Editorial:

The Year Ahead

Frank J. Rauscher, III
Cancer Res 2009 69: 1. doi: 10.1158/0008-5472.CAN-69-1-ED [Full Text] [PDF]  

Reviews:

Macrophage Inhibitory Cytokine-1: Possible Bridge Molecule of Inflammation and Prostate Cancer

Dev Karan, Jeffrey Holzbeierlein, and J. Brantley Thrasher
Cancer Res 2009 69: 2-5. doi: 10.1158/0008-5472.CAN-08-1230 [Abstract] [Full Text] [PDF]  

Adenoviral E1A Function through Myc

Abhishek A. Chakraborty and William P. Tansey
Cancer Res 2009 69: 6-9. doi: 10.1158/0008-5472.CAN-08-3026 [Abstract] [Full Text] [PDF]  

Priority Reports:

Sequence Variants at 22q13 Are Associated with Prostate Cancer Risk

Jielin Sun, Siqun Lilly Zheng, Fredrik Wiklund, Sarah D. Isaacs, Ge Li, Kathleen E. Wiley, Seong-Tae Kim, Yi Zhu, Zheng Zhang, Fang-Chi Hsu, Aubrey R. Turner, Pär Stattin, Wennuan Liu, Jin Woo Kim, David Duggan, John Carpten, William Isaacs, Henrik Grönberg, Jianfeng Xu, and Bao-Li Chang
Cancer Res 2009 69: 10-15. doi: 10.1158/0008-5472.CAN-08-3464 [Abstract] [Full Text] [PDF] Supplementary Data  

Ligand-Independent Androgen Receptor Variants Derived from Splicing of Cryptic Exons Signify Hormone-Refractory Prostate Cancer

Rong Hu, Thomas A. Dunn, Shuanzeng Wei, Sumit Isharwal, Robert W. Veltri, Elizabeth Humphreys, Misop Han, Alan W. Partin, Robert L. Vessella, William B. Isaacs, G. Steven Bova, and Jun Luo
Cancer Res 2009 69: 16-22. doi: 10.1158/0008-5472.CAN-08-2764 [Abstract] [Full Text] [PDF] Supplementary Data  

GEMS (Gene Expression Metasignatures), a Web Resource for Querying Meta-analysis of Expression Microarray Datasets: 17β-Estradiol in MCF-7 Cells

Scott A. Ochsner, David L. Steffen, Susan G. Hilsenbeck, Edward S. Chen, Christopher Watkins, and Neil J. McKenna
Cancer Res 2009 69: 23-26. doi: 10.1158/0008-5472.CAN-08-3492 [Abstract] [Full Text] [PDF] Supplementary Data  

Cell, Tumor, and Stem Cell Biology:

Functional Interaction between BubR1 and Securin in an Anaphase-Promoting Complex/Cyclosome^Cdc20–Independent Manner

Hyun-Soo Kim, Yoon-Kyung Jeon, Geun-Hyoung Ha, Hye-Young Park, Yu-Jin Kim, Hyun-Jin Shin, Chang Geun Lee, Doo-Hyun Chung, and Chang-Woo Lee
Cancer Res 2009 69: 27-36. doi: 10.1158/0008-5472.CAN-08-0820 [Abstract] [Full Text] [PDF] Supplementary Data  

TGFBI Deficiency Predisposes Mice to Spontaneous Tumor Development

Ye Zhang, Gengyun Wen, Genze Shao, Cuidong Wang, Chyuansheng Lin, Hongbo Fang, Adayabalam S. Balajee, Govind Bhagat, Tom K. Hei, and Yongliang Zhao
Cancer Res 2009 69: 37-44. doi: 10.1158/0008-5472.CAN-08-1648 [Abstract] [Full Text] [PDF] Supplementary Data  

Impaired Bub1 Function In vivo Compromises Tension-Dependent Checkpoint Function Leading to Aneuploidy and Tumorigenesis

Mark Schliekelman, Dale O. Cowley, Ryan O'Quinn, Trudy G. Oliver, Lucy Lu, E.D. Salmon, and Terry Van Dyke
Cancer Res 2009 69: 45-54. doi: 10.1158/0008-5472.CAN-07-6330 [Abstract] [Full Text] [PDF] Supplementary Data  

Inhibition of DNA Methyltransferase Activates Tumor Necrosis Factor –Induced Monocytic Differentiation in Acute Myeloid Leukemia Cells

Anna Laurenzana, Luca A. Petruccelli, Filippa Pettersson, Maria Eugenia Figueroa, Ari Melnick, Albert S. Baldwin, Francesco Paoletti, and Wilson H. Miller, Jr.
Cancer Res 2009 69: 55-64. doi: 10.1158/0008-5472.CAN-08-0245 [Abstract] [Full Text] [PDF] Supplementary Data  

A Feed-Forward Loop Involving Protein Kinase C and MicroRNAs Regulates Tumor Cell Cycle

Ezra E.W. Cohen, Hongyan Zhu, Mark W. Lingen, Leslie E. Martin, Wen-Liang Kuo, Eugene A. Choi, Masha Kocherginsky, Joel S. Parker, Christine H. Chung, and Marsha Rich Rosner
Cancer Res 2009 69: 65-74. doi: 10.1158/0008-5472.CAN-08-0377 [Abstract] [Full Text] [PDF] Supplementary Data  

Silencing PinX1 Compromises Telomere Length Maintenance As Well As Tumorigenicity in Telomerase-Positive Human Cancer Cells

Bin Zhang, Yun Xiu Bai, Hang Hang Ma, Feng Feng, Rui Jin, Zhi Long Wang, Jian Lin, Shi Peng Sun, Pingxun Yang, Xiao Xiong Wang, Pei Tang Huang, Cui Fen Huang, Ying Peng, Yang Chao Chen, Hsiang-fu Kung, and Jun Jian Huang
Cancer Res 2009 69: 75-83. doi: 10.1158/0008-5472.CAN-08-1393 [Abstract] [Full Text] [PDF] Supplementary Data  

Distinct Roles for Mammalian Target of Rapamycin Complexes in the Fibroblast Response to Transforming Growth Factor-β

Rod A. Rahimi, Mahefatiana Andrianifahanana, Mark C. Wilkes, Maryanne Edens, Theodore J. Kottom, John Blenis, and Edward B. Leof
Cancer Res 2009 69: 84-93. doi: 10.1158/0008-5472.CAN-08-2146 [Abstract] [Full Text] [PDF]  

K-ras and Wnt Signaling Synergize to Accelerate Prostate Tumorigenesis in the Mouse

Helen B. Pearson, Toby J. Phesse, and Alan R. Clarke
Cancer Res 2009 69: 94-101. doi: 10.1158/0008-5472.CAN-08-2895 [Abstract] [Full Text] [PDF] Supplementary Data  

PCPH/ENTPD5 Expression Confers to Prostate Cancer Cells Resistance against Cisplatin-Induced Apoptosis through Protein Kinase C–Mediated Bcl-2 Stabilization

Joaquín Villar, Humair S. Quadri, Insun Song, York Tomita, Oscar M. Tirado, and Vicente Notario
Cancer Res 2009 69: 102-110. doi: 10.1158/0008-5472.CAN-08-2922 [Abstract] [Full Text] [PDF] Supplementary Data  

BRCA1-Associated Protein 1 Interferes with BRCA1/BARD1 RING Heterodimer Activity

Hiroyuki Nishikawa, Wenwen Wu, Ayaka Koike, Ryoko Kojima, Hiromichi Gomi, Mamoru Fukuda, and Tomohiko Ohta
Cancer Res 2009 69: 111-119. doi: 10.1158/0008-5472.CAN-08-3355 [Abstract] [Full Text] [PDF] Supplementary Data  

Clinical Research:

A New Model for Prediction of Drug Distribution in Tumor and Normal Tissues: Pharmacokinetics of Temozolomide in Glioma Patients

Lula Rosso, Cathryn S. Brock, James M. Gallo, Azeem Saleem, Patricia M. Price, Federico E. Turkheimer, and Eric O. Aboagye
Cancer Res 2009 69: 120-127. doi: 10.1158/0008-5472.CAN-08-2356 [Abstract] [Full Text] [PDF]  

Endocrinology:

Regulation of Estrogen-Dependent Transcription by the LIM Cofactors CLIM and RLIM in Breast Cancer

Steven A. Johnsen, Cenap Güngör, Tanja Prenzel, Sabine Riethdorf, Lutz Riethdorf, Naoko Taniguchi-Ishigaki, Thomas Rau, Baris Tursun, J. David Furlow, Guido Sauter, Martin Scheffner, Klaus Pantel, Frank Gannon, and Ingolf Bach
Cancer Res 2009 69: 128-136. doi: 10.1158/0008-5472.CAN-08-1630 [Abstract] [Full Text] [PDF] Supplementary Data  

Amyloid Precursor Protein Is a Primary Androgen Target Gene That Promotes Prostate Cancer Growth

Ken-ichi Takayama, Shuichi Tsutsumi, Takashi Suzuki, Kuniko Horie-Inoue, Kazuhiro Ikeda, Kiyofumi Kaneshiro, Tetsuya Fujimura, Jinpei Kumagai, Tomohiko Urano, Yoshiyuki Sakaki, Katsuhiko Shirahige, Hironobu Sasano, Satoru Takahashi, Tadaichi Kitamura, Yasuyoshi Ouchi, Hiroyuki Aburatani, and Satoshi Inoue
Cancer Res 2009 69: 137-142. doi: 10.1158/0008-5472.CAN-08-3633 [Abstract] [Full Text] [PDF] Supplementary Data  

Experimental Therapeutics, Molecular Targets, and Chemical Biology:

Mutations in the Phosphatidylinositol-3-Kinase Pathway Predict for Antitumor Activity of the Inhibitor PX-866 whereas Oncogenic Ras Is a Dominant Predictor for Resistance

Nathan T. Ihle, Robert Lemos, Jr., Peter Wipf, Adly Yacoub, Clint Mitchell, Doris Siwak, Gordon B. Mills, Paul Dent, D. Lynn Kirkpatrick, and Garth Powis
Cancer Res 2009 69: 143-150. doi: 10.1158/0008-5472.CAN-07-6656 [Abstract] [Full Text] [PDF]  

Aberrant Activation of Androgen Receptor in a New Neuropeptide-Autocrine Model of Androgen-Insensitive Prostate Cancer

Joy C. Yang, Joon-ha Ok, J. Erik Busby, Alexander D. Borowsky, Hsing-Jien Kung, and Christopher P. Evans
Cancer Res 2009 69: 151-160. doi: 10.1158/0008-5472.CAN-08-0442 [Abstract] [Full Text] [PDF] Supplementary Data  

The Mechanisms of Differential Sensitivity to an Insulin-like Growth Factor-1 Receptor Inhibitor (BMS-536924) and Rationale for Combining with EGFR/HER2 Inhibitors

Fei Huang, Ann Greer, Warren Hurlburt, Xia Han, Rameh Hafezi, Gayle M. Wittenberg, Karen Reeves, Jiwen Chen, Douglas Robinson, Aixin Li, Francis Y. Lee, Marco M. Gottardis, Edwin Clark, Lee Helman, Ricardo M. Attar, Ashok Dongre, and Joan M. Carboni
Cancer Res 2009 69: 161-170. doi: 10.1158/0008-5472.CAN-08-0835 [Abstract] [Full Text] [PDF] Supplementary Data  

Indibulin, a Novel Microtubule Inhibitor, Discriminates between Mature Neuronal and Nonneuronal Tubulin

Anke Wienecke and Gerald Bacher
Cancer Res 2009 69: 171-177. doi: 10.1158/0008-5472.CAN-08-1342 [Abstract] [Full Text] [PDF]  

Human Multidrug Resistance Protein 7 (ABCC10) Is a Resistance Factor for Nucleoside Analogues and Epothilone B

Elizabeth Hopper-Borge, Xiu Xu, Tong Shen, Zhi Shi, Zhe-Sheng Chen, and Gary D. Kruh
Cancer Res 2009 69: 178-184. doi: 10.1158/0008-5472.CAN-08-1420 [Abstract] [Full Text] [PDF] Supplementary Data  

Pretargeted Radioimmunotherapy Using Anti-CD45 Monoclonal Antibodies to Deliver Radiation to Murine Hematolymphoid Tissues and Human Myeloid Leukemia

John M. Pagel, Dana C. Matthews, Aimee Kenoyer, Donald K. Hamlin, Daniel S. Wilbur, Darrell R. Fisher, Ajay K. Gopal, Yukang Lin, Laura Saganic, Frederick R. Appelbaum, and Oliver W. Press
Cancer Res 2009 69: 185-192. doi: 10.1158/0008-5472.CAN-08-2513 [Abstract] [Full Text] [PDF]  

Cryptotanshinone Inhibits Constitutive Signal Transducer and Activator of Transcription 3 Function through Blocking the Dimerization in DU145 Prostate Cancer Cells

Dae-Seop Shin, Hye-Nan Kim, Ki Deok Shin, Young Ju Yoon, Seung-Jun Kim, Dong Cho Han, and Byoung-Mog Kwon
Cancer Res 2009 69: 193-202. doi: 10.1158/0008-5472.CAN-08-2575 [Abstract] [Full Text] [PDF] Supplementary Data  

Immunology:

Identification of an Indispensable Role for Tyrosine Kinase 2 in CTL-Mediated Tumor Surveillance

Olivia Simma, Eva Zebedin, Nina Neugebauer, Carola Schellack, Andreas Pilz, Souyet Chang-Rodriguez, Karen Lingnau, Eva Weisz, Eva Maria Putz, Winfried F. Pickl, Thomas Felzmann, Mathias Müller, Thomas Decker, Veronika Sexl, and Dagmar Stoiber
Cancer Res 2009 69: 203-211. doi: 10.1158/0008-5472.CAN-08-1705 [Abstract] [Full Text] [PDF]  

Genetic Regulation of the Response to Her-2 DNA Vaccination in Human Her-2 Transgenic Mice

Olga Radkevich-Brown, Jennifer Jacob, Michael Kershaw, and Wei-Zen Wei
Cancer Res 2009 69: 212-218. doi: 10.1158/0008-5472.CAN-08-3092 [Abstract] [Full Text] [PDF] Supplementary Data  

Molecular Biology, Pathobiology, and Genetics:

Tumor Protein 53–Induced Nuclear Protein 1 Is a Major Mediator of p53 Antioxidant Function

Carla E. Cano, Julien Gommeaux, Sylvia Pietri, Marcel Culcasi, Stéphane Garcia, Mylène Seux, Sarah Barelier, Sophie Vasseur, Rose P. Spoto, Marie-Josèphe Pébusque, Nelson J. Dusetti, Juan L. Iovanna, and Alice Carrier
Cancer Res 2009 69: 219-226. doi: 10.1158/0008-5472.CAN-08-2320 [Abstract] [Full Text] [PDF] Supplementary Data  

Epigenetic Profiles Distinguish Pleural Mesothelioma from Normal Pleura and Predict Lung Asbestos Burden and Clinical Outcome

Brock C. Christensen, E.A. Houseman, John J. Godleski, Carmen J. Marsit, Jennifer L. Longacker, Cora R. Roelofs, Margaret R. Karagas, Margaret R. Wrensch, Ru-Fang Yeh, Heather H. Nelson, Joe L. Wiemels, Shichun Zheng, John K. Wiencke, Raphael Bueno, David J. Sugarbaker, and Karl T. Kelsey
Cancer Res 2009 69: 227-234. doi: 10.1158/0008-5472.CAN-08-2586 [Abstract] [Full Text] [PDF] Supplementary Data  

NORE1B Is a Putative Tumor Suppressor in Hepatocarcinogenesis and May Act via RASSF1A

Doris Macheiner, Christine Gauglhofer, Chantal Rodgarkia-Dara, Michael Grusch, Andreas Brachner, Christoph Bichler, Daniela Kandioler, Hedwig Sutterlüty, Wolfgang Mikulits, Rolf Schulte-Hermann, and Bettina Grasl-Kraupp
Cancer Res 2009 69: 235-242. doi: 10.1158/0008-5472.CAN-08-2144 [Abstract] [Full Text] [PDF]  

Quantitative Analysis of DNA Methylation Profiles in Lung Cancer Identifies Aberrant DNA Methylation of Specific Genes and Its Association with Gender and Cancer Risk Factors

Thomas Vaissière, Rayjean J. Hung, David Zaridze, Anush Moukeria, Cyrille Cuenin, Virginie Fasolo, Gilles Ferro, Anupam Paliwal, Pierre Hainaut, Paul Brennan, Jörg Tost, Paolo Boffetta, and Zdenko Herceg
Cancer Res 2009 69: 243-252. doi: 10.1158/0008-5472.CAN-08-2489 [Abstract] [Full Text] [PDF] Supplementary Data  

Role of Cyclin D1 as a Mediator of c-Met– and β-Catenin–Induced Hepatocarcinogenesis

Mohini A. Patil, Susie A. Lee, Everardo Macias, Ernest T. Lam, Chuanrui Xu, Kirk D. Jones, Coral Ho, Marcelo Rodriguez-Puebla, and Xin Chen
Cancer Res 2009 69: 253-261. doi: 10.1158/0008-5472.CAN-08-2514 [Abstract] [Full Text] [PDF] Supplementary Data  

Consistent Up-regulation of Stat3 Independently of Jak2 Mutations in a New Murine Model of Essential Thrombocythemia

Vitalyi Senyuk, Ciro Roberto Rinaldi, Donglan Li, Francesca Cattaneo, Aleksandra Stojanovic, Fabrizio Pane, Xiaoping Du, Nadim Mahmud, Jerome Dickstein, and Giuseppina Nucifora
Cancer Res 2009 69: 262-271. doi: 10.1158/0008-5472.CAN-08-2534 [Abstract] [Full Text] [PDF]  

Cyclin-Dependent Kinase-3–Mediated c-Jun Phosphorylation at Ser63 and Ser73 Enhances Cell Transformation

Yong-Yeon Cho, Faqing Tang, Ke Yao, Chengrong Lu, Feng Zhu, Duo Zheng, Angelo Pugliese, Ann M. Bode, and Zigang Dong
Cancer Res 2009 69: 272-281. doi: 10.1158/0008-5472.CAN-08-3125 [Abstract] [Full Text] [PDF] Supplementary Data  

A Multifactorial Signature of DNA Sequence and Polycomb Binding Predicts Aberrant CpG Island Methylation

Michael T. McCabe, Eva K. Lee, and Paula M. Vertino
Cancer Res 2009 69: 282-291. doi: 10.1158/0008-5472.CAN-08-3274 [Abstract] [Full Text] [PDF] Supplementary Data  

High Frequency of LMAN1 Abnormalities in Colorectal Tumors with Microsatellite Instability

Nina Roeckel, Stefan M. Woerner, Matthias Kloor, Yan-Ping Yuan, Georgios Patsos, Roland Gromes, Juergen Kopitz, and Johannes Gebert
Cancer Res 2009 69: 292-299. doi: 10.1158/0008-5472.CAN-08-3314 [Abstract] [Full Text] [PDF] Supplementary Data  

Systems Biology and Emerging Technologies:

Identification of Novel Alternative Splice Isoforms of Circulating Proteins in a Mouse Model of Human Pancreatic Cancer

Rajasree Menon, Qing Zhang, Yan Zhang, Damian Fermin, Nabeel Bardeesy, Ronald A. DePinho, Chunxia Lu, Samir M. Hanash, Gilbert S. Omenn, and David J. States
Cancer Res 2009 69: 300-309. doi: 10.1158/0008-5472.CAN-08-2145 [Abstract] [Full Text] [PDF] Supplementary Data  

The Origins of Breast Cancer Prognostic Gene Expression Profiles

Luanne Lukes, Nigel P.S. Crawford, Renard Walker, and Kent W. Hunter
Cancer Res 2009 69: 310-318. doi: 10.1158/0008-5472.CAN-08-3520 [Abstract] [Full Text] [PDF] Supplementary Data  

Tumor Microenvironment:

Inducible Cutaneous Inflammation Reveals a Protumorigenic Role for Keratinocyte CXCR2 in Skin Carcinogenesis

Christophe Cataisson, Rebecca Ohman, Gopal Patel, Andrea Pearson, Margaret Tsien, Steve Jay, Lisa Wright, Henry Hennings, and Stuart H. Yuspa
Cancer Res 2009 69: 319-328. doi: 10.1158/0008-5472.CAN-08-2490 [Abstract] [Full Text] [PDF] Supplementary Data  

Interleukin-6 in the Bone Marrow Microenvironment Promotes the Growth and Survival of Neuroblastoma Cells

Tasnim Ara, Liping Song, Hiroyuki Shimada, Nino Keshelava, Heidi V. Russell, Leonid S. Metelitsa, Susan G. Groshen, Robert C. Seeger, and Yves A. DeClerck
Cancer Res 2009 69: 329-337. doi: 10.1158/0008-5472.CAN-08-0613 [Abstract] [Full Text] [PDF] Supplementary Data  

Low Levels of Tumor Necrosis Factor Increase Tumor Growth by Inducing an Endothelial Phenotype of Monocytes Recruited to the Tumor Site

Bin Li, Alicia Vincent, Justin Cates, Dana M. Brantley-Sieders, D. Brent Polk, and Pampee P. Young
Cancer Res 2009 69: 338-348. doi: 10.1158/0008-5472.CAN-08-1565 [Abstract] [Full Text] [PDF] Supplementary Data  

Vascular Endothelial Growth Factor-C and C-C Chemokine Receptor 7 in Tumor Cell–Lymphatic Cross-talk Promote Invasive Phenotype

Amine Issa, Thomas X. Le, Alexander N. Shoushtari, Jacqueline D. Shields, and Melody A. Swartz
Cancer Res 2009 69: 349-357. doi: 10.1158/0008-5472.CAN-08-1875 [Abstract] [Full Text] [PDF] Supplementary Data  

Hypoxia-Inducible Carbonic Anhydrase IX and XII Promote Tumor Cell Growth by Counteracting Acidosis through the Regulation of the Intracellular pH

Johanna Chiche, Karine Ilc, Julie Laferrière, Eric Trottier, Frédéric Dayan, Nathalie M. Mazure, M. Christiane Brahimi-Horn, and Jacques Pouysségur
Cancer Res 2009 69: 358-368. doi: 10.1158/0008-5472.CAN-08-2470 [Abstract] [Full Text] [PDF] Supplementary Data  

Paracrine Signaling by Platelet-Derived Growth Factor-CC Promotes Tumor Growth by Recruitment of Cancer-Associated Fibroblasts

Charlotte Anderberg, Hong Li, Linda Fredriksson, Johanna Andrae, Christer Betsholtz, Xuri Li, Ulf Eriksson, and Kristian Pietras
Cancer Res 2009 69: 369-378. doi: 10.1158/0008-5472.CAN-08-2724 [Abstract] [Full Text] [PDF]  

Letters to the Editor:

Comment re: Cancer Incidence Falls for Oldest

Tengiz Mdzinarishvili, Michael X. Gleason, and Simon Sherman
Cancer Res 2009 69: 379. doi: 10.1158/0008-5472.CAN-08-2973 [Full Text] [PDF]  

Comment re: Cancer Incidence Falls for Oldest

Charles Harding, Francesco Pompei, Ellen E. Lee, and Richard Wilson
Cancer Res 2009 69: 379. doi: 10.1158/0008-5472.CAN-08-3577 [Full Text] [PDF]  

Corrections:

Correction: Article on HPV Acquisition and Clearance

Cancer Res 2009 69: 381. doi: 10.1158/0008-5472.CAN-69-1-COR1 [Full Text] [PDF]  

Correction: Article on Lysosomal Cathepsin B Functions in Podosome

Cancer Res 2009 69: 381. doi: 10.1158/0008-5472.CAN-69-1-COR2 [Full Text] [PDF]  

Correction: Article on HGF Induces Gefitinib Resistance

Cancer Res 2009 69: 381. doi: 10.1158/0008-5472.CAN-69-1-COR3 [Full Text] [PDF]  

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