AACR Centennial Series:

Biological Research in the Evolution of Cancer Surgery: A Personal Perspective

Bernard Fisher
Cancer Res 2008 68: 10007-10020. doi: 10.1158/0008-5472.CAN-08-0186 [Abstract] [Full Text] [PDF]  

Reviews:

Drug Resistance Caused by Reversion Mutation

Alan Ashworth
Cancer Res 2008 68: 10021-10023. doi: 10.1158/0008-5472.CAN-08-2287 [Abstract] [Full Text] [PDF]  

Chromosomal Rearrangements Leading to MLL Gene Fusions: Clinical and Biological Aspects

David P. Harper and Peter D. Aplan
Cancer Res 2008 68: 10024-10027. doi: 10.1158/0008-5472.CAN-08-2208 [Abstract] [Full Text] [PDF]  

Meeting Reports:

Approaches to Complex Pathways in Molecular Epidemiology: Summary of a Special Conference of the American Association for Cancer Research

Duncan C. Thomas, James W. Baurley, Elizabeth E. Brown, Jane C. Figueiredo, Alisa Goldstein, Aditi Hazra, Robin T. Wilson, and Nathaniel Rothman
Cancer Res 2008 68: 10028-10030. doi: 10.1158/0008-5472.CAN-08-1690 [Full Text] [PDF]  

Eph Receptors and Ephrins in Cancer: Common Themes and Controversies

Jin Chen, Guanglei Zhuang, Leslie Frieden, and Waldemar Debinski
Cancer Res 2008 68: 10031-10033. doi: 10.1158/0008-5472.CAN-08-3010 [Full Text] [PDF] Supplementary Data  

Priority Reports:

p53 Small-Molecule Inhibitor Enhances Temozolomide Cytotoxic Activity against Intracranial Glioblastoma Xenografts

Eduard B. Dinca, Kan V. Lu, Jann N. Sarkaria, Russell O. Pieper, Michael D. Prados, Daphne A. Haas-Kogan, Scott R. VandenBerg, Mitchel S. Berger, and C. David James
Cancer Res 2008 68: 10034-10039. doi: 10.1158/0008-5472.CAN-08-1687 [Abstract] [Full Text] [PDF] Supplementary Data  

Negative Regulation of AKT Activation by BRCA1

Tao Xiang, Amiko Ohashi, Yuping Huang, Tej K. Pandita, Thomas Ludwig, Simon N. Powell, and Qin Yang
Cancer Res 2008 68: 10040-10044. doi: 10.1158/0008-5472.CAN-08-3009 [Abstract] [Full Text] [PDF] Supplementary Data  

Racial Disparity in Breast Cancer and Functional Germ Line Mutation in Galectin-3 (rs4644): A Pilot Study

Vitaly Balan, Pratima Nangia-Makker, Ann G. Schwartz, Young Suk Jung, Larry Tait, Victor Hogan, Tirza Raz, Yi Wang, Zeng Quan Yang, Gen Sheng Wu, Yongjun Guo, Huixiang Li, Judith Abrams, Fergus J. Couch, Wilma L. Lingle, Ricardo V. Lloyd, Stephen P. Ethier, Michael A. Tainsky, and Avraham Raz
Cancer Res 2008 68: 10045-10050. doi: 10.1158/0008-5472.CAN-08-3224 [Abstract] [Full Text] [PDF] Supplementary Data  

Cell, Tumor, and Stem Cell Biology:

Cancer Stem Cells Are Enriched in the Side Population Cells in a Mouse Model of Glioma

Molly A. Harris, Hyuna Yang, Benjamin E. Low, Joydeep Mukherje, Abhijit Guha, Roderick T. Bronson, Leonard D. Shultz, Mark A. Israel, and Kyuson Yun
Cancer Res 2008 68: 10051-10059. doi: 10.1158/0008-5472.CAN-08-0786 [Abstract] [Full Text] [PDF] Supplementary Data  

The Innate Immune Receptor Nod1 Protects the Intestine from Inflammation-Induced Tumorigenesis

Grace Y. Chen, Michael H. Shaw, Gloria Redondo, and Gabriel Núñez
Cancer Res 2008 68: 10060-10067. doi: 10.1158/0008-5472.CAN-08-2061 [Abstract] [Full Text] [PDF]  

Tissue Factor Regulation by Epidermal Growth Factor Receptor and Epithelial-to-Mesenchymal Transitions: Effect on Tumor Initiation and Angiogenesis

Chloe C. Milsom, Joanne L. Yu, Nigel Mackman, Johann Micallef, G. Mark Anderson, Abhijit Guha, and Janusz W. Rak
Cancer Res 2008 68: 10068-10076. doi: 10.1158/0008-5472.CAN-08-2067 [Abstract] [Full Text] [PDF]  

Heparanase Augments Epidermal Growth Factor Receptor Phosphorylation: Correlation with Head and Neck Tumor Progression

Victoria Cohen-Kaplan, Ilana Doweck, Inna Naroditsky, Israel Vlodavsky, and Neta Ilan
Cancer Res 2008 68: 10077-10085. doi: 10.1158/0008-5472.CAN-08-2910 [Abstract] [Full Text] [PDF] Supplementary Data  

Altered Detoxification Status and Increased Resistance to Oxidative Stress by K-Ras Transformation

Christian V. Recktenwald, Roland Kellner, Rudolf Lichtenfels, and Barbara Seliger
Cancer Res 2008 68: 10086-10093. doi: 10.1158/0008-5472.CAN-08-0360 [Abstract] [Full Text] [PDF]  

p53-Responsive MicroRNAs 192 and 215 Are Capable of Inducing Cell Cycle Arrest

Christian J. Braun, Xin Zhang, Irina Savelyeva, Sonja Wolff, Ute M. Moll, Troels Schepeler, Torben F. Ørntoft, Claus L. Andersen, and Matthias Dobbelstein
Cancer Res 2008 68: 10094-10104. doi: 10.1158/0008-5472.CAN-08-1569 [Abstract] [Full Text] [PDF] Supplementary Data  

Coordinated Regulation of Cell Cycle Transcripts by p53-Inducible microRNAs, miR-192 and miR-215

Sara A. Georges, Matthew C. Biery, Soo-yeon Kim, Janell M. Schelter, Jane Guo, Aaron N. Chang, Aimee L. Jackson, Michael O. Carleton, Peter S. Linsley, Michele A. Cleary, and B. Nelson Chau
Cancer Res 2008 68: 10105-10112. doi: 10.1158/0008-5472.CAN-08-1846 [Abstract] [Full Text] [PDF] Supplementary Data  

Hypoxia-Inducible Factor 1 Mediates Anoikis Resistance via Suppression of 5 Integrin

Nadine Rohwer, Martina Welzel, Katjana Daskalow, David Pfander, Bertram Wiedenmann, Katharina Detjen, and Thorsten Cramer
Cancer Res 2008 68: 10113-10120. doi: 10.1158/0008-5472.CAN-08-1839 [Abstract] [Full Text] [PDF] Supplementary Data  

The High-Mobility Group A1a/Signal Transducer and Activator of Transcription-3 Axis: An Achilles Heel for Hematopoietic Malignancies?

Joelle Hillion, Surajit Dhara, Takita Felder Sumter, Mita Mukherjee, Francescopaolo Di Cello, Amy Belton, James Turkson, Souyma Jaganathan, Linzhao Cheng, Zhaohui Ye, Richard Jove, Peter Aplan, Ying-Wei Lin, Kelsey Wertzler, Ray Reeves, Ossama Elbahlouh, Jeanne Kowalski, Raka Bhattacharya, and Linda M. S. Resar
Cancer Res 2008 68: 10121-10127. doi: 10.1158/0008-5472.CAN-08-2121 [Abstract] [Full Text] [PDF] Supplementary Data  

MicroRNAs Impair MET-Mediated Invasive Growth

Cristina Migliore, Annalisa Petrelli, Elena Ghiso, Simona Corso, Lorena Capparuccia, Adriana Eramo, Paolo M. Comoglio, and Silvia Giordano
Cancer Res 2008 68: 10128-10136. doi: 10.1158/0008-5472.CAN-08-2148 [Abstract] [Full Text] [PDF] Supplementary Data  

In vivo Dynamics of Stable Chronic Lymphocytic Leukemia Inversely Correlate with Somatic Hypermutation Levels and Suggest No Major Leukemic Turnover in Bone Marrow

Rogier van Gent, Arnon P. Kater, Sigrid A. Otto, A. Jaspers, José A.M. Borghans, Nienke Vrisekoop, Mariëtte A.T. Ackermans, An F.C. Ruiter, Shulamiet Wittebol, Eric Eldering, Marinus H.J. van Oers, Kiki Tesselaar, Marie José Kersten, and Frank Miedema
Cancer Res 2008 68: 10137-10144. doi: 10.1158/0008-5472.CAN-08-2325 [Abstract] [Full Text] [PDF] Supplementary Data  

Wnt1 Expression Induces Short-Range and Long-Range Cell Recruitments That Modify Mammary Tumor Development and Are Not Induced by a Cell-Autonomous β-Catenin Effector

Young Chul Kim, Rod J. Clark, Erik A. Ranheim, and Caroline M. Alexander
Cancer Res 2008 68: 10145-10153. doi: 10.1158/0008-5472.CAN-08-2992 [Abstract] [Full Text] [PDF] Supplementary Data  

Endocrinology:

The SWI/SNF ATPase Brm Is a Gatekeeper of Proliferative Control in Prostate Cancer

Hui Shen, Nathan Powers, Nitin Saini, Clay E.S. Comstock, Ankur Sharma, Katherine Weaver, Monica P. Revelo, William Gerald, Erin Williams, Walter J. Jessen, Bruce J. Aronow, Gary Rosson, Bernard Weissman, Christian Muchardt, Moshe Yaniv, and Karen E. Knudsen
Cancer Res 2008 68: 10154-10162. doi: 10.1158/0008-5472.CAN-08-1794 [Abstract] [Full Text] [PDF] Supplementary Data  

Somatostatin Receptor sst2 Decreases Cell Viability and Hormonal Hypersecretion and Reverses Octreotide Resistance of Human Pituitary Adenomas

Julie Acunzo, Sylvie Thirion, Catherine Roche, Alexandru Saveanu, Ginette Gunz, Anne Laure Germanetti, Bettina Couderc, Richard Cohen, Dominique Figarella-Branger, Henry Dufour, Thierry Brue, Alain Enjalbert, and Anne Barlier
Cancer Res 2008 68: 10163-10170. doi: 10.1158/0008-5472.CAN-08-1857 [Abstract] [Full Text] [PDF] Supplementary Data  

Epidemiology:

Interaction between Single Nucleotide Polymorphisms in Selenoprotein P and Mitochondrial Superoxide Dismutase Determines Prostate Cancer Risk

Matthew L. Cooper, Hans-Olov Adami, Henrik Grönberg, Fredrik Wiklund, Fiona R. Green, and Margaret P. Rayman
Cancer Res 2008 68: 10171-10177. doi: 10.1158/0008-5472.CAN-08-1827 [Abstract] [Full Text] [PDF] Supplementary Data  

Genetic Variants in Apoptosis and Immunoregulation-Related Genes Are Associated with Risk of Chronic Lymphocytic Leukemia

Anna Enjuanes, Yolanda Benavente, Francesc Bosch, Idoia Martín-Guerrero, Dolors Colomer, Susana Pérez-Álvarez, Oscar Reina, Maria T. Ardanaz, Pedro Jares, Africa García-Orad, Miguel A. Pujana, Emili Montserrat, Silvia de Sanjosé, and Elias Campo
Cancer Res 2008 68: 10178-10186. doi: 10.1158/0008-5472.CAN-08-2221 [Abstract] [Full Text] [PDF] Supplementary Data  

Experimental Therapeutics, Molecular Targets, and Chemical Biology:

Phospholipase C1 Is Required for Metastasis Development and Progression

Gianluca Sala, Francesco Dituri, Claudio Raimondi, Sara Previdi, Tania Maffucci, Marco Mazzoletti, Cosmo Rossi, Manuela Iezzi, Rossano Lattanzio, Mauro Piantelli, Stefano Iacobelli, Massimo Broggini, and Marco Falasca
Cancer Res 2008 68: 10187-10196. doi: 10.1158/0008-5472.CAN-08-1181 [Abstract] [Full Text] [PDF] Supplementary Data  

Molecular Mechanisms of Patupilone Resistance

Simona Mozzetti, Raffaella Iantomasi, Ilaria De Maria, Silvia Prislei, Marisa Mariani, Alessia Camperchioli, Silvia Bartollino, Daniela Gallo, Giovanni Scambia, and Cristiano Ferlini
Cancer Res 2008 68: 10197-10204. doi: 10.1158/0008-5472.CAN-08-2091 [Abstract] [Full Text] [PDF] Supplementary Data  

Wnt5A Regulates Expression of Tumor-Associated Antigens in Melanoma via Changes in Signal Transducers and Activators of Transcription 3 Phosphorylation

Samudra K. Dissanayake, Purevdorj B. Olkhanud, Michael P. O'Connell, Arnell Carter, Amanda D. French, Tura C. Camilli, Chineye D. Emeche, Kyle J. Hewitt, Devin T. Rosenthal, Poloko D. Leotlela, Michael S. Wade, Sherry W. Yang, Larry Brant, Brian J. Nickoloff, Jane L. Messina, Arya Biragyn, Keith S. Hoek, Dennis D. Taub, Dan L. Longo, Vernon K. Sondak, Stephen M. Hewitt, and Ashani T. Weeraratna
Cancer Res 2008 68: 10205-10214. doi: 10.1158/0008-5472.CAN-08-2149 [Abstract] [Full Text] [PDF] Supplementary Data  

IL-6–Induced Stimulation of c-Myc Translation in Multiple Myeloma Cells Is Mediated by Myc Internal Ribosome Entry Site Function and the RNA-Binding Protein, hnRNP A1

Yijiang Shi, Patrick J. Frost, Bao Q. Hoang, Angelica Benavides, Sanjai Sharma, Joseph F. Gera, and Alan K. Lichtenstein
Cancer Res 2008 68: 10215-10222. doi: 10.1158/0008-5472.CAN-08-1066 [Abstract] [Full Text] [PDF] Supplementary Data  

IB Kinase- Regulates Endothelial Cell Motility and Tumor Angiogenesis

Laura M. DeBusk, Pierre P. Massion, and P. Charles Lin
Cancer Res 2008 68: 10223-10228. doi: 10.1158/0008-5472.CAN-08-1833 [Abstract] [Full Text] [PDF]  

Timosaponin A-III Induces Autophagy Preceding Mitochondria-Mediated Apoptosis in HeLa Cancer Cells

Lai-King Sy, Siu-Cheong Yan, Chun-Nam Lok, Ricky Y.K. Man, and Chi-Ming Che
Cancer Res 2008 68: 10229-10237. doi: 10.1158/0008-5472.CAN-08-1983 [Abstract] [Full Text] [PDF]  

Phosphorylated Insulin-Like Growth Factor-I/Insulin Receptor Is Present in All Breast Cancer Subtypes and Is Related to Poor Survival

Jennifer H. Law, Golareh Habibi, Kaiji Hu, Hamid Masoudi, Michelle Y.C. Wang, Anna L. Stratford, Eugene Park, Julia M.W. Gee, Pauline Finlay, Helen E. Jones, Robert I. Nicholson, Joan Carboni, Marco Gottardis, Michael Pollak, and Sandra E. Dunn
Cancer Res 2008 68: 10238-10246. doi: 10.1158/0008-5472.CAN-08-2755 [Abstract] [Full Text] [PDF] Supplementary Data  

Immunology:

Systemic Blockade of Transforming Growth Factor-β Signaling Augments the Efficacy of Immunogene Therapy

Samuel Kim, George Buchlis, Zvi G. Fridlender, Jing Sun, Veena Kapoor, Guanjun Cheng, Andrew Haas, Hung Kam Cheung, Xiamei Zhang, Michael Corbley, Larry R. Kaiser, Leona Ling, and Steven M. Albelda
Cancer Res 2008 68: 10247-10256. doi: 10.1158/0008-5472.CAN-08-1494 [Abstract] [Full Text] [PDF] Supplementary Data  

Molecular Biology, Pathobiology, and Genetics:

Breast Cancer–Associated Fibroblasts Confer AKT1-Mediated Epigenetic Silencing of Cystatin M in Epithelial Cells

Huey-Jen L. Lin, Tao Zuo, Ching-Hung Lin, Chieh Ti Kuo, Sandya Liyanarachchi, Shuying Sun, Rulong Shen, Daniel E. Deatherage, Dustin Potter, Lisa Asamoto, Shili Lin, Pearlly S. Yan, Ann-Lii Cheng, Michael C. Ostrowski, and Tim H.-M. Huang
Cancer Res 2008 68: 10257-10266. doi: 10.1158/0008-5472.CAN-08-0288 [Abstract] [Full Text] [PDF] Supplementary Data  

Common Transcriptional Signature of Tumor-Infiltrating Mononuclear Inflammatory Cells and Peripheral Blood Mononuclear Cells in Hepatocellular Carcinoma Patients

Yoshio Sakai, Masao Honda, Haruo Fujinaga, Isamu Tatsumi, Eishiro Mizukoshi, Yasunari Nakamoto, and Shuichi Kaneko
Cancer Res 2008 68: 10267-10279. doi: 10.1158/0008-5472.CAN-08-0911 [Abstract] [Full Text] [PDF] Supplementary Data  

Methylation of Polycomb Target Genes in Intestinal Cancer Is Mediated by Inflammation

Maria A. Hahn, Torsten Hahn, Dong-Hyun Lee, R. Steven Esworthy, Byung-wook Kim, Arthur D. Riggs, Fong-Fong Chu, and Gerd P. Pfeifer
Cancer Res 2008 68: 10280-10289. doi: 10.1158/0008-5472.CAN-08-1957 [Abstract] [Full Text] [PDF] Supplementary Data  

A Transcription-Independent Function of FOXO1 in Inhibition of Androgen-Independent Activation of the Androgen Receptor in Prostate Cancer Cells

Ping Liu, Shangwei Li, Lu Gan, Timothy P. Kao, and Haojie Huang
Cancer Res 2008 68: 10290-10299. doi: 10.1158/0008-5472.CAN-08-2038 [Abstract] [Full Text] [PDF]  

Mutational Inactivation of PTPRD in Glioblastoma Multiforme and Malignant Melanoma

David A. Solomon, Jung-Sik Kim, Julia C. Cronin, Zita Sibenaller, Timothy Ryken, Steven A. Rosenberg, Habtom Ressom, Walter Jean, Darell Bigner, Hai Yan, Yardena Samuels, and Todd Waldman
Cancer Res 2008 68: 10300-10306. doi: 10.1158/0008-5472.CAN-08-3272 [Abstract] [Full Text] [PDF] Supplementary Data  

MicroRNA Microarray Identifies Let-7i as a Novel Biomarker and Therapeutic Target in Human Epithelial Ovarian Cancer

Nuo Yang, Sippy Kaur, Stefano Volinia, Joel Greshock, Heini Lassus, Kosei Hasegawa, Shun Liang, Arto Leminen, Shan Deng, Lori Smith, Cameron N. Johnstone, Xian-Ming Chen, Chang-Gong Liu, Qihong Huang, Dionyssios Katsaros, George Adrian Calin, Barbara L. Weber, Ralf Bützow, Carlo M. Croce, George Coukos, and Lin Zhang
Cancer Res 2008 68: 10307-10314. doi: 10.1158/0008-5472.CAN-08-1954 [Abstract] [Full Text] [PDF] Supplementary Data  

Overexpression of OATP1B3 Confers Apoptotic Resistance in Colon Cancer

Wooin Lee, Abbes Belkhiri, A. Craig Lockhart, Nipun Merchant, Hartmut Glaeser, Elizabeth I. Harris, M. Kay Washington, Elizabeth M. Brunt, Alex Zaika, Richard B. Kim, and Wael El-Rifai
Cancer Res 2008 68: 10315-10323. doi: 10.1158/0008-5472.CAN-08-1984 [Abstract] [Full Text] [PDF]  

A Mutant Collagen XIII Alters Intestinal Expression of Immune Response Genes and Predisposes Transgenic Mice to Develop B-Cell Lymphomas

Anne Tuomisto, Malin Sund, Jenni Tahkola, Anne Latvanlehto, Eeva-Riitta Savolainen, Helena Autio-Harmainen, Annikki Liakka, Raija Sormunen, Jussi Vuoristo, Anne West, Riitta Lahesmaa, Herbert C. Morse, III, and Taina Pihlajaniemi
Cancer Res 2008 68: 10324-10332. doi: 10.1158/0008-5472.CAN-08-2582 [Abstract] [Full Text] [PDF] Supplementary Data  

Genome-wide Allelic State Analysis on Flow-Sorted Tumor Fractions Provides an Accurate Measure of Chromosomal Aberrations

Willem E. Corver, Anneke Middeldorp, Natalja T. ter Haar, Ekaterina S. Jordanova, Marjo van Puijenbroek, Ronald van Eijk, Cees J. Cornelisse, Gert Jan Fleuren, Hans Morreau, Jan Oosting, and Tom van Wezel
Cancer Res 2008 68: 10333-10340. doi: 10.1158/0008-5472.CAN-08-2665 [Abstract] [Full Text] [PDF] Supplementary Data  

Premature Cell Cycle Entry Induced by Hepatitis B Virus Regulatory HBx Protein during Compensatory Liver Regeneration

Amanda J. Hodgson, Victor V. Keasler, and Betty L. Slagle
Cancer Res 2008 68: 10341-10348. doi: 10.1158/0008-5472.CAN-08-2695 [Abstract] [Full Text] [PDF] Supplementary Data  

250K Single Nucleotide Polymorphism Array Karyotyping Identifies Acquired Uniparental Disomy and Homozygous Mutations, Including Novel Missense Substitutions of c-Cbl, in Myeloid Malignancies

Andrew J. Dunbar, Lukasz P. Gondek, Christine L. O'Keefe, Hideki Makishima, Manjot S. Rataul, Hadrian Szpurka, Mikkael A. Sekeres, Xiao Fei Wang, Michael A. McDevitt, and Jaroslaw P. Maciejewski
Cancer Res 2008 68: 10349-10357. doi: 10.1158/0008-5472.CAN-08-2754 [Abstract] [Full Text] [PDF] Supplementary Data  

Tumor Microenvironment:

Increased c-Jun-NH₂-Kinase Signaling in Neurofibromatosis-1 Heterozygous Microglia Drives Microglia Activation and Promotes Optic Glioma Proliferation

Girish C. Daginakatte, Scott M. Gianino, Nina W. Zhao, Alexander S. Parsadanian, and David H. Gutmann
Cancer Res 2008 68: 10358-10366. doi: 10.1158/0008-5472.CAN-08-2506 [Abstract] [Full Text] [PDF] Supplementary Data  

CXCR6 Induces Prostate Cancer Progression by the AKT/Mammalian Target of Rapamycin Signaling Pathway

Jianhua Wang, Yi Lu, Jingchen Wang, Alisa E. Koch, Jian Zhang, and Russell S. Taichman
Cancer Res 2008 68: 10367-10377. doi: 10.1158/0008-5472.CAN-08-2780 [Abstract] [Full Text] [PDF] Supplementary Data  

Epithelial-Mesenchymal Transition Induced by Growth Suppressor p12^CDK2-AP1 Promotes Tumor Cell Local Invasion but Suppresses Distant Colony Growth

Takanori Tsuji, Soichiro Ibaragi, Kaori Shima, Miaofen G. Hu, Miki Katsurano, Akira Sasaki, and Guo-fu Hu
Cancer Res 2008 68: 10377-10386. doi: 10.1158/0008-5472.CAN-08-1444 [Abstract] [Full Text] [PDF]  

Correction:

Correction: Reversal of Multidrug Resistance by Lapatinib

Cancer Res 2008 68: 10387. doi: 10.1158/0008-5472.CAN-68-24-COR [Full Text] [PDF]  

Acknowledgment to Reviewers:

Cancer Res 2008 68: 10388-10403. doi: 10.1158/0008-5472.CAN-68-24-ACK [Full Text] [PDF]  

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