Reviews:

Cannabinoids for Cancer Treatment: Progress and Promise

Sami Sarfaraz, Vaqar M. Adhami, Deeba N. Syed, Farrukh Afaq, and Hasan Mukhtar
Cancer Res 2008 68: 339-342. doi: 10.1158/0008-5472.CAN-07-2785 [Abstract] [Full Text] [PDF]  

Acquired Lymphedema: An Urgent Need for Adequate Animal Models

Catarina Hadamitzky and Reinhard Pabst
Cancer Res 2008 68: 343-345. doi: 10.1158/0008-5472.CAN-07-2454 [Abstract] [Full Text] [PDF]  

Priority Reports:

Nerve Growth Factor Is a Potential Therapeutic Target in Breast Cancer

Eric Adriaenssens, Elsa Vanhecke, Pasquine Saule, Alexandra Mougel, Adeline Page, Rodrigue Romon, Victor Nurcombe, Xuefen Le Bourhis, and Hubert Hondermarck
Cancer Res 2008 68: 346-351. doi: 10.1158/0008-5472.CAN-07-1183 [Abstract] [Full Text] [PDF] Supplementary Data  

p53-Dependent and p53-Independent Activation of Autophagy by ARF

Wassim M. Abida and Wei Gu
Cancer Res 2008 68: 352-357. doi: 10.1158/0008-5472.CAN-07-2069 [Abstract] [Full Text] [PDF] Supplementary Data  

Multiple Rare Nonsynonymous Variants in the Adenomatous Polyposis Coli Gene Predispose to Colorectal Adenomas

Duncan Azzopardi, Anthony R. Dallosso, Kristilyn Eliason, Brant C. Hendrickson, Natalie Jones, Edward Rawstorne, James Colley, Valentina Moskvina, Cynthia Frye, Julian R. Sampson, Richard Wenstrup, Thomas Scholl, and Jeremy P. Cheadle
Cancer Res 2008 68: 358-363. doi: 10.1158/0008-5472.CAN-07-5733 [Abstract] [Full Text] [PDF] Supplementary Data  

Activating Transcription Factor 3 Is a Novel Repressor of the Nuclear Factor Erythroid-Derived 2–Related Factor 2 (Nrf2)–Regulated Stress Pathway

Stephan L. Brown, Konjeti R. Sekhar, Girish Rachakonda, Soumya Sasi, and Michael L. Freeman
Cancer Res 2008 68: 364-368. doi: 10.1158/0008-5472.CAN-07-2170 [Abstract] [Full Text] [PDF]  

Molecular Biology, Pathobiology, and Genetics:

Revealing Targeted Therapy for Human Cancer by Gene Module Maps

David J. Wong, Dimitry S.A. Nuyten, Aviv Regev, Meihong Lin, Adam S. Adler, Eran Segal, Marc J. van de Vijver, and Howard Y. Chang
Cancer Res 2008 68: 369-378. doi: 10.1158/0008-5472.CAN-07-0382 [Abstract] [Full Text] [PDF] Supplementary Data  

Regulation of Gastric Carcinogenesis by Helicobacter pylori Virulence Factors

Aime T. Franco, Elizabeth Johnston, Uma Krishna, Yoshio Yamaoka, Dawn A. Israel, Toni A. Nagy, Lydia E. Wroblewski, Maria Blanca Piazuelo, Pelayo Correa, and Richard M. Peek, Jr.
Cancer Res 2008 68: 379-387. doi: 10.1158/0008-5472.CAN-07-0824 [Abstract] [Full Text] [PDF]  

2-6–Linked Sialic Acids on N-Glycans Modulate Carcinoma Differentiation In vivo

Maria Hedlund, Elisa Ng, Ajit Varki, and Nissi M. Varki
Cancer Res 2008 68: 388-394. doi: 10.1158/0008-5472.CAN-07-1340 [Abstract] [Full Text] [PDF]  

t-Darpp Promotes Cancer Cell Survival by Up-regulation of Bcl2 through Akt-Dependent Mechanism

Abbes Belkhiri, Altaf A. Dar, Alexander Zaika, Mark Kelley, and Wael El-Rifai
Cancer Res 2008 68: 395-403. doi: 10.1158/0008-5472.CAN-07-1580 [Abstract] [Full Text] [PDF]  

The Kringle 1 Domain of Hepatocyte Growth Factor Has Antiangiogenic and Antitumor Cell Effects on Hepatocellular Carcinoma

Zan Shen, Zhen Fan Yang, Yi Gao, Ji Cheng Li, Hai Xiao Chen, Ching Chiu Liu, Ronnie T.P. Poon, Sheung Tat Fan, John M. Luk, Kong Hung Sze, Tsai Ping Li, Ren Bao Gan, Ming Liang He, Hsiang Fu Kung, and Marie C.M. Lin
Cancer Res 2008 68: 404-414. doi: 10.1158/0008-5472.CAN-07-2081 [Abstract] [Full Text] [PDF] Supplementary Data  

Integrating Global Gene Expression and Radiation Survival Parameters across the 60 Cell Lines of the National Cancer Institute Anticancer Drug Screen

Sally A. Amundson, Khanh T. Do, Lisa C. Vinikoor, R. Anthony Lee, Christine A. Koch-Paiz, Jaeyong Ahn, Mark Reimers, Yidong Chen, Dominic A. Scudiero, John N. Weinstein, Jeffrey M. Trent, Michael L. Bittner, Paul S. Meltzer, and Albert J. Fornace, Jr.
Cancer Res 2008 68: 415-424. doi: 10.1158/0008-5472.CAN-07-2120 [Abstract] [Full Text] [PDF] Supplementary Data  

MicroRNA Expression Profiling in Human Ovarian Cancer: miR-214 Induces Cell Survival and Cisplatin Resistance by Targeting PTEN

Hua Yang, William Kong, Lili He, Jian-Jun Zhao, Joshua D. O'Donnell, Jiawang Wang, Robert M. Wenham, Domenico Coppola, Patricia A. Kruk, Santo V. Nicosia, and Jin Q. Cheng
Cancer Res 2008 68: 425-433. doi: 10.1158/0008-5472.CAN-07-2488 [Abstract] [Full Text] [PDF]  

Glioma Pathogenesis-Related Protein 1 Exerts Tumor Suppressor Activities through Proapoptotic Reactive Oxygen Species–c-Jun–NH₂ Kinase Signaling

Likun Li, ElMoataz Abdel Fattah, Guangwen Cao, Chengzhen Ren, Guang Yang, Alexei A. Goltsov, A. Craig Chinault, Wei-Wen Cai, Terry L. Timme, and Timothy C. Thompson
Cancer Res 2008 68: 434-443. doi: 10.1158/0008-5472.CAN-07-2931 [Abstract] [Full Text] [PDF] Supplementary Data  

Mammalian Target of Rapamycin Is the Key Effector of Phosphatidylinositol-3-OH–Initiated Proliferative Signals in the Thyroid Follicular Epithelium

Nicole Yeager, Charlene Brewer, Kathy Qi Cai, Xiang-Xi Xu, and Antonio Di Cristofano
Cancer Res 2008 68: 444-449. doi: 10.1158/0008-5472.CAN-07-3030 [Abstract] [Full Text] [PDF]  

Indirect Macrophage Responses to Ionizing Radiation: Implications for Genotype-Dependent Bystander Signaling

Philip J. Coates, Jana K. Rundle, Sally A. Lorimore, and Eric G. Wright
Cancer Res 2008 68: 450-456. doi: 10.1158/0008-5472.CAN-07-3050 [Abstract] [Full Text] [PDF] Supplementary Data  

Regulation of Vascular Endothelial Growth Factor D by Orphan Receptors Hepatocyte Nuclear Factor-4 and Chicken Ovalbumin Upstream Promoter Transcription Factors 1 and 2

Georgia Schäfer, Christoph Wißmann, Johannes Hertel, Victoria Lunyak, and Michael Höcker
Cancer Res 2008 68: 457-466. doi: 10.1158/0008-5472.CAN-07-5136 [Abstract] [Full Text] [PDF] Supplementary Data  

Cell, Tumor, and Stem Cell Biology:

Cyclooxygenase-2 Expression during Immortalization and Breast Cancer Progression

Xiangshan Zhao, Monica Goswami, Nidhi Pokhriyal, Hui Ma, Hongyan Du, Jun Yao, Thomas A. Victor, Kornelia Polyak, Charles D. Sturgis, Hamid Band, and Vimla Band
Cancer Res 2008 68: 467-475. doi: 10.1158/0008-5472.CAN-07-0782 [Abstract] [Full Text] [PDF] Supplementary Data  

p19^Arf Inhibits the Invasion of Hepatocellular Carcinoma Cells by Binding to C-terminal Binding Protein

Ya-Wen Chen, Seema Paliwal, Kyle Draheim, Steven R. Grossman, and Brian C. Lewis
Cancer Res 2008 68: 476-482. doi: 10.1158/0008-5472.CAN-07-1960 [Abstract] [Full Text] [PDF] Supplementary Data  

Hyaluronic Acid Synthase-1 Expression Regulates Bladder Cancer Growth, Invasion, and Angiogenesis through CD44

Roozbeh Golshani, Luis Lopez, Veronica Estrella, Mario Kramer, Naoko Iida, and Vinata B. Lokeshwar
Cancer Res 2008 68: 483-491. doi: 10.1158/0008-5472.CAN-07-2140 [Abstract] [Full Text] [PDF]  

The Adenocarcinoma-Associated Antigen, AGR2, Promotes Tumor Growth, Cell Migration, and Cellular Transformation

Zheng Wang, Ying Hao, and Anson W. Lowe
Cancer Res 2008 68: 492-497. doi: 10.1158/0008-5472.CAN-07-2930 [Abstract] [Full Text] [PDF]  

Critical Role of the Stress Chaperone GRP78/BiP in Tumor Proliferation, Survival, and Tumor Angiogenesis in Transgene-Induced Mammary Tumor Development

Dezheng Dong, Min Ni, Jianze Li, Shigang Xiong, Wei Ye, Jenilyn J. Virrey, Changhui Mao, Risheng Ye, Miao Wang, Ligaya Pen, Louis Dubeau, Susan Groshen, Florence M. Hofman, and Amy S. Lee
Cancer Res 2008 68: 498-505. doi: 10.1158/0008-5472.CAN-07-2950 [Abstract] [Full Text] [PDF]  

CSN5 Isopeptidase Activity Links COP9 Signalosome Activation to Breast Cancer Progression

Adam S. Adler, Laurie E. Littlepage, Meihong Lin, Tiara L.A. Kawahara, David J. Wong, Zena Werb, and Howard Y. Chang
Cancer Res 2008 68: 506-515. doi: 10.1158/0008-5472.CAN-07-3060 [Abstract] [Full Text] [PDF] Supplementary Data  

Induction of Cancer Metastasis by Cyclophosphamide Pretreatment of Host Mice: An Opposite Effect of Chemotherapy

Kensuke Yamauchi, Meng Yang, Katsuhiro Hayashi, Ping Jiang, Norio Yamamoto, Hiroyuki Tsuchiya, Katsuro Tomita, Abdool R. Moossa, Michael Bouvet, and Robert M. Hoffman
Cancer Res 2008 68: 516-520. doi: 10.1158/0008-5472.CAN-07-3063 [Abstract] [Full Text] [PDF]  

Vascular Endothelial Growth Factor–Mediated Decrease in Plasma Soluble Vascular Endothelial Growth Factor Receptor-2 Levels as a Surrogate Biomarker for Tumor Growth

John M.L. Ebos, Christina R. Lee, Elena Bogdanovic, Jennifer Alami, Paul Van Slyke, Giulio Francia, Ping Xu, Anthony J. Mutsaers, Daniel J. Dumont, and Robert S. Kerbel
Cancer Res 2008 68: 521-529. doi: 10.1158/0008-5472.CAN-07-3217 [Abstract] [Full Text] [PDF] Supplementary Data  

Development of a New Tracking Tool for the Human Monomeric Laminin-2 Chain In vitro and In vivo

Naohiko Koshikawa, Tomoko Minegishi, Kazuki Nabeshima, and Motoharu Seiki
Cancer Res 2008 68: 530-536. doi: 10.1158/0008-5472.CAN-07-5269 [Abstract] [Full Text] [PDF]  

The Transcriptional Repressor ZEB1 Promotes Metastasis and Loss of Cell Polarity in Cancer

Simone Spaderna, Otto Schmalhofer, Mandy Wahlbuhl, Arno Dimmler, Katja Bauer, Aneesa Sultan, Falk Hlubek, Andreas Jung, Dennis Strand, Andreas Eger, Thomas Kirchner, Jürgen Behrens, and Thomas Brabletz
Cancer Res 2008 68: 537-544. doi: 10.1158/0008-5472.CAN-07-5682 [Abstract] [Full Text] [PDF] Supplementary Data  

Regulation of Angiogenic Factors by HDM2 in Renal Cell Carcinoma

Veronica A. Carroll and Margaret Ashcroft
Cancer Res 2008 68: 545-552. doi: 10.1158/0008-5472.CAN-06-4738 [Abstract] [Full Text] [PDF] Supplementary Data  

Experimental Therapeutics, Molecular Targets, and Chemical Biology:

Cyclooxygenase-2–Derived Prostaglandin E₂ Activates β-Catenin in Human Cholangiocarcinoma Cells: Evidence for Inhibition of These Signaling Pathways by 3 Polyunsaturated Fatty Acids

Kyu Lim, Chang Han, Lihong Xu, Kumiko Isse, Anthony J. Demetris, and Tong Wu
Cancer Res 2008 68: 553-560. doi: 10.1158/0008-5472.CAN-07-2295 [Abstract] [Full Text] [PDF] Supplementary Data  

Antibody-Mediated Blockade of Integrin _vβ₆ Inhibits Tumor Progression In vivo by a Transforming Growth Factor-β–Regulated Mechanism

Louise A. Koopman Van Aarsen, Diane R. Leone, Steffan Ho, Brian M. Dolinski, Patricia E. McCoon, Doreen J. LePage, Rebecca Kelly, Glenna Heaney, Paul Rayhorn, Carl Reid, Kenneth J. Simon, Gerald S. Horan, Nianjun Tao, Humphrey A. Gardner, Marilyn M. Skelly, Allen M. Gown, Gareth J. Thomas, Paul H. Weinreb, Stephen E. Fawell, and Shelia M. Violette
Cancer Res 2008 68: 561-570. doi: 10.1158/0008-5472.CAN-07-2307 [Abstract] [Full Text] [PDF]  

Impact of Common Epidermal Growth Factor Receptor and HER2 Variants on Receptor Activity and Inhibition by Lapatinib

Tona M. Gilmer, Louann Cable, Krystal Alligood, David Rusnak, Glenn Spehar, Kathleen T. Gallagher, Ermias Woldu, H. Luke Carter, Anne T. Truesdale, Lisa Shewchuk, and Edgar R. Wood
Cancer Res 2008 68: 571-579. doi: 10.1158/0008-5472.CAN-07-2404 [Abstract] [Full Text] [PDF] Supplementary Data  

Phosphatidylinositol Ether Lipid Analogues Induce AMP-Activated Protein Kinase–Dependent Death in LKB1-Mutant Non–Small Cell Lung Cancer Cells

Regan M. Memmott, Joell J. Gills, Melinda Hollingshead, Margaret C. Powers, Zhiping Chen, Bruce Kemp, Alan Kozikowski, and Phillip A. Dennis
Cancer Res 2008 68: 580-588. doi: 10.1158/0008-5472.CAN-07-3091 [Abstract] [Full Text] [PDF]  

Inhibition of Hsp90 Down-regulates Mutant Epidermal Growth Factor Receptor (EGFR) Expression and Sensitizes EGFR Mutant Tumors to Paclitaxel

Ayana Sawai, Sarat Chandarlapaty, Heidi Greulich, Mithat Gonen, Qing Ye, Carlos L. Arteaga, William Sellers, Neal Rosen, and David B. Solit
Cancer Res 2008 68: 589-596. doi: 10.1158/0008-5472.CAN-07-1570 [Abstract] [Full Text] [PDF] Supplementary Data  

Superior Activity of Fusion Protein scFvRit:sFasL over Cotreatment with Rituximab and Fas Agonists

Edwin Bremer, Bram ten Cate, Douwe F. Samplonius, Nicole Mueller, Harald Wajant, Alja J. Stel, Martine Chamuleau, Arjan A. van de Loosdrecht, Julia Stieglmaier, Georg H. Fey, and Wijnand Helfrich
Cancer Res 2008 68: 597-604. doi: 10.1158/0008-5472.CAN-07-5171 [Abstract] [Full Text] [PDF]  

Chronic Hypoxia Decreases Synthesis of Homologous Recombination Proteins to Offset Chemoresistance and Radioresistance

Norman Chan, Marianne Koritzinsky, Helen Zhao, Ranjit Bindra, Peter M. Glazer, Simon Powell, Abdellah Belmaaza, Brad Wouters, and Robert G. Bristow
Cancer Res 2008 68: 605-614. doi: 10.1158/0008-5472.CAN-07-5472 [Abstract] [Full Text] [PDF]  

Immunology:

Protective Role of Toll-like Receptor 4 during the Initiation Stage of Cutaneous Chemical Carcinogenesis

Nabiha Yusuf, Tahseen H. Nasti, J. Alan Long, Mohammed Naseemuddin, Alan P. Lucas, Hui Xu, and Craig A. Elmets
Cancer Res 2008 68: 615-622. doi: 10.1158/0008-5472.CAN-07-5219 [Abstract] [Full Text] [PDF]  

Letters to the Editor:

Is Mitochondrial DNA Variation Associated with Sporadic Breast Cancer Risk?

Ana Mosquera-Miguel, Vanesa Álvarez-Iglesias, Ángel Carracedo, Antonio Salas, Ana Vega, Ángel Carracedo, Roger Milne, Antonio Cabrera de León, Javier Benitez, Ángel Carracedo, and Antonio Salas
Cancer Res 2008 68: 623-625. doi: 10.1158/0008-5472.CAN-07-2385 [Full Text] [PDF]  

Ren-Kui Bai, Suzanne M. Leal, Daniel Covarrubias, Lee-Jun C. Wong, Daniel Covarrubias, and Aiyi Liu
Cancer Res 2008 68: 624. doi: 10.1158/0008-5472.CAN-07-5706 [Full Text] [PDF]  

Correction:

Correction: MDSC and ATRA

Cancer Res 2008 68: 626. doi: 10.1158/0008-5472.CAN-68-2-COR [Full Text] [PDF]  

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