Jeon and colleagues characterized peritoneal lymphatic vessels in advanced ovarian cancer (OVCA) mice, a model generated by implantation of human OVCA cells into athymic nude mice. At 14 days after the implantation of OVCA cells [OVCA (14d)], the mice displayed formation of gigantic mesh-like lymphatic sheets in the central tendon region of diaphragm. However, these newly formed lymphatic vessels were nonfunctional in draining peritoneal fluid. VEGF ligands from CD11b⁺ macrophages are responsible for this dysfunctional lymphangiogenesis. In comparison, the mice treated with control PBS (Control ) displayed a rare distribution of lymphatic vessels. The cover image shows lymphatic endothelial cells of the diaphragm stained for LYVE-1⁺ (red ) and Prox-1⁺ (green). For details, see the article by Jeon and colleagues on page 1100 of this issue.

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