1158/0008-5472.CAN-07-2946 [Abstract] [Full Text] [PDF]  

Correction:

Correction: The Interaction of MUC1 and Myelin-Associated Glycoprotein

Cancer Res 2008 68: 338 [Full Text] [PDF]  

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