Reviews:

iASPP Inhibition: Increased Options in Targeting the p53 Family for Cancer Therapy

Helen S. Bell and Kevin M. Ryan
Cancer Res 2008 68: 4959-4962. doi: 10.1158/0008-5472.CAN-08-0182 [Abstract] [Full Text] [PDF]  

C-Myc Is a Critical Mediator of the Phenotypes of Apc Loss in the Intestine

Julie A. Wilkins and Owen J. Sansom
Cancer Res 2008 68: 4963-4966. doi: 10.1158/0008-5472.CAN-07-5558 [Abstract] [Full Text] [PDF]  

Meeting Report:

Derepression in the Desert: The Third Workshop on Clinical Translation of Epigenetics in Cancer Therapeutics

Arthur Zelent, Kevin Petrie, Manuel Boix-Chornet, Ari M. Melnick, Samuel Waxman, and Steven D. Gore
Cancer Res 2008 68: 4967-4970. doi: 10.1158/0008-5472.CAN-07-6779 [Full Text] [PDF] Supplementary Data  

Priority Reports:

Identification of Novel Isoforms of the EML4-ALK Transforming Gene in Non–Small Cell Lung Cancer

Young Lim Choi, Kengo Takeuchi, Manabu Soda, Kentaro Inamura, Yuki Togashi, Satoko Hatano, Munehiro Enomoto, Toru Hamada, Hidenori Haruta, Hideki Watanabe, Kentaro Kurashina, Hisashi Hatanaka, Toshihide Ueno, Shuji Takada, Yoshihiro Yamashita, Yukihiko Sugiyama, Yuichi Ishikawa, and Hiroyuki Mano
Cancer Res 2008 68: 4971-4976. doi: 10.1158/0008-5472.CAN-07-6158 [Abstract] [Full Text] [PDF] Supplementary Data  

Single-Cell Transcription Site Activation Predicts Chemotherapy Response in Human Colorectal Tumors

Rossanna C. Pezo, Saumil J. Gandhi, L. Andrew Shirley, Richard G. Pestell, Leonard H. Augenlicht, and Robert H. Singer
Cancer Res 2008 68: 4977-4982. doi: 10.1158/0008-5472.CAN-07-6770 [Abstract] [Full Text] [PDF] Supplementary Data  

Transporter-Mediated Protection against Thiopurine-Induced Hematopoietic Toxicity

Partha Krishnamurthy, Matthias Schwab, Kazumasa Takenaka, Deepa Nachagari, Jessica Morgan, Mark Leslie, Weinan Du, Kelli Boyd, Meyling Cheok, Hiromitsu Nakauchi, Catia Marzolini, Richard B. Kim, Balasubramanian Poonkuzhali, Erin Schuetz, William Evans, Mary Relling, and John D. Schuetz
Cancer Res 2008 68: 4983-4989. doi: 10.1158/0008-5472.CAN-07-6790 [Abstract] [Full Text] [PDF] Supplementary Data  

Noninvasive Imaging and Quantification of Epidermal Growth Factor Receptor Kinase Activation In vivo

Wenrong Li, Fang Li, Qian Huang, Barbara Frederick, Shideng Bao, and Chuan-Yuan Li
Cancer Res 2008 68: 4990-4997. doi: 10.1158/0008-5472.CAN-07-5984 [Abstract] [Full Text] [PDF] Supplementary Data  

Complement-Dependent Tumor Cell Lysis Triggered by Combinations of Epidermal Growth Factor Receptor Antibodies

Michael Dechant, Wencke Weisner, Sven Berger, Matthias Peipp, Thomas Beyer, Tanja Schneider-Merck, Jeroen J. Lammerts van Bueren, Wim K. Bleeker, Paul W.H.I. Parren, Jan G.J. van de Winkel, and Thomas Valerius
Cancer Res 2008 68: 4998-5003. doi: 10.1158/0008-5472.CAN-07-6226 [Abstract] [Full Text] [PDF] Supplementary Data  

miR-206 Expression Is Down-regulated in Estrogen Receptor –Positive Human Breast Cancer

Naoto Kondo, Tatsuya Toyama, Hiroshi Sugiura, Yoshitaka Fujii, and Hiroko Yamashita
Cancer Res 2008 68: 5004-5008. doi: 10.1158/0008-5472.CAN-08-0180 [Abstract] [Full Text] [PDF]  

Frequent Detection of Merkel Cell Polyomavirus in Human Merkel Cell Carcinomas and Identification of a Unique Deletion in the VP1 Gene

Ahmad Kassem, Anja Schöpflin, Carlos Diaz, Wolfgang Weyers, Elmar Stickeler, Martin Werner, and Axel zur Hausen
Cancer Res 2008 68: 5009-5013. doi: 10.1158/0008-5472.CAN-08-0949 [Abstract] [Full Text] [PDF]  

Molecular Biology, Pathobiology, and Genetics:

The Cullin 4B–Based UV-Damaged DNA-Binding Protein Ligase Binds to UV-Damaged Chromatin and Ubiquitinates Histone H2A

Jennifer Guerrero-Santoro, Maria G. Kapetanaki, Ching L. Hsieh, Ilya Gorbachinsky, Arthur S. Levine, and Vesna Rapic-Otrin
Cancer Res 2008 68: 5014-5022. doi: 10.1158/0008-5472.CAN-07-6162 [Abstract] [Full Text] [PDF]  

A Syngeneic Variance Library for Functional Annotation of Human Variation: Application to BRCA2

Tomas Hucl, Carlo Rago, Eike Gallmeier, Jonathan R. Brody, Myriam Gorospe, and Scott E. Kern
Cancer Res 2008 68: 5023-5030. doi: 10.1158/0008-5472.CAN-07-6189 [Abstract] [Full Text] [PDF]  

c-Jun NH₂-Terminal Kinase 1 Is a Critical Regulator for the Development of Gastric Cancer in Mice

Wataru Shibata, Shin Maeda, Yohko Hikiba, Ayako Yanai, Kei Sakamoto, Hayato Nakagawa, Keiji Ogura, Michael Karin, and Masao Omata
Cancer Res 2008 68: 5031-5039. doi: 10.1158/0008-5472.CAN-07-6332 [Abstract] [Full Text] [PDF] Supplementary Data  

15-Hydroxyprostaglandin Dehydrogenase is a Target of Hepatocyte Nuclear Factor 3β and a Tumor Suppressor in Lung Cancer

Guosheng Huang, Rosana Eisenberg, Min Yan, Stefano Monti, Earl Lawrence, Pingfu Fu, Jaclyn Walbroehl, Ester Löwenberg, Todd Golub, Jaime Merchan, Daniel G. Tenen, Sanford D. Markowitz, and Balazs Halmos
Cancer Res 2008 68: 5040-5048. doi: 10.1158/0008-5472.CAN-07-6575 [Abstract] [Full Text] [PDF] Supplementary Data  

Methylation Mediated Silencing of MicroRNA-1 Gene and Its Role in Hepatocellular Carcinogenesis

Jharna Datta, Huban Kutay, Mohd W. Nasser, Gerard J. Nuovo, Bo Wang, Sarmila Majumder, Chang-Gong Liu, Stefano Volinia, Carlo M. Croce, Thomas D. Schmittgen, Kalpana Ghoshal, and Samson T. Jacob
Cancer Res 2008 68: 5049-5058. doi: 10.1158/0008-5472.CAN-07-6655 [Abstract] [Full Text] [PDF] Supplementary Data  

Zebrafish with Mutations in Mismatch Repair Genes Develop Neurofibromas and Other Tumors

Harma Feitsma, Raoul V. Kuiper, Jeroen Korving, Isaac J. Nijman, and Edwin Cuppen
Cancer Res 2008 68: 5059-5066. doi: 10.1158/0008-5472.CAN-08-0019 [Abstract] [Full Text] [PDF]  

Frequent Inactivation of a Putative Tumor Suppressor, Angiopoietin-Like Protein 2, in Ovarian Cancer

Ryoko Kikuchi, Hitoshi Tsuda, Ken-ichi Kozaki, Yae Kanai, Takahiro Kasamatsu, Kazuo Sengoku, Setsuo Hirohashi, Johji Inazawa, and Issei Imoto
Cancer Res 2008 68: 5067-5075. doi: 10.1158/0008-5472.CAN-08-0062 [Abstract] [Full Text] [PDF] Supplementary Data  

Pim Kinases Promote Cell Cycle Progression by Phosphorylating and Down-regulating p27^Kip1 at the Transcriptional and Posttranscriptional Levels

Daisuke Morishita, Ryohei Katayama, Kazuhisa Sekimizu, Takashi Tsuruo, and Naoya Fujita
Cancer Res 2008 68: 5076-5085. doi: 10.1158/0008-5472.CAN-08-0634 [Abstract] [Full Text] [PDF] Supplementary Data  

Cell, Tumor, and Stem Cell Biology:

Inhibition of Fibroblast Growth Factor 19 Reduces Tumor Growth by Modulating β-Catenin Signaling

Rama Pai, Debra Dunlap, Jing Qing, Iman Mohtashemi, Kathy Hotzel, and Dorothy M. French
Cancer Res 2008 68: 5086-5095. doi: 10.1158/0008-5472.CAN-07-2325 [Abstract] [Full Text] [PDF] Supplementary Data  

Loss of the ssecks/gravin/akap12 Gene Results in Prostatic Hyperplasia

Shin Akakura, Changhui Huang, Peter J. Nelson, Barbara Foster, and Irwin H. Gelman
Cancer Res 2008 68: 5096-5103. doi: 10.1158/0008-5472.CAN-07-5619 [Abstract] [Full Text] [PDF] Supplementary Data  

Rb Depletion Results in Deregulation of E-Cadherin and Induction of Cellular Phenotypic Changes that Are Characteristic of the Epithelial-to-Mesenchymal Transition

Yoshimi Arima, Yasumichi Inoue, Tatsuhiro Shibata, Hidemi Hayashi, Osamu Nagano, Hideyuki Saya, and Yoichi Taya
Cancer Res 2008 68: 5104-5112. doi: 10.1158/0008-5472.CAN-07-5680 [Abstract] [Full Text] [PDF] Supplementary Data  

-Irradiation–Induced DNA Damage Checkpoint Activation Involves Feedback Regulation between Extracellular Signal-Regulated Kinase 1/2 and BRCA1

Ying Yan, Claudine P. Black, Phu T. Cao, Jamie L. Haferbier, Ryan H. Kolb, Rebecca S. Spieker, Alexandra M. Ristow, and Kenneth H. Cowan
Cancer Res 2008 68: 5113-5121. doi: 10.1158/0008-5472.CAN-07-5818 [Abstract] [Full Text] [PDF]  

The p53 Homologue Np63 Interacts with the Nuclear Factor-B Pathway to Modulate Epithelial Cell Growth

Kathryn E. King, Roshini M. Ponnamperuma, Clint Allen, Hai Lu, Praveen Duggal, Zhong Chen, Carter Van Waes, and Wendy C. Weinberg
Cancer Res 2008 68: 5122-5131. doi: 10.1158/0008-5472.CAN-07-6123 [Abstract] [Full Text] [PDF]  

Genomic and Proteomic Analysis Reveals a Threshold Level of MYC Required for Tumor Maintenance

Catherine M. Shachaf, Andrew J. Gentles, Sailaja Elchuri, Debashis Sahoo, Yoav Soen, Orr Sharpe, Omar D. Perez, Maria Chang, Dennis Mitchel, William H. Robinson, David Dill, Garry P. Nolan, Sylvia K. Plevritis, and Dean W. Felsher
Cancer Res 2008 68: 5132-5142. doi: 10.1158/0008-5472.CAN-07-6192 [Abstract] [Full Text] [PDF] Supplementary Data  

Haploinsufficiency of the Maspin Tumor Suppressor Gene Leads to Hyperplastic Lesions in Prostate

Long-jiang Shao, Heidi Y. Shi, Gustavo Ayala, David Rowley, and Ming Zhang
Cancer Res 2008 68: 5143-5151. doi: 10.1158/0008-5472.CAN-08-0163 [Abstract] [Full Text] [PDF]  

Serotonin Regulates Macrophage-Mediated Angiogenesis in a Mouse Model of Colon Cancer Allografts

Antonio Nocito, Felix Dahm, Wolfram Jochum, Jae Hwi Jang, Panco Georgiev, Michael Bader, Rolf Graf, and Pierre-Alain Clavien
Cancer Res 2008 68: 5152-5158. doi: 10.1158/0008-5472.CAN-08-0202 [Abstract] [Full Text] [PDF] Supplementary Data  

NO Signaling Confers Cytoprotectivity through the Survivin Network in Ovarian Carcinomas

Knut Engels, Shirley K. Knauer, Sibylle Loibl, Verena Fetz, Philipp Harter, Andrea Schweitzer, Annette Fisseler-Eckhoff, Friedrich Kommoss, Lars Hanker, Valentina Nekljudova, Iris Hermanns, Hartmut Kleinert, Wolf Mann, Andreas du Bois, and Roland H. Stauber
Cancer Res 2008 68: 5159-5166. doi: 10.1158/0008-5472.CAN-08-0406 [Abstract] [Full Text] [PDF] Supplementary Data  

Mechanisms by which E-Selectin Regulates Diapedesis of Colon Cancer Cells under Flow Conditions

Pierre-Luc Tremblay, Jacques Huot, and François A. Auger
Cancer Res 2008 68: 5167-5176. doi: 10.1158/0008-5472.CAN-08-1229 [Abstract] [Full Text] [PDF] Supplementary Data  

Hypoxia-Inducible Factor-1 Obstructs a Wnt Signaling Pathway by Inhibiting the hARD1-Mediated Activation of β-Catenin

Ji-Hong Lim, Yang-Sook Chun, and Jong-Wan Park
Cancer Res 2008 68: 5177-5184. doi: 10.1158/0008-5472.CAN-07-6234 [Abstract] [Full Text] [PDF] Supplementary Data  

Curcumin Blocks RON Tyrosine Kinase–Mediated Invasion of Breast Carcinoma Cells

Madhusudhanan Narasimhan and Sudhakar Ammanamanchi
Cancer Res 2008 68: 5185-5192. doi: 10.1158/0008-5472.CAN-07-6883 [Abstract] [Full Text] [PDF] Supplementary Data  

Loss of the Transmembrane but not the Soluble Kit Ligand Isoform Increases Testicular Germ Cell Tumor Susceptibility in Mice

Jason D. Heaney, Man-Yee J. Lam, Megan V. Michelson, and Joseph H. Nadeau
Cancer Res 2008 68: 5193-5197. doi: 10.1158/0008-5472.CAN-08-0779 [Abstract] [Full Text] [PDF]  

Tumor Microenvironment:

The Warburg Effect in Leukemia-Stroma Cocultures Is Mediated by Mitochondrial Uncoupling Associated with Uncoupling Protein 2 Activation

Ismael Samudio, Michael Fiegl, Teresa McQueen, Karen Clise-Dwyer, and Michael Andreeff
Cancer Res 2008 68: 5198-5205. doi: 10.1158/0008-5472.CAN-08-0555 [Abstract] [Full Text] [PDF] Supplementary Data  

OX40 Agonist Therapy Enhances CD8 Infiltration and Decreases Immune Suppression in the Tumor

Michael J. Gough, Carl E. Ruby, William L. Redmond, Birat Dhungel, Alexis Brown, and Andrew D. Weinberg
Cancer Res 2008 68: 5206-5215. doi: 10.1158/0008-5472.CAN-07-6484 [Abstract] [Full Text] [PDF] Supplementary Data  

Experimental Therapeutics, Molecular Targets, and Chemical Biology:

Aplidin, a Marine Organism–Derived Compound with Potent Antimyeloma Activity In vitro and In vivo

Constantine S. Mitsiades, Enrique M. Ocio, Atanasio Pandiella, Patricia Maiso, Consuelo Gajate, Mercedes Garayoa, David Vilanova, Juan Carlos Montero, Nicholas Mitsiades, Ciaran J. McMullan, Nikhil C. Munshi, Teru Hideshima, Dharminder Chauhan, Pablo Aviles, Gabriel Otero, Glynn Faircloth, M. Victoria Mateos, Paul G. Richardson, Faustino Mollinedo, Jesus F. San-Miguel, and Kenneth C. Anderson
Cancer Res 2008 68: 5216-5225. doi: 10.1158/0008-5472.CAN-07-5725 [Abstract] [Full Text] [PDF] Supplementary Data  

Cross-talk between Notch and the Estrogen Receptor in Breast Cancer Suggests Novel Therapeutic Approaches

Paola Rizzo, Haixi Miao, Gwendolyn D'Souza, Clodia Osipo, Jieun Yun, Huiping Zhao, Joaquina Mascarenhas, Debra Wyatt, Giovanni Antico, Lu Hao, Katharine Yao, Prabha Rajan, Chindo Hicks, Kalliopi Siziopikou, Suzanne Selvaggi, Amina Bashir, Deepali Bhandari, Adriano Marchese, Urban Lendahl, Jian-Zhong Qin, Debra A. Tonetti, Kathy Albain, Brian J. Nickoloff, and Lucio Miele
Cancer Res 2008 68: 5226-5235. doi: 10.1158/0008-5472.CAN-07-5744 [Abstract] [Full Text] [PDF] Supplementary Data  

Dissecting and Targeting the Growth Factor–Dependent and Growth Factor–Independent Extracellular Signal-Regulated Kinase Pathway in Human Schwannoma

Sylwia Ammoun, Christine Flaiz, Natalia Ristic, Jennifer Schuldt, and C. Oliver Hanemann
Cancer Res 2008 68: 5236-5245. doi: 10.1158/0008-5472.CAN-07-5849 [Abstract] [Full Text] [PDF] Supplementary Data  

Mitochondrial Cholesterol Contributes to Chemotherapy Resistance in Hepatocellular Carcinoma

Joan Montero, Albert Morales, Laura Llacuna, Josep M. Lluis, Oihana Terrones, Gorka Basañez, Bruno Antonsson, Jesús Prieto, Carmen García-Ruiz, Anna Colell, and José C. Fernández-Checa
Cancer Res 2008 68: 5246-5256. doi: 10.1158/0008-5472.CAN-07-6161 [Abstract] [Full Text] [PDF] Supplementary Data  

Triptolide-Induced Transcriptional Arrest Is Associated with Changes in Nuclear Substructure

Stephanie J. Leuenroth and Craig M. Crews
Cancer Res 2008 68: 5257-5266. doi: 10.1158/0008-5472.CAN-07-6207 [Abstract] [Full Text] [PDF]  

Nitrosoureas Inhibit the Stathmin-Mediated Migration and Invasion of Malignant Glioma Cells

Xing-Jie Liang, Yong Choi, Dan L. Sackett, and John K. Park
Cancer Res 2008 68: 5267-5272. doi: 10.1158/0008-5472.CAN-07-6482 [Abstract] [Full Text] [PDF]  

Molecular Dependence of Estrogen Receptor–Negative Breast Cancer on a Notch-Survivin Signaling Axis

Connie W. Lee, Christopher M. Raskett, Igor Prudovsky, and Dario C. Altieri
Cancer Res 2008 68: 5273-5281. doi: 10.1158/0008-5472.CAN-07-6673 [Abstract] [Full Text] [PDF]  

Improved Therapeutic Results by Pretargeted Radioimmunotherapy of Non–Hodgkin's Lymphoma with a New Recombinant, Trivalent, Anti-CD20, Bispecific Antibody

Robert M. Sharkey, Habibe Karacay, Samuel Litwin, Edmund A. Rossi, William J. McBride, Chien-Hsing Chang, and David M. Goldenberg
Cancer Res 2008 68: 5282-5290. doi: 10.1158/0008-5472.CAN-08-0037 [Abstract] [Full Text] [PDF] Supplementary Data  

Pyrimethamine Induces Apoptosis of Melanoma Cells via a Caspase and Cathepsin Double-Edged Mechanism

Anna Maria Giammarioli, Angela Maselli, Andrea Casagrande, Lucrezia Gambardella, Angelo Gallina, Massimo Spada, Antonello Giovannetti, Enrico Proietti, Walter Malorni, and Marina Pierdominici
Cancer Res 2008 68: 5291-5300. doi: 10.1158/0008-5472.CAN-08-0222 [Abstract] [Full Text] [PDF] Supplementary Data  

Improved Cellular Pharmacokinetics and Pharmacodynamics Underlie the Wide Anticancer Activity of Sagopilone

Jens Hoffmann, Ilio Vitale, Bernd Buchmann, Lorenzo Galluzzi, Wolfgang Schwede, Laura Senovilla, Werner Skuballa, Sonia Vivet, Rosemarie B. Lichtner, José M. Vicencio, Theocharis Panaretakis, Gerhard Siemeister, Hermann Lage, Lisa Nanty, Stefanie Hammer, Kevin Mittelstaedt, Sebastian Winsel, Julia Eschenbrenner, Maria Castedo, Carine Demarche, Ulrich Klar, and Guido Kroemer
Cancer Res 2008 68: 5301-5308. doi: 10.1158/0008-5472.CAN-08-0237 [Abstract] [Full Text] [PDF] Supplementary Data  

ATM Mediates Cytotoxicity of a Mutant Telomerase RNA in Human Cancer Cells

Bradley A. Stohr and Elizabeth H. Blackburn
Cancer Res 2008 68: 5309-5317. doi: 10.1158/0008-5472.CAN-08-0504 [Abstract] [Full Text] [PDF]  

Synthesis and Anticancer Properties of Water-Soluble Zinc Ionophores

Darren Magda, Philip Lecane, Zhong Wang, Weilin Hu, Patricia Thiemann, Xuan Ma, Patricia K. Dranchak, Xiaoming Wang, Vincent Lynch, Wenhao Wei, Viktor Csokai, Joseph G. Hacia, and Jonathan L. Sessler
Cancer Res 2008 68: 5318-5325. doi: 10.1158/0008-5472.CAN-08-0601 [Abstract] [Full Text] [PDF] Supplementary Data  

c-Myc and eIF4F Are Components of a Feedforward Loop that Links Transcription and Translation

Chen-Ju Lin, Regina Cencic, John R. Mills, Francis Robert, and Jerry Pelletier
Cancer Res 2008 68: 5326-5334. doi: 10.1158/0008-5472.CAN-07-5876 [Abstract] [Full Text] [PDF] Supplementary Data  

CAAT/Enhancer Binding Protein Homologous Protein–Dependent Death Receptor 5 Induction Is a Major Component of SHetA2-Induced Apoptosis in Lung Cancer Cells

Yi-Dan Lin, Shuzhen Chen, Ping Yue, Wei Zou, Doris M. Benbrook, Shengquan Liu, Thanh C. Le, K. Darrell Berlin, Fadlo R. Khuri, and Shi-Yong Sun
Cancer Res 2008 68: 5335-5344. doi: 10.1158/0008-5472.CAN-07-6209 [Abstract] [Full Text] [PDF] Supplementary Data  

Curcumin Decreases Specificity Protein Expression in Bladder Cancer Cells

Gayathri Chadalapaka, Indira Jutooru, Sudhakar Chintharlapalli, Sabitha Papineni, Roger Smith, III, Xiangrong Li, and Stephen Safe
Cancer Res 2008 68: 5345-5354. doi: 10.1158/0008-5472.CAN-07-6805 [Abstract] [Full Text] [PDF] Supplementary Data  

Activation of Protein Kinase G Increases the Expression of p21^CIP1, p27^KIP1, and Histidine Triad Protein 1 through Sp1

Bo Cen, Atsuko Deguchi, and I. Bernard Weinstein
Cancer Res 2008 68: 5355-5362. doi: 10.1158/0008-5472.CAN-07-6869 [Abstract] [Full Text] [PDF]  

Increasing Melanoma Cell Death Using Inhibitors of Protein Disulfide Isomerases to Abrogate Survival Responses to Endoplasmic Reticulum Stress

Penny E. Lovat, Marco Corazzari, Jane L. Armstrong, Shaun Martin, Vittoria Pagliarini, David Hill, Anna M. Brown, Mauro Piacentini, Mark A. Birch-Machin, and Christopher P.F. Redfern
Cancer Res 2008 68: 5363-5369. doi: 10.1158/0008-5472.CAN-08-0035 [Abstract] [Full Text] [PDF]  

Berberine Modifies Cysteine 179 of IB Kinase, Suppresses Nuclear Factor-B–Regulated Antiapoptotic Gene Products, and Potentiates Apoptosis

Manoj K. Pandey, Bokyung Sung, Ajaikumar B. Kunnumakkara, Gautam Sethi, Madan M. Chaturvedi, and Bharat B. Aggarwal
Cancer Res 2008 68: 5370-5379. doi: 10.1158/0008-5472.CAN-08-0511 [Abstract] [Full Text] [PDF] Supplementary Data  

Systems Biology and Emerging Technologies:

Functional Genomics Identifies ABCC3 as a Mediator of Taxane Resistance in HER2-Amplified Breast Cancer

Carol O'Brien, Guy Cavet, Ajay Pandita, Xiaolan Hu, Lauren Haydu, Sankar Mohan, Karen Toy, Celina Sanchez Rivers, Zora Modrusan, Lukas C. Amler, and Mark R. Lackner
Cancer Res 2008 68: 5380-5389. doi: 10.1158/0008-5472.CAN-08-0234 [Abstract] [Full Text] [PDF] Supplementary Data  

Immunology:

In vivo Colocalization of Antigen and CpG within Dendritic Cells Is Associated with the Efficacy of Cancer Immunotherapy

Stefan Nierkens, Martijn H. den Brok, Roger P.M. Sutmuller, Oliver M. Grauer, Erik Bennink, Mary E. Morgan, Carl G. Figdor, Theo J.M. Ruers, and Gosse J. Adema
Cancer Res 2008 68: 5390-5396. doi: 10.1158/0008-5472.CAN-07-6023 [Abstract] [Full Text] [PDF] Supplementary Data  

Tumor-Induced Suppressor of Cytokine Signaling 3 Inhibits Toll-like Receptor 3 Signaling in Dendritic Cells via Binding to Tyrosine Kinase 2

Bin Zeng, Haijie Li, Yu Liu, Zhuohan Zhang, Yuan Zhang, and Rongcun Yang
Cancer Res 2008 68: 5397-5404. doi: 10.1158/0008-5472.CAN-07-6792 [Abstract] [Full Text] [PDF] Supplementary Data  

The Humoral Immune System Has a Key Prognostic Impact in Node-Negative Breast Cancer

Marcus Schmidt, Daniel Böhm, Christian von Törne, Eric Steiner, Alexander Puhl, Henryk Pilch, Hans-Anton Lehr, Jan G. Hengstler, Heinz Kölbl, and Mathias Gehrmann
Cancer Res 2008 68: 5405-5413. doi: 10.1158/0008-5472.CAN-07-5206 [Abstract] [Full Text] [PDF] Supplementary Data  

GM1 Expression of Non-Hodgkin's Lymphoma Determines Susceptibility to Rituximab Treatment

Christian Meyer zum Büschenfelde, Yvonne Feuerstacke, Katharina S. Götze, Katrin Scholze, and Christian Peschel
Cancer Res 2008 68: 5414-5422. doi: 10.1158/0008-5472.CAN-07-5601 [Abstract] [Full Text] [PDF]  

Implications of Aging and Self-Tolerance on the Generation of Immune and Antitumor Immune Responses

Ana Lucia Dominguez and Joseph Lustgarten
Cancer Res 2008 68: 5423-5431. doi: 10.1158/0008-5472.CAN-07-6436 [Abstract] [Full Text] [PDF]  

Tumor-Induced Immune Suppression of In vivo Effector T-Cell Priming Is Mediated by the B7-H1/PD-1 Axis and Transforming Growth Factor β

Shuang Wei, Andrew B. Shreiner, Nobuhiro Takeshita, Lieping Chen, Weiping Zou, and Alfred E. Chang
Cancer Res 2008 68: 5432-5438. doi: 10.1158/0008-5472.CAN-07-6598 [Abstract] [Full Text] [PDF]  

Myeloid-Derived Suppressor Cells Promote Cross-Tolerance in B-Cell Lymphoma by Expanding Regulatory T Cells

Paolo Serafini, Stephanie Mgebroff, Kimberly Noonan, and Ivan Borrello
Cancer Res 2008 68: 5439-5449. doi: 10.1158/0008-5472.CAN-07-6621 [Abstract] [Full Text] [PDF] Supplementary Data  

Endocrinology:

Phosphoinositide 3-kinase/AKT Signaling Can Promote AIB1 Stability Independently of GSK3 Phosphorylation

Macarena Ferrero, Álvaro Avivar, María Carmen García-Macías, and Jaime Font de Mora
Cancer Res 2008 68: 5450-5459. doi: 10.1158/0008-5472.CAN-07-6433 [Abstract] [Full Text] [PDF] Supplementary Data  

Steroid Receptor Coactivator-3/AIB1 Promotes Cell Migration and Invasiveness through Focal Adhesion Turnover and Matrix Metalloproteinase Expression

Jun Yan, Halime Erdem, Rile Li, Yi Cai, Gustavo Ayala, Michael Ittmann, Li-yuan Yu-Lee, Sophia Y. Tsai, and Ming-Jer Tsai
Cancer Res 2008 68: 5460-5468. doi: 10.1158/0008-5472.CAN-08-0955 [Abstract] [Full Text] [PDF] Supplementary Data  

Splicing of a Novel Androgen Receptor Exon Generates a Constitutively Active Androgen Receptor that Mediates Prostate Cancer Therapy Resistance

Scott M. Dehm, Lucy J. Schmidt, Hannelore V. Heemers, Robert L. Vessella, and Donald J. Tindall
Cancer Res 2008 68: 5469-5477. doi: 10.1158/0008-5472.CAN-08-0594 [Abstract] [Full Text] [PDF]  

Clinical Research:

A Gene Signature Predicting for Survival in Suboptimally Debulked Patients with Ovarian Cancer

Tomas Bonome, Douglas A. Levine, Joanna Shih, Mike Randonovich, Cindy A. Pise-Masison, Faina Bogomolniy, Laurent Ozbun, John Brady, J. Carl Barrett, Jeff Boyd, and Michael J. Birrer
Cancer Res 2008 68: 5478-5486. doi: 10.1158/0008-5472.CAN-07-6595 [Abstract] [Full Text] [PDF] Supplementary Data  

Prevention:

Serotonin Receptors, Novel Targets of Sulforaphane Identified by Proteomic Analysis in Caco-2 Cells

Lina Mastrangelo, Aedin Cassidy, Francis Mulholland, Wei Wang, and Yongping Bao
Cancer Res 2008 68: 5487-5491. doi: 10.1158/0008-5472.CAN-07-6171 [Abstract] [Full Text] [PDF]  

Dietary Energy Restriction Modulates the Activity of AMP-Activated Protein Kinase, Akt, and Mammalian Target of Rapamycin in Mammary Carcinomas, Mammary Gland, and Liver

Weiqin Jiang, Zongjian Zhu, and Henry J. Thompson
Cancer Res 2008 68: 5492-5499. doi: 10.1158/0008-5472.CAN-07-6721 [Abstract] [Full Text] [PDF]  

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