Reviews:

Cell Cycle Regulation by MicroRNAs in Embryonic Stem Cells

Yangming Wang and Robert Blelloch
Cancer Res 2009 69: 4093-4096. Published Online First May 12, 2009. doi: 10.1158/0008-5472.CAN-09-0309 [Abstract] [Full Text] [PDF]  

A Three-Dimensional Osteogenic Tissue Model for the Study of Metastatic Tumor Cell Interactions with Bone

Andrea M. Mastro and Erwin A. Vogler
Cancer Res 2009 69: 4097-4100. Published Online First May 12, 2009. doi: 10.1158/0008-5472.CAN-08-4437 [Abstract] [Full Text] [PDF]  

Priority Reports:

A Genetic Screen Identifies Topoisomerase 1 as a Regulator of Senescence

Nicolas Humbert, Sébastien Martien, Arnaud Augert, Marco Da Costa, Sébastien Mauen, Corinne Abbadie, Yvan de Launoit, Jesús Gil, and David Bernard
Cancer Res 2009 69: 4101-4106. Published Online First May 12, 2009. doi: 10.1158/0008-5472.CAN-08-2864 [Abstract] [Full Text] [PDF] Supplementary Data  

RIP1 Activates PI3K-Akt via a Dual Mechanism Involving NF-B–Mediated Inhibition of the mTOR-S6K-IRS1 Negative Feedback Loop and Down-regulation of PTEN

Seongmi Park, Dawen Zhao, Kimmo J. Hatanpaa, Bruce E. Mickey, Debabrata Saha, David A. Boothman, Michael D. Story, Eric T. Wong, Sandeep Burma, Maria-Magdalena Georgescu, Vivek M. Rangnekar, Sandili S. Chauncey, and Amyn A. Habib
Cancer Res 2009 69: 4107-4111. Published Online First May 12, 2009. doi: 10.1158/0008-5472.CAN-09-0474 [Abstract] [Full Text] [PDF] Supplementary Data  

A Multicenter, Double-Blinded Validation Study of Methylation Biomarkers for Progression Prediction in Barrett's Esophagus

Zhe Jin, Yulan Cheng, Wen Gu, Yingye Zheng, Fumiaki Sato, Yuriko Mori, Alexandru V. Olaru, Bogdan C. Paun, Jian Yang, Takatsugu Kan, Tetsuo Ito, James P. Hamilton, Florin M. Selaru, Rachana Agarwal, Stefan David, John M. Abraham, Herbert C. Wolfsen, Michael B. Wallace, Nicholas J. Shaheen, Kay Washington, Jean Wang, Marcia Irene Canto, Achyut Bhattacharyya, Mark A. Nelson, Paul D. Wagner, Yvonne Romero, Kenneth K. Wang, Ziding Feng, Richard E. Sampliner, and Stephen J. Meltzer
Cancer Res 2009 69: 4112-4115. Published Online First May 12, 2009. doi: 10.1158/0008-5472.CAN-09-0028 [Abstract] [Full Text] [PDF] Supplementary Data  

Cell, Tumor, and Stem Cell Biology:

Characterization of a Naturally Occurring Breast Cancer Subset Enriched in Epithelial-to-Mesenchymal Transition and Stem Cell Characteristics

Bryan T. Hennessy, Ana-Maria Gonzalez-Angulo, Katherine Stemke-Hale, Michael Z. Gilcrease, Savitri Krishnamurthy, Ju-Seog Lee, Jane Fridlyand, Aysegul Sahin, Roshan Agarwal, Corwin Joy, Wenbin Liu, David Stivers, Keith Baggerly, Mark Carey, Ana Lluch, Carlos Monteagudo, Xiaping He, Victor Weigman, Cheng Fan, Juan Palazzo, Gabriel N. Hortobagyi, Laura K. Nolden, Nicholas J. Wang, Vicente Valero, Joe W. Gray, Charles M. Perou, and Gordon B. Mills
Cancer Res 2009 69: 4116-4124. Published Online First May 12, 2009. doi: 10.1158/0008-5472.CAN-08-3441 [Abstract] [Full Text] [PDF] Supplementary Data  

Haploinsufficiency of Krüppel-Like Factor 5 Rescues the Tumor-Initiating Effect of the Apc^Min Mutation in the Intestine

Beth B. McConnell, Agnieszka B. Bialkowska, Mandayam O. Nandan, Amr M. Ghaleb, Frank J. Gordon, and Vincent W. Yang
Cancer Res 2009 69: 4125-4133. Published Online First May 12, 2009. doi: 10.1158/0008-5472.CAN-08-4402 [Abstract] [Full Text] [PDF] Supplementary Data  

Mesenchymal Stem Cell Delivery of TRAIL Can Eliminate Metastatic Cancer

Michael R. Loebinger, Ayad Eddaoudi, Derek Davies, and Sam M. Janes
Cancer Res 2009 69: 4134-4142. Published Online First May 12, 2009. doi: 10.1158/0008-5472.CAN-08-4698 [Abstract] [Full Text] [PDF] Supplementary Data  

Comparison of Primary Neuroblastoma Tumors and Derivative Early-Passage Cell Lines Using Genome-Wide Single Nucleotide Polymorphism Array Analysis

Samuel L. Volchenboum, Cheng Li, Shuli Li, Edward F. Attiyeh, C. Patrick Reynolds, John M. Maris, A. Thomas Look, and Rani E. George
Cancer Res 2009 69: 4143-4149. Published Online First May 12, 2009. doi: 10.1158/0008-5472.CAN-08-3112 [Abstract] [Full Text] [PDF] Supplementary Data  

AZD1152 Rapidly and Negatively Affects the Growth and Survival of Human Acute Myeloid Leukemia Cells In vitro and In vivo

Adedayo Oke, Daniel Pearce, Robert W. Wilkinson, Claire Crafter, Rajesh Odedra, Jamie Cavenagh, Jude Fitzgibbon, Andrew T. Lister, Simon Joel, and Dominique Bonnet
Cancer Res 2009 69: 4150-4158. Published Online First April 14, 2009. doi: 10.1158/0008-5472.CAN-08-3203 [Abstract] [Full Text] [PDF] Supplementary Data  

Rapamycin Prevents Early Onset of Tumorigenesis in an Oral-Specific K-ras and p53 Two-Hit Carcinogenesis Model

Ana R. Raimondi, Alfredo Molinolo, and J. Silvio Gutkind
Cancer Res 2009 69: 4159-4166. Published Online First May 12, 2009. doi: 10.1158/0008-5472.CAN-08-4645 [Abstract] [Full Text] [PDF] Supplementary Data  

The Mechanical Rigidity of the Extracellular Matrix Regulates the Structure, Motility, and Proliferation of Glioma Cells

Theresa A. Ulrich, Elena M. de Juan Pardo, and Sanjay Kumar
Cancer Res 2009 69: 4167-4174. Published Online First May 12, 2009. doi: 10.1158/0008-5472.CAN-08-4859 [Abstract] [Full Text] [PDF] Supplementary Data  

Clinical Research:

Lack of T-Cell Receptor–Induced Signaling Is Crucial for CD95 Ligand Up-regulation and Protects Cutaneous T-Cell Lymphoma Cells from Activation-Induced Cell Death

Claus-Detlev Klemke, Dirk Brenner, Eva-Maria Weiβ, Marc Schmidt, Martin Leverkus, Karsten Gülow, and Peter H. Krammer
Cancer Res 2009 69: 4175-4183. Published Online First May 12, 2009. doi: 10.1158/0008-5472.CAN-08-4631 [Abstract] [Full Text] [PDF] Supplementary Data  

Host Genetic Variants in the Interleukin-6 Promoter Predict Poor Outcome in Patients with Estrogen Receptor-Positive, Node-Positive Breast Cancer

Angela DeMichele, Robert Gray, Michelle Horn, Jinbo Chen, Richard Aplenc, William P. Vaughan, and Martin S. Tallman
Cancer Res 2009 69: 4184-4191. Published Online First May 12, 2009. doi: 10.1158/0008-5472.CAN-08-2989 [Abstract] [Full Text] [PDF] Supplementary Data  

Endocrinology:

Loss of Phosphatase and Tensin Homologue Deleted on Chromosome 10 Engages ErbB3 and Insulin-Like Growth Factor-I Receptor Signaling to Promote Antiestrogen Resistance in Breast Cancer

Todd W. Miller, Marianela Pérez-Torres, Archana Narasanna, Marta Guix, Olle Stål, Gizeh Pérez-Tenorio, Ana M. Gonzalez-Angulo, Bryan T. Hennessy, Gordon B. Mills, J. Phillip Kennedy, Craig W. Lindsley, and Carlos L. Arteaga
Cancer Res 2009 69: 4192-4201. Published Online First May 12, 2009. doi: 10.1158/0008-5472.CAN-09-0042 [Abstract] [Full Text] [PDF] Supplementary Data  

Gonadotropin-Releasing Hormone Type II Induces Apoptosis of Human Endometrial Cancer Cells by Activating GADD45

Hsien-Ming Wu, Jung-Chien Cheng, Hsin-Shih Wang, Hong-Yuan Huang, Colin D. MacCalman, and Peter C.K. Leung
Cancer Res 2009 69: 4202-4208. Published Online First April 14, 2009. doi: 10.1158/0008-5472.CAN-08-4591 [Abstract] [Full Text] [PDF]  

Heregulin Regulates Prolactinoma Gene Expression

George Vlotides, Odelia Cooper, Yen-Hao Chen, Song-Guang Ren, Yona Greenman, and Shlomo Melmed
Cancer Res 2009 69: 4209-4216. Published Online First April 28, 2009. doi: 10.1158/0008-5472.CAN-08-4934 [Abstract] [Full Text] [PDF] Supplementary Data  

Epidemiology:

Genetic Variation in B-Cell–Activating Factor Is Associated with an Increased Risk of Developing B-Cell Non–Hodgkin Lymphoma

Anne J. Novak, Susan L. Slager, Zachary S. Fredericksen, Alice H. Wang, Michelle M. Manske, Steven Ziesmer, Mark Liebow, William R. Macon, Stacey R. Dillon, Thomas E. Witzig, James R. Cerhan, and Stephen M. Ansell
Cancer Res 2009 69: 4217-4224. Published Online First April 21, 2009. doi: 10.1158/0008-5472.CAN-08-4915 [Abstract] [Full Text] [PDF]  

Experimental Therapeutics, Molecular Targets, and Chemical Biology:

Chemical Genomics Identifies the Unfolded Protein Response as a Target for Selective Cancer Cell Killing during Glucose Deprivation

Sakae Saito, Aki Furuno, Junko Sakurai, Asami Sakamoto, Hae-Ryong Park, Kazuo Shin-ya, Takashi Tsuruo, and Akihiro Tomida
Cancer Res 2009 69: 4225-4234. Published Online First May 12, 2009. doi: 10.1158/0008-5472.CAN-08-2689 [Abstract] [Full Text] [PDF] Supplementary Data  

Proteasome Inhibition Potentiates Antitumor Effects of Photodynamic Therapy in Mice through Induction of Endoplasmic Reticulum Stress and Unfolded Protein Response

Angelika Szokalska, Marcin Makowski, Dominika Nowis, Grzegorz M. Wilczynski, Marek Kujawa, Cezary Wójcik, Izabela Mlynarczuk-Bialy, Pawel Salwa, Jacek Bil, Sylwia Janowska, Patrizia Agostinis, Tom Verfaillie, Marek Bugajski, Jan Gietka, Tadeusz Issat, Eliza Glodkowska, Piotr Mrówka, Tomasz Stoklosa, Michael R. Hamblin, Pawel Mróz, Marek Jakóbisiak, and Jakub Golab
Cancer Res 2009 69: 4235-4243. Published Online First May 12, 2009. doi: 10.1158/0008-5472.CAN-08-3439 [Abstract] [Full Text] [PDF] HTML Page - index.htslpSupplementary Data  

RLIP76: A Target for Kidney Cancer Therapy

Sharad S. Singhal, Jyotsana Singhal, Sushma Yadav, Mukesh Sahu, Yogesh C. Awasthi, and Sanjay Awasthi
Cancer Res 2009 69: 4244-4251. Published Online First May 5, 2009. doi: 10.1158/0008-5472.CAN-08-3521 [Abstract] [Full Text] [PDF] Supplementary Data  

EGFRvIII and DNA Double-Strand Break Repair: A Molecular Mechanism for Radioresistance in Glioblastoma

Bipasha Mukherjee, Brian McEllin, Cristel V. Camacho, Nozomi Tomimatsu, Shyam Sirasanagandala, Suraj Nannepaga, Kimmo J. Hatanpaa, Bruce Mickey, Christopher Madden, Elizabeth Maher, David A. Boothman, Frank Furnari, Webster K. Cavenee, Robert M. Bachoo, and Sandeep Burma
Cancer Res 2009 69: 4252-4259. Published Online First May 12, 2009. doi: 10.1158/0008-5472.CAN-08-4853 [Abstract] [Full Text] [PDF]  

Epithelial-to-Mesenchymal Transition and Resistance to Ingenol 3-Angelate, a Novel Protein Kinase C Modulator, in Colon Cancer Cells

Aïda Ghoul, Maria Serova, Lucile Astorgues-Xerri, Ivan Bieche, Guilhem Bousquet, Mariana Varna, Michel Vidaud, Edelmira Phillips, Sophie Weill, Karim A. Benhadji, François Lokiec, Esteban Cvitkovic, Sandrine Faivre, and Eric Raymond
Cancer Res 2009 69: 4260-4269. Published Online First May 5, 2009. doi: 10.1158/0008-5472.CAN-08-2837 [Abstract] [Full Text] [PDF] Supplementary Data  

The Trifunctional Antibody Ertumaxomab Destroys Tumor Cells That Express Low Levels of Human Epidermal Growth Factor Receptor 2

Michael Jäger, Alexandra Schoberth, Peter Ruf, Jürgen Hess, and Horst Lindhofer
Cancer Res 2009 69: 4270-4276. Published Online First May 12, 2009. doi: 10.1158/0008-5472.CAN-08-2861 [Abstract] [Full Text] [PDF]  

A New Class of Quinoline-Based DNA Hypomethylating Agents Reactivates Tumor Suppressor Genes by Blocking DNA Methyltransferase 1 Activity and Inducing Its Degradation

Jharna Datta, Kalpana Ghoshal, William A. Denny, Swarna A. Gamage, Darby G. Brooke, Pasit Phiasivongsa, Sanjeev Redkar, and Samson T. Jacob
Cancer Res 2009 69: 4277-4285. Published Online First May 5, 2009. doi: 10.1158/0008-5472.CAN-08-3669 [Abstract] [Full Text] [PDF] Supplementary Data  

PI3K Pathway Activation Mediates Resistance to MEK Inhibitors in KRAS Mutant Cancers

Susan Wee, Zainab Jagani, Kay Xiaoqin Xiang, Alice Loo, Marion Dorsch, Yung-Mae Yao, William R. Sellers, Christoph Lengauer, and Frank Stegmeier
Cancer Res 2009 69: 4286-4293. Published Online First April 28, 2009. doi: 10.1158/0008-5472.CAN-08-4765 [Abstract] [Full Text] [PDF] Supplementary Data  

Enhancing the Antitumor Activity of Adriamycin and Ionizing Radiation

Wenqing Sun, Amanda L. Kalen, Brian J. Smith, Joseph J. Cullen, and Larry W. Oberley
Cancer Res 2009 69: 4294-4300. Published Online First April 28, 2009. doi: 10.1158/0008-5472.CAN-09-0396 [Abstract] [Full Text] [PDF]  

Immunology:

Regulation of Secondary Antigen-Specific CD8⁺ T-Cell Responses by Natural Killer T Cells

Changwan Hong, Hyunji Lee, Yoon-Kyung Park, Junghoon Shin, Sundo Jung, Hoyeon Kim, Seokmann Hong, and Se-Ho Park
Cancer Res 2009 69: 4301-4308. Published Online First April 28, 2009. doi: 10.1158/0008-5472.CAN-08-1721 [Abstract] [Full Text] [PDF] Supplementary Data  

Cyclophosphamide Augments Antitumor Immunity: Studies in an Autochthonous Prostate Cancer Model

Satoshi Wada, Kiyoshi Yoshimura, Edward L. Hipkiss, Tim J. Harris, Hung-Rong Yen, Monica V. Goldberg, Joseph F. Grosso, Derese Getnet, Angelo M. Demarzo, George J. Netto, Robert Anders, Drew M. Pardoll, and Charles G. Drake
Cancer Res 2009 69: 4309-4318. Published Online First May 12, 2009. doi: 10.1158/0008-5472.CAN-08-4102 [Abstract] [Full Text] [PDF] Supplementary Data  

Costimulation as a Platform for the Development of Vaccines: A Peptide-Based Vaccine Containing a Novel Form of 4-1BB Ligand Eradicates Established Tumors

Rajesh K. Sharma, Kutlu G. Elpek, Esma S. Yolcu, Rich-Henry Schabowsky, Hong Zhao, Laura Bandura-Morgan, and Haval Shirwan
Cancer Res 2009 69: 4319-4326. Published Online First May 12, 2009. doi: 10.1158/0008-5472.CAN-08-3141 [Abstract] [Full Text] [PDF] Supplementary Data  

Intracellular Bacterial Vectors That Induce CD8⁺ T Cells with Similar Cytolytic Abilities but Disparate Memory Phenotypes Provide Contrasting Tumor Protection

Felicity C. Stark, Subash Sad, and Lakshmi Krishnan
Cancer Res 2009 69: 4327-4334. Published Online First May 12, 2009. doi: 10.1158/0008-5472.CAN-08-3160 [Abstract] [Full Text] [PDF] Supplementary Data  

The CD4⁺ T-Cell Response of Melanoma Patients to a MAGE-A3 Peptide Vaccine Involves Potential Regulatory T Cells

Violaine François, Sabrina Ottaviani, Nicolina Renkvist, Julie Stockis, Gerold Schuler, Kris Thielemans, Didier Colau, Marie Marchand, Thierry Boon, Sophie Lucas, and Pierre van der Bruggen
Cancer Res 2009 69: 4335-4345. Published Online First May 12, 2009. doi: 10.1158/0008-5472.CAN-08-3726 [Abstract] [Full Text] [PDF] Supplementary Data  

Cancer Vaccine Enhanced, Non–Tumor-Reactive CD8⁺ T Cells Exhibit a Distinct Molecular Program Associated with "Division Arrest Anergy"

Marc Beyer, Julia Karbach, Michael R. Mallmann, Thomas Zander, Daniela Eggle, Sabine Classen, Svenja Debey-Pascher, Michael Famulok, Elke Jäger, and Joachim L. Schultze
Cancer Res 2009 69: 4346-4354. Published Online First May 12, 2009. doi: 10.1158/0008-5472.CAN-08-3796 [Abstract] [Full Text] [PDF] Supplementary Data  

From Chronic Feed-Induced Intestinal Inflammation to Adenocarcinoma with Metastases in Salmonid Fish

Ole B. Dale, Brit Tørud, Agnar Kvellestad, Hanna S. Koppang, and Erling O. Koppang
Cancer Res 2009 69: 4355-4362. Published Online First May 5, 2009. doi: 10.1158/0008-5472.CAN-08-4877 [Abstract] [Full Text] [PDF] Supplementary Data  

Molecular Biology, Pathobiology, and Genetics:

Ewing Sarcoma Fusion Protein EWSR1/FLI1 Interacts with EWSR1 Leading to Mitotic Defects in Zebrafish Embryos and Human Cell Lines

Lisa J. Embree, Mizuki Azuma, and Dennis D. Hickstein
Cancer Res 2009 69: 4363-4371. Published Online First May 5, 2009. doi: 10.1158/0008-5472.CAN-08-3229 [Abstract] [Full Text] [PDF] Supplementary Data  

Role of MUTYH and MSH2 in the Control of Oxidative DNA Damage, Genetic Instability, and Tumorigenesis

Maria Teresa Russo, Gabriele De Luca, Ida Casorelli, Paolo Degan, Sara Molatore, Flavia Barone, Filomena Mazzei, Tania Pannellini, Piero Musiani, and Margherita Bignami
Cancer Res 2009 69: 4372-4379. Published Online First May 12, 2009. doi: 10.1158/0008-5472.CAN-08-3292 [Abstract] [Full Text] [PDF] Supplementary Data  

Loss of the SMRT/NCoR2 Corepressor Correlates with JAG2 Overexpression in Multiple Myeloma

Pushpankur Ghoshal, Alain J. Nganga, Joseph Moran-Giuati, Angela Szafranek, Timothy R. Johnson, Ashley J. Bigelow, Christiane M. Houde, Herve Avet-Loiseau, Dominic J. Smiraglia, Noreen Ersing, Asher A. Chanan-Khan, and Lionel J. Coignet
Cancer Res 2009 69: 4380-4387. Published Online First May 5, 2009. doi: 10.1158/0008-5472.CAN-08-3467 [Abstract] [Full Text] [PDF]  

Identification of PDE4D as a Proliferation Promoting Factor in Prostate Cancer Using a Sleeping Beauty Transposon-Based Somatic Mutagenesis Screen

Eric P. Rahrmann, Lara S. Collier, Todd P. Knutson, Meghan E. Doyal, Sheri L. Kuslak, Laura E. Green, Rita L. Malinowski, Laura Roethe, Keiko Akagi, Michelle Waknitz, Wei Huang, David A. Largaespada, and Paul C. Marker
Cancer Res 2009 69: 4388-4397. Published Online First April 28, 2009. doi: 10.1158/0008-5472.CAN-08-3901 [Abstract] [Full Text] [PDF] Supplementary Data  

A Regulatory Mechanism for RSK2 NH₂-Terminal Kinase Activity

Yong-Yeon Cho, Ke Yao, Angelo Pugliese, Margarita L. Malakhova, Ann M. Bode, and Zigang Dong
Cancer Res 2009 69: 4398-4406. Published Online First May 12, 2009. doi: 10.1158/0008-5472.CAN-08-4959 [Abstract] [Full Text] [PDF] Supplementary Data  

Persistence of High-Grade Cervical Dysplasia and Cervical Cancer Requires the Continuous Expression of the Human Papillomavirus Type 16 E7 Oncogene

Sean F. Jabbar, Linda Abrams, Adam Glick, and Paul F. Lambert
Cancer Res 2009 69: 4407-4414. Published Online First May 12, 2009. doi: 10.1158/0008-5472.CAN-09-0023 [Abstract] [Full Text] [PDF] Supplementary Data  

The Role of ATF4 Stabilization and Autophagy in Resistance of Breast Cancer Cells Treated with Bortezomib

Manuela Milani, Tomasz Rzymski, Howard R. Mellor, Luke Pike, Alberto Bottini, Daniele Generali, and Adrian L. Harris
Cancer Res 2009 69: 4415-4423. Published Online First May 5, 2009. doi: 10.1158/0008-5472.CAN-08-2839 [Abstract] [Full Text] [PDF] Supplementary Data  

Association between Transcriptional Activity, Local Chromatin Structure, and the Efficiencies of Both Subpathways of Nucleotide Excision Repair of Melphalan Adducts

Hara Episkopou, Soterios A. Kyrtopoulos, Petros P. Sfikakis, Maria Fousteri, Meletios A. Dimopoulos, Leon H.F. Mullenders, and Vassilis L. Souliotis
Cancer Res 2009 69: 4424-4433. Published Online First May 5, 2009. doi: 10.1158/0008-5472.CAN-08-3489 [Abstract] [Full Text] [PDF]  

Treatment-Dependent Androgen Receptor Mutations in Prostate Cancer Exploit Multiple Mechanisms to Evade Therapy

Mara P. Steinkamp, Orla A. O'Mahony, Michele Brogley, Haniya Rehman, Elizabeth W. LaPensee, Saravana Dhanasekaran, Matthias D. Hofer, Rainer Kuefer, Arul Chinnaiyan, Mark A. Rubin, Kenneth J. Pienta, and Diane M. Robins
Cancer Res 2009 69: 4434-4442. Published Online First April 14, 2009. doi: 10.1158/0008-5472.CAN-08-3605 [Abstract] [Full Text] [PDF] Supplementary Data  

Epigenetic Silencing of the Tumor Suppressor MicroRNA Hsa-miR-124a Regulates CDK6 Expression and Confers a Poor Prognosis in Acute Lymphoblastic Leukemia

Xabier Agirre, Amaia Vilas-Zornoza, Antonio Jiménez-Velasco, José Ignacio Martin-Subero, Lucia Cordeu, Leire Gárate, Edurne San José-Eneriz, Gloria Abizanda, Paula Rodríguez-Otero, Puri Fortes, José Rifón, Eva Bandrés, María José Calasanz, Vanesa Martín, Anabel Heiniger, Antonio Torres, Reiner Siebert, José Román-Gomez, and Felipe Prósper
Cancer Res 2009 69: 4443-4453. Published Online First May 12, 2009. doi: 10.1158/0008-5472.CAN-08-4025 [Abstract] [Full Text] [PDF] Supplementary Data  

Complex Oncogenic Translocations with Gene Amplification Are Initiated by Specific DNA Breaks in Lymphocytes

Sarah M. Wright, Yong H. Woo, Travis L. Alley, Bobbi-Jo Shirley, Ellen C. Akeson, Kathy J. Snow, Sarah A. Maas, Rachel L. Elwell, Oded Foreman, and Kevin D. Mills
Cancer Res 2009 69: 4454-4460. Published Online First May 12, 2009. doi: 10.1158/0008-5472.CAN-08-4515 [Abstract] [Full Text] [PDF] Supplementary Data  

Endoplasmic Reticulum Stress Triggers XBP-1–Mediated Up-regulation of an EBV Oncoprotein in Nasopharyngeal Carcinoma

Jenn-Ren Hsiao, Kung-Chao Chang, Chaio-Wei Chen, Shih-Yi Wu, Ih-Jen Su, Mei-Chi Hsu, Ying-Tai Jin, Sen-Tien Tsai, Kenzo Takada, and Yao Chang
Cancer Res 2009 69: 4461-4467. Published Online First May 12, 2009. doi: 10.1158/0008-5472.CAN-09-0277 [Abstract] [Full Text] [PDF] Supplementary Data  

Prevention:

3,3'-Diindolylmethane Enhances Taxotere-Induced Apoptosis in Hormone-Refractory Prostate Cancer Cells through Survivin Down-regulation

KM Wahidur Rahman, Sanjeev Banerjee, Shadan Ali, Aamir Ahmad, Zhiwei Wang, Dejuan Kong, and Wael A. Sakr
Cancer Res 2009 69: 4468-4475. Published Online First May 12, 2009. doi: 10.1158/0008-5472.CAN-08-4423 [Abstract] [Full Text] [PDF]  

Association between Rectal Optical Signatures and Colonic Neoplasia: Potential Applications for Screening

Hemant K. Roy, Vladimir Turzhitsky, Young Kim, Michael J. Goldberg, Patrice Watson, Jeremy D. Rogers, Andrew J. Gomes, Alexey Kromine, Randall E. Brand, Mohammed Jameel, Andrej Bogovejic, Prabhakar Pradhan, and Vadim Backman
Cancer Res 2009 69: 4476-4483. Published Online First May 5, 2009. doi: 10.1158/0008-5472.CAN-08-4780 [Abstract] [Full Text] [PDF]  

Mathematical Oncology:

Prediction of Drug Response in Breast Cancer Using Integrative Experimental/Computational Modeling

Hermann B. Frieboes, Mary E. Edgerton, John P. Fruehauf, Felicity R.A.J. Rose, Lisa K. Worrall, Robert A. Gatenby, Mauro Ferrari, and Vittorio Cristini
Cancer Res 2009 69: 4484-4492. Published Online First April 14, 2009. doi: 10.1158/0008-5472.CAN-08-3740 [Abstract] [Full Text] [PDF]  

Multiparameter Computational Modeling of Tumor Invasion

Elaine L. Bearer, John S. Lowengrub, Hermann B. Frieboes, Yao-Li Chuang, Fang Jin, Steven M. Wise, Mauro Ferrari, David B. Agus, and Vittorio Cristini
Cancer Res 2009 69: 4493-4501. Published Online First April 14, 2009. doi: 10.1158/0008-5472.CAN-08-3834 [Abstract] [Full Text] [PDF] Supplementary Data  

Quantitative Metrics of Net Proliferation and Invasion Link Biological Aggressiveness Assessed by MRI with Hypoxia Assessed by FMISO-PET in Newly Diagnosed Glioblastomas

Mindy D. Szeto, Gargi Chakraborty, Jennifer Hadley, Russ Rockne, Mark Muzi, Ellsworth C. Alvord, Jr., Kenneth A. Krohn, Alexander M. Spence, and Kristin R. Swanson
Cancer Res 2009 69: 4502-4509. Published Online First April 14, 2009. doi: 10.1158/0008-5472.CAN-08-3884 [Abstract] [Full Text] [PDF]  

Systems Biology and Emerging Technologies:

A Novel Technology for the Imaging of Acidic Prostate Tumors by Positron Emission Tomography

Amy L. Vavere, Gráinne B. Biddlecombe, William M. Spees, Joel R. Garbow, Dayanjali Wijesinghe, Oleg A. Andreev, Donald M. Engelman, Yana K. Reshetnyak, and Jason S. Lewis
Cancer Res 2009 69: 4510-4516. Published Online First May 5, 2009. doi: 10.1158/0008-5472.CAN-08-3781 [Abstract] [Full Text] [PDF]  

Tumor Microenvironment:

Up-regulation of L1CAM in Pancreatic Duct Cells Is Transforming Growth Factor β1– and Slug-Dependent: Role in Malignant Transformation of Pancreatic Cancer

Claudia Geismann, Mascha Morscheck, Dorothee Koch, Frank Bergmann, Hendrik Ungefroren, Alexander Arlt, Ming-Sound Tsao, Max G. Bachem, Peter Altevogt, Bence Sipos, Ulrich R. Fölsch, Heiner Schäfer, and Susanne Sebens Müerköster
Cancer Res 2009 69: 4517-4526. Published Online First May 12, 2009. doi: 10.1158/0008-5472.CAN-08-3493 [Abstract] [Full Text] [PDF] Supplementary Data  

Cellular Source and Amount of Vascular Endothelial Growth Factor and Platelet-Derived Growth Factor in Tumors Determine Response to Angiogenesis Inhibitors

Barbara Sennino, Frank Kuhnert, Sebastien P. Tabruyn, Michael R. Mancuso, Dana D. Hu-Lowe, Calvin J. Kuo, and Donald M. McDonald
Cancer Res 2009 69: 4527-4536. Published Online First April 28, 2009. doi: 10.1158/0008-5472.CAN-08-3779 [Abstract] [Full Text] [PDF] Supplementary Data  

VEGF-A Induces Angiogenesis by Perturbing the Cathepsin-Cysteine Protease Inhibitor Balance in Venules, Causing Basement Membrane Degradation and Mother Vessel Formation

Sung-Hee Chang, Keizo Kanasaki, Vasilena Gocheva, Galia Blum, Jay Harper, Marsha A. Moses, Shou-Ching Shih, Janice A. Nagy, Johanna Joyce, Matthew Bogyo, Raghu Kalluri, and Harold F. Dvorak
Cancer Res 2009 69: 4537-4544. Published Online First May 12, 2009. doi: 10.1158/0008-5472.CAN-08-4539 [Abstract] [Full Text] [PDF]  

Interaction of E-cadherin and PTEN Regulates Morphogenesis and Growth Arrest in Human Mammary Epithelial Cells

Marcia V. Fournier, Jimmie E. Fata, Katherine J. Martin, Paul Yaswen, and Mina J. Bissell
Cancer Res 2009 69: 4545-4552. Published Online First May 5, 2009. doi: 10.1158/0008-5472.CAN-08-1694 [Abstract] [Full Text] [PDF] Supplementary Data  

Corrections:

Correction: Article on IRF-9/STAT2 Drives the Expression of RIG-G Gene

Cancer Res 2009 69: 4553. Published Online First May 5, 2009. doi: 10.1158/0008-5472.CAN-69-10-COR1 [Full Text] [PDF]  

Correction: Article on Vaccination Reveals a Long Dominant CTL Epitope

Cancer Res 2009 69: 4553. Published Online First May 5, 2009. doi: 10.1158/0008-5472.CAN-69-10-COR2 [Full Text] [PDF]  

Correction: Article on EphB4 Is Up-regulated in Colorectal Cancer

Cancer Res 2009 69: 4554. Published Online First May 5, 2009. doi: 10.1158/0008-5472.CAN-69-10-COR3 [Full Text] [PDF]  

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