Reviews:

Staging of Breast Cancer in the Neoadjuvant Setting

Jacqueline S. Jeruss, Elizabeth A. Mittendorf, Susan L. Tucker, Ana M. Gonzalez-Angulo, Thomas A. Buchholz, Aysegul A. Sahin, Janice N. Cormier, Aman U. Buzdar, Gabriel N. Hortobagyi, and Kelly K. Hunt
Cancer Res 2008 68: 6477-6481. doi: 10.1158/0008-5472.CAN-07-6520 [Abstract] [Full Text] [PDF]  

Tumors Sound the Alarmin(s)

Seth B. Coffelt and Aline B. Scandurro
Cancer Res 2008 68: 6482-6485. doi: 10.1158/0008-5472.CAN-08-0044 [Abstract] [Full Text] [PDF]  

Priority Reports:

Variants in the ATM Gene Associated with a Reduced Risk of Contralateral Breast Cancer

Patrick Concannon, Robert W. Haile, Anne-Lise Børresen-Dale, Barry S. Rosenstein, Richard A. Gatti, Sharon N. Teraoka, Anh T. Diep, Laila Jansen, David P. Atencio, Bryan Langholz, Marinela Capanu, Xiaolin Liang, Colin B. Begg, Duncan C. Thomas, Leslie Bernstein, Jørgen H. Olsen, Kathleen E. Malone, Charles F. Lynch, Hoda Anton-Culver, Jonine L. Bernstein for the Women's Environment, Cancer, and Radiation Epidemiology Study Collaborative Group
Cancer Res 2008 68: 6486-6491. doi: 10.1158/0008-5472.CAN-08-0134 [Abstract] [Full Text] [PDF]  

Chromosome 17q12 Variants Contribute to Risk of Early-Onset Prostate Cancer

Albert M. Levin, Mitchell J. Machiela, Kimberly A. Zuhlke, Anna M. Ray, Kathleen A. Cooney, and Julie A. Douglas
Cancer Res 2008 68: 6492-6495. doi: 10.1158/0008-5472.CAN-08-0348 [Abstract] [Full Text] [PDF]  

Cell, Tumor, and Stem Cell Biology:

AMP-Activated Protein Kinase Signaling Results in Cytoplasmic Sequestration of p27

John D. Short, Kevin D. Houston, Ruhee Dere, Sheng-Li Cai, Jinhee Kim, Charles L. Johnson, Russell R. Broaddus, Jianjun Shen, Susie Miyamoto, Fuyuhiko Tamanoi, David Kwiatkowski, Gordon B. Mills, and Cheryl Lyn Walker
Cancer Res 2008 68: 6496-6506. doi: 10.1158/0008-5472.CAN-07-5756 [Abstract] [Full Text] [PDF] Supplementary Data  

BMI-1 Promotes Ewing Sarcoma Tumorigenicity Independent of CDKN2A Repression

Dorothea Douglas, Jessie Hao-Ru Hsu, Long Hung, Aaron Cooper, Diana Abdueva, John van Doorninck, Grace Peng, Hiro Shimada, Timothy J. Triche, and Elizabeth R. Lawlor
Cancer Res 2008 68: 6507-6515. doi: 10.1158/0008-5472.CAN-07-6152 [Abstract] [Full Text] [PDF] Supplementary Data  

S6K1 Plays a Key Role in Glial Transformation

Jean L. Nakamura, Edna Garcia, and Russell O. Pieper
Cancer Res 2008 68: 6516-6523. doi: 10.1158/0008-5472.CAN-07-6188 [Abstract] [Full Text] [PDF]  

p70 S6 Kinase Promotes Epithelial to Mesenchymal Transition through Snail Induction in Ovarian Cancer Cells

Yuen L. Pon, Hong Y. Zhou, Annie N.Y. Cheung, Hextan Y.S. Ngan, and Alice S.T. Wong
Cancer Res 2008 68: 6524-6532. doi: 10.1158/0008-5472.CAN-07-6302 [Abstract] [Full Text] [PDF] Supplementary Data  

Octamer 4 Small Interfering RNA Results in Cancer Stem Cell–Like Cell Apoptosis

Tingsong Hu, Shanrong Liu, Deborah R. Breiter, Fang Wang, Ying Tang, and Shuhan Sun
Cancer Res 2008 68: 6533-6540. doi: 10.1158/0008-5472.CAN-07-6642 [Abstract] [Full Text] [PDF]  

Phosphatidylcholine-Specific Phospholipase C Activation in Epithelial Ovarian Cancer Cells

Francesca Spadaro, Carlo Ramoni, Delia Mezzanzanica, Silvia Miotti, Paola Alberti, Serena Cecchetti, Egidio Iorio, Vincenza Dolo, Silvana Canevari, and Franca Podo
Cancer Res 2008 68: 6541-6549. doi: 10.1158/0008-5472.CAN-07-6763 [Abstract] [Full Text] [PDF] Supplementary Data  

Peptide Aptamers Targeting Mutant p53 Induce Apoptosis in Tumor Cells

Elisa Guida, Andrea Bisso, Cristina Fenollar-Ferrer, Marco Napoli, Claudio Anselmi, Javier E. Girardini, Paolo Carloni, and Giannino Del Sal
Cancer Res 2008 68: 6550-6558. doi: 10.1158/0008-5472.CAN-08-0137 [Abstract] [Full Text] [PDF] Supplementary Data  

R-Cadherin Expression Inhibits Myogenesis and Induces Myoblast Transformation via Rac1 GTPase

Jérôme Kucharczak, Sophie Charrasse, Franck Comunale, Jacques Zappulla, Bruno Robert, Isabelle Teulon-Navarro, André Pèlegrin, and Cécile Gauthier-Rouvière
Cancer Res 2008 68: 6559-6568. doi: 10.1158/0008-5472.CAN-08-0196 [Abstract] [Full Text] [PDF] Supplementary Data  

Cross-talk between LPA₁ and Epidermal Growth Factor Receptors Mediates Up-regulation of Sphingosine Kinase 1 to Promote Gastric Cancer Cell Motility and Invasion

Dai Shida, Xianjun Fang, Tomasz Kordula, Kazuaki Takabe, Sandrine Lépine, Sergio E. Alvarez, Sheldon Milstien, and Sarah Spiegel
Cancer Res 2008 68: 6569-6577. doi: 10.1158/0008-5472.CAN-08-0411 [Abstract] [Full Text] [PDF]  

Peroxisome Proliferator-Activated Receptor- Induces Cell Proliferation by a Cyclin E1–Dependent Mechanism and Is Up-regulated in Thyroid Tumors

Lingchun Zeng, Yan Geng, Maria Tretiakova, Xuemei Yu, Peter Sicinski, and Todd G. Kroll
Cancer Res 2008 68: 6578-6586. doi: 10.1158/0008-5472.CAN-08-0855 [Abstract] [Full Text] [PDF] Supplementary Data  

Mouse Mesenchymal Stem Cells Expressing PAX-FKHR Form Alveolar Rhabdomyosarcomas by Cooperating with Secondary Mutations

Yue-Xin Ren, Friedrich Graf Finckenstein, Diana A. Abdueva, Violette Shahbazian, Brile Chung, Kenneth I. Weinberg, Timothy J. Triche, Hiroyuki Shimada, and Michael J. Anderson
Cancer Res 2008 68: 6587-6597. doi: 10.1158/0008-5472.CAN-08-0859 [Abstract] [Full Text] [PDF] Supplementary Data  

Effects of the Dual Phosphatidylinositol 3-Kinase/Mammalian Target of Rapamycin Inhibitor NVP-BEZ235 on the Tumor Vasculature: Implications for Clinical Imaging

Christian R. Schnell, Frédéric Stauffer, Peter R. Allegrini, Terence O'Reilly, Paul M.J. McSheehy, Celine Dartois, Michael Stumm, Robert Cozens, Amanda Littlewood-Evans, Carlos García-Echeverría, and Sauveur-Michel Maira
Cancer Res 2008 68: 6598-6607. doi: 10.1158/0008-5472.CAN-08-1044 [Abstract] [Full Text] [PDF] Supplementary Data  

K-Ras Nanoclustering Is Subverted by Overexpression of the Scaffold Protein Galectin-3

Ruby Shalom-Feuerstein, Sarah J. Plowman, Barak Rotblat, Nicholas Ariotti, Tianhai Tian, John F. Hancock, and Yoel Kloog
Cancer Res 2008 68: 6608-6616. doi: 10.1158/0008-5472.CAN-08-1117 [Abstract] [Full Text] [PDF]  

Clinical Research:

Disturbed Patterns of Immunocompetent Cells in Usual-Type Vulvar Intraepithelial Neoplasia

Manon van Seters, Ilse Beckmann, Claudia Heijmans-Antonissen, Marc van Beurden, Patricia C. Ewing, Freek J. Zijlstra, Theo J.M. Helmerhorst, and Alex KleinJan
Cancer Res 2008 68: 6617-6622. doi: 10.1158/0008-5472.CAN-08-0327 [Abstract] [Full Text] [PDF]  

Experimental Therapeutics, Molecular Targets, and Chemical Biology:

Sensitization to the Lysosomal Cell Death Pathway by Oncogene-Induced Down-regulation of Lysosome-Associated Membrane Proteins 1 and 2

Nicole Fehrenbacher, Lone Bastholm, Thomas Kirkegaard-Sørensen, Bo Rafn, Trine Bøttzauw, Christina Nielsen, Ekkehard Weber, Senji Shirasawa, Tuula Kallunki, and Marja Jäättelä
Cancer Res 2008 68: 6623-6633. doi: 10.1158/0008-5472.CAN-08-0463 [Abstract] [Full Text] [PDF] Supplementary Data  

A Novel Diterpene Suppresses CWR22Rv1 Tumor Growth In vivo through Antiproliferation and Proapoptosis

Feng-Min Lin, Chin-Hsien Tsai, Yu-Chih Yang, Wei-Chun Tu, Li-Ru Chen, Yun-Sa Liang, Sheng-Yang Wang, Lie-Fen Shyur, Shih-Chang Chien, Tai-Lung Cha, and Pei-Wen Hsiao
Cancer Res 2008 68: 6634-6642. doi: 10.1158/0008-5472.CAN-08-0635 [Abstract] [Full Text] [PDF] Supplementary Data  

Glycogen Synthase Kinase-3 Inhibition Induces Glioma Cell Death through c-MYC, Nuclear Factor-B, and Glucose Regulation

Svetlana Kotliarova, Sandra Pastorino, Lara C. Kovell, Yuri Kotliarov, Hua Song, Wei Zhang, Rolanda Bailey, Dragan Maric, Jean Claude Zenklusen, Jeongwu Lee, and Howard A. Fine
Cancer Res 2008 68: 6643-6651. doi: 10.1158/0008-5472.CAN-08-0850 [Abstract] [Full Text] [PDF] Supplementary Data  

Drug Delivery with Carbon Nanotubes for In vivo Cancer Treatment

Zhuang Liu, Kai Chen, Corrine Davis, Sarah Sherlock, Qizhen Cao, Xiaoyuan Chen, and Hongjie Dai
Cancer Res 2008 68: 6652-6660. doi: 10.1158/0008-5472.CAN-08-1468 [Abstract] [Full Text] [PDF] Supplementary Data  

Overcoming Glutathione S-Transferase P1–Related Cisplatin Resistance in Osteosarcoma

Michela Pasello, Francesca Michelacci, Isabella Scionti, Claudia Maria Hattinger, Monia Zuntini, Anna Maria Caccuri, Katia Scotlandi, Piero Picci, and Massimo Serra
Cancer Res 2008 68: 6661-6668. doi: 10.1158/0008-5472.CAN-07-5840 [Abstract] [Full Text] [PDF] Supplementary Data  

CHR-2797: An Antiproliferative Aminopeptidase Inhibitor that Leads to Amino Acid Deprivation in Human Leukemic Cells

David Krige, Lindsey A. Needham, Lindsay J. Bawden, Nicolas Flores, Hannah Farmer, Lauren E.C. Miles, Erica Stone, Juliana Callaghan, Stephen Chandler, Vanessa L. Clark, Patricia Kirwin-Jones, Valérie Legris, Jo Owen, Thakor Patel, Steve Wood, Gary Box, David Laber, Rajesh Odedra, Annette Wright, L. Michael Wood, Suzanne A. Eccles, Elisabeth A. Bone, Andrew Ayscough, and Alan H. Drummond
Cancer Res 2008 68: 6669-6679. doi: 10.1158/0008-5472.CAN-07-6627 [Abstract] [Full Text] [PDF] Supplementary Data  

Identification of a Novel Recepteur d'Origine Nantais/c-Met Small-Molecule Kinase Inhibitor with Antitumor Activity In vivo

Yihong Zhang, Paula J. Kaplan-Lefko, Karen Rex, Yajing Yang, Jodi Moriguchi, Tao Osgood, Bethany Mattson, Angela Coxon, Monica Reese, Tae-Seong Kim, Jasmine Lin, April Chen, Teresa L. Burgess, and Isabelle Dussault
Cancer Res 2008 68: 6680-6687. doi: 10.1158/0008-5472.CAN-07-6782 [Abstract] [Full Text] [PDF] Supplementary Data  

Inhibition of the Sodium/Potassium ATPase Impairs N-Glycan Expression and Function

Reza Beheshti Zavareh, Ken S. Lau, Rose Hurren, Alessandro Datti, David J. Ashline, Marcela Gronda, Pam Cheung, Craig D. Simpson, Wei Liu, Amanda R. Wasylishen, Paul C. Boutros, Hui Shi, Amudha Vengopal, Igor Jurisica, Linda Z. Penn, Vern N. Reinhold, Shereen Ezzat, Jeff Wrana, David R. Rose, Harry Schachter, James W. Dennis, and Aaron D. Schimmer
Cancer Res 2008 68: 6688-6697. doi: 10.1158/0008-5472.CAN-07-6833 [Abstract] [Full Text] [PDF]  

Down-regulation of Phospho-Akt Is a Major Molecular Determinant of Bortezomib-Induced Apoptosis in Hepatocellular Carcinoma Cells

Kuen-Feng Chen, Pei-Yen Yeh, Kun-Huei Yeh, Yen-Shen Lu, Shang-Yi Huang, and Ann-Lii Cheng
Cancer Res 2008 68: 6698-6707. doi: 10.1158/0008-5472.CAN-08-0257 [Abstract] [Full Text] [PDF]  

Up-regulation of Mcl-1 Is Critical for Survival of Human Melanoma Cells upon Endoplasmic Reticulum Stress

Chen Chen Jiang, Keryn Lucas, Kelly A. Avery-Kiejda, Margaret Wade, Charles E. deBock, Rick F. Thorne, John Allen, Peter Hersey, and Xu Dong Zhang
Cancer Res 2008 68: 6708-6717. doi: 10.1158/0008-5472.CAN-08-0349 [Abstract] [Full Text] [PDF] Supplementary Data  

Sp1-Mediated TRAIL Induction in Chemosensitization

Jing Xu, Jun-Ying Zhou, Wei-Zen Wei, Sjaak Philipsen, and Gen Sheng Wu
Cancer Res 2008 68: 6718-6726. doi: 10.1158/0008-5472.CAN-08-0657 [Abstract] [Full Text] [PDF]  

A Novel Acetylenic Tricyclic bis-(Cyano Enone) Potently Induces Phase 2 Cytoprotective Pathways and Blocks Liver Carcinogenesis Induced by Aflatoxin

Karen Liby, Mark M. Yore, Bill D. Roebuck, Karen J. Baumgartner, Tadashi Honda, Chitra Sundararajan, Hidenori Yoshizawa, Gordon W. Gribble, Charlotte R. Williams, Renee Risingsong, Darlene B. Royce, Albena T. Dinkova-Kostova, Katherine K. Stephenson, Patricia A. Egner, Melinda S. Yates, John D. Groopman, Thomas W. Kensler, and Michael B. Sporn
Cancer Res 2008 68: 6727-6733. doi: 10.1158/0008-5472.CAN-08-1123 [Abstract] [Full Text] [PDF]  

Immunology:

Modulation of Protective T Cell Immunity by Complement Inhibitor Expression on Tumor Cells

Juan C. Varela, Masaki Imai, Carl Atkinson, Rieko Ohta, Michelle Rapisardo, and Stephen Tomlinson
Cancer Res 2008 68: 6734-6742. doi: 10.1158/0008-5472.CAN-08-0502 [Abstract] [Full Text] [PDF]  

Molecular Biology, Pathobiology, and Genetics:

Re-Expression of Transcription Factor ATF5 in Hepatocellular Carcinoma Induces G₂-M Arrest

Jennifer W-M. Gho, Wai-Ki Ip, Kathy Y-Y. Chan, Priscilla T-Y. Law, Paul B-S. Lai, and Nathalie Wong
Cancer Res 2008 68: 6743-6751. doi: 10.1158/0008-5472.CAN-07-6469 [Abstract] [Full Text] [PDF] Supplementary Data  

Leptin Enhances Cholangiocarcinoma Cell Growth

Giammarco Fava, Gianfranco Alpini, Chiara Rychlicki, Stefania Saccomanno, Sharon DeMorrow, Luciano Trozzi, Cinzia Candelaresi, Julie Venter, Antonio Di Sario, Marco Marzioni, Italo Bearzi, Shannon Glaser, Domenico Alvaro, Luca Marucci, Heather Francis, Gianluca Svegliati-Baroni, and Antonio Benedetti
Cancer Res 2008 68: 6752-6761. doi: 10.1158/0008-5472.CAN-07-6682 [Abstract] [Full Text] [PDF]  

The Nuclear Factor-B Pathway Controls the Progression of Prostate Cancer to Androgen-Independent Growth

Ren Jie Jin, Yongsoo Lho, Linda Connelly, Yongqing Wang, Xiuping Yu, Leshana Saint Jean, Thomas C. Case, Katharine Ellwood-Yen, Charles L. Sawyers, Neil A. Bhowmick, Timothy S. Blackwell, Fiona E. Yull, and Robert J. Matusik
Cancer Res 2008 68: 6762-6769. doi: 10.1158/0008-5472.CAN-08-0107 [Abstract] [Full Text] [PDF] Supplementary Data  

Loss of the CBX7 Gene Expression Correlates with a Highly Malignant Phenotype in Thyroid Cancer

Pierlorenzo Pallante, Antonella Federico, Maria Teresa Berlingieri, Mimma Bianco, Angelo Ferraro, Floriana Forzati, Antonino Iaccarino, Maria Russo, Giovanna Maria Pierantoni, Vincenza Leone, Silvana Sacchetti, Giancarlo Troncone, Massimo Santoro, and Alfredo Fusco
Cancer Res 2008 68: 6770-6778. doi: 10.1158/0008-5472.CAN-08-0695 [Abstract] [Full Text] [PDF] Supplementary Data  

Focal Gains of VEGFA and Molecular Classification of Hepatocellular Carcinoma

Derek Y. Chiang, Augusto Villanueva, Yujin Hoshida, Judit Peix, Philippa Newell, Beatriz Minguez, Amanda C. LeBlanc, Diana J. Donovan, Swan N. Thung, Manel Solé, Victoria Tovar, Clara Alsinet, Alex H. Ramos, Jordi Barretina, Sasan Roayaie, Myron Schwartz, Samuel Waxman, Jordi Bruix, Vincenzo Mazzaferro, Azra H. Ligon, Vesna Najfeld, Scott L. Friedman, William R. Sellers, Matthew Meyerson, and Josep M. Llovet
Cancer Res 2008 68: 6779-6788. doi: 10.1158/0008-5472.CAN-08-0742 [Abstract] [Full Text] [PDF] Supplementary Data  

Suppression of Inhibitor of Differentiation 2, a Target of Mutant p53, Is Required for Gain-of-Function Mutations

Wensheng Yan, Gang Liu, Ariane Scoumanne, and Xinbin Chen
Cancer Res 2008 68: 6789-6796. doi: 10.1158/0008-5472.CAN-08-0810 [Abstract] [Full Text] [PDF]  

Aging and Cancer-Related Loss of Insulin-like Growth Factor 2 Imprinting in the Mouse and Human Prostate

Vivian X. Fu, Joseph R. Dobosy, Joshua A. Desotelle, Nima Almassi, Jonathan A. Ewald, Rajini Srinivasan, Mark Berres, John Svaren, Richard Weindruch, and David F. Jarrard
Cancer Res 2008 68: 6797-6802. doi: 10.1158/0008-5472.CAN-08-1714 [Abstract] [Full Text] [PDF] Supplementary Data  

Mutation of Genes Affecting the RAS Pathway Is Common in Childhood Acute Lymphoblastic Leukemia

Marian Case, Elizabeth Matheson, Lynne Minto, Rosline Hassan, Christine J. Harrison, Nick Bown, Simon Bailey, Josef Vormoor, Andrew G. Hall, and Julie A.E. Irving
Cancer Res 2008 68: 6803-6809. doi: 10.1158/0008-5472.CAN-08-0101 [Abstract] [Full Text] [PDF] Supplementary Data  

Role of hMOF-Dependent Histone H4 Lysine 16 Acetylation in the Maintenance of TMS1/ASC Gene Activity

Priya Kapoor-Vazirani, Jacob D. Kagey, Doris R. Powell, and Paula M. Vertino
Cancer Res 2008 68: 6810-6821. doi: 10.1158/0008-5472.CAN-08-0141 [Abstract] [Full Text] [PDF]  

Prevention:

Stage-Specific Inhibitory Effects and Associated Mechanisms of Silibinin on Tumor Progression and Metastasis in Transgenic Adenocarcinoma of the Mouse Prostate Model

Komal Raina, Subapriya Rajamanickam, Rana P. Singh, Gagan Deep, Manesh Chittezhath, and Rajesh Agarwal
Cancer Res 2008 68: 6822-6830. doi: 10.1158/0008-5472.CAN-08-1332 [Abstract] [Full Text] [PDF]  

Tumor Microenvironment:

Centrosomal PKCβII and Pericentrin Are Critical for Human Prostate Cancer Growth and Angiogenesis

Jeewon Kim, Yoon-La Choi, Alice Vallentin, Ben S. Hunrichs, Marc K. Hellerstein, Donna M. Peehl, and Daria Mochly-Rosen
Cancer Res 2008 68: 6831-6839. doi: 10.1158/0008-5472.CAN-07-6195 [Abstract] [Full Text] [PDF] Supplementary Data  

CC-Chemokine Ligand 20/Macrophage Inflammatory Protein-3 and CC-Chemokine Receptor 6 Are Overexpressed in Myeloma Microenvironment Related to Osteolytic Bone Lesions

Nicola Giuliani, Gina Lisignoli, Simona Colla, Mirca Lazzaretti, Paola Storti, Cristina Mancini, Sabrina Bonomini, Cristina Manferdini, Katia Codeluppi, Andrea Facchini, and Vittorio Rizzoli
Cancer Res 2008 68: 6840-6850. doi: 10.1158/0008-5472.CAN-08-0402 [Abstract] [Full Text] [PDF]  

Platelet Granule Secretion Continuously Prevents Intratumor Hemorrhage

Benoit Ho-Tin-Noé, Tobias Goerge, Stephen M. Cifuni, Daniel Duerschmied, and Denisa D. Wagner
Cancer Res 2008 68: 6851-6858. doi: 10.1158/0008-5472.CAN-08-0718 [Abstract] [Full Text] [PDF] Supplementary Data  

Corrections:

Correction: Prediction of Response to Cetuximab

Cancer Res 2008 68: 6859. doi: 10.1158/0008-5472.CAN-68-16-COR1 [Full Text] [PDF]  

Correction: EGCG Negatively Regulates PP-2A to Promote Apoptosis

Cancer Res 2008 68: 6859. doi: 10.1158/0008-5472.CAN-68-16-COR2 [Full Text] [PDF]  

Correction: Colocalizing Antigen and CpG Determines Immunity

Cancer Res 2008 68: 6859. doi: 10.1158/0008-5472.CAN-68-16-COR3 [Full Text] [PDF]  

To see an article, click its [Full Text] or [PDF] link. To review many abstracts, check the boxes to the left of the titles you want, and click the 'Get All Checked Abstract(s)' button. To see one abstract at a time, click its [Abstract] link.