AACR Centennial Series:

The History of Cancer Research: Introducing an AACR Centennial Series

I. Bernard Weinstein and Kathleen Case
Cancer Res 2008 68: 6861-6862. doi: 10.1158/0008-5472.CAN-08-2827 [Full Text] [PDF]  

Advances in Chemical Carcinogenesis: A Historical Review and Prospective

Lawrence A. Loeb and Curtis C. Harris
Cancer Res 2008 68: 6863-6872. doi: 10.1158/0008-5472.CAN-08-2852 [Full Text] [PDF]  

REVIEWS:

Pontin and Reptin, Two Related ATPases with Multiple Roles in Cancer

Otmar Huber, Ludovic Ménard, Valérie Haurie, Alexandra Nicou, Danièle Taras, and Jean Rosenbaum
Cancer Res 2008 68: 6873-6876. doi: 10.1158/0008-5472.CAN-08-0547 [Abstract] [Full Text] [PDF]  

Priority Reports:

Podoplanin Is a Novel Fos Target Gene in Skin Carcinogenesis

Moritz Durchdewald, Juan Guinea-Viniegra, Daniel Haag, Astrid Riehl, Peter Lichter, Meinhard Hahn, Erwin F. Wagner, Peter Angel, and Jochen Hess
Cancer Res 2008 68: 6877-6883. doi: 10.1158/0008-5472.CAN-08-0299 [Abstract] [Full Text] [PDF] Supplementary Data  

BCR/ABL and Other Kinases from Chronic Myeloproliferative Disorders Stimulate Single-Strand Annealing, an Unfaithful DNA Double-Strand Break Repair

Kimberly Cramer, Margaret Nieborowska-Skorska, Mateusz Koptyra, Artur Slupianek, Emir Tyrone P. Penserga, Connie J. Eaves, Walter Aulitzky, and Tomasz Skorski
Cancer Res 2008 68: 6884-6888. doi: 10.1158/0008-5472.CAN-08-1101 [Abstract] [Full Text] [PDF] Supplementary Data  

Efficient Cross-presentation Depends on Autophagy in Tumor Cells

Yuhuan Li, Li-Xin Wang, Guojun Yang, Fang Hao, Walter J. Urba, and Hong-Ming Hu
Cancer Res 2008 68: 6889-6895. doi: 10.1158/0008-5472.CAN-08-0161 [Abstract] [Full Text] [PDF] Supplementary Data  

Inflammatory Cytokines Induce Phosphorylation and Ubiquitination of Prostate Suppressor Protein NKX3.1

Mark C. Markowski, Cai Bowen, and Edward P. Gelmann
Cancer Res 2008 68: 6896-6901. doi: 10.1158/0008-5472.CAN-08-0578 [Abstract] [Full Text] [PDF]  

Inhibition of Activated Fibroblast Growth Factor Receptor 2 in Endometrial Cancer Cells Induces Cell Death Despite PTEN Abrogation

Sara A. Byron, Michael G. Gartside, Candice L. Wellens, Mary A. Mallon, Jack B. Keenan, Matthew A. Powell, Paul J. Goodfellow, and Pamela M. Pollock
Cancer Res 2008 68: 6902-6907. doi: 10.1158/0008-5472.CAN-08-0770 [Abstract] [Full Text] [PDF] Supplementary Data  

PTEN Acetylation Modulates Its Interaction with PDZ Domain

Tsuneo Ikenoue, Ken Inoki, Bin Zhao, and Kun-Liang Guan
Cancer Res 2008 68: 6908-6912. doi: 10.1158/0008-5472.CAN-08-1107 [Abstract] [Full Text] [PDF]  

Cell, Tumor, and Stem Cell Biology:

PIK3CA Mutations and Copy Number Gains in Human Lung Cancers

Hiromasa Yamamoto, Hisayuki Shigematsu, Masaharu Nomura, William W. Lockwood, Mitsuo Sato, Naoki Okumura, Junichi Soh, Makoto Suzuki, Ignacio I. Wistuba, Kwun M. Fong, Huei Lee, Shinichi Toyooka, Hiroshi Date, Wan L. Lam, John D. Minna, and Adi F. Gazdar
Cancer Res 2008 68: 6913-6921. doi: 10.1158/0008-5472.CAN-07-5084 [Abstract] [Full Text] [PDF] Supplementary Data  

Semaphorin-3B Is an Angiogenesis Inhibitor That Is Inactivated by Furin-Like Pro-Protein Convertases

Asya Varshavsky, Ofra Kessler, Sivan Abramovitch, Boaz Kigel, Shelly Zaffryar, Gal Akiri, and Gera Neufeld
Cancer Res 2008 68: 6922-6931. doi: 10.1158/0008-5472.CAN-07-5408 [Abstract] [Full Text] [PDF]  

A Stochastic Model for Cancer Stem Cell Origin in Metastatic Colon Cancer

Christine Odoux, Helene Fohrer, Toshitaka Hoppo, Lynda Guzik, Donna Beer Stolz, Dale W. Lewis, Susanne M. Gollin, T. Clark Gamblin, David A. Geller, and Eric Lagasse
Cancer Res 2008 68: 6932-6941. doi: 10.1158/0008-5472.CAN-07-5779 [Abstract] [Full Text] [PDF]  

Combined Lysophosphatidic Acid/Platelet-Derived Growth Factor Signaling Triggers Glioma Cell Migration in a Tenascin-C Microenvironment

Katrin Lange, Martial Kammerer, Falk Saupe, Monika E. Hegi, Stefan Grotegut, Erika Fluri, and Gertraud Orend
Cancer Res 2008 68: 6942-6952. doi: 10.1158/0008-5472.CAN-08-0347 [Abstract] [Full Text] [PDF] Supplementary Data  

BRCA1-Associated Protein-1 Is a Tumor Suppressor that Requires Deubiquitinating Activity and Nuclear Localization

Karen H. Ventii, Narra S. Devi, Kenneth L. Friedrich, Tatiana A. Chernova, Mourad Tighiouart, Erwin G. Van Meir, and Keith D. Wilkinson
Cancer Res 2008 68: 6953-6962. doi: 10.1158/0008-5472.CAN-08-0365 [Abstract] [Full Text] [PDF]  

EBV Is Necessary for Proliferation of Dually Infected Primary Effusion Lymphoma Cells

Amanda A. Mack and Bill Sugden
Cancer Res 2008 68: 6963-6968. doi: 10.1158/0008-5472.CAN-08-0627 [Abstract] [Full Text] [PDF] Supplementary Data  

Illegitimate WNT Pathway Activation by β-Catenin Mutation or Autocrine Stimulation in T-Cell Malignancies

Richard W.J. Groen, Monique E.C.M. Oud, Esther J.M. Schilder-Tol, Marije B. Overdijk, Derk ten Berge, Roel Nusse, Marcel Spaargaren, and Steven T. Pals
Cancer Res 2008 68: 6969-6977. doi: 10.1158/0008-5472.CAN-08-1322 [Abstract] [Full Text] [PDF] Supplementary Data  

Nonsteroidal Anti-inflammatory Drugs Suppress Glioma via 15-Hydroxyprostaglandin Dehydrogenase

Naoki Wakimoto, Ido Wolf, Dong Yin, James O'Kelly, Tadayuki Akagi, Lilach Abramovitz, Keith L. Black, Hsin-Hsiung Tai, and H. Phillip Koeffler
Cancer Res 2008 68: 6978-6986. doi: 10.1158/0008-5472.CAN-07-5675 [Abstract] [Full Text] [PDF]  

Glycogen Synthase Kinase 3β Regulates Cell Death Induced by Synthetic Triterpenoids

Roberta Venè, Patrizia Larghero, Giuseppe Arena, Michael B. Sporn, Adriana Albini, and Francesca Tosetti
Cancer Res 2008 68: 6987-6996. doi: 10.1158/0008-5472.CAN-07-6362 [Abstract] [Full Text] [PDF] Supplementary Data  

EBV Latent Membrane Protein 1 Effects on Plakoglobin, Cell Growth, and Migration

Kathy H.Y. Shair, Caroline I. Schnegg, and Nancy Raab-Traub
Cancer Res 2008 68: 6997-7005. doi: 10.1158/0008-5472.CAN-08-1178 [Abstract] [Full Text] [PDF]  

Clinical Research:

The Relative Contribution of Point Mutations and Genomic Rearrangements in BRCA1 and BRCA2 in High-Risk Breast Cancer Families

Maurizia Dalla Palma, Susan M. Domchek, Jill Stopfer, Julie Erlichman, Jill D. Siegfried, Jessica Tigges-Cardwell, Bernard A. Mason, Timothy R. Rebbeck, and Katherine L. Nathanson
Cancer Res 2008 68: 7006-7014. Published Online First August 14, 2008. doi: 10.1158/0008-5472.CAN-08-0599 [Abstract] [Full Text] [PDF] Supplementary Data  

Endocrinology:

HEXIM1 Regulates 17β-Estradiol/Estrogen Receptor-–Mediated Expression of Cyclin D1 in Mammary Cells via Modulation of P-TEFb

Ndiya Ogba, Laura J. Chaplin, Yong Qiu Doughman, Koh Fujinaga, and Monica M. Montano
Cancer Res 2008 68: 7015-7024. doi: 10.1158/0008-5472.CAN-08-0814 [Abstract] [Full Text] [PDF] Supplementary Data  

Epidemiology:

Functional Genetic Variations in Cytotoxic T-Lymphocyte Antigen 4 and Susceptibility to Multiple Types of Cancer

Tong Sun, Yifeng Zhou, Ming Yang, Zhibin Hu, Wen Tan, Xiaohong Han, Yuankai Shi, Jiarui Yao, Yongli Guo, Dianke Yu, Tian Tian, Xiaoyi Zhou, Hongbing Shen, and Dongxin Lin
Cancer Res 2008 68: 7025-7034. doi: 10.1158/0008-5472.CAN-08-0806 [Abstract] [Full Text] [PDF] Supplementary Data  

Experimental Therapeutics, Molecular Targets, and Chemical Biology:

Molecular Basis for the Induction of an Angiogenesis Inhibitor, Thrombospondin-1, by 5-Fluorouracil

Hong-Ye Zhao, Akio Ooyama, Masatatsu Yamamoto, Ryuji Ikeda, Misako Haraguchi, Sho Tabata, Tatsuhiko Furukawa, Xiao-Fang Che, Shaoxuan Zhang, Toshinori Oka, Masakazu Fukushima, Masayuki Nakagawa, Mayumi Ono, Michihiko Kuwano, and Shin-ichi Akiyama
Cancer Res 2008 68: 7035-7041. doi: 10.1158/0008-5472.CAN-07-6496 [Abstract] [Full Text] [PDF] Supplementary Data  

Vessel Fractions in Tumor Xenografts Depicted by Flow- or Contrast-Sensitive Three-Dimensional High-Frequency Doppler Ultrasound Respond Differently to Antiangiogenic Treatment

Moritz Palmowski, Jochen Huppert, Peter Hauff, Michael Reinhardt, Karin Schreiner, Michaela A. Socher, Peter Hallscheidt, Guenter W. Kauffmann, Wolfhard Semmler, and Fabian Kiessling
Cancer Res 2008 68: 7042-7049. doi: 10.1158/0008-5472.CAN-08-0285 [Abstract] [Full Text] [PDF]  

Gemcitabine and Cytosine Arabinoside Cytotoxicity: Association with Lymphoblastoid Cell Expression

Liang Li, Brooke Fridley, Krishna Kalari, Gregory Jenkins, Anthony Batzler, Stephanie Safgren, Michelle Hildebrandt, Matthew Ames, Daniel Schaid, and Liewei Wang
Cancer Res 2008 68: 7050-7058. doi: 10.1158/0008-5472.CAN-08-0405 [Abstract] [Full Text] [PDF] Supplementary Data  

ATM Acts Downstream of ATR in the DNA Damage Response Signaling of Bystander Cells

Susanne Burdak-Rothkamm, Kai Rothkamm, and Kevin M. Prise
Cancer Res 2008 68: 7059-7065. doi: 10.1158/0008-5472.CAN-08-0545 [Abstract] [Full Text] [PDF]  

Chemoprevention and Treatment of Experimental Cowden's Disease by mTOR Inhibition with Rapamycin

Cristiane H. Squarize, Rogerio M. Castilho, and J. Silvio Gutkind
Cancer Res 2008 68: 7066-7072. doi: 10.1158/0008-5472.CAN-08-0922 [Abstract] [Full Text] [PDF] Supplementary Data  

Isoaspartate-Glycine-Arginine: A New Tumor Vasculature–Targeting Motif

Flavio Curnis, Angelina Sacchi, Anna Gasparri, Renato Longhi, Angela Bachi, Claudio Doglioni, Claudio Bordignon, Catia Traversari, Gian-Paolo Rizzardi, and Angelo Corti
Cancer Res 2008 68: 7073-7082. doi: 10.1158/0008-5472.CAN-08-1272 [Abstract] [Full Text] [PDF] Supplementary Data  

Synergistic Inhibition with a Dual Epidermal Growth Factor Receptor/HER-2/neu Tyrosine Kinase Inhibitor and a Disintegrin and Metalloprotease Inhibitor

Lois Witters, Peggy Scherle, Steven Friedman, Jordan Fridman, Eian Caulder, Robert Newton, and Allan Lipton
Cancer Res 2008 68: 7083-7089. doi: 10.1158/0008-5472.CAN-08-0739 [Abstract] [Full Text] [PDF]  

Immunology:

Thrombospondin 1 Promotes Tumor Macrophage Recruitment and Enhances Tumor Cell Cytotoxicity of Differentiated U937 Cells

Gema Martin-Manso, Susana Galli, Lisa A. Ridnour, Maria Tsokos, David A. Wink, and David D. Roberts
Cancer Res 2008 68: 7090-7099. doi: 10.1158/0008-5472.CAN-08-0643 [Abstract] [Full Text] [PDF]  

Molecular Biology, Pathobiology, and Genetics:

EWS-FLI1 Suppresses NOTCH-Activated p53 in Ewing's Sarcoma

Jozef Ban, Idriss M. Bennani-Baiti, Max Kauer, Karl-Ludwig Schaefer, Christopher Poremba, Gunhild Jug, Raphaela Schwentner, Oskar Smrzka, Karin Muehlbacher, Dave N.T. Aryee, and Heinrich Kovar
Cancer Res 2008 68: 7100-7109. doi: 10.1158/0008-5472.CAN-07-6145 [Abstract] [Full Text] [PDF]  

Tissue Prostate-Specific Antigen Facilitates Refractory Prostate Tumor Progression via Enhancing ARA70-Regulated Androgen Receptor Transactivation

Yuanjie Niu, Shuyuan Yeh, Hiroshi Miyamoto, Gonghui Li, Saleh Altuwaijri, Jianqun Yuan, Ruifa Han, Tengxiang Ma, Hann-Chorng Kuo, and Chawnshang Chang
Cancer Res 2008 68: 7110-7119. doi: 10.1158/0008-5472.CAN-07-6507 [Abstract] [Full Text] [PDF] Supplementary Data  

Malignant Pleural Mesothelioma–Targeted CREBBP/EP300 Inhibitory Protein 1 Promoter System for Gene Therapy and Virotherapy

Takuya Fukazawa, Junji Matsuoka, Yoshio Naomoto, Yutaka Maeda, Mary L. Durbin, and Noriaki Tanaka
Cancer Res 2008 68: 7120-7129. doi: 10.1158/0008-5472.CAN-08-0047 [Abstract] [Full Text] [PDF] Supplementary Data  

Nitric Oxide Is a Key Component in Inflammation-Accelerated Tumorigenesis

S. Perwez Hussain, Peijun He, Jeffery Subleski, Lorne J. Hofseth, Glenwood E. Trivers, Leah Mechanic, Anne B. Hofseth, Mark Bernard, Jonathan Schwank, Giang Nguyen, Ewy Mathe, Draginja Djurickovic, Diana Haines, Jonathan Weiss, Timothy Back, Eilene Gruys, Victor E. Laubach, Robert H. Wiltrout, and Curtis C. Harris
Cancer Res 2008 68: 7130-7136. doi: 10.1158/0008-5472.CAN-08-0410 [Abstract] [Full Text] [PDF] Supplementary Data  

CXCL13 Is Highly Produced by Sézary Cells and Enhances Their Migratory Ability via a Synergistic Mechanism Involving CCL19 and CCL21 Chemokines

Maria Cristina Picchio, Enrico Scala, Debora Pomponi, Elisabetta Caprini, Marina Frontani, Irene Angelucci, Antonella Mangoni, Cristina Lazzeri, Marie Perez, Daniele Remotti, Emanuela Bonoldi, Roberto Benucci, Giannandrea Baliva, Giuseppe Alfonso Lombardo, Monica Napolitano, Giandomenico Russo, and Maria Grazia Narducci
Cancer Res 2008 68: 7137-7146. doi: 10.1158/0008-5472.CAN-08-0602 [Abstract] [Full Text] [PDF] Supplementary Data  

LRRC3B, Encoding a Leucine-Rich Repeat-Containing Protein, Is a Putative Tumor Suppressor Gene in Gastric Cancer

Mirang Kim, Jeong-Hwan Kim, Hay-Ran Jang, Hwan-Mook Kim, Chang-Woo Lee, Seung-Moo Noh, Kyu-Sang Song, June-Sik Cho, Hyun-Yong Jeong, Yoonsoo Hahn, Young-Il Yeom, Hyang-Sook Yoo, and Yong Sung Kim
Cancer Res 2008 68: 7147-7155. doi: 10.1158/0008-5472.CAN-08-0667 [Abstract] [Full Text] [PDF] Supplementary Data  

CREB3L2-PPAR Fusion Mutation Identifies a Thyroid Signaling Pathway Regulated by Intramembrane Proteolysis

Weng-Onn Lui, Lingchun Zeng, Victoria Rehrmann, Seema Deshpande, Maria Tretiakova, Edwin L. Kaplan, Ingo Leibiger, Barbara Leibiger, Ulla Enberg, Anders Höög, Catharina Larsson, and Todd G. Kroll
Cancer Res 2008 68: 7156-7164. doi: 10.1158/0008-5472.CAN-08-1085 [Abstract] [Full Text] [PDF] Supplementary Data  

Characterization of the Recurrent 8p11-12 Amplicon Identifies PPAPDC1B, a Phosphatase Protein, as a New Therapeutic Target in Breast Cancer

Isabelle Bernard-Pierrot, Nadège Gruel, Nicolas Stransky, Anne Vincent-Salomon, Fabien Reyal, Virginie Raynal, Céline Vallot, Gaëlle Pierron, François Radvanyi, and Olivier Delattre
Cancer Res 2008 68: 7165-7175. doi: 10.1158/0008-5472.CAN-08-1360 [Abstract] [Full Text] [PDF] Supplementary Data  

RET/PTC Rearrangements Preferentially Occurred in Papillary Thyroid Cancer among Atomic Bomb Survivors Exposed to High Radiation Dose

Kiyohiro Hamatani, Hidetaka Eguchi, Reiko Ito, Mayumi Mukai, Keiko Takahashi, Masataka Taga, Kazue Imai, John Cologne, Midori Soda, Koji Arihiro, Megumu Fujihara, Kuniko Abe, Tomayoshi Hayashi, Masahiro Nakashima, Ichiro Sekine, Wataru Yasui, Yuzo Hayashi, and Kei Nakachi
Cancer Res 2008 68: 7176-7182. doi: 10.1158/0008-5472.CAN-08-0293 [Abstract] [Full Text] [PDF] Supplementary Data  

Systems Biology and Emerging Technologies:

Manipulation of [¹¹C]-5-Hydroxytryptophan and 6-[¹⁸F]Fluoro-3,4-Dihydroxy-L-Phenylalanine Accumulation in Neuroendocrine Tumor Cells

Oliver C. Neels, Klaas P. Koopmans, Pieter L. Jager, Laya Vercauteren, Aren van Waarde, Janine Doorduin, Hetty Timmer-Bosscha, Adrienne H. Brouwers, Elisabeth G.E. de Vries, Rudi A.J.O. Dierckx, Ido P. Kema, and Philip H. Elsinga
Cancer Res 2008 68: 7183-7190. doi: 10.1158/0008-5472.CAN-08-0095 [Abstract] [Full Text] [PDF]  

Tumor Microenvironment:

Chondroitin Sulfate E Fragments Enhance CD44 Cleavage and CD44-Dependent Motility in Tumor Cells

Kazuki N. Sugahara, Takako Hirata, Toshiyuki Tanaka, Shinji Ogino, Mitsuhiro Takeda, Hiroaki Terasawa, Ichio Shimada, Jun-ichi Tamura, Gerdy B. ten Dam, Toin H. van Kuppevelt, and Masayuki Miyasaka
Cancer Res 2008 68: 7191-7199. doi: 10.1158/0008-5472.CAN-07-6198 [Abstract] [Full Text] [PDF]  

Transforming Growth Factor β1 Promotes Chromosomal Instability in Human Papillomavirus 16 E6E7–Infected Cervical Epithelial Cells

Wen Deng, Sai Wah Tsao, Yvonne K. Kwok, Esther Wong, Xiao Ru Huang, Si Liu, Chi M. Tsang, Hextan Y.S. Ngan, Annie N.Y. Cheung, Hui Yao Lan, Xin-Yuan Guan, and Annie L.M. Cheung
Cancer Res 2008 68: 7200-7209. doi: 10.1158/0008-5472.CAN-07-6569 [Abstract] [Full Text] [PDF] Supplementary Data  

Mitochondrial/Cell-Surface Protein p32/gC1qR as a Molecular Target in Tumor Cells and Tumor Stroma

Valentina Fogal, Lianglin Zhang, Stan Krajewski, and Erkki Ruoslahti
Cancer Res 2008 68: 7210-7218. doi: 10.1158/0008-5472.CAN-07-6752 [Abstract] [Full Text] [PDF] Supplementary Data  

Protease-Activated Receptor (PAR) 2, but not PAR1, Signaling Promotes the Development of Mammary Adenocarcinoma in Polyoma Middle T Mice

Henri H. Versteeg, Florence Schaffner, Marjolein Kerver, Lesley G. Ellies, Patricia Andrade-Gordon, Barbara M. Mueller, and Wolfram Ruf
Cancer Res 2008 68: 7219-7227. doi: 10.1158/0008-5472.CAN-08-0419 [Abstract] [Full Text] [PDF]  

Tumor-Associated Galectin-3 Modulates the Function of Tumor-Reactive T Cells

Weiyi Peng, Helen Y. Wang, Yoshihiro Miyahara, Guangyong Peng, and Rong-Fu Wang
Cancer Res 2008 68: 7228-7236. doi: 10.1158/0008-5472.CAN-08-1245 [Abstract] [Full Text] [PDF] Supplementary Data  

Identification of Secreted Proteins that Mediate Cell-Cell Interactions in an In vitro Model of the Lung Cancer Microenvironment

Li Zhong, Jonathon Roybal, Raghothama Chaerkady, Wan Zhang, Kuicheon Choi, Cristina A. Alvarez, Hai Tran, Chad J. Creighton, Shaoyu Yan, Robert M. Strieter, Akhilesh Pandey, and Jonathan M. Kurie
Cancer Res 2008 68: 7237-7245. doi: 10.1158/0008-5472.CAN-08-1529 [Abstract] [Full Text] [PDF] Supplementary Data  

Corrections:

Correction: Estrogen Modulates Notch Activity

Cancer Res 2008 68: 7246. doi: 10.1158/0008-5472.CAN-68-17-COR1 [Full Text] [PDF]  

Correction: c-Myc and eIF4F Link Translation and Transcription

Cancer Res 2008 68: 7246. doi: 10.1158/0008-5472.CAN-68-17-COR2 [Full Text] [PDF]  

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