Reviews:

Targeted Delivery of Small Interfering RNA: Approaching Effective Cancer Therapies

Kathleen F. Pirollo and Esther H. Chang
Cancer Res 2008 68: 1247-1250. doi: 10.1158/0008-5472.CAN-07-5810 [Abstract] [Full Text] [PDF]  

CDC25A Phosphatase: a Rate-Limiting Oncogene That Determines Genomic Stability

Dipankar Ray and Hiroaki Kiyokawa
Cancer Res 2008 68: 1251-1253. doi: 10.1158/0008-5472.CAN-07-5983 [Abstract] [Full Text] [PDF]  

Priority Reports:

Translation Inhibitor Pdcd4 Is Targeted for Degradation during Tumor Promotion

Tobias Schmid, Aaron P. Jansen, Alyson R. Baker, Glenn Hegamyer, John P. Hagan, and Nancy H. Colburn
Cancer Res 2008 68: 1254-1260. Published Online First February 22, 2008. doi: 10.1158/0008-5472.CAN-07-1719 [Abstract] [Full Text] [PDF] Supplementary Data  

Macrophage Inflammatory Protein–1: A Novel Osteoclast Stimulating Factor Secreted by Renal Cell Carcinoma Bone Metastasis

Scott L. Kominsky, Samir M. Abdelmagid, Michele Doucet, Kelly Brady, and Kristy L. Weber
Cancer Res 2008 68: 1261-1266. doi: 10.1158/0008-5472.CAN-07-6122 [Abstract] [Full Text] [PDF] Supplementary Data  

Molecular Biology, Pathobiology, and Genetics:

Rad9 Has a Functional Role in Human Prostate Carcinogenesis

Aiping Zhu, Charles Xia Zhang, and Howard B. Lieberman
Cancer Res 2008 68: 1267-1274. doi: 10.1158/0008-5472.CAN-07-2304 [Abstract] [Full Text] [PDF]  

Inhibition of the Ras-Net (Elk-3) Pathway by a Novel Pyrazole that Affects Microtubules

Christine Wasylyk, Hong Zheng, Christelle Castell, Laurent Debussche, Marie-Christine Multon, and Bohdan Wasylyk
Cancer Res 2008 68: 1275-1283. doi: 10.1158/0008-5472.CAN-07-2674 [Abstract] [Full Text] [PDF] Supplementary Data  

Chromosomal Breakpoints in Primary Colon Cancer Cluster at Sites of Structural Variants in the Genome

Jordi Camps, Marian Grade, Quang Tri Nguyen, Patrick Hörmann, Sandra Becker, Amanda B. Hummon, Virginia Rodriguez, Settara Chandrasekharappa, Yidong Chen, Michael J. Difilippantonio, Heinz Becker, B. Michael Ghadimi, and Thomas Ried
Cancer Res 2008 68: 1284-1295. doi: 10.1158/0008-5472.CAN-07-2864 [Abstract] [Full Text] [PDF] Supplementary Data  

A Novel Recurrent Chromosomal Inversion Implicates the Homeobox Gene Dlx5 in T-Cell Lymphomas from Lck-Akt2 Transgenic Mice

Yinfei Tan, Roman A. Timakhov, Mamta Rao, Deborah A. Altomare, Jinfei Xu, Zemin Liu, Qingshen Gao, Suresh C. Jhanwar, Antonio Di Cristofano, David L. Wiest, Janice E. Knepper, and Joseph R. Testa
Cancer Res 2008 68: 1296-1302. doi: 10.1158/0008-5472.CAN-07-3218 [Abstract] [Full Text] [PDF] Supplementary Data  

Loss of Keap1 Function Activates Nrf2 and Provides Advantages for Lung Cancer Cell Growth

Tsutomu Ohta, Kumiko Iijima, Mamiko Miyamoto, Izumi Nakahara, Hiroshi Tanaka, Makiko Ohtsuji, Takafumi Suzuki, Akira Kobayashi, Jun Yokota, Tokuki Sakiyama, Tatsuhiro Shibata, Masayuki Yamamoto, and Setsuo Hirohashi
Cancer Res 2008 68: 1303-1309. doi: 10.1158/0008-5472.CAN-07-5003 [Abstract] [Full Text] [PDF] Supplementary Data  

An Actin-Binding Protein Girdin Regulates the Motility of Breast Cancer Cells

Ping Jiang, Atsushi Enomoto, Mayumi Jijiwa, Takuya Kato, Taisaku Hasegawa, Maki Ishida, Tomoko Sato, Naoya Asai, Yoshiki Murakumo, and Masahide Takahashi
Cancer Res 2008 68: 1310-1318. doi: 10.1158/0008-5472.CAN-07-5111 [Abstract] [Full Text] [PDF] Supplementary Data  

TGFBR1*6A Enhances the Migration and Invasion of MCF-7 Breast Cancer Cells through RhoA Activation

Diana S. Rosman, Sharbani Phukan, Chiang-Ching Huang, and Boris Pasche
Cancer Res 2008 68: 1319-1328. doi: 10.1158/0008-5472.CAN-07-5424 [Abstract] [Full Text] [PDF]  

Synergistic Effect of Oncogenic RET and Loss of p18 on Medullary Thyroid Carcinoma Development

Wendy van Veelen, Carola J.R. van Gasteren, Dennis S. Acton, David S. Franklin, Ruud Berger, Cornelis J.M. Lips, and Jo W.M. Höppener
Cancer Res 2008 68: 1329-1337. doi: 10.1158/0008-5472.CAN-07-5754 [Abstract] [Full Text] [PDF] Supplementary Data  

A Novel RET Kinase–β-Catenin Signaling Pathway Contributes to Tumorigenesis in Thyroid Carcinoma

Taranjit S. Gujral, Wendy van Veelen, Douglas S. Richardson, Shirley M. Myers, Jalna A. Meens, Dennis S. Acton, Mireia Duñach, Bruce E. Elliott, Jo W.M. Höppener, and Lois M. Mulligan
Cancer Res 2008 68: 1338-1346. doi: 10.1158/0008-5472.CAN-07-6052 [Abstract] [Full Text] [PDF] Supplementary Data  

Mouse Models for Xeroderma Pigmentosum Group A and Group C Show Divergent Cancer Phenotypes

Joost P.M. Melis, Susan W.P. Wijnhoven, Rudolf B. Beems, Marianne Roodbergen, Jolanda van den Berg, Hojin Moon, Errol Friedberg, Gijsbertus T.J. van der Horst, Jan H.J. Hoeijmakers, Jan Vijg, and Harry van Steeg
Cancer Res 2008 68: 1347-1353. doi: 10.1158/0008-5472.CAN-07-6067 [Abstract] [Full Text] [PDF]  

Oncogene-Mediated Inhibition of Glycogen Synthase Kinase 3β Impairs Degradation of Prolactin Receptor

Alexander Plotnikov, Ying Li, Thai H. Tran, Weigang Tang, Juan P. Palazzo, Hallgeir Rui, and Serge Y. Fuchs
Cancer Res 2008 68: 1354-1361. doi: 10.1158/0008-5472.CAN-07-6094 [Abstract] [Full Text] [PDF] Supplementary Data  

MicroRNA-137 Targets Microphthalmia-Associated Transcription Factor in Melanoma Cell Lines

Lynne T. Bemis, Robert Chen, Carol M. Amato, Elizabeth H. Classen, Steven E. Robinson, David G. Coffey, Paul F. Erickson, Yiqun G. Shellman, and William A. Robinson
Cancer Res 2008 68: 1362-1368. doi: 10.1158/0008-5472.CAN-07-2912 [Abstract] [Full Text] [PDF]  

p21^Waf1/Cip1 Expression by Curcumin in U-87MG Human Glioma Cells: Role of Early Growth Response-1 Expression

Byeong Hyeok Choi, Chang Gun Kim, Young-Seuk Bae, Yoongho Lim, Young Han Lee, and Soon Young Shin
Cancer Res 2008 68: 1369-1377. doi: 10.1158/0008-5472.CAN-07-5222 [Abstract] [Full Text] [PDF] Supplementary Data  

Cell, Tumor, and Stem Cell Biology:

A Human Breast Cell Model of Preinvasive to Invasive Transition

Aylin Rizki, Valerie M. Weaver, Sun-Young Lee, Gabriela I. Rozenberg, Koei Chin, Connie A. Myers, Jamie L. Bascom, Joni D. Mott, Jeremy R. Semeiks, Leslie R. Grate, I. Saira Mian, Alexander D. Borowsky, Roy A. Jensen, Michael O. Idowu, Fanqing Chen, David J. Chen, Ole W. Petersen, Joe W. Gray, and Mina J. Bissell
Cancer Res 2008 68: 1378-1387. doi: 10.1158/0008-5472.CAN-07-2225 [Abstract] [Full Text] [PDF] Supplementary Data  

Vascular Endothelial Cadherin Promotes Breast Cancer Progression via Transforming Growth Factor β Signaling

Myriam Labelle, Hans J. Schnittler, Daniela E. Aust, Katrin Friedrich, Gustavo Baretton, Dietmar Vestweber, and Georg Breier
Cancer Res 2008 68: 1388-1397. doi: 10.1158/0008-5472.CAN-07-2706 [Abstract] [Full Text] [PDF] Supplementary Data  

DNA Damage–Dependent Translocation of B23 and p19^ARF Is Regulated by the Jun N-Terminal Kinase Pathway

Orli Yogev, Keren Saadon, Shira Anzi, Kazushi Inoue, and Eitan Shaulian
Cancer Res 2008 68: 1398-1406. doi: 10.1158/0008-5472.CAN-07-2865 [Abstract] [Full Text] [PDF] Supplementary Data  

T-cadherin Supports Angiogenesis and Adiponectin Association with the Vasculature in a Mouse Mammary Tumor Model

Lionel W. Hebbard, Michèle Garlatti, Lawrence J.T. Young, Robert D. Cardiff, Robert G. Oshima, and Barbara Ranscht
Cancer Res 2008 68: 1407-1416. doi: 10.1158/0008-5472.CAN-07-2953 [Abstract] [Full Text] [PDF] Supplementary Data  

Clonal Selection in Malignant Transformation of Human Fibroblasts Transduced with Defined Cellular Oncogenes

Alka M. Mahale, Zahid A.T. Khan, Makoto Igarashi, Gouri J. Nanjangud, Rui Fang Qiao, Shen Yao, Sam W. Lee, and Stuart A. Aaronson
Cancer Res 2008 68: 1417-1426. doi: 10.1158/0008-5472.CAN-07-3021 [Abstract] [Full Text] [PDF] Supplementary Data  

Survival Advantage of EBV-Associated Gastric Carcinoma: Survivin Up-regulation by Viral Latent Membrane Protein 2A

Rumi Hino, Hiroshi Uozaki, Yoko Inoue, Yukako Shintani, Tetsuo Ushiku, Takashi Sakatani, Kenzo Takada, and Masashi Fukayama
Cancer Res 2008 68: 1427-1435. doi: 10.1158/0008-5472.CAN-07-3027 [Abstract] [Full Text] [PDF]  

EBV MicroRNAs in Primary Lymphomas and Targeting of CXCL-11 by ebv-mir-BHRF1-3

Tianli Xia, Andrea O'Hara, Iguaracyra Araujo, Jose Barreto, Eny Carvalho, Jose Bahia Sapucaia, Juan Carlos Ramos, Estela Luz, Celia Pedroso, Michele Manrique, Ngoc L. Toomey, Carlos Brites, Dirk P. Dittmer, and William J. Harrington, Jr.
Cancer Res 2008 68: 1436-1442. doi: 10.1158/0008-5472.CAN-07-5126 [Abstract] [Full Text] [PDF] Supplementary Data  

Anti–Tumor Necrosis Factor Therapy Inhibits Pancreatic Tumor Growth and Metastasis

Jan-Hendrik Egberts, Vera Cloosters, Andreas Noack, Bodo Schniewind, Lutz Thon, Stefanie Klose, Bastian Kettler, Corinna von Forstner, Christian Kneitz, Jürgen Tepel, Dieter Adam, Harald Wajant, Holger Kalthoff, and Anna Trauzold
Cancer Res 2008 68: 1443-1450. doi: 10.1158/0008-5472.CAN-07-5704 [Abstract] [Full Text] [PDF] Supplementary Data  

EpCAM and -Fetoprotein Expression Defines Novel Prognostic Subtypes of Hepatocellular Carcinoma

Taro Yamashita, Marshonna Forgues, Wei Wang, Jin Woo Kim, Qinghai Ye, Huliang Jia, Anuradha Budhu, Krista A. Zanetti, Yidong Chen, Lun-Xiu Qin, Zhao-You Tang, and Xin Wei Wang
Cancer Res 2008 68: 1451-1461. doi: 10.1158/0008-5472.CAN-07-6013 [Abstract] [Full Text] [PDF] Supplementary Data  

Altered TAB1:IB Kinase Interaction Promotes Transforming Growth Factor β–Mediated Nuclear Factor-B Activation during Breast Cancer Progression

Jason R. Neil and William P. Schiemann
Cancer Res 2008 68: 1462-1470. doi: 10.1158/0008-5472.CAN-07-3094 [Abstract] [Full Text] [PDF] Supplementary Data  

Met Receptor Contributes to Trastuzumab Resistance of Her2-Overexpressing Breast Cancer Cells

David L. Shattuck, Jamie K. Miller, Kermit L. Carraway, III, and Colleen Sweeney
Cancer Res 2008 68: 1471-1477. doi: 10.1158/0008-5472.CAN-07-5962 [Abstract] [Full Text] [PDF]  

Molecular Basis of Nuclear Factor-B Activation by Astrocyte Elevated Gene-1

Devanand Sarkar, Eun Sook Park, Luni Emdad, Seok-Geun Lee, Zao-zhong Su, and Paul B. Fisher
Cancer Res 2008 68: 1478-1484. doi: 10.1158/0008-5472.CAN-07-6164 [Abstract] [Full Text] [PDF]  

Experimental Therapeutics, Molecular Targets, and Chemical Biology:

Blocked Autophagy Sensitizes Resistant Carcinoma Cells to Radiation Therapy

Anja Apel, Ingrid Herr, Heinz Schwarz, H. Peter Rodemann, and Andreas Mayer
Cancer Res 2008 68: 1485-1494. doi: 10.1158/0008-5472.CAN-07-0562 [Abstract] [Full Text] [PDF] Supplementary Data  

Multidrug Resistance-Associated Protein–Overexpressing Teniposide-Resistant Human Lymphomas Undergo Apoptosis by a Tubulin-Binding Agent

Ritu Aneja, Min Liu, Clayton Yates, Jinmin Gao, Xin Dong, Binfei Zhou, Surya N. Vangapandu, Jun Zhou, and Harish C. Joshi
Cancer Res 2008 68: 1495-1503. doi: 10.1158/0008-5472.CAN-07-1874 [Abstract] [Full Text] [PDF]  

Expression of HER2 and Estrogen Receptor Depends upon Nuclear Localization of Y-Box Binding Protein-1 in Human Breast Cancers

Teruhiko Fujii, Akihiko Kawahara, Yuji Basaki, Satoshi Hattori, Kazutaka Nakashima, Kenji Nakano, Kazuo Shirouzu, Kimitoshi Kohno, Takashi Yanagawa, Hideaki Yamana, Kazuto Nishio, Mayumi Ono, Michihiko Kuwano, and Masayoshi Kage
Cancer Res 2008 68: 1504-1512. doi: 10.1158/0008-5472.CAN-07-2362 [Abstract] [Full Text] [PDF] Supplementary Data  

Selective Inhibition of Histone Deacetylase 2 Silences Progesterone Receptor–Mediated Signaling

Elona Biçaku, Douglas C. Marchion, Morgen L. Schmitt, and Pamela N. Münster
Cancer Res 2008 68: 1513-1519. doi: 10.1158/0008-5472.CAN-07-2822 [Abstract] [Full Text] [PDF]  

Preclinical Cancer Therapy in a Mouse Model of Neurofibromatosis-1 Optic Glioma

Balazs Hegedus, Debasish Banerjee, Tu-Hsueh Yeh, Stefan Rothermich, Arie Perry, Joshua B. Rubin, Joel R. Garbow, and David H. Gutmann
Cancer Res 2008 68: 1520-1528. doi: 10.1158/0008-5472.CAN-07-5916 [Abstract] [Full Text] [PDF] Supplementary Data  

H-2K^b–Restricted CTL Epitopes from Mouse Heparanase Elicit an Antitumor Immune Response In vivo

Xu-Dong Tang, Yin Wan, Ling Chen, Ting Chen, Song-Tao Yu, Zhen Xiong, Dian-Chun Fang, Guang-Ping Liang, and Shi-Ming Yang
Cancer Res 2008 68: 1529-1537. doi: 10.1158/0008-5472.CAN-07-5965 [Abstract] [Full Text] [PDF]  

Co-Targeting Insulin-Like Growth Factor I Receptor and HER2: Dramatic Effects of HER2 Inhibitors on Nonoverexpressing Breast Cancer

Ashok K. Chakraborty, Ke Liang, and Michael P. DiGiovanna
Cancer Res 2008 68: 1538-1545. doi: 10.1158/0008-5472.CAN-07-5935 [Abstract] [Full Text] [PDF]  

Immunology:

Selective Induction of Expression of a Ligand for the NKG2D Receptor by Proteasome Inhibitors

Mar Valés-Gómez, Susan E. Chisholm, Robin L. Cassady-Cain, Pedro Roda-Navarro, and Hugh T. Reyburn
Cancer Res 2008 68: 1546-1554. doi: 10.1158/0008-5472.CAN-07-2973 [Abstract] [Full Text] [PDF]  

Endosomal Proteases Influence the Repertoire of MAGE-A3 Epitopes Recognized In vivo by CD4⁺ T Cells

Jill Marturano, Renato Longhi, Vincenzo Russo, and Maria Pia Protti
Cancer Res 2008 68: 1555-1562. doi: 10.1158/0008-5472.CAN-07-5233 [Abstract] [Full Text] [PDF]  

Equilibrium between Host and Cancer Caused by Effector T Cells Killing Tumor Stroma

Bin Zhang, Yi Zhang, Natalie A. Bowerman, Andrea Schietinger, Yang-Xin Fu, David M. Kranz, Donald A. Rowley, and Hans Schreiber
Cancer Res 2008 68: 1563-1571. doi: 10.1158/0008-5472.CAN-07-5324 [Abstract] [Full Text] [PDF] Supplementary Data  

Endocrinology:

Discovery and Validation of Protein Abundance Differences between Follicular Thyroid Neoplasms

Romana T. Netea-Maier, Stephen W. Hunsucker, Brigiet M. Hoevenaars, Steve M. Helmke, Pieter J. Slootweg, Ad R. Hermus, Bryan R. Haugen, and Mark W. Duncan
Cancer Res 2008 68: 1572-1580. doi: 10.1158/0008-5472.CAN-07-5020 [Abstract] [Full Text] [PDF] Supplementary Data  

Clinical Research:

Inhibition of Multiple Vascular Endothelial Growth Factor Receptors (VEGFR) Blocks Lymph Node Metastases but Inhibition of VEGFR-2 Is Sufficient to Sensitize Tumor Cells to Platinum-Based Chemotherapeutics

Patrizia Sini, Ivana Samarzija, Fabienne Baffert, Amanda Littlewood-Evans, Christian Schnell, Andreas Theuer, Sven Christian, Anja Boos, Holger Hess-Stumpp, John A. Foekens, Buddy Setyono-Han, Jeanette Wood, and Nancy E. Hynes
Cancer Res 2008 68: 1581-1592. doi: 10.1158/0008-5472.CAN-06-4685 [Abstract] [Full Text] [PDF] Supplementary Data  

Prevention:

Inhibition of Urinary Bladder Carcinogenesis by Broccoli Sprouts

Rex Munday, Paulette Mhawech-Fauceglia, Christine M. Munday, Joseph D. Paonessa, Li Tang, John S. Munday, Carolyn Lister, Paula Wilson, Jed W. Fahey, Warren Davis, and Yuesheng Zhang
Cancer Res 2008 68: 1593-1600. Published Online First February 29, 2008. doi: 10.1158/0008-5472.CAN-07-5009 [Abstract] [Full Text] [PDF]  

Tempol Protects against Oxidative Damage and Delays Epithelial Tumor Onset in Fanconi Anemia Mice

Qing-Shuo Zhang, Laura Eaton, Eric R. Snyder, Scott Houghtaling, James B. Mitchell, Milton Finegold, Carter Van Waes, and Markus Grompe
Cancer Res 2008 68: 1601-1608. doi: 10.1158/0008-5472.CAN-07-5186 [Abstract] [Full Text] [PDF]  

Corrections:

Correction: Ada3 Requirement for ER-Dependent Cell Proliferation

Cancer Res 2008 68: 1609 [Full Text] [PDF]  

Correction: COX-2 Expression Decreases in Breast Cancer Progression

Cancer Res 2008 68: 1609 [Full Text] [PDF]  

Correction: TLR4 in Cutaneous DMBA Carcinogenesis

Cancer Res 2008 68: 1609 [Full Text] [PDF]  

Correction: miRNA Profiling in Ovarian Cancer and miR-214 Targets PTEN

Cancer Res 2008 68: 1609 [Full Text] [PDF]  

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